{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:33:53Z","timestamp":1790922833624,"version":"4.1.0"},"reference-count":149,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomofunctional mechanisms governing human behaviour, in addition to the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. Although the ventral tegmental area has been targeted successfully with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region is not fully understood.<\/jats:p>\n               <jats:p>Here, using fibre microdissections in human cadaveric hemispheres, population-based high-definition fibre tractography and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain and prefrontal cortex, which is implicated in the treatment of obsessive\u2013compulsive disorder, major depressive disorder, Alzheimer\u2019s disease, cluster headaches and aggressive behaviours.<\/jats:p>","DOI":"10.1093\/brain\/awae173","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T10:40:46Z","timestamp":1716979246000},"page":"3083-3098","source":"Crossref","is-referenced-by-count":18,"title":["Establishing connectivity through microdissections of midbrain stimulation-related neural circuits"],"prefix":"10.1093","volume":"147","author":[{"given":"Georgios P","family":"Skandalakis","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Dartmouth Hitchcock Medical Center , Lebanon, NH 03756 , USA"},{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital , Athens 10676 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Neudorfer","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115 , USA"},{"name":"MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Department of Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , 10117 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin A","family":"Payne","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Dartmouth Hitchcock Medical Center , Lebanon, NH 03756 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evalina","family":"Bond","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Dartmouth Hitchcock Medical Center , Lebanon, NH 03756 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin D","family":"Tavakkoli","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Dartmouth Hitchcock Medical Center , Lebanon, NH 03756 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Barrios-Martinez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C","family":"Trutti","sequence":"additional","affiliation":[{"name":"Integrative Model-Based Cognitive Neuroscience Research Unit, University of Amsterdam , Amsterdam 15926 , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Koutsarnakis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital , Athens 10676 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker A","family":"Coenen","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery, Medical Center of the University of Freiburg , Freiburg 79106 , Germany"},{"name":"Medical Faculty of the University of Freiburg , Freiburg 79110 , Germany"},{"name":"Center for Deep Brain Stimulation, Medical Center of the University of Freiburg , Freiburg 79106 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-414X","authenticated-orcid":false,"given":"Spyridon","family":"Komaitis","sequence":"additional","affiliation":[{"name":"Queens Medical Center, Nottingham University Hospitals NHS Foundation Trust , Nottingham NG7 2UH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos G","family":"Hadjipanayis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Stranjalis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens Medical School, Evangelismos General Hospital , Athens 10676 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Cheng","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Banihashemi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh , Pittsburgh, PA 15213 , USA"},{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6680-0495","authenticated-orcid":false,"given":"Jennifer","family":"Hong","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Dartmouth Hitchcock Medical Center , Lebanon, NH 03756 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University Health Network, University of Toronto , Toronto, ON M5T 1P5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of New Mexico School of Medicine , Albuquerque, NM 87106 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115 , USA"},{"name":"MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Department of Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , 10117 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linton T","family":"Evans","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Dartmouth Hitchcock Medical Center , Lebanon, NH 03756 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis","family":"Kalyvas","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University Health Network, University of Toronto , Toronto, ON M5T 1P5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"2024090322172273800_awae173-B1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn.2016.165","article-title":"Ventral tegmental area: Cellular heterogeneity, connectivity and behaviour","volume":"18","author":"Morales","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"2024090322172273800_awae173-B2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.biopsych.2022.06.011","article-title":"Somatodendritic release of cholecystokinin potentiates GABAergic synapses onto ventral tegmental area dopamine cells","volume":"93","author":"Martinez Damonte","year":"2023","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B3","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41593-023-01310-x","article-title":"Dopaminergic prediction errors in the ventral tegmental area reflect a multithreaded predictive model","volume":"26","author":"Takahashi","year":"2023","journal-title":"Nat Neurosci"},{"key":"2024090322172273800_awae173-B4","doi-asserted-by":"crossref","first-page":"eade5420","DOI":"10.1126\/sciadv.ade5420","article-title":"Dopamine error signal to actively cope with lack of expected reward","volume":"9","author":"Ishino","year":"2023","journal-title":"Sci Adv"},{"key":"2024090322172273800_awae173-B5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-022-04954-0","article-title":"Dopamine subsystems that track internal states","volume":"608","author":"Grove","year":"2022","journal-title":"Nature"},{"key":"2024090322172273800_awae173-B6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41593-022-01076-8","article-title":"Adolescent sleep shapes social novelty preference in mice","volume":"25","author":"Bian","year":"2022","journal-title":"Nat Neurosci"},{"key":"2024090322172273800_awae173-B7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41593-021-00972-9","article-title":"VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error","volume":"25","author":"Soli\u00e9","year":"2022","journal-title":"Nat Neurosci"},{"key":"2024090322172273800_awae173-B8","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/brain\/awaa374","article-title":"Deep brain stimulation of the brainstem","volume":"144","author":"Elias","year":"2021","journal-title":"Brain J Neurol"},{"key":"2024090322172273800_awae173-B9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2020.06.031","article-title":"Four deep brain stimulation targets for obsessive-compulsive disorder: Are they different?","volume":"90","author":"Haber","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41380-021-01100-6","article-title":"Deep brain stimulation of the \u201cmedial forebrain bundle\u201d: A strategy to modulate the reward system and manage treatment-resistant depression","volume":"27","author":"Fenoy","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2024090322172273800_awae173-B11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41398-018-0160-4","article-title":"A longitudinal study on deep brain stimulation of the medial forebrain bundle for treatment-resistant depression","volume":"8","author":"Fenoy","year":"2018","journal-title":"Transl Psychiatry"},{"key":"2024090322172273800_awae173-B12","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.biopsych.2013.01.034","article-title":"Rapid effects of deep brain stimulation for treatment-resistant major depression","volume":"73","author":"Schlaepfer","year":"2013","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B13","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.biopsych.2018.07.025","article-title":"Discontinuation of superolateral medial forebrain bundle deep brain stimulation for treatment-resistant depression leads to critical relapse","volume":"85","author":"Kilian","year":"2019","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.nicl.2018.08.020","article-title":"Tractography-assisted deep brain stimulation of the superolateral branch of the medial forebrain bundle (slMFB DBS) in major depression","volume":"20","author":"Coenen","year":"2018","journal-title":"Neuroimage Clin"},{"key":"2024090322172273800_awae173-B15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/cne.902060106","article-title":"The medial forebrain bundle of the rat. I. General introduction","volume":"206","author":"Nieuwenhuys","year":"1982","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.biopsych.2018.12.019","article-title":"Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder","volume":"85","author":"Baldermann","year":"2019","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B17","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/s41467-020-16734-3","article-title":"A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B18","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3171\/2020.2.JNS193177","article-title":"Dissecting the default mode network: Direct structural evidence on the morphology and axonal connectivity of the fifth component of the cingulum bundle","volume":"134","author":"Skandalakis","year":"2020","journal-title":"J Neurosurg"},{"key":"2024090322172273800_awae173-B19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3171\/2018.11.JNS182908","article-title":"Dorsal component of the superior longitudinal fasciculus revisited: Novel insights from a focused fiber dissection study","volume":"132","author":"Komaitis","year":"2019","journal-title":"J Neurosurg"},{"key":"2024090322172273800_awae173-B20","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00429-021-02231-w","article-title":"A probabilistic atlas of the human ventral tegmental area (VTA) based on 7 Tesla MRI data","volume":"226","author":"Trutti","year":"2021","journal-title":"Brain Struct Funct"},{"key":"2024090322172273800_awae173-B21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41597-019-0254-8","article-title":"7 Tesla MRI of the ex vivo human brain at 100 micron resolution","volume":"6","author":"Edlow","year":"2019","journal-title":"Sci Data"},{"key":"2024090322172273800_awae173-B22","doi-asserted-by":"crossref","first-page":"118135","DOI":"10.1016\/j.neuroimage.2021.118135","article-title":"A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging","volume":"237","author":"Adil","year":"2021","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B23","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1002\/cne.24080","article-title":"Comprehensive cellular-resolution atlas of the adult human brain","volume":"524","author":"Ding","year":"2016","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B24","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S1053-8119(09)70884-5","article-title":"Unbiased nonlinear average age-appropriate brain templates from birth to adulthood","volume":"47","author":"Fonov","year":"2009","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B25","doi-asserted-by":"crossref","first-page":"giy082","DOI":"10.1093\/gigascience\/giy082","article-title":"Nighres: Processing tools for high-resolution neuroimaging","volume":"7","author":"Huntenburg","year":"2018","journal-title":"GigaScience"},{"key":"2024090322172273800_awae173-B26","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1038\/s41467-022-32595-4","article-title":"Population-based tract-to-region connectome of the human brain and its hierarchical topology","volume":"13","author":"Yeh","year":"2022","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mri.2019.01.018","article-title":"A fiber coherence index for quality control of B-table orientation in diffusion MRI scans","volume":"58","author":"Schilling","year":"2019","journal-title":"Magn Reson Imaging"},{"key":"2024090322172273800_awae173-B28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/mrm.26143","article-title":"Mapping immune cell infiltration using restricted diffusion MRI","volume":"77","author":"Yeh","year":"2017","journal-title":"Magn Reson Med"},{"key":"2024090322172273800_awae173-B29","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1109\/TMI.2010.2045126","article-title":"Generalized q-sampling imaging","volume":"29","author":"Yeh","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"2024090322172273800_awae173-B30","doi-asserted-by":"crossref","first-page":"e80713","DOI":"10.1371\/journal.pone.0080713","article-title":"Deterministic diffusion fiber tracking improved by quantitative anisotropy","volume":"8","author":"Yeh","year":"2013","journal-title":"PLoS One"},{"key":"2024090322172273800_awae173-B31","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/nn.4361","article-title":"The human connectome project\u2019s neuroimaging approach","volume":"19","author":"Glasser","year":"2016","journal-title":"Nat Neurosci"},{"key":"2024090322172273800_awae173-B32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41597-021-00904-z","article-title":"In vivo human whole-brain Connectom diffusion MRI dataset at 760 \u00b5m isotropic resolution","volume":"8","author":"Wang","year":"2021","journal-title":"Sci Data"},{"key":"2024090322172273800_awae173-B33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroimage.2011.06.021","article-title":"NTU-90: A high angular resolution brain atlas constructed by q-space diffeomorphic reconstruction","volume":"58","author":"Yeh","year":"2011","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B34","doi-asserted-by":"crossref","first-page":"119146","DOI":"10.1016\/j.neuroimage.2022.119146","article-title":"Post mortem mapping of connectional anatomy for the validation of diffusion MRI","volume":"256","author":"Yendiki","year":"2022","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B35","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/brain\/awae021","article-title":"Multimodal study of multilevel pulvino-temporal connections: A new piece in the puzzle of lexical retrieval networks","volume":"147","author":"Maldonado","year":"2024","journal-title":"Brain J Neurol"},{"key":"2024090322172273800_awae173-B36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00429-019-01987-6","article-title":"Mapping the human middle longitudinal fasciculus through a focused anatomo-imaging study: Shifting the paradigm of its segmentation and connectivity pattern","volume":"225","author":"Kalyvas","year":"2020","journal-title":"Brain Struct Funct"},{"key":"2024090322172273800_awae173-B37","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1523\/JNEUROSCI.2335-17.2017","article-title":"Functional segmentation of the anterior limb of the internal capsule: Linking white matter abnormalities to specific connections","volume":"38","author":"Safadi","year":"2018","journal-title":"J Neurosci"},{"key":"2024090322172273800_awae173-B38","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuroimage.2017.02.004","article-title":"Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space","volume":"150","author":"Horn","year":"2017","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B39","doi-asserted-by":"crossref","first-page":"119862","DOI":"10.1016\/j.neuroimage.2023.119862","article-title":"Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks","volume":"268","author":"Neudorfer","year":"2023","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12938-018-0463-y","article-title":"The FieldTrip-SimBio pipeline for EEG forward solutions","volume":"17","author":"Vorwerk","year":"2018","journal-title":"Biomed Eng Online"},{"key":"2024090322172273800_awae173-B41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuroimage.2018.08.068","article-title":"Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging","volume":"184","author":"Horn","year":"2019","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B42","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1109\/TBME.2014.2363494","article-title":"Relationship between neural activation and electric field distribution during deep brain stimulation","volume":"62","author":"\u00c5str\u00f6m","year":"2015","journal-title":"IEEE Trans Biomed Eng"},{"key":"2024090322172273800_awae173-B43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1176\/appi.ajp.2019.19060656","article-title":"Efficacy of deep brain stimulation of the ventral anterior limb of the internal capsule for refractory obsessive-compulsive disorder: A clinical cohort of 70 patients","volume":"177","author":"Denys","year":"2020","journal-title":"Am J Psychiatry"},{"key":"2024090322172273800_awae173-B44","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/sj.npp.1301165","article-title":"Three-year outcomes in deep brain stimulation for highly resistant obsessive\u2013compulsive disorder","volume":"31","author":"Greenberg","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"2024090322172273800_awae173-B45","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.brs.2022.03.004","article-title":"Efficacy of superolateral medial forebrain bundle deep brain stimulation in obsessive-compulsive disorder","volume":"15","author":"Meyer","year":"2022","journal-title":"Brain Stimul"},{"key":"2024090322172273800_awae173-B46","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/mp.2015.124","article-title":"Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder","volume":"21","author":"Luyten","year":"2016","journal-title":"Mol Psychiatry"},{"key":"2024090322172273800_awae173-B47","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/978-3-211-33081-4_44","volume-title":"Operative neuromodulation, Vol. 2, Neural networks surgery","author":"Jim\u00e9nez","year":"2007"},{"key":"2024090322172273800_awae173-B48","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jocn.2013.10.003","article-title":"The anteromedial GPi as a new target for deep brain stimulation in obsessive compulsive disorder","volume":"21","author":"Nair","year":"2014","journal-title":"J Clin Neurosci"},{"key":"2024090322172273800_awae173-B49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3171\/2015.6.JNS15716","article-title":"Bilateral deep brain stimulation of the fornix for Alzheimer\u2019s disease: Surgical safety in the ADvance trial","volume":"125","author":"Ponce","year":"2016","journal-title":"J Neurosurg"},{"key":"2024090322172273800_awae173-B50","doi-asserted-by":"crossref","first-page":"106179","DOI":"10.1016\/j.nbd.2023.106179","article-title":"Reduction of aggressive behaviour following hypothalamic deep brain stimulation: Involvement of 5-HT1A and testosterone","volume":"183","author":"Gouveia","year":"2023","journal-title":"Neurobiol Dis"},{"key":"2024090322172273800_awae173-B51","doi-asserted-by":"crossref","first-page":"102165","DOI":"10.1016\/j.nicl.2020.102165","article-title":"Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders","volume":"25","author":"Coenen","year":"2020","journal-title":"Neuroimage Clin"},{"key":"2024090322172273800_awae173-B52","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/ana.25887","article-title":"Deep brain stimulation for chronic cluster headache: Meta-analysis of individual patient data","volume":"88","author":"Nowacki","year":"2020","journal-title":"Ann Neurol"},{"key":"2024090322172273800_awae173-B53","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41593-023-01324-5","article-title":"Augmenting hippocampal\u2013prefrontal neuronal synchrony during sleep enhances memory consolidation in humans","volume":"26","author":"Geva-Sagiv","year":"2023","journal-title":"Nat Neurosci"},{"key":"2024090322172273800_awae173-B54","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1093\/brain\/awac070","article-title":"Cholinergic and hippocampal systems facilitate cross-domain cognitive recovery after stroke","volume":"145","author":"O\u2019Sullivan","year":"2022","journal-title":"Brain"},{"key":"2024090322172273800_awae173-B55","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3390\/brainsci12091248","article-title":"Imaging the limbic system in Parkinson\u2019s disease\u2014A review of limbic pathology and clinical symptoms","volume":"12","author":"Banwinkler","year":"2022","journal-title":"Brain Sci"},{"key":"2024090322172273800_awae173-B56","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biopsych.2021.04.009","article-title":"The neurocircuitry of posttraumatic stress disorder and major depression: Insights into overlapping and distinct circuit dysfunction\u2014A tribute to Ron Duman","volume":"90","author":"Ploski","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B57","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopsych.2019.09.021","article-title":"Cognition and reward circuits in schizophrenia: Synergistic, not separate","volume":"87","author":"Robison","year":"2020","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B58","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41562-022-01310-0","article-title":"Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG","volume":"6","author":"Bijanzadeh","year":"2022","journal-title":"Nat Hum Behav"},{"key":"2024090322172273800_awae173-B59","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1212\/WNL.0000000000005733","article-title":"Relating structural and functional brainstem connectivity to disease measures in epilepsy","volume":"91","author":"Englot","year":"2018","journal-title":"Neurology"},{"key":"2024090322172273800_awae173-B60","first-page":"273","article-title":"Effect of deep brain stimulation in the ventral tegmental area on neuronal activity in local and remote brain regions in kindled mice","volume":"25","author":"Esmaeili Tazangi","year":"2023","journal-title":"Cell J"},{"key":"2024090322172273800_awae173-B61","doi-asserted-by":"crossref","first-page":"107073","DOI":"10.1016\/j.eplepsyres.2022.107073","article-title":"Tonic and phasic stimulations of ventral tegmental area have opposite effects on pentylenetetrazol kindled seizures in mice","volume":"189","author":"Rezaei","year":"2023","journal-title":"Epilepsy Res"},{"key":"2024090322172273800_awae173-B62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopsych.2023.03.004","article-title":"Neural network functional interactions mediate or suppress white matter\u2013emotional behavior relationships in infants","volume":"94","author":"Banihashemi","year":"2023","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B63","volume-title":"Connectomic deep brain stimulation","author":"Horn","year":"2021"},{"key":"2024090322172273800_awae173-B64","doi-asserted-by":"crossref","first-page":"117180","DOI":"10.1016\/j.neuroimage.2020.117180","article-title":"Opportunities of connectomic neuromodulation","volume":"221","author":"Horn","year":"2020","journal-title":"Neuroimage"},{"key":"2024090322172273800_awae173-B65","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.biopsych.2023.01.020","article-title":"Decoding depression severity from intracranial neural activity","volume":"94","author":"Xiao","year":"2023","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B66","doi-asserted-by":"crossref","DOI":"10.1101\/2023.04.06.535959","article-title":"Monosynaptic inputs to ventral tegmental area glutamate and GABA co-transmitting neurons.","volume-title":"bioRxiv","author":"Pr\u00e9vost"},{"key":"2024090322172273800_awae173-B67","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1038\/s41380-022-01661-0","article-title":"The serotonin theory of depression: A systematic umbrella review of the evidence","volume":"28","author":"Moncrieff","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2024090322172273800_awae173-B68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.brainresrev.2007.01.002","article-title":"The dorsal raphe nucleus\u2014From silver stainings to a role in depression","volume":"55","author":"Michelsen","year":"2007","journal-title":"Brain Res Rev"},{"key":"2024090322172273800_awae173-B69","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41593-022-01062-0","article-title":"A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice","volume":"25","author":"Cai","year":"2022","journal-title":"Nat Neurosci"},{"key":"2024090322172273800_awae173-B70","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.brs.2019.01.020","article-title":"Chronic brain stimulation rewarding experience ameliorates depression-induced cognitive deficits and restores aberrant plasticity in the prefrontal cortex","volume":"12","author":"Chakraborty","year":"2019","journal-title":"Brain Stimulat"},{"key":"2024090322172273800_awae173-B71","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)00912-6","article-title":"The dorsal raphe nucleus and serotonin: Implications for neuroplasticity linked to major depression and Alzheimer\u2019s disease","volume":"172","author":"Michelsen","year":"2008","journal-title":"Prog Brain Res"},{"key":"2024090322172273800_awae173-B72","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/mds.28722","article-title":"Serotonergic and dopaminergic lesions underlying parkinsonian neuropsychiatric signs","volume":"36","author":"Maillet","year":"2021","journal-title":"Mov Disord"},{"key":"2024090322172273800_awae173-B73","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/brain\/awv215","article-title":"Clinical correlates of raphe serotonergic dysfunction in early Parkinson\u2019s disease","volume":"138","author":"Qamhawi","year":"2015","journal-title":"Brain"},{"key":"2024090322172273800_awae173-B74","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1093\/brain\/aww162","article-title":"The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson\u2019s disease","volume":"139","author":"Maillet","year":"2016","journal-title":"Brain"},{"key":"2024090322172273800_awae173-B75","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fnsys.2017.00050","article-title":"Lateral hypothalamic control of the ventral tegmental area: Reward evaluation and the driving of motivated behavior","volume":"11","author":"Tyree","year":"2017","journal-title":"Front Syst Neurosci"},{"key":"2024090322172273800_awae173-B76","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuropharm.2019.05.014","article-title":"Diversity in the lateral hypothalamic input to the ventral tegmental area","volume":"154","author":"Godfrey","year":"2019","journal-title":"Neuropharmacology"},{"key":"2024090322172273800_awae173-B77","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1038\/s41467-022-34625-7","article-title":"Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food","volume":"13","author":"Linders","year":"2022","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B78","doi-asserted-by":"crossref","first-page":"e0158885","DOI":"10.1371\/journal.pone.0158885","article-title":"Optogenetic activation of a lateral hypothalamic-ventral tegmental drive-reward pathway","volume":"11","author":"Gigante","year":"2016","journal-title":"PLoS One"},{"key":"2024090322172273800_awae173-B79","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/npp.2017.228","article-title":"Drive and reinforcement circuitry in the brain: Origins, neurotransmitters, and projection fields","volume":"43","author":"Wise","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2024090322172273800_awae173-B80","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00701-014-2335-y","article-title":"DTI-based deterministic fibre tracking of the medial forebrain bundle","volume":"157","author":"Anthofer","year":"2015","journal-title":"Acta Neurochir (Wien)"},{"key":"2024090322172273800_awae173-B81","volume-title":"Netter\u2019s atlas of neuroscience","author":"Felten","year":"2015"},{"key":"2024090322172273800_awae173-B82","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s41386-019-0369-9","article-title":"Superolateral medial forebrain bundle deep brain stimulation in major depression: A gateway trial","volume":"44","author":"Coenen","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"2024090322172273800_awae173-B83","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/brain\/awab170","article-title":"Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation","volume":"144","author":"Neudorfer","year":"2021","journal-title":"Brain J Neurol"},{"key":"2024090322172273800_awae173-B84","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.neuron.2016.04.035","article-title":"Inhibitory input from the lateral hypothalamus to the ventral tegmental area disinhibits dopamine neurons and promotes behavioral activation","volume":"90","author":"Nieh","year":"2016","journal-title":"Neuron"},{"key":"2024090322172273800_awae173-B85","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1749-6632.1995.tb44714.x","article-title":"Sensitization to stress and psychostimulants. Involvement of dopamine transmission versus the HPA axis","volume":"771","author":"Prasad","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"2024090322172273800_awae173-B86","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.abn0853","article-title":"A specific circuit in the midbrain detects stress and induces restorative sleep","volume":"377","author":"Yu","year":"2022","journal-title":"Science"},{"key":"2024090322172273800_awae173-B87","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/cne.901690403","article-title":"The efferent connections of the ventromedial nucleus of the hypothalamus of the rat","volume":"169","author":"Saper","year":"1976","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B88","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/cne.20668","article-title":"Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions","volume":"490","author":"Geisler","year":"2005","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B89","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0006-8993(93)91653-A","article-title":"3\u03b1-OH-DHP and 5\u03b1-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus","volume":"612","author":"Frye","year":"1993","journal-title":"Brain Res"},{"key":"2024090322172273800_awae173-B90","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1210\/endo-103-3-957","article-title":"Organization of the medial hypothalamus for control of adrenocorticotropin in the cat","volume":"103","author":"Maran","year":"1978","journal-title":"Endocrinology"},{"key":"2024090322172273800_awae173-B91","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cobeha.2018.06.011","article-title":"Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression","volume":"24","author":"Yamaguchi","year":"2018","journal-title":"Curr Opin Behav Sci"},{"key":"2024090322172273800_awae173-B92","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neubiorev.2014.07.025","article-title":"How do mammillary body inputs contribute to anterior thalamic function?","volume":"54","author":"Dillingham","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"2024090322172273800_awae173-B93","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(68)90028-0","article-title":"Self-stimulation of the lateral hypothalamus after electrolytic injury of the medial forebrain bundle in the cat","volume":"11","author":"Umemoto","year":"1968","journal-title":"Brain Res"},{"key":"2024090322172273800_awae173-B94","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/cne.901860408","article-title":"The connections of the septal region in the rat","volume":"186","author":"Swanson","year":"1979","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B95","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1093\/brain\/awp175","article-title":"Gudden\u2019s ventral tegmental nucleus is vital for memory: Re-evaluating diencephalic inputs for amnesia","volume":"132","author":"Vann","year":"2009","journal-title":"Brain"},{"key":"2024090322172273800_awae173-B96","doi-asserted-by":"crossref","first-page":"e00736","DOI":"10.7554\/eLife.00736","article-title":"Dismantling the Papez circuit for memory in rats","volume":"2","author":"Vann","year":"2013","journal-title":"eLife"},{"key":"2024090322172273800_awae173-B97","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1523\/JNEUROSCI.23-09-03930.2003","article-title":"Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area","volume":"23","author":"Floresco","year":"2003","journal-title":"J Neurosci"},{"key":"2024090322172273800_awae173-B98","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/jnnp-2019-322375","article-title":"Anatomy and function of the fornix in the context of its potential as a therapeutic target","volume":"91","author":"Senova","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024090322172273800_awae173-B99","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/ner.13305","article-title":"Deep brain stimulation for Alzheimer\u2019s disease: Tackling circuit dysfunction","volume":"24","author":"Lam","year":"2021","journal-title":"Neuromodulation Technol Neural Interface"},{"key":"2024090322172273800_awae173-B100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuropharm.2017.09.034","article-title":"Lateral septum stimulation disinhibits dopaminergic neurons in the antero-ventral region of the ventral tegmental area: Role of GABA-A alpha 1 receptors","volume":"128","author":"Vega-Quiroga","year":"2018","journal-title":"Neuropharmacology"},{"key":"2024090322172273800_awae173-B101","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/cne.20859","article-title":"Afferents to the orexin neurons of the rat brain","volume":"494","author":"Yoshida","year":"2006","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B102","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41380-022-01809-y","article-title":"D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum","volume":"28","author":"Tong","year":"2023","journal-title":"Mol Psychiatry"},{"key":"2024090322172273800_awae173-B103","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1038\/s41467-021-27092-z","article-title":"Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections","volume":"12","author":"Mahadevia","year":"2021","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B104","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/cne.21983","article-title":"Afferents to the GABAergic tail of the ventral tegmental area in the rat","volume":"513","author":"Kaufling","year":"2009","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B105","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1523\/JNEUROSCI.0012-07.2007","article-title":"Glutamatergic afferents of the ventral tegmental area in the rat","volume":"27","author":"Geisler","year":"2007","journal-title":"J Neurosci"},{"key":"2024090322172273800_awae173-B106","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuint.2018.02.003","article-title":"Cholinergic tone in ventral tegmental area: Functional organization and behavioral implications","volume":"114","author":"Zhang","year":"2018","journal-title":"Neurochem Int"},{"key":"2024090322172273800_awae173-B107","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-7091-0643-3_11","volume-title":"Advances in research on neurodegeneration","author":"Bosboom","year":"2003"},{"key":"2024090322172273800_awae173-B108","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1002\/cne.23415","article-title":"Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer\u2019s disease","volume":"521","author":"Mesulam","year":"2013","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B109","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cobeha.2018.10.003","article-title":"The role of the bed nucleus of the stria terminalis in pain-induced aversive motivation","volume":"26","author":"Minami","year":"2019","journal-title":"Curr Opin Behav Sci"},{"key":"2024090322172273800_awae173-B110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13041-020-00684-4","article-title":"Inhibitory synaptic transmissions to the bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area are enhanced in rats exposed to chronic mild stress","volume":"13","author":"Hara","year":"2020","journal-title":"Mol Brain"},{"key":"2024090322172273800_awae173-B111","doi-asserted-by":"crossref","first-page":"107759","DOI":"10.1016\/j.neuropharm.2019.107759","article-title":"Chronic intermittent ethanol exposure dysregulates a GABAergic microcircuit in the bed nucleus of the stria terminalis","volume":"168","author":"Pati","year":"2020","journal-title":"Neuropharmacology"},{"key":"2024090322172273800_awae173-B112","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature12041","article-title":"Distinct extended amygdala circuits for divergent motivational states","volume":"496","author":"Jennings","year":"2013","journal-title":"Nature"},{"key":"2024090322172273800_awae173-B113","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.brs.2018.04.013","article-title":"A pilot study of bed nucleus of the stria terminalis deep brain stimulation in treatment-resistant depression","volume":"11","author":"Fitzgerald","year":"2018","journal-title":"Brain Stimulat"},{"key":"2024090322172273800_awae173-B114","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1038\/s41380-022-01726-0","article-title":"Brain metabolic changes and clinical response to superolateral medial forebrain bundle deep brain stimulation for treatment-resistant depression","volume":"27","author":"Conner","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2024090322172273800_awae173-B115","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1523\/JNEUROSCI.0945-22.2022","article-title":"Midbrain\u2013hippocampus structural connectivity selectively predicts motivated memory encoding","volume":"42","author":"Elliott","year":"2022","journal-title":"J Neurosci"},{"key":"2024090322172273800_awae173-B116","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41586-021-03948-8","article-title":"Dopamine facilitates associative memory encoding in the entorhinal cortex","volume":"598","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"2024090322172273800_awae173-B117","doi-asserted-by":"crossref","first-page":"14727","DOI":"10.1038\/ncomms14727","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B118","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-171018","article-title":"Volume and connectivity of the ventral tegmental area are linked to neurocognitive signatures of Alzheimer\u2019s disease in humans","volume":"63","author":"De Marco","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2024090322172273800_awae173-B119","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41467-022-29155-1","article-title":"Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors","volume":"13","author":"Morel","year":"2022","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B120","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/WNP.0000000000000377","article-title":"Structure and function of the human insula","volume":"34","author":"Uddin","year":"2017","journal-title":"J Clin Neurophysiol"},{"key":"2024090322172273800_awae173-B121","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3389\/fphar.2019.00720","article-title":"The insula: A brain stimulation target for the treatment of addiction","volume":"10","author":"Ibrahim","year":"2019","journal-title":"Front Pharmacol"},{"key":"2024090322172273800_awae173-B122","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.schres.2010.08.027","article-title":"The role of the insula in schizophrenia","volume":"123","author":"Wylie","year":"2010","journal-title":"Schizophr Res"},{"key":"2024090322172273800_awae173-B123","doi-asserted-by":"crossref","first-page":"109464","DOI":"10.1016\/j.neuropharm.2023.109464","article-title":"Salience to remember: VTA-IC dopaminergic pathway activity is necessary for object recognition memory formation","volume":"228","author":"Ramirez-Mejia","year":"2023","journal-title":"Neuropharmacology"},{"key":"2024090322172273800_awae173-B124","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1523\/JNEUROSCI.1114-22.2022","article-title":"The angiotensin antagonist losartan modulates social reward motivation and punishment sensitivity via modulating midbrain-striato-frontal circuits","volume":"43","author":"Zhou","year":"2023","journal-title":"J Neurosci"},{"key":"2024090322172273800_awae173-B125","doi-asserted-by":"crossref","first-page":"109749","DOI":"10.1016\/j.drugalcdep.2022.109749","article-title":"Brain recovery of the NAc fibers and prediction of craving changes in person with heroin addiction: A longitudinal study","volume":"243","author":"Lu","year":"2023","journal-title":"Drug Alcohol Depend"},{"key":"2024090322172273800_awae173-B126","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/s42003-022-04165-3","article-title":"Neurocomputational mechanisms of affected beliefs","volume":"5","author":"M\u00fcller-Pinzler","year":"2022","journal-title":"Commun Biol"},{"key":"2024090322172273800_awae173-B127","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders, 5th edition: DSM-5","author":"American Psychiatric Association","year":"2013"},{"key":"2024090322172273800_awae173-B128","doi-asserted-by":"crossref","first-page":"103226","DOI":"10.1016\/j.nicl.2022.103226","article-title":"Decreased reward circuit connectivity during reward anticipation in major depression","volume":"36","author":"Geugies","year":"2022","journal-title":"NeuroImage Clin"},{"key":"2024090322172273800_awae173-B129","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.biopsych.2022.02.013","article-title":"Translational structural and functional signatures of chronic alcohol effects in mice","volume":"91","author":"Degiorgis","year":"2022","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B130","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1016\/j.cub.2022.08.010","article-title":"Distinct neural representations for prosocial and self-benefiting effort","volume":"32","author":"Lockwood","year":"2022","journal-title":"Curr Biol"},{"key":"2024090322172273800_awae173-B131","doi-asserted-by":"crossref","first-page":"E558","DOI":"10.1093\/neuros\/nyz285","article-title":"Tractography-guided deep brain stimulation of the anteromedial globus pallidus internus for refractory obsessive-compulsive disorder: Case report","volume":"86","author":"Azriel","year":"2020","journal-title":"Neurosurgery"},{"key":"2024090322172273800_awae173-B132","doi-asserted-by":"crossref","first-page":"110775","DOI":"10.1016\/j.celrep.2022.110775","article-title":"An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement","volume":"39","author":"Tian","year":"2022","journal-title":"Cell Rep"},{"key":"2024090322172273800_awae173-B133","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJMra1511480","article-title":"Neurobiologic advances from the brain disease model of addiction","volume":"374","author":"Volkow","year":"2016","journal-title":"N Engl J Med"},{"key":"2024090322172273800_awae173-B134","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.biopsych.2023.01.006","article-title":"The rostral zona incerta: A subcortical integrative hub and potential deep brain stimulation target for obsessive-compulsive disorder","volume":"93","author":"Haber","year":"2023","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B135","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fnhum.2012.00341","article-title":"DBS in the basolateral amygdala improves symptoms of autism and related self-injurious behavior: A case report and hypothesis on the pathogenesis of the disorder","volume":"6","author":"Sturm","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"2024090322172273800_awae173-B136","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.biopsych.2021.02.017","article-title":"Identification of novel neurocircuitry through which leptin targets multiple inputs to the dopamine system to reduce food reward seeking","volume":"90","author":"Omrani","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B137","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41467-022-28190-2","article-title":"NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model","volume":"13","author":"Qi","year":"2022","journal-title":"Nat Commun"},{"key":"2024090322172273800_awae173-B138","doi-asserted-by":"crossref","first-page":"eaba4788","DOI":"10.1126\/sciadv.aba4788","article-title":"Medial forebrain bundle structure is linked to human impulsivity","volume":"6","author":"MacNiven","year":"2020","journal-title":"Sci Adv"},{"key":"2024090322172273800_awae173-B139","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biopsych.2021.02.014","article-title":"Chronic stress induces sex-specific functional and morphological alterations in corticoaccumbal and corticotegmental pathways","volume":"90","author":"Bittar","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2024090322172273800_awae173-B140","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.nicl.2018.03.019","article-title":"The anatomy of the human medial forebrain bundle: Ventral tegmental area connections to reward-associated subcortical and frontal lobe regions","volume":"18","author":"Coenen","year":"2018","journal-title":"NeuroImage Clin"},{"key":"2024090322172273800_awae173-B141","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/cne.903060408","article-title":"Organization of ascending hypothalamic projections to the rostral forebrain with special reference to the innervation of cholinergic projection neurons","volume":"306","author":"Cullinan","year":"1991","journal-title":"J Comp Neurol"},{"key":"2024090322172273800_awae173-B142","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0361-9230(83)90045-X","article-title":"Monoamine distribution in primate brain V. Monoaminergic nuclei: Anatomy, pathways and local organization","volume":"10","author":"Felten","year":"1983","journal-title":"Brain Res Bull"},{"key":"2024090322172273800_awae173-B143","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0361-9230(81)90101-5","article-title":"Afferent connections to the lateral hypothalamus: A horseradish peroxidase study in the rat","volume":"7","author":"Barone","year":"1981","journal-title":"Brain Res Bull"},{"key":"2024090322172273800_awae173-B144","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.brs.2023.03.012","article-title":"Tomographic tract tracing and data driven approaches to unravel complex 3D fiber anatomy of DBS relevant prefrontal projections to the diencephalic-mesencephalic junction in the marmoset","volume":"16","author":"Coenen","year":"2023","journal-title":"Brain Stimulat"},{"key":"2024090322172273800_awae173-B145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev-neuro-110122-110434","article-title":"Deep brain stimulation for obsessive-compulsive disorder and depression","volume":"46","author":"Sheth","year":"2023","journal-title":"Annu Rev Neurosci"},{"key":"2024090322172273800_awae173-B146","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41398-021-01384-w","article-title":"The role of the orbitofrontal cortex and the nucleus accumbens for craving in alcohol use disorder","volume":"11","author":"Bracht","year":"2021","journal-title":"Transl Psychiatry"},{"key":"2024090322172273800_awae173-B147","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jad.2020.05.008","article-title":"Reduced tract length of the medial forebrain bundle and the anterior thalamic radiation in bipolar disorder with melancholic depression","volume":"274","author":"Denier","year":"2020","journal-title":"J Affect Disord"},{"key":"2024090322172273800_awae173-B148","doi-asserted-by":"crossref","first-page":"102044","DOI":"10.1016\/j.nicl.2019.102044","article-title":"Increased structural connectivity of the medial forebrain bundle in schizophrenia spectrum disorders is associated with delusions of paranoid threat and grandiosity","volume":"24","author":"Bracht","year":"2019","journal-title":"NeuroImage Clin"},{"key":"2024090322172273800_awae173-B149","doi-asserted-by":"crossref","first-page":"1214629","DOI":"10.3389\/fnana.2023.1214629","article-title":"The anatomy of the four streams of the prefrontal cortex. Preliminary evidence from a population based high definition tractography study","volume":"17","author":"Skandalakis","year":"2023","journal-title":"Front Neuroanat"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae173\/58858560\/awae173.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/9\/3083\/59004413\/awae173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/9\/3083\/59004413\/awae173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T10:54:18Z","timestamp":1725447258000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/9\/3083\/7684362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":149,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5,29]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae173","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,5,29]]}}}