{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:02:17Z","timestamp":1785211337660,"version":"3.55.0"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH099578"],"award-info":[{"award-number":["R01 MH099578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG072298"],"award-info":[{"award-number":["R01AG072298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS110776"],"award-info":[{"award-number":["R01NS110776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Huntington\u2019s disease and juvenile-onset schizophrenia have long been regarded as distinct disorders. However, both manifest cell-intrinsic abnormalities in glial differentiation, with resultant astrocytic dysfunction and hypomyelination. To assess whether a common mechanism might underlie the similar glial pathology of these otherwise disparate conditions, we used comparative correlation network approaches to analyse RNA-sequencing data from human glial progenitor cells (hGPCs) produced from disease-derived pluripotent stem cells.<\/jats:p>\n               <jats:p>We identified gene sets preserved between Huntington\u2019s disease and schizophrenia hGPCs yet distinct from normal controls that included 174 highly connected genes in the shared disease-associated network, focusing on genes involved in synaptic signalling. These synaptic genes were largely suppressed in both schizophrenia and Huntington\u2019s disease hGPCs, and gene regulatory network analysis identified a core set of upstream regulators of this network, of which OLIG2 and TCF7L2 were prominent. Among their downstream targets, ADGRL3, a modulator of glutamatergic synapses, was notably suppressed in both schizophrenia and Huntington\u2019s disease hGPCs. Chromatin immunoprecipitation sequencing confirmed that OLIG2 and TCF7L2 each bound to the regulatory region of ADGRL3, whose expression was then rescued by lentiviral overexpression of these transcription factors.<\/jats:p>\n               <jats:p>These data suggest that the disease-associated suppression of OLIG2 and TCF7L2-dependent transcription of glutamate signalling regulators may impair glial receptivity to neuronal glutamate. The consequent loss of activity-dependent mobilization of hGPCs may yield deficient oligodendrocyte production, and hence the hypomyelination noted in these disorders, as well as the disrupted astrocytic differentiation and attendant synaptic dysfunction associated with each. Together, these data highlight the importance of convergent glial molecular pathology in both the pathogenesis and phenotypic similarities of two otherwise unrelated disorders, Huntington\u2019s disease and schizophrenia.<\/jats:p>","DOI":"10.1093\/brain\/awae166","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T16:44:25Z","timestamp":1721407465000},"page":"3099-3112","source":"Crossref","is-referenced-by-count":11,"title":["Shared patterns of glial transcriptional dysregulation link Huntington\u2019s disease and schizophrenia"],"prefix":"10.1093","volume":"147","author":[{"given":"Nguyen P T","family":"Huynh","sequence":"first","affiliation":[{"name":"Center for Translational Neuromedicine, University of Copenhagen, Faculty of Health and Medical Sciences , 2200 Copenhagen , Denmark"},{"name":"Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Osipovitch","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Copenhagen, Faculty of Health and Medical Sciences , 2200 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Foti","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Copenhagen, Faculty of Health and Medical Sciences , 2200 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Bates","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mansky","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C","family":"Cano","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Benraiss","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuntao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q Richard","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-4303","authenticated-orcid":false,"given":"Steven A","family":"Goldman","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Copenhagen, Faculty of Health and Medical Sciences , 2200 Copenhagen , Denmark"},{"name":"Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"2024090322144286100_awae166-B1","first-page":"35","article-title":"Recent advances in the genetics of schizophrenia","volume":"4","author":"Avramopoulos","year":"2018","journal-title":"Mol Neuropsychiatry"},{"issue":"1\u20133","key":"2024090322144286100_awae166-B2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.schres.2015.10.042","article-title":"Differentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia","volume":"169","author":"Mauney","year":"2015","journal-title":"Schizophr Res"},{"key":"2024090322144286100_awae166-B3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pneurobio.2010.09.004","article-title":"Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia","volume":"93","author":"Takahashi","year":"2011","journal-title":"Prog Neurobiol"},{"key":"2024090322144286100_awae166-B4","doi-asserted-by":"crossref","first-page":"492367","DOI":"10.1155\/2015\/492367","article-title":"Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder","volume":"2015","author":"Miyata","year":"2015","journal-title":"Biomed Res Int"},{"key":"2024090322144286100_awae166-B5","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.neuron.2015.02.026","article-title":"Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes","volume":"85","author":"Huang","year":"2015","journal-title":"Neuron"},{"key":"2024090322144286100_awae166-B6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1552-6569.2012.00779.x","article-title":"White matter alterations in early stages of schizophrenia: A systematic review of diffusion tensor imaging studies","volume":"24","author":"Samartzis","year":"2014","journal-title":"J Neuroimaging"},{"key":"2024090322144286100_awae166-B7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tins.2017.05.002","article-title":"Unravelling and exploiting astrocyte dysfunction in Huntington's disease","volume":"40","author":"Khakh","year":"2017","journal-title":"Trends Neurosci"},{"key":"2024090322144286100_awae166-B8","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S2215-0366(19)30302-5","article-title":"Glial cells in schizophrenia: A unified hypothesis","volume":"7","author":"Dietz","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"2024090322144286100_awae166-B9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1474-4422(11)70263-0","article-title":"Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: Analysis of 24 month observational data","volume":"11","author":"Tabrizi","year":"2012","journal-title":"Lancet Neurol"},{"issue":"2\u20133","key":"2024090322144286100_awae166-B10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.schres.2008.09.016","article-title":"A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia","volume":"106","author":"Munoz Maniega","year":"2008","journal-title":"Schizophr Res"},{"key":"2024090322144286100_awae166-B11","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.biopsych.2008.07.026","article-title":"White matter tractography in bipolar disorder and schizophrenia","volume":"64","author":"McIntosh","year":"2008","journal-title":"Biol Psychiatry"},{"key":"2024090322144286100_awae166-B12","doi-asserted-by":"crossref","first-page":"15979","DOI":"10.1073\/pnas.0806485105","article-title":"Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry","volume":"105","author":"Gogtay","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024090322144286100_awae166-B13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tins.2008.04.001","article-title":"White matter in learning, cognition and psychiatric disorders","volume":"31","author":"Fields","year":"2008","journal-title":"Trends Neurosci"},{"key":"2024090322144286100_awae166-B14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijdevneu.2010.07.236","article-title":"White matter neuron alterations in schizophrenia and related disorders","volume":"29","author":"Connor","year":"2011","journal-title":"Int J Dev Neurosci"},{"key":"2024090322144286100_awae166-B15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.schres.2014.09.040","article-title":"Myelin, myelin-related disorders, and psychosis","volume":"161","author":"Mighdoll","year":"2015","journal-title":"Schizophr Res"},{"key":"2024090322144286100_awae166-B16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.psc.2009.12.003","article-title":"The role of genetics in the etiology of schizophrenia","volume":"33","author":"Gejman","year":"2010","journal-title":"Psychiatr Clin North Am"},{"key":"2024090322144286100_awae166-B17","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2024090322144286100_awae166-B18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/B978-0-12-381328-2.00015-8","article-title":"Pathogenic mechanisms in Huntington\u2019s disease","volume":"98","author":"Jones","year":"2011","journal-title":"Int Rev Neurobiol"},{"key":"2024090322144286100_awae166-B19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"The Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"2024090322144286100_awae166-B20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Schizophrenia Working Group of the Psychiatric Genomics Consortium","year":"2014","journal-title":"Nature"},{"key":"2024090322144286100_awae166-B21","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1038\/ncomms11758","article-title":"Human glia can both induce and rescue aspects of disease phenotype in Huntington disease","volume":"7","author":"Benraiss","year":"2016","journal-title":"Nat Commun"},{"key":"2024090322144286100_awae166-B22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.stem.2018.11.010","article-title":"Human ESC-derived chimeric mouse models of Huntington\u2019s disease reveal cell-intrinsic defects in glial progenitor cell differentiation","volume":"24","author":"Osipovitch","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2024090322144286100_awae166-B23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.stem.2017.06.012","article-title":"Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia","volume":"21","author":"Windrem","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2024090322144286100_awae166-B24","doi-asserted-by":"crossref","first-page":"e109676","DOI":"10.1371\/journal.pone.0109676","article-title":"Deep white matter in Huntington\u2019s disease","volume":"9","author":"Phillips","year":"2014","journal-title":"PLoS One"},{"key":"2024090322144286100_awae166-B25","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1038\/npp.2013.80","article-title":"Combined white matter imaging suggests myelination defects in visual processing regions in schizophrenia","volume":"38","author":"Palaniyappan","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"2024090322144286100_awae166-B26","doi-asserted-by":"crossref","first-page":"109308","DOI":"10.1016\/j.celrep.2021.109308","article-title":"Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease","volume":"36","author":"Benraiss","year":"2021","journal-title":"Cell Rep"},{"key":"2024090322144286100_awae166-B27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: An R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2024090322144286100_awae166-B28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cels.2016.06.012","article-title":"A scalable permutation approach reveals replication and preservation patterns of network modules in large datasets","volume":"3","author":"Ritchie","year":"2016","journal-title":"Cell Syst"},{"key":"2024090322144286100_awae166-B29","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1038\/ncomms10883","article-title":"Dual regulatory switch through interactions of Tcf7l2\/Tcf4 with stage-specific partners propels oligodendroglial maturation","volume":"7","author":"Zhao","year":"2016","journal-title":"Nat Commun"},{"key":"2024090322144286100_awae166-B30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"ENCODE Project Consortium","year":"2012","journal-title":"Nature"},{"key":"2024090322144286100_awae166-B31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.stem.2012.12.002","article-title":"Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination","volume":"12","author":"Wang","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"Pt 17","key":"2024090322144286100_awae166-B32","first-page":"3873","article-title":"The antagonistic modulation of Arp2\/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology","volume":"126","author":"Murk","year":"2013","journal-title":"J Cell Sci"},{"issue":"1\u20132","key":"2024090322144286100_awae166-B33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0891-0618(94)90012-4","article-title":"Contractile units in stress fibers of fetal human astroglia in tissue culture","volume":"7","author":"Abd-el-Basset","year":"1994","journal-title":"J Chem Neuroanat"},{"key":"2024090322144286100_awae166-B34","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1523\/JNEUROSCI.18-21-08794.1998","article-title":"Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling","volume":"18","author":"Cotrina","year":"1998","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B35","doi-asserted-by":"crossref","first-page":"105732","DOI":"10.1016\/j.isci.2022.105732","article-title":"Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits","volume":"26","author":"Reyes-Ortiz","year":"2023","journal-title":"iScience"},{"key":"2024090322144286100_awae166-B36","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.113.2.417","article-title":"The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin","volume":"113","author":"Lein","year":"1991","journal-title":"J Cell Biol"},{"key":"2024090322144286100_awae166-B37","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/glia.20959","article-title":"Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes","volume":"58","author":"Yonezawa","year":"2010","journal-title":"Glia"},{"issue":"3\u20134","key":"2024090322144286100_awae166-B38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12079-009-0078-y","article-title":"The role of astrocyte-secreted matricellular proteins in central nervous system development and function","volume":"3","author":"Eroglu","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"2024090322144286100_awae166-B39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2004.12.020","article-title":"Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis","volume":"120","author":"Christopherson","year":"2005","journal-title":"Cell"},{"key":"2024090322144286100_awae166-B40","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1038\/npp.2008.19","article-title":"Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes","volume":"33","author":"Katsel","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"2024090322144286100_awae166-B41","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: Single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat Methods"},{"key":"2024090322144286100_awae166-B42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fcell.2019.00123","article-title":"CREB3 transcription factors: ER-Golgi stress transducers as hubs for cellular homeostasis","volume":"7","author":"Sampieri","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"2024090322144286100_awae166-B43","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1128\/MCB.01552-06","article-title":"BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer","volume":"27","author":"Kondo","year":"2007","journal-title":"Mol Cell Biol"},{"key":"2024090322144286100_awae166-B44","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1523\/JNEUROSCI.3493-03.2004","article-title":"CRE-mediated transcription is increased in Huntington's disease transgenic mice","volume":"24","author":"Obrietan","year":"2004","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B45","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1038\/s41598-017-06231-x","article-title":"CREB regulates distinct adaptive transcriptional programs in astrocytes and neurons","volume":"7","author":"Pardo","year":"2017","journal-title":"Sci Rep"},{"key":"2024090322144286100_awae166-B46","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/nar\/gkq951","article-title":"Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer","volume":"39","author":"Kuspert","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2024090322144286100_awae166-B47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ydbio.2006.10.007","article-title":"Induction of oligodendrocyte differentiation by Olig2 and Sox10: Evidence for reciprocal interactions and dosage-dependent mechanisms","volume":"302","author":"Liu","year":"2007","journal-title":"Dev Biol"},{"key":"2024090322144286100_awae166-B48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0896-6273(00)80897-1","article-title":"Sonic hedgehog\u2013regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system","volume":"25","author":"Lu","year":"2000","journal-title":"Neuron"},{"key":"2024090322144286100_awae166-B49","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/stem.480","article-title":"Gain-of-function of Olig transcription factors enhances oligodendrogenesis and myelination","volume":"28","author":"Maire","year":"2010","journal-title":"Stem Cells"},{"issue":"Pt 1","key":"2024090322144286100_awae166-B50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/brain\/awu375","article-title":"Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination","volume":"138","author":"Wegener","year":"2015","journal-title":"Brain"},{"key":"2024090322144286100_awae166-B51","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1242\/dev.126409","article-title":"How to make an oligodendrocyte","volume":"142","author":"Goldman","year":"2015","journal-title":"Development"},{"key":"2024090322144286100_awae166-B52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1101\/gad.215802","article-title":"Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10","volume":"16","author":"Stolt","year":"2002","journal-title":"Genes Dev"},{"key":"2024090322144286100_awae166-B53","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.devcel.2006.08.011","article-title":"Soxd proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function","volume":"11","author":"Stolt","year":"2006","journal-title":"Dev Cell"},{"key":"2024090322144286100_awae166-B54","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nbt.1972","article-title":"CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells","volume":"29","author":"Sim","year":"2011","journal-title":"Nat Biotechnol"},{"key":"2024090322144286100_awae166-B55","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1523\/JNEUROSCI.4787-14.2015","article-title":"The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt\/\u03b2-catenin signaling","volume":"35","author":"Hammond","year":"2015","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B56","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.mp.4001621","article-title":"Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization","volume":"10","author":"Zhou","year":"2005","journal-title":"Mol Psychiatry"},{"key":"2024090322144286100_awae166-B57","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.celrep.2017.07.044","article-title":"The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons","volume":"20","author":"Yamakawa","year":"2017","journal-title":"Cell Rep"},{"key":"2024090322144286100_awae166-B58","doi-asserted-by":"crossref","first-page":"25976","DOI":"10.1074\/jbc.272.41.25976","article-title":"Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta4 subunit gene","volume":"272","author":"Bigger","year":"1997","journal-title":"J Biol Chem"},{"key":"2024090322144286100_awae166-B59","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1523\/JNEUROSCI.4679-11.2012","article-title":"Soxc transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis","volume":"32","author":"Mu","year":"2012","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B60","first-page":"831","article-title":"Modulation of cell cycle regulators by HDACs","volume":"4","author":"Telles","year":"2012","journal-title":"Front Biosci (Schol Ed)"},{"key":"2024090322144286100_awae166-B61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrm714","article-title":"Sibling rivalry in the E2F family","volume":"3","author":"Trimarchi","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"D1","key":"2024090322144286100_awae166-B62","doi-asserted-by":"crossref","first-page":"D877","DOI":"10.1093\/nar\/gkw1012","article-title":"MalaCards: An amalgamated human disease compendium with diverse clinical and genetic annotation and structured search","volume":"45","author":"Rappaport","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2024090322144286100_awae166-B63","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/npp.2016.211","article-title":"Towards an immunophenotype of schizophrenia: Progress, potential mechanisms, and future directions","volume":"42","author":"Miller","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"2024090322144286100_awae166-B64","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cell.2012.12.006","article-title":"Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation","volume":"152","author":"Yu","year":"2013","journal-title":"Cell"},{"key":"2024090322144286100_awae166-B65","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1242\/dev.02847","article-title":"A crucial role for Olig2 in white matter astrocyte development","volume":"134","author":"Cai","year":"2007","journal-title":"Development"},{"key":"2024090322144286100_awae166-B66","doi-asserted-by":"crossref","first-page":"14375","DOI":"10.1523\/JNEUROSCI.4456-07.2007","article-title":"Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes","volume":"27","author":"Li","year":"2007","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B67","doi-asserted-by":"crossref","first-page":"e1003907","DOI":"10.1371\/journal.pgen.1003907","article-title":"The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes","volume":"9","author":"Hornig","year":"2013","journal-title":"PLoS Genet"},{"key":"2024090322144286100_awae166-B68","doi-asserted-by":"crossref","first-page":"111291","DOI":"10.1016\/j.celrep.2022.111291","article-title":"A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice","volume":"40","author":"Benraiss","year":"2022","journal-title":"Cell Rep"},{"key":"2024090322144286100_awae166-B69","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0960-9822(02)00926-0","article-title":"The basic helix-loop-helix factor Olig2 is essential for the development of motoneuron and oligodendrocyte lineages","volume":"12","author":"Takebayashi","year":"2002","journal-title":"Curr Biol"},{"key":"2024090322144286100_awae166-B70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0092-8674(02)00678-5","article-title":"Common developmental requirement for Olig function indicates a motor neuron\/oligodendrocyte connection","volume":"109","author":"Lu","year":"2002","journal-title":"Cell"},{"key":"2024090322144286100_awae166-B71","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.neuron.2012.01.018","article-title":"FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development","volume":"73","author":"O'Sullivan","year":"2012","journal-title":"Neuron"},{"key":"2024090322144286100_awae166-B72","doi-asserted-by":"crossref","first-page":"eaaw8546","DOI":"10.1126\/scitranslmed.aaw8546","article-title":"Astrocyte molecular signatures in Huntington\u2019s disease","volume":"11","author":"Diaz-Castro","year":"2019","journal-title":"Sci Transl Med"},{"key":"2024090322144286100_awae166-B73","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40478-020-0880-6","article-title":"Single-nucleus RNA-seq identifies Huntington disease astrocyte states","volume":"8","author":"Al-Dalahmah","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"2024090322144286100_awae166-B74","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.3693-15.2016","article-title":"Dysfunctional calcium and glutamate signaling in striatal astrocytes from Huntington\u2019s disease model mice","volume":"36","author":"Jiang","year":"2016","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B75","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B76","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nn1854","article-title":"Vesicular release of glutamate from unmyelinated axons in white matter","volume":"10","author":"Ziskin","year":"2007","journal-title":"Nat Neurosci"},{"key":"2024090322144286100_awae166-B77","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn1850","article-title":"Vesicular glutamate release from axons in white matter","volume":"10","author":"Kukley","year":"2007","journal-title":"Nat Neurosci"},{"key":"2024090322144286100_awae166-B78","doi-asserted-by":"crossref","first-page":"8518","DOI":"10.1038\/ncomms9518","article-title":"Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors","volume":"6","author":"Gautier","year":"2015","journal-title":"Nat Commun"},{"key":"2024090322144286100_awae166-B79","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41593-023-01553-8","article-title":"Synaptic input and Ca(2+) activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation","volume":"27","author":"Li","year":"2024","journal-title":"Nat Neurosci"},{"key":"2024090322144286100_awae166-B80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog Neurobiol"},{"key":"2024090322144286100_awae166-B81","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1016\/j.celrep.2019.05.088","article-title":"Dysregulated glial differentiation in schizophrenia may be relieved by suppression of SMAD4- and REST-dependent signaling","volume":"27","author":"Liu","year":"2019","journal-title":"Cell Rep"},{"key":"2024090322144286100_awae166-B82","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/glia.22335","article-title":"Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus","volume":"60","author":"Verbich","year":"2012","journal-title":"Glia"},{"key":"2024090322144286100_awae166-B83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/nyas.14372","article-title":"Glial evolution as a determinant of human behavior and its disorders","volume":"1471","author":"Goldman","year":"2020","journal-title":"Ann N Y Acad Sci"},{"key":"2024090322144286100_awae166-B84","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.neuron.2021.02.003","article-title":"Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination","volume":"109","author":"Pease-Raissi","year":"2021","journal-title":"Neuron"},{"key":"2024090322144286100_awae166-B85","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1093\/cercor\/bhx116","article-title":"Oligodendrocyte- and neuron-specific Nogo-A restrict dendritic branching and spine density in the adult mouse motor cortex","volume":"28","author":"Zemmar","year":"2018","journal-title":"Cereb Cortex"},{"key":"2024090322144286100_awae166-B86","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1523\/JNEUROSCI.0074-18.2018","article-title":"Activity-Dependent myelination of parvalbumin interneurons mediated by axonal morphological plasticity","volume":"38","author":"Stedehouder","year":"2018","journal-title":"J Neurosci"},{"key":"2024090322144286100_awae166-B87","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1093\/cercor\/bhx203","article-title":"Fast-spiking parvalbumin interneurons are frequently myelinated in the cerebral cortex of mice and humans","volume":"27","author":"Stedehouder","year":"2017","journal-title":"Cereb Cortex"},{"key":"2024090322144286100_awae166-B88","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.neuron.2018.07.017","article-title":"Enhancing oligodendrocyte myelination rescues synaptic loss and improves functional recovery after chronic hypoxia","volume":"99","author":"Wang","year":"2018","journal-title":"Neuron"},{"key":"2024090322144286100_awae166-B89","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nn.4043","article-title":"Diversity of astrocyte functions and phenotypes in neural circuits","volume":"18","author":"Khakh","year":"2015","journal-title":"Nat Neurosci"},{"key":"2024090322144286100_awae166-B90","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.isci.2018.04.019","article-title":"A comprehensive mutagenesis screen of the adhesion GPCR latrophilin-1\/ADGRL1","volume":"3","author":"Nazarko","year":"2018","journal-title":"iScience"},{"key":"2024090322144286100_awae166-B91","doi-asserted-by":"crossref","first-page":"e1005624","DOI":"10.1371\/journal.pgen.1005624","article-title":"Oriented cell division in the C. elegans embryo is coordinated by G-protein signaling dependent on the adhesion GPCR LAT-1","volume":"11","author":"M\u00fcller","year":"2015","journal-title":"PLoS Genet"},{"key":"2024090322144286100_awae166-B92","doi-asserted-by":"crossref","first-page":"e70514","DOI":"10.7554\/eLife.70514","article-title":"Activity-dependent modulation of synapse-regulating genes in astrocytes","volume":"10","author":"Farhy-Tselnicker","year":"2021","journal-title":"Elife"},{"key":"2024090322144286100_awae166-B93","doi-asserted-by":"crossref","first-page":"15132","DOI":"10.1038\/ncomms15132","article-title":"Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism","volume":"8","author":"Hasel","year":"2017","journal-title":"Nat Commun"},{"key":"2024090322144286100_awae166-B94","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nn.4256","article-title":"Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice","volume":"19","author":"Langfelder","year":"2016","journal-title":"Nat Neurosci"},{"key":"2024090322144286100_awae166-B95","doi-asserted-by":"crossref","first-page":"111988","DOI":"10.1016\/j.celrep.2022.111988","article-title":"Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons","volume":"42","author":"Pietilainen","year":"2023","journal-title":"Cell Rep"},{"key":"2024090322144286100_awae166-B96","doi-asserted-by":"crossref","first-page":"E1253","DOI":"10.1073\/pnas.1621321114","article-title":"Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand","volume":"114","author":"Sterky","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"2024090322144286100_awae166-B97","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cell.2015.11.034","article-title":"Astrocytes assemble thalamocortical synapses by bridging NRX1\u03b1 and NL1 via Hevin","volume":"164","author":"Singh","year":"2016","journal-title":"Cell"},{"key":"2024090322144286100_awae166-B98","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nature24638","article-title":"Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis","volume":"551","author":"Stogsdill","year":"2017","journal-title":"Nature"},{"key":"2024090322144286100_awae166-B99","doi-asserted-by":"crossref","first-page":"e65717","DOI":"10.7554\/eLife.65717","article-title":"Latrophilin GPCR signaling mediates synapse formation","volume":"10","author":"Sando","year":"2021","journal-title":"Elife"},{"key":"2024090322144286100_awae166-B100","doi-asserted-by":"crossref","first-page":"eaav7969","DOI":"10.1126\/science.aav7969","article-title":"Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins","volume":"363","author":"Sando","year":"2019","journal-title":"Science"},{"key":"2024090322144286100_awae166-B101","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/s41467-020-16029-7","article-title":"Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"2024090322144286100_awae166-B102","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/s41467-022-29751-1","article-title":"Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae166\/58599482\/awae166.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/9\/3099\/59004350\/awae166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/9\/3099\/59004350\/awae166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T10:52:30Z","timestamp":1725447150000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/9\/3099\/7716914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":102,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,7,19]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae166","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,7,19]]}}}