{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:34:25Z","timestamp":1792892065958,"version":"4.5.0"},"reference-count":202,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["RO1NS117609"],"award-info":[{"award-number":["RO1NS117609"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hydrocephalus, characterized by progressive expansion of the CSF-filled ventricles (ventriculomegaly), is the most common reason for brain surgery. \u2018Communicating\u2019 (i.e. non-obstructive) hydrocephalus is classically attributed to a primary derangement in CSF homeostasis, such as choroid plexus-dependent CSF hypersecretion, impaired cilia-mediated CSF flow currents, or decreased CSF reabsorption via the arachnoid granulations or other pathways. Emerging data suggest that abnormal biomechanical properties of the brain parenchyma are an under-appreciated driver of ventriculomegaly in multiple forms of communicating hydrocephalus across the lifespan. We discuss recent evidence from human and animal studies that suggests impaired neurodevelopment in congenital hydrocephalus, neurodegeneration in elderly normal pressure hydrocephalus and, in all age groups, inflammation-related neural injury in post-infectious and post-haemorrhagic hydrocephalus, can result in loss of stiffness and viscoelasticity of the brain parenchyma. Abnormal brain biomechanics create barrier alterations at the brain\u2013CSF interface that pathologically facilitates secondary enlargement of the ventricles, even at normal or low intracranial pressures. This \u2018brain-centric\u2019 paradigm has implications for the diagnosis, treatment and study of hydrocephalus from womb to tomb.<\/jats:p>","DOI":"10.1093\/brain\/awae155","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T16:50:25Z","timestamp":1716655825000},"page":"3274-3285","source":"Crossref","is-referenced-by-count":23,"title":["Biomechanical instability of the brain\u2013CSF interface in hydrocephalus"],"prefix":"10.1093","volume":"147","author":[{"given":"Phan Q","family":"Duy","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Virginia School of Medicine , Charlottesville, VA 22908 ,","place":["USA"]},{"name":"Department of Neuroscience, University of Virginia School of Medicine , Charlottesville, VA 22908 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel H","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-7547","authenticated-orcid":false,"given":"Kristopher T","family":"Kahle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital , Boston, MA 02115 ,","place":["USA"]},{"name":"Department of Neurosurgery, Boston Children\u2019s Hospital , Boston, MA 02115 ,","place":["USA"]},{"name":"Division of Genetics and Genomics, Boston Children\u2019s Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]},{"name":"Developmental Brain and CSF Disorders Program, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Program in Neuroscience, Harvard University , Cambridge, MA 02142 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"issue":"2\u20133","key":"2024100318044715500_awae155-B1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s101430050035","article-title":"The scientific history of hydrocephalus and its treatment","volume":"22","author":"Aschoff","year":"1999","journal-title":"Neurosurg Rev"},{"key":"2024100318044715500_awae155-B2","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra2116504","article-title":"Infantile and childhood hydrocephalus","volume":"387","author":"Whitehead","year":"2022","journal-title":"N Engl J Med"},{"key":"2024100318044715500_awae155-B3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(15)60694-8","article-title":"Hydrocephalus in children","volume":"387","author":"Kahle","year":"2016","journal-title":"Lancet"},{"key":"2024100318044715500_awae155-B4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ana.25046","article-title":"Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration","volume":"82","author":"Espay","year":"2017","journal-title":"Ann Neurol"},{"key":"2024100318044715500_awae155-B5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1590\/S1980-57642009DN30100003","article-title":"Normal pressure hydrocephalus: Diagnostic and predictive evaluationon","volume":"3","author":"Damasceno","year":"2009","journal-title":"Dement Neuropsychol"},{"key":"2024100318044715500_awae155-B6","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/cns.13526","article-title":"Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus","volume":"26","author":"Wang","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"2024100318044715500_awae155-B7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-8454-5-2","article-title":"The definition and classification of hydrocephalus: A personal recommendation to stimulate debate","volume":"5","author":"Rekate","year":"2008","journal-title":"Cerebrospinal Fluid Res"},{"key":"2024100318044715500_awae155-B8","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"key":"2024100318044715500_awae155-B9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-8454-1-2","article-title":"Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species","volume":"1","author":"Johnston","year":"2004","journal-title":"Cerebrospinal Fluid Res"},{"key":"2024100318044715500_awae155-B10","first-page":"421","volume-title":"Pathophysiology of the blood-brain barrier","author":"McComb","year":"1990"},{"key":"2024100318044715500_awae155-B11","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/hmg\/ddh219","article-title":"Dysfunction of axonemal dynein heavy chain mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation","volume":"13","author":"Iba\u00f1ez-Tallon","year":"2004","journal-title":"Hum Mol Genet"},{"key":"2024100318044715500_awae155-B12","doi-asserted-by":"crossref","first-page":"105776","DOI":"10.1016\/j.nbd.2022.105776","article-title":"Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease","volume":"170","author":"Mehta","year":"2022","journal-title":"Neurobiol Dis"},{"key":"2024100318044715500_awae155-B13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/jnnp.51.1.105","article-title":"Outcome of shunt operation on urinary incontinence in normal pressure hydrocephalus predicted by lumbar puncture","volume":"51","author":"Ahlberg","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024100318044715500_awae155-B14","first-page":"4112","article-title":"Low- and negative-pressure hydrocephalus: New report of six cases and literature review","volume":"12","author":"Godoy Hurtado","year":"2023","journal-title":"J Clin Med Res"},{"key":"2024100318044715500_awae155-B15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1227\/00006123-199410000-00010","article-title":"Low-pressure hydrocephalic state and viscoelastic alterations in the brain","volume":"35","author":"Pang","year":"1994","journal-title":"Neurosurgery"},{"key":"2024100318044715500_awae155-B16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0022-510X(65)90016-X","article-title":"The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics","volume":"2","author":"Hakim","year":"1965","journal-title":"J Neurol Sci"},{"key":"2024100318044715500_awae155-B17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3171\/jns.1985.63.1.0069","article-title":"Biomechanical and hydrodynamic characterization of the hydrocephalic infant","volume":"63","author":"Shapiro","year":"1985","journal-title":"J Neurosurg"},{"key":"2024100318044715500_awae155-B18","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1016\/j.wneu.2019.08.167","article-title":"Adult outcome in shunted pediatric hydrocephalus: Long-term functional, social, and neurocognitive results","volume":"132","author":"Gmeiner","year":"2019","journal-title":"World Neurosurg"},{"key":"2024100318044715500_awae155-B19","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3171\/2021.2.PEDS20949","article-title":"Brain growth after surgical treatment for infant postinfectious hydrocephalus in sub-saharan Africa: 2-year results of a randomized trial","volume":"28","author":"Schiff","year":"2021","journal-title":"J Neurosurg Pediatr"},{"key":"2024100318044715500_awae155-B20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3171\/2021.8.PEDS21146","article-title":"Impact of ventricle size on neuropsychological outcomes in treated pediatric hydrocephalus: An HCRN prospective cohort study","volume":"29","author":"Riva-Cambrin","year":"2021","journal-title":"J Neurosurg Pediatr"},{"key":"2024100318044715500_awae155-B21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00381-021-05051-9","article-title":"Neurodevelopmental outcomes after ventriculoperitoneal shunt placement in children with non-infectious hydrocephalus: A meta-analysis","volume":"37","author":"Sobana","year":"2021","journal-title":"Childs Nerv Syst"},{"key":"2024100318044715500_awae155-B22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neucir.2021.06.002","article-title":"Evaluation of developmental profiles of children with hydrocephalus","volume":"33","author":"G\u00f6n\u00fcll\u00fc Polat","year":"2022","journal-title":"Neurocirugia"},{"key":"2024100318044715500_awae155-B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/NEU.0b013e31827414b3","article-title":"Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus","volume":"72","author":"Koivisto","year":"2013","journal-title":"Neurosurgery"},{"key":"2024100318044715500_awae155-B24","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1212\/WNL.0b013e31822f02f5","article-title":"Normal pressure hydrocephalus: How often does the diagnosis hold water?","volume":"77","author":"Klassen","year":"2011","journal-title":"Neurology"},{"key":"2024100318044715500_awae155-B25","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ana.25053","article-title":"Is there even such a thing as \u201cidiopathic normal pressure hydrocephalus\u201d?","volume":"82","author":"Saper","year":"2017","journal-title":"Ann Neurol"},{"key":"2024100318044715500_awae155-B26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1159\/000453074","article-title":"Neural stem cells and fetal-onset hydrocephalus","volume":"52","author":"Rodr\u00edguez","year":"2017","journal-title":"Pediatr Neurosurg"},{"key":"2024100318044715500_awae155-B27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4067\/S0716-97602012000300005","article-title":"A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus","volume":"45","author":"Rodr\u00edguez","year":"2012","journal-title":"Biol Res"},{"key":"2024100318044715500_awae155-B28","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1093\/cercor\/bhac341","article-title":"A neural stem cell paradigm of pediatric hydrocephalus","volume":"33","author":"Duy","year":"2022","journal-title":"Cereb Cortex"},{"key":"2024100318044715500_awae155-B29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuron.2021.12.009","article-title":"Brain ventricles as windows into brain development and disease","volume":"110","author":"Duy","year":"2022","journal-title":"Neuron"},{"key":"2024100318044715500_awae155-B30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41593-022-01043-3","article-title":"Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus","volume":"25","author":"Duy","year":"2022","journal-title":"Nat Neurosci"},{"key":"2024100318044715500_awae155-B31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ng1302","article-title":"The hyh mutation uncovers roles for alpha snap in apical protein localization and control of neural cell fate","volume":"36","author":"Chae","year":"2004","journal-title":"Nat Genet"},{"key":"2024100318044715500_awae155-B32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/jnen\/60.11.1105","article-title":"A programmed ependymal denudation precedes congenital hydrocephalus in the hyh mutant mouse","volume":"60","author":"Jim\u00e9nez","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024100318044715500_awae155-B33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/nbm.1602","article-title":"In vivo viscoelastic properties of the brain in normal pressure hydrocephalus","volume":"24","author":"Streitberger","year":"2011","journal-title":"NMR Biomed"},{"key":"2024100318044715500_awae155-B34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00234-011-0871-1","article-title":"Alteration of brain viscoelasticity after shunt treatment in normal pressure hydrocephalus","volume":"54","author":"Freimann","year":"2012","journal-title":"Neuroradiology"},{"key":"2024100318044715500_awae155-B35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3174\/ajnr.A8108","article-title":"Prediction of surgical outcomes in normal pressure hydrocephalus by MR elastography","volume":"45","author":"Karki","year":"2024","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024100318044715500_awae155-B36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40478-019-0748-9","article-title":"Alzheimer\u2019s disease neuropathological change and loss of matrix\/neuropil in patients with idiopathic normal pressure hydrocephalus, a model of Alzheimer\u2019s disease","volume":"7","author":"Libard","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"2024100318044715500_awae155-B37","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ana.22100","article-title":"Amyloid and tau proteins in cortical brain biopsy and Alzheimer\u2019s disease","volume":"68","author":"Leinonen","year":"2010","journal-title":"Ann Neurol"},{"key":"2024100318044715500_awae155-B38","doi-asserted-by":"crossref","first-page":"bhae001","DOI":"10.1093\/cercor\/bhae001","article-title":"Utility of cortical tissue analysis in normal pressure hydrocephalus","volume":"34","author":"Greenberg","year":"2024","journal-title":"Cereb Cortex"},{"key":"2024100318044715500_awae155-B39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12987-018-0099-0","article-title":"Nimodipine treatment does not benefit juvenile ferrets with kaolin-induced hydrocephalus","volume":"15","author":"Di Curzio","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"2024100318044715500_awae155-B40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.expneurol.2006.02.113","article-title":"Brain damage in neonatal rats following kaolin induction of hydrocephalus","volume":"200","author":"Khan","year":"2006","journal-title":"Exp Neurol"},{"key":"2024100318044715500_awae155-B41","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1093\/cercor\/bhy217","article-title":"GSK3\u03b2 inhibition restores impaired neurogenesis in preterm neonates with intraventricular hemorrhage","volume":"29","author":"Dohare","year":"2019","journal-title":"Cereb Cortex"},{"key":"2024100318044715500_awae155-B42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41582-020-00447-8","article-title":"White matter injury in infants with intraventricular haemorrhage: Mechanisms and therapies","volume":"17","author":"Ballabh","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"2024100318044715500_awae155-B43","doi-asserted-by":"crossref","first-page":"e2103084118","DOI":"10.1073\/pnas.2103084118","article-title":"PPAR-\u03b3 activation enhances myelination and neurological recovery in premature rabbits with intraventricular hemorrhage","volume":"118","author":"Krishna","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024100318044715500_awae155-B44","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1227\/NEU.0b013e3182690a0c","article-title":"Intracranial biomechanics of acute experimental hydrocephalus in live rats","volume":"71","author":"Shulyakov","year":"2012","journal-title":"Neurosurgery"},{"key":"2024100318044715500_awae155-B45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-3-642-73987-3_72","volume-title":"Intracranial pressure VII","author":"Zee","year":"1989"},{"key":"2024100318044715500_awae155-B46","doi-asserted-by":"crossref","first-page":"102579","DOI":"10.1016\/j.nicl.2021.102579","article-title":"MR elastography demonstrates reduced white matter shear stiffness in early-onset hydrocephalus","volume":"30","author":"Wagshul","year":"2021","journal-title":"Neuroimage Clin"},{"key":"2024100318044715500_awae155-B47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000445900","article-title":"Magnetic resonance elastography demonstrating low brain stiffness in a patient with low-pressure hydrocephalus: Case report","volume":"51","author":"Olivero","year":"2016","journal-title":"Pediatr Neurosurg"},{"key":"2024100318044715500_awae155-B48","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/s41591-020-1090-2","article-title":"Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus","volume":"26","author":"Jin","year":"2020","journal-title":"Nat Med"},{"key":"2024100318044715500_awae155-B49","doi-asserted-by":"crossref","first-page":"109085","DOI":"10.1016\/j.celrep.2021.109085","article-title":"Multi-omic analysis elucidates the genetic basis of hydrocephalus","volume":"35","author":"Hale","year":"2021","journal-title":"Cell Rep"},{"key":"2024100318044715500_awae155-B50","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/ana.24964","article-title":"The genetic landscape of familial congenital hydrocephalus","volume":"81","author":"Shaheen","year":"2017","journal-title":"Ann Neurol"},{"key":"2024100318044715500_awae155-B51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40246-023-00464-w","article-title":"Congenital hydrocephalus: New Mendelian mutations and evidence for oligogenic inheritance","volume":"17","author":"Jacquemin","year":"2023","journal-title":"Hum Genomics"},{"key":"2024100318044715500_awae155-B52","doi-asserted-by":"crossref","first-page":"e2343384","DOI":"10.1001\/jamanetworkopen.2023.43384","article-title":"Molecular diagnostic yield of exome sequencing in patients with congenital hydrocephalus","volume":"6","author":"Greenberg","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2024100318044715500_awae155-B53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/ng1092-107","article-title":"Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus","volume":"2","author":"Rosenthal","year":"1992","journal-title":"Nat Genet"},{"key":"2024100318044715500_awae155-B54","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1086\/510137","article-title":"Mutations in the gene encoding the sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation","volume":"79","author":"Tarpey","year":"2006","journal-title":"Am J Hum Genet"},{"key":"2024100318044715500_awae155-B55","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/jmedgenet-2012-101294","article-title":"Mutation in MPDZ causes severe congenital hydrocephalus","volume":"50","author":"Al-Dosari","year":"2013","journal-title":"J Med Genet"},{"key":"2024100318044715500_awae155-B56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000319859","article-title":"Disturbed wnt signalling due to a mutation in CCDC88C causes an autosomal recessive non-syndromic hydrocephalus with medial diverticulum","volume":"1","author":"Ekici","year":"2010","journal-title":"Mol Syndromol"},{"key":"2024100318044715500_awae155-B57","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/jmedgenet-2012-101190","article-title":"Two novel CCDC88C mutations confirm the role of DAPLE in autosomal recessive congenital hydrocephalus","volume":"49","author":"Drielsma","year":"2012","journal-title":"J Med Genet"},{"key":"2024100318044715500_awae155-B58","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000472311","article-title":"CRASH syndrome: Clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1","volume":"3","author":"Fransen","year":"1995","journal-title":"Eur J Hum Genet"},{"key":"2024100318044715500_awae155-B59","doi-asserted-by":"crossref","first-page":"e9540","DOI":"10.15252\/emmm.201809540","article-title":"Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus","volume":"11","author":"Yang","year":"2019","journal-title":"EMBO Mol Med"},{"key":"2024100318044715500_awae155-B60","doi-asserted-by":"crossref","first-page":"890","DOI":"10.15252\/emmm.201606430","article-title":"Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice","volume":"9","author":"Feldner","year":"2017","journal-title":"EMBO Mol Med"},{"key":"2024100318044715500_awae155-B61","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.celrep.2017.06.089","article-title":"Daple coordinates planar polarized microtubule dynamics in ependymal cells and contributes to hydrocephalus","volume":"20","author":"Takagishi","year":"2017","journal-title":"Cell Rep"},{"key":"2024100318044715500_awae155-B62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0960-9822(98)70017-X","article-title":"Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1","volume":"8","author":"Cohen","year":"1998","journal-title":"Curr Biol"},{"key":"2024100318044715500_awae155-B63","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0959-4388(98)80012-3","article-title":"Neural cell recognition molecule L1: From cell biology to human hereditary brain malformations","volume":"8","author":"Br\u00fcmmendorf","year":"1998","journal-title":"Curr Opin Neurobiol"},{"key":"2024100318044715500_awae155-B64","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1084\/jem.20150951","article-title":"Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation","volume":"213","author":"Patzke","year":"2016","journal-title":"J Exp Med"},{"key":"2024100318044715500_awae155-B65","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/hmg\/7.6.999","article-title":"L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns","volume":"7","author":"Fransen","year":"1998","journal-title":"Hum Mol Genet"},{"key":"2024100318044715500_awae155-B66","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1093\/cercor\/bhad206","article-title":"Floppy brain\u201d in congenital hydrocephalus","volume":"33","author":"Duy","year":"2023","journal-title":"Cereb Cortex"},{"key":"2024100318044715500_awae155-B67","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1091\/mbc.E19-02-0091","article-title":"DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction","volume":"30","author":"Marivin","year":"2019","journal-title":"Mol Biol Cell"},{"key":"2024100318044715500_awae155-B68","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1083\/jcb.201811174","article-title":"GPCR-independent activation of G proteins promotes apical cell constriction in vivo","volume":"218","author":"Marivin","year":"2019","journal-title":"J Cell Biol"},{"key":"2024100318044715500_awae155-B69","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/ajmg.c.31751","article-title":"EML1-associated brain overgrowth syndrome with ribbon-like heterotopia","volume":"181","author":"Oegema","year":"2019","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2024100318044715500_awae155-B70","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s40478-021-01207-5","article-title":"Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants","volume":"9","author":"Marguet","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"2024100318044715500_awae155-B71","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1212\/NXG.0000000000000034","article-title":"Mutation in the sixth immunoglobulin domain of L1CAM is associated with migrational brain anomalies","volume":"1","author":"Shieh","year":"2015","journal-title":"Neurol Genet"},{"key":"2024100318044715500_awae155-B72","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuron.2018.06.019","article-title":"De Novo mutation in genes regulating neural stem cell fate in human congenital hydrocephalus","volume":"99","author":"Furey","year":"2018","journal-title":"Neuron"},{"key":"2024100318044715500_awae155-B73","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1101\/gad.187641.112","article-title":"The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling","volume":"26","author":"Chen","year":"2012","journal-title":"Genes Dev"},{"key":"2024100318044715500_awae155-B74","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.isci.2018.05.014","article-title":"Chromatin remodeling BAF155 subunit regulates the genesis of basal progenitors in developing Cortex","volume":"4","author":"Narayanan","year":"2018","journal-title":"iScience"},{"key":"2024100318044715500_awae155-B75","doi-asserted-by":"crossref","first-page":"e45961","DOI":"10.7554\/eLife.45961","article-title":"PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice","volume":"8","author":"Roy","year":"2019","journal-title":"Elife"},{"key":"2024100318044715500_awae155-B76","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1126\/science.1065518","article-title":"Negative regulation of neural stem\/progenitor cell proliferation by the Pten tumor suppressor gene in vivo","volume":"294","author":"Groszer","year":"2001","journal-title":"Science"},{"key":"2024100318044715500_awae155-B77","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.tins.2021.08.007","article-title":"PTEN mutations in autism spectrum disorder and congenital hydrocephalus: Developmental pleiotropy and therapeutic targets","volume":"44","author":"DeSpenza","year":"2021","journal-title":"Trends Neurosci"},{"key":"2024100318044715500_awae155-B78","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.molmed.2019.03.004","article-title":"Trim71\/lin-41 links an ancient miRNA pathway to human congenital hydrocephalus","volume":"25","author":"Duy","year":"2019","journal-title":"Trends Mol Med"},{"key":"2024100318044715500_awae155-B79","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1101\/gad.207266.112","article-title":"LIN-41\/TRIM71: Emancipation of a miRNA target","volume":"27","author":"Ecsedi","year":"2013","journal-title":"Genes Dev"},{"key":"2024100318044715500_awae155-B80","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41562-023-01722-6","article-title":"Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits","volume":"8","author":"Ge","year":"2023","journal-title":"Nat Hum Behav."},{"key":"2024100318044715500_awae155-B81","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/NEN.0000000000000203","article-title":"Cell junction pathology of neural stem cells is associated with ventricular zone disruption, hydrocephalus, and abnormal neurogenesis","volume":"74","author":"Guerra","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024100318044715500_awae155-B82","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00441-020-03182-0","article-title":"Neural stem cell therapy of foetal onset hydrocephalus using the HTx rat as experimental model","volume":"381","author":"Henzi","year":"2020","journal-title":"Cell Tissue Res"},{"issue":"Pt 8","key":"2024100318044715500_awae155-B83","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/brain\/awf182","article-title":"Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: A role for CSF","volume":"125","author":"Mashayekhi","year":"2002","journal-title":"Brain"},{"issue":"Pt 3","key":"2024100318044715500_awae155-B84","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/brain\/awg058","article-title":"Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat","volume":"126","author":"Owen-Lynch","year":"2003","journal-title":"Brain"},{"key":"2024100318044715500_awae155-B85","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/dneu.22142","article-title":"A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice","volume":"74","author":"Harmacek","year":"2014","journal-title":"Dev Neurobiol"},{"key":"2024100318044715500_awae155-B86","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/brain\/awad405","article-title":"A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus","volume":"147","author":"Singh","year":"2023","journal-title":"Brain."},{"key":"2024100318044715500_awae155-B87","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1093\/hmg\/ddad107","article-title":"Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity","volume":"32","author":"Pigoni","year":"2023","journal-title":"Hum Mol Genet"},{"key":"2024100318044715500_awae155-B88","doi-asserted-by":"crossref","first-page":"e54027","DOI":"10.15252\/embr.202154027","article-title":"Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation","volume":"23","author":"Jabali","year":"2022","journal-title":"EMBO Rep"},{"key":"2024100318044715500_awae155-B89","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0896-6273(03)00755-4","article-title":"Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis","volume":"40","author":"Li","year":"2003","journal-title":"Neuron"},{"key":"2024100318044715500_awae155-B90","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1093\/cercor\/bhz292","article-title":"SEPT7 interacts with KIF20A and regulates the proliferative state of neural progenitor cells during cortical development","volume":"30","author":"Qiu","year":"2020","journal-title":"Cereb Cortex"},{"key":"2024100318044715500_awae155-B91","first-page":"201","article-title":"mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis","volume":"144","author":"Foerster","year":"2017","journal-title":"Development"},{"key":"2024100318044715500_awae155-B92","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ydbio.2019.03.011","article-title":"Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities","volume":"450","author":"Shimada","year":"2019","journal-title":"Dev Biol"},{"key":"2024100318044715500_awae155-B93","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1038\/s41467-018-05152-1","article-title":"KIF20A\/MKLP2 regulates the division modes of neural progenitor cells during cortical development","volume":"9","author":"Geng","year":"2018","journal-title":"Nat Commun"},{"key":"2024100318044715500_awae155-B94","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1002\/stem.2423","article-title":"Ulk4 regulates neural stem cell pool","volume":"34","author":"Liu","year":"2016","journal-title":"Stem Cells"},{"key":"2024100318044715500_awae155-B95","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.celrep.2015.08.031","article-title":"Suppressor of fused is critical for maintenance of neuronal progenitor identity during corticogenesis","volume":"12","author":"Yabut","year":"2015","journal-title":"Cell Rep"},{"key":"2024100318044715500_awae155-B96","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ydbio.2011.02.026","article-title":"A key role for Pak4 in proliferation and differentiation of neural progenitor cells","volume":"353","author":"Tian","year":"2011","journal-title":"Dev Biol"},{"key":"2024100318044715500_awae155-B97","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1038\/cdd.2010.131","article-title":"P73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis","volume":"17","author":"Talos","year":"2010","journal-title":"Cell Death Differ"},{"key":"2024100318044715500_awae155-B98","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1128\/MCB.26.10.3764-3772.2006","article-title":"Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO","volume":"26","author":"Zhang","year":"2006","journal-title":"Mol Cell Biol"},{"key":"2024100318044715500_awae155-B99","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1007\/s00381-021-05255-z","article-title":"Inflammatory hydrocephalus","volume":"37","author":"Robert","year":"2021","journal-title":"Childs Nerv Syst"},{"key":"2024100318044715500_awae155-B100","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41582-020-0321-y","article-title":"Inflammation in acquired hydrocephalus: Pathogenic mechanisms and therapeutic targets","volume":"16","author":"Karimy","year":"2020","journal-title":"Nat Rev Neurol"},{"issue":"Suppl 1","key":"2024100318044715500_awae155-B101","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12975-012-0182-9","article-title":"Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage","volume":"3","author":"Strahle","year":"2012","journal-title":"Transl Stroke Res"},{"key":"2024100318044715500_awae155-B102","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nm.4361","article-title":"Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus","volume":"23","author":"Karimy","year":"2017","journal-title":"Nat Med"},{"key":"2024100318044715500_awae155-B103","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cell.2023.01.017","article-title":"The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus","volume":"186","author":"Robert","year":"2023","journal-title":"Cell"},{"key":"2024100318044715500_awae155-B104","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12987-022-00360-w","article-title":"Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters","volume":"19","author":"Lolansen","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"2024100318044715500_awae155-B105","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s12276-023-00955-9","article-title":"NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood-cerebrospinal fluid barrier in the choroid plexus","volume":"55","author":"Zhang","year":"2023","journal-title":"Exp Mol Med"},{"key":"2024100318044715500_awae155-B106","doi-asserted-by":"crossref","first-page":"151595","DOI":"10.1016\/j.semperi.2022.151595","article-title":"Cerebral gray matter injuries in infants with intraventricular hemorrhage","volume":"46","author":"Sharma","year":"2022","journal-title":"Semin Perinatol"},{"key":"2024100318044715500_awae155-B107","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/3-211-30714-1_45","article-title":"Hydrocephalus in a rat model of intraventricular hemorrhage","volume":"96","author":"Lodhia","year":"2006","journal-title":"Acta Neurochir Suppl"},{"key":"2024100318044715500_awae155-B108","doi-asserted-by":"crossref","first-page":"99ra87","DOI":"10.1126\/scitranslmed.3002095","article-title":"Lysophosphatidic acid signaling may initiate fetal hydrocephalus","volume":"3","author":"Yung","year":"2011","journal-title":"Sci Transl Med"},{"key":"2024100318044715500_awae155-B109","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/jnen\/62.11.1154","article-title":"Periventricular\/intraventricular hemorrhage in neonatal mouse cerebrum","volume":"62","author":"Xue","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"issue":"Pt 5","key":"2024100318044715500_awae155-B110","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/brain\/awr052","article-title":"Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage","volume":"134","author":"Del Bigio","year":"2011","journal-title":"Brain"},{"key":"2024100318044715500_awae155-B111","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/jnen\/nlx017","article-title":"Ventricular zone disruption in human neonates with intraventricular hemorrhage","volume":"76","author":"McAllister","year":"2017","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024100318044715500_awae155-B112","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1742-2094-10-100","article-title":"Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation","volume":"10","author":"Gram","year":"2013","journal-title":"J Neuroinflammation"},{"key":"2024100318044715500_awae155-B113","doi-asserted-by":"crossref","first-page":"114472","DOI":"10.1016\/j.expneurol.2023.114472","article-title":"Innate immune activation and white matter injury in a rat model of neonatal intraventricular hemorrhage are dependent on developmental stage","volume":"367","author":"Zamorano","year":"2023","journal-title":"Exp Neurol"},{"key":"2024100318044715500_awae155-B114","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1212\/WNL.0000000000013080","article-title":"Microstructural periventricular white matter injury in post-hemorrhagic ventricular dilatation","volume":"98","author":"Isaacs","year":"2022","journal-title":"Neurology"},{"key":"2024100318044715500_awae155-B115","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.3174\/ajnr.A3988","article-title":"Impaired white matter development in extremely low-birth-weight infants with previous brain hemorrhage","volume":"35","author":"Ou","year":"2014","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024100318044715500_awae155-B116","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/jnc.15851","article-title":"Toll-like receptor 4-mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage","volume":"13","author":"Peng","year":"2023","journal-title":"J Neurochem"},{"key":"2024100318044715500_awae155-B117","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1161\/STROKEAHA.107.510883","article-title":"Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage","volume":"39","author":"Georgiadis","year":"2008","journal-title":"Stroke"},{"key":"2024100318044715500_awae155-B118","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3174\/ajnr.A3351","article-title":"Distributed, limbic gray matter atrophy in patients after bacterial meningitis","volume":"34","author":"Focke","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024100318044715500_awae155-B119","doi-asserted-by":"crossref","first-page":"16334","DOI":"10.1523\/JNEUROSCI.0708-13.2013","article-title":"Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron","volume":"33","author":"Lieblein-Boff","year":"2013","journal-title":"J Neurosci"},{"key":"2024100318044715500_awae155-B120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejpn.2004.09.002","article-title":"Cerebral white matter injury in the newborn following Escherichia coli meningitis","volume":"9","author":"Shah","year":"2005","journal-title":"Eur J Paediatr Neurol"},{"key":"2024100318044715500_awae155-B121","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40478-016-0297-4","article-title":"Pneumococcal meningitis: Clinical-pathological correlations (MeninGene-path)","volume":"4","author":"Engelen-Lee","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"2024100318044715500_awae155-B122","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/01616412.1998.11740586","article-title":"The microglial response to progressive hydrocephalus in a model of inherited aqueductal stenosis","volume":"20","author":"Mangano","year":"1998","journal-title":"Neurol Res"},{"key":"2024100318044715500_awae155-B123","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12987-022-00313-3","article-title":"Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter","volume":"19","author":"Garcia-Bonilla","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"2024100318044715500_awae155-B124","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.expneurol.2013.06.004","article-title":"Reduced subventricular zone proliferation and white matter damage in juvenile ferrets with kaolin-induced hydrocephalus","volume":"248","author":"Di Curzio","year":"2013","journal-title":"Exp Neurol"},{"key":"2024100318044715500_awae155-B125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ana.10453","article-title":"Chronic hydrocephalus in rats and humans: White matter loss and behavior changes","volume":"53","author":"Del Bigio","year":"2003","journal-title":"Ann Neurol"},{"key":"2024100318044715500_awae155-B126","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.expneurol.2009.05.015","article-title":"Characterization of juvenile and young adult mice following induction of hydrocephalus with kaolin","volume":"219","author":"da Silva Lopes","year":"2009","journal-title":"Exp Neurol"},{"key":"2024100318044715500_awae155-B127","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1523\/JNEUROSCI.4329-15.2016","article-title":"AMPA-kainate receptor inhibition promotes neurologic recovery in premature rabbits with intraventricular hemorrhage","volume":"36","author":"Dohare","year":"2016","journal-title":"J Neurosci"},{"key":"2024100318044715500_awae155-B128","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/exnr.1998.6922","article-title":"Cell death, axonal damage, and cell birth in the immature rat brain following induction of hydrocephalus","volume":"154","author":"Del Bigio","year":"1998","journal-title":"Exp Neurol"},{"key":"2024100318044715500_awae155-B129","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1471-2202-13-148","article-title":"Minocycline reduces reactive gliosis in the rat model of hydrocephalus","volume":"13","author":"Xu","year":"2012","journal-title":"BMC Neurosci"},{"key":"2024100318044715500_awae155-B130","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1203\/01.PDR.0000061561.42921.5B","article-title":"Magnesium sulfate therapy is of mild benefit to young rats with kaolin-induced hydrocephalus","volume":"53","author":"Khan","year":"2003","journal-title":"Pediatr Res"},{"issue":"Pt 9","key":"2024100318044715500_awae155-B131","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1093\/brain\/awt203","article-title":"Decorin prevents the development of juvenile communicating hydrocephalus","volume":"136","author":"Botfield","year":"2013","journal-title":"Brain"},{"issue":"Pt 2","key":"2024100318044715500_awae155-B132","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/brain\/awh711","article-title":"Neuropsychological sequelae of bacterial and viral meningitis","volume":"129","author":"Schmidt","year":"2006","journal-title":"Brain"},{"key":"2024100318044715500_awae155-B133","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000149904","article-title":"Intellectual functioning in children with early shunted posthemorrhagic hydrocephalus","volume":"44","author":"Lacy","year":"2008","journal-title":"Pediatr Neurosurg"},{"key":"2024100318044715500_awae155-B134","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/ane.12815","article-title":"Life situation 5 years after subarachnoid haemorrhage","volume":"137","author":"Persson","year":"2018","journal-title":"Acta Neurol Scand"},{"key":"2024100318044715500_awae155-B135","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1073\/pnas.1200151109","article-title":"Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography","volume":"109","author":"Schregel","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024100318044715500_awae155-B136","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0024-3205(67)90356-6","article-title":"Studies on the induction of hydrocephalus and spongy degeneration by cuprizone feeding and attempts to antidote the toxicity","volume":"6","author":"Carlton","year":"1967","journal-title":"Life Sci"},{"key":"2024100318044715500_awae155-B137","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0041-008X(66)90062-7","article-title":"Response of mice to the chelating agents sodium diethyldithiocarbamate, alpha-benzoinoxime, and biscyclohexanone oxaldihydrazone","volume":"8","author":"Carlton","year":"1966","journal-title":"Toxicol Appl Pharmacol"},{"key":"2024100318044715500_awae155-B138","doi-asserted-by":"crossref","first-page":"e0152480","DOI":"10.1371\/journal.pone.0152480","article-title":"Spatio-Temporal patterns of demyelination and remyelination in the cuprizone mouse model","volume":"11","author":"Tagge","year":"2016","journal-title":"PLoS One"},{"key":"2024100318044715500_awae155-B139","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0014-4800(70)90091-2","article-title":"Aqueductal stenosis as the cause of hydrocephalus in mice fed the substituted hydrazine, cuprizone","volume":"13","author":"Kesterson","year":"1970","journal-title":"Exp Mol Pathol"},{"key":"2024100318044715500_awae155-B140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.actbio.2016.07.040","article-title":"Brain stiffness increases with myelin content","volume":"42","author":"Weickenmeier","year":"2016","journal-title":"Acta Biomater"},{"key":"2024100318044715500_awae155-B141","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jmbbm.2017.04.017","article-title":"The mechanical importance of myelination in the central nervous system","volume":"76","author":"Weickenmeier","year":"2017","journal-title":"J Mech Behav Biomed Mater"},{"key":"2024100318044715500_awae155-B142","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jmbbm.2015.02.024","article-title":"Mechanical properties of gray and white matter brain tissue by indentation","volume":"46","author":"Budday","year":"2015","journal-title":"J Mech Behav Biomed Mater"},{"key":"2024100318044715500_awae155-B143","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0000000000000342","article-title":"Prevalence of idiopathic normal-pressure hydrocephalus","volume":"82","author":"Jaraj","year":"2014","journal-title":"Neurology"},{"key":"2024100318044715500_awae155-B144","first-page":"1586","article-title":"Normal pressure hydrocephalus: New concepts on etiology and diagnosis","volume":"21","author":"Bradley","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024100318044715500_awae155-B145","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/brain\/awx191","article-title":"Glymphatic MRI in idiopathic normal pressure hydrocephalus","volume":"140","author":"Ringstad","year":"2017","journal-title":"Brain"},{"key":"2024100318044715500_awae155-B146","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.molmed.2019.11.008","article-title":"Glymphatic system impairment in Alzheimer\u2019s disease and idiopathic normal pressure hydrocephalus","volume":"26","author":"Reeves","year":"2020","journal-title":"Trends Mol Med"},{"key":"2024100318044715500_awae155-B147","doi-asserted-by":"crossref","first-page":"e13249","DOI":"10.15252\/emmm.202013249","article-title":"Deletions in CWH43 cause idiopathic normal pressure hydrocephalus","volume":"13","author":"Yang","year":"2021","journal-title":"EMBO Mol Med"},{"key":"2024100318044715500_awae155-B148","doi-asserted-by":"crossref","first-page":"e2364","DOI":"10.1212\/WNL.0000000000007505","article-title":"Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities","volume":"92","author":"Morimoto","year":"2019","journal-title":"Neurology"},{"key":"2024100318044715500_awae155-B149","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1017\/S1355617722000868","article-title":"Longitudinal post-shunt outcomes in idiopathic normal pressure hydrocephalus with and without comorbid Alzheimer\u2019s disease","volume":"29","author":"Gold","year":"2023","journal-title":"J Int Neuropsychol Soc"},{"key":"2024100318044715500_awae155-B150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1212\/WNL.42.1.54","article-title":"Shunting normal-pressure hydrocephalus: Do the benefits outweigh the risks? A multicenter study and literature review","volume":"42","author":"Vanneste","year":"1992","journal-title":"Neurology"},{"key":"2024100318044715500_awae155-B151","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-3-211-85578-2_25","article-title":"Course of disease in patients with idiopathic normal pressure hydrocephalus (iNPH): A follow-up study 3, 4 and 5 years following shunt implantation","volume":"102","author":"Meier","year":"2008","journal-title":"Acta Neurochir Suppl"},{"key":"2024100318044715500_awae155-B152","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3171\/jns.2004.100.6.1036","article-title":"Correlation between decreased ventricular size and positive clinical outcome following shunt placement in patients with normal-pressure hydrocephalus","volume":"100","author":"Meier","year":"2004","journal-title":"J Neurosurg"},{"key":"2024100318044715500_awae155-B153","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1192\/bjp.167.6.739","article-title":"Brain atrophy in normal ageing and Alzheimer\u2019s disease. Volumetric discrimination and clinical correlations","volume":"167","author":"F\u00f6rstl","year":"1995","journal-title":"Br J Psychiatry"},{"key":"2024100318044715500_awae155-B154","doi-asserted-by":"crossref","first-page":"102079","DOI":"10.1016\/j.nicl.2019.102079","article-title":"Frontotemporal lobar degeneration neuroimaging initiative. Deformation based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia","volume":"24","author":"Manera","year":"2019","journal-title":"Neuroimage Clin"},{"key":"2024100318044715500_awae155-B155","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/alzrt144","article-title":"Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions","volume":"4","author":"Mahoney","year":"2012","journal-title":"Alzheimers Res Ther"},{"key":"2024100318044715500_awae155-B156","doi-asserted-by":"crossref","first-page":"fcac319","DOI":"10.1093\/braincomms\/fcac319","article-title":"Idiopathic normal pressure hydrocephalus and frontotemporal dementia: An unexpected association","volume":"4","author":"de Guilhem de Lataillade","year":"2022","journal-title":"Brain Commun"},{"issue":"1\u20134","key":"2024100318044715500_awae155-B157","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000335155","article-title":"Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus","volume":"10","author":"Leinonen","year":"2012","journal-title":"Neurodegener Dis"},{"key":"2024100318044715500_awae155-B158","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12987-022-00368-2","article-title":"In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: Prevalence and associations with clinical features and surgery outcome","volume":"19","author":"Giannini","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"2024100318044715500_awae155-B159","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.wneu.2016.03.004","article-title":"Normal pressure hydrocephalus and parkinsonism: Preliminary data on neurosurgical and neurological treatment","volume":"90","author":"Broggi","year":"2016","journal-title":"World Neurosurg"},{"key":"2024100318044715500_awae155-B160","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jalz.2010.12.008","article-title":"Frequency of Alzheimer\u2019s disease pathology at autopsy in patients with clinical normal pressure hydrocephalus","volume":"7","author":"Cabral","year":"2011","journal-title":"Alzheimers Dement"},{"key":"2024100318044715500_awae155-B161","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1016\/j.cell.2023.08.005","article-title":"Early Alzheimer\u2019s disease pathology in human cortex involves transient cell states","volume":"186","author":"Gazestani","year":"2023","journal-title":"Cell"},{"key":"2024100318044715500_awae155-B162","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3233\/JAD-190334","article-title":"Predicting development of Alzheimer\u2019s disease in patients with shunted idiopathic normal pressure hydrocephalus","volume":"71","author":"Luikku","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"S6","key":"2024100318044715500_awae155-B163","doi-asserted-by":"crossref","first-page":"e046282","DOI":"10.1002\/alz.046282","article-title":"Idiopathic normal pressure hydrocephalus as a novel window for Alzheimer\u2019s disease","volume":"16","author":"Leinonen","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"1\u20132","key":"2024100318044715500_awae155-B164","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000497306","article-title":"Prevalence of C9ORF72 expansion in a large series of patients with idiopathic normal-pressure hydrocephalus","volume":"47","author":"Korhonen","year":"2019","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2024100318044715500_awae155-B165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12987-017-0060-7","article-title":"Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): A short review of literature and an unusual case","volume":"14","author":"Korhonen","year":"2017","journal-title":"Fluids Barriers CNS"},{"key":"2024100318044715500_awae155-B166","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2054-7072-1-2","article-title":"Hydrocephalic parkinsonism: Lessons from normal pressure hydrocephalus mimics","volume":"1","author":"Starr","year":"2014","journal-title":"J Clin Mov Disord"},{"key":"2024100318044715500_awae155-B167","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/jnnp.47.11.1244","article-title":"Computed tomography findings in 15 cases of Creutzfeldt-Jakob disease with histological verification","volume":"47","author":"G\u00e1lvez","year":"1984","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3\u20134","key":"2024100318044715500_awae155-B168","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01406749","article-title":"Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease) associated with normal-pressure hydrocephalus anatomoclinical report of one case","volume":"51","author":"G\u00e1lvez","year":"1980","journal-title":"Acta Neurochir"},{"key":"2024100318044715500_awae155-B169","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/jmri.22707","article-title":"Decreased brain stiffness in Alzheimer\u2019s disease determined by magnetic resonance elastography","volume":"34","author":"Murphy","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"2024100318044715500_awae155-B170","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/RLI.0000000000000630","article-title":"Identification of normal pressure hydrocephalus by disease-specific patterns of brain stiffness and damping ratio","volume":"55","author":"Murphy","year":"2020","journal-title":"Invest Radiol"},{"key":"2024100318044715500_awae155-B171","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/imammb\/dqr001","article-title":"Aging impact on brain biomechanics with applications to hydrocephalus","volume":"29","author":"Wilkie","year":"2012","journal-title":"Math Med Biol"},{"key":"2024100318044715500_awae155-B172","first-page":"36","article-title":"A mathematical investigation of the role of intracranial pressure pulsations and small gradients in the pathogenesis of hydrocephalus","volume":"3","author":"Wilkie","year":"2012","journal-title":"Int J Numer Anal Model B"},{"key":"2024100318044715500_awae155-B173","first-page":"59","article-title":"Communicating hydrocephalus: The biomechanics of progressive ventricular enlargement revisited","volume":"81","author":"Pe\u00f1a","year":"2002","journal-title":"Acta Neurochir Suppl"},{"key":"2024100318044715500_awae155-B174","doi-asserted-by":"crossref","first-page":"R1312","DOI":"10.1152\/ajpregu.00307.2009","article-title":"Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats","volume":"297","author":"Nagra","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2024100318044715500_awae155-B175","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3171\/jns.1985.63.1.0082","article-title":"Experimental feline hydrocephalus. The role of biomechanical changes in ventricular enlargement in cats","volume":"63","author":"Shapiro","year":"1985","journal-title":"J Neurosurg"},{"key":"2024100318044715500_awae155-B176","first-page":"278","article-title":"Experimental hydrocephalus: Cerebrospinal fluid dynamics and ventricular distensibility during early stages","volume":"4","author":"Drapkin","year":"1978","journal-title":"Childs Brain"},{"key":"2024100318044715500_awae155-B177","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000120735","article-title":"Abnormal brain biomechanics in the hydrocephalic child. From: Concepts in pediatric neurosurgery, 1982, vol 2","volume":"19","author":"Shapiro","year":"1993","journal-title":"Pediatr Neurosurg"},{"key":"2024100318044715500_awae155-B178","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3171\/jns.1986.65.2.0211","article-title":"Subtle deterioration in shunted childhood hydrocephalus. A biomechanical and clinical profile","volume":"65","author":"Fried","year":"1986","journal-title":"J Neurosurg"},{"key":"2024100318044715500_awae155-B179","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.wneu.2016.12.121","article-title":"Clinical correlation of abnormal findings on magnetic resonance elastography in idiopathic normal pressure hydrocephalus","volume":"99","author":"Perry","year":"2017","journal-title":"World Neurosurg"},{"key":"2024100318044715500_awae155-B180","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3174\/ajnr.A4560","article-title":"MR elastography demonstrates increased brain stiffness in normal pressure hydrocephalus","volume":"37","author":"Fattahi","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024100318044715500_awae155-B181","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.acra.2020.03.009","article-title":"Poroelastic mechanical properties of the brain tissue of normal pressure hydrocephalus patients during lumbar drain treatment using intrinsic actuation MR elastography","volume":"28","author":"Solamen","year":"2021","journal-title":"Acad Radiol"},{"key":"2024100318044715500_awae155-B182","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2214\/AJR.16.17455","article-title":"MR elastography demonstrates unique regional brain stiffness patterns in dementias","volume":"209","author":"ElSheikh","year":"2017","journal-title":"AJR Am J Roentgenol"},{"key":"2024100318044715500_awae155-B183","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/ddrr.94","article-title":"Neuropathology and structural changes in hydrocephalus","volume":"16","author":"Del Bigio","year":"2010","journal-title":"Dev Disabil Res Rev"},{"key":"2024100318044715500_awae155-B184","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnana.2019.00038","article-title":"Dendritic and synaptic degeneration in pyramidal neurons of the sensorimotor Cortex in neonatal mice with kaolin-induced hydrocephalus","volume":"13","author":"Femi-Akinlosotu","year":"2019","journal-title":"Front Neuroanat"},{"key":"2024100318044715500_awae155-B185","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1471-4159.1997.68010305.x","article-title":"Neurochemical changes in the cerebral cortex of treated and untreated hydrocephalic rat pups quantified with in vitro 1H-NMR spectroscopy","volume":"68","author":"Harris","year":"1997","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"2024100318044715500_awae155-B186","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2008-1071253","article-title":"Cell death in the brain of the HTx rat","volume":"8","author":"Miyan","year":"1998","journal-title":"Eur J Pediatr Surg"},{"key":"2024100318044715500_awae155-B187","first-page":"159","article-title":"Submicroscopic pathology of human and experimental hydrocephalic cerebral cortex","volume":"48","author":"Castej\u00f3n","year":"2010","journal-title":"Folia Neuropathol"},{"key":"2024100318044715500_awae155-B188","first-page":"29","article-title":"Transmission electron microscope study of human hydrocephalic cerebral cortex","volume":"26","author":"Castejon","year":"1994","journal-title":"J Submicrosc Cytol Pathol"},{"key":"2024100318044715500_awae155-B189","doi-asserted-by":"crossref","first-page":"19552","DOI":"10.1038\/s41598-021-98054-0","article-title":"Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus","volume":"11","author":"Rau","year":"2021","journal-title":"Sci Rep"},{"key":"2024100318044715500_awae155-B190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-8118-9-19","article-title":"The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats","volume":"9","author":"Olopade","year":"2012","journal-title":"Fluids Barriers CNS"},{"key":"2024100318044715500_awae155-B191","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0090-3019(96)00422-3","article-title":"African neurosurgery. Part I: Historical outline","volume":"49","author":"El Khamlichi","year":"1998","journal-title":"Surg Neurol"},{"key":"2024100318044715500_awae155-B192","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/hmg\/11.6.715","article-title":"Loss of function of axonemal dynein mdnah5 causes primary ciliary dyskinesia and hydrocephalus","volume":"11","author":"Iba\u00f1ez-Tallon","year":"2002","journal-title":"Hum Mol Genet"},{"key":"2024100318044715500_awae155-B193","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.200710162","article-title":"Mutations in hydin impair ciliary motility in mice","volume":"180","author":"Lechtreck","year":"2008","journal-title":"J Cell Biol"},{"key":"2024100318044715500_awae155-B194","doi-asserted-by":"crossref","first-page":"105913","DOI":"10.1016\/j.nbd.2022.105913","article-title":"Rethinking the cilia hypothesis of hydrocephalus","volume":"175","author":"Duy","year":"2022","journal-title":"Neurobiol Dis"},{"key":"2024100318044715500_awae155-B195","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1523\/JNEUROSCI.1160-21.2021","article-title":"The anti-inflammatory agent bindarit attenuates the impairment of neural development through suppression of microglial activation in a neonatal hydrocephalus mouse model","volume":"42","author":"Iwasawa","year":"2022","journal-title":"J Neurosci"},{"key":"2024100318044715500_awae155-B196","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/35003607","article-title":"p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours","volume":"404","author":"Yang","year":"2000","journal-title":"Nature"},{"key":"2024100318044715500_awae155-B197","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/dneu.22356","article-title":"P73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture","volume":"76","author":"Gonzalez-Cano","year":"2016","journal-title":"Dev Neurobiol"},{"key":"2024100318044715500_awae155-B198","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF00685139","article-title":"New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis","volume":"21","author":"Borit","year":"1972","journal-title":"Acta Neuropathol"},{"key":"2024100318044715500_awae155-B199","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1001\/archneur.1977.00500130038008","article-title":"Pathogenesis of reovirus type 1 hydrocephalus in mice. Significance of aqueductal changes","volume":"34","author":"Masters","year":"1977","journal-title":"Arch Neurol"},{"key":"2024100318044715500_awae155-B200","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3171\/jns.1979.51.6.0812","article-title":"Communicating hydrocephalus as a cause of aqueductal stenosis","volume":"51","author":"Nugent","year":"1979","journal-title":"J Neurosurg"},{"key":"2024100318044715500_awae155-B201","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-3-7091-0923-6_25","article-title":"Indications for endoscopic third ventriculostomy in normal pressure hydrocephalus","volume":"113","author":"Paidakakos","year":"2012","journal-title":"Acta Neurochir Suppl"},{"key":"2024100318044715500_awae155-B202","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.wneu.2023.08.071","article-title":"The efficacy of endoscopic third ventriculostomy for idiopathic normal pressure hydrocephalus","volume":"179","author":"Mehta","year":"2023","journal-title":"World Neurosurg"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae155\/59149969\/awae155.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/10\/3274\/59561295\/awae155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/10\/3274\/59561295\/awae155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T14:05:43Z","timestamp":1727964343000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/10\/3274\/7682509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":202,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5,27]]},"published-print":{"date-parts":[[2024,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae155","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,5,27]]}}}