{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:05:20Z","timestamp":1793480720982,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100015997","name":"Deutsche Parkinson Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390857198"],"award-info":[{"award-number":["390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EK1605A"],"award-info":[{"award-number":["01EK1605A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"L\u00fcneburg heritage"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Four-repeat (4R) tauopathies are neurodegenerative diseases characterized by cerebral accumulation of 4R tau pathology. The most prominent 4R tauopathies are progressive supranuclear palsy (PSP) and corticobasal degeneration characterized by subcortical tau accumulation and cortical neuronal dysfunction, as shown by PET-assessed hypoperfusion and glucose hypometabolism. Yet, there is a spatial mismatch between subcortical tau deposition patterns and cortical neuronal dysfunction, and it is unclear how these two pathological brain changes are interrelated. Here, we hypothesized that subcortical tau pathology induces remote neuronal dysfunction in functionally connected cortical regions to test a pathophysiological model that mechanistically links subcortical tau accumulation to cortical neuronal dysfunction in 4R tauopathies.<\/jats:p>\n               <jats:p>We included 51 A\u03b2-negative patients with clinically diagnosed PSP variants (n = 26) or corticobasal syndrome (n = 25) who underwent structural MRI and 18F-PI-2620 tau-PET. 18F-PI-2620 tau-PET was recorded using a dynamic one-stop-shop acquisition protocol to determine an early 0.5\u20132.5 min post tracer-injection perfusion window for assessing cortical neuronal dysfunction, as well as a 20\u201340 min post tracer-injection window to determine 4R-tau load. Perfusion-PET (i.e. early window) was assessed in 200 cortical regions, and tau-PET was assessed in 32 subcortical regions of established functional brain atlases. We determined tau epicentres as subcortical regions with the highest 18F-PI-2620 tau-PET signal and assessed the connectivity of tau epicentres to cortical regions of interest using a resting-state functional MRI-based functional connectivity template derived from 69 healthy elderly controls from the ADNI cohort. Using linear regression, we assessed whether: (i) higher subcortical tau-PET was associated with reduced cortical perfusion; and (ii) cortical perfusion reductions were observed preferentially in regions closely connected to subcortical tau epicentres.<\/jats:p>\n               <jats:p>As hypothesized, higher subcortical tau-PET was associated with overall lower cortical perfusion, which remained consistent when controlling for cortical tau-PET. Using group-average and subject-level PET data, we found that the seed-based connectivity pattern of subcortical tau epicentres aligned with cortical perfusion patterns, where cortical regions that were more closely connected to the tau epicentre showed lower perfusion.<\/jats:p>\n               <jats:p>Together, subcortical tau-accumulation is associated with remote perfusion reductions indicative of neuronal dysfunction in functionally connected cortical regions in 4R-tauopathies. This suggests that subcortical tau pathology may induce cortical dysfunction, which may contribute to clinical disease manifestation and clinical heterogeneity.<\/jats:p>","DOI":"10.1093\/brain\/awae174","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:23:58Z","timestamp":1717694638000},"page":"2428-2439","source":"Crossref","is-referenced-by-count":20,"title":["Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies"],"prefix":"10.1093","volume":"147","author":[{"given":"Sebastian N","family":"Roemer","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-2843","authenticated-orcid":false,"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Munich Cluster for Systems Neurology (SyNergy) , 81377 Munich , Germany"},{"name":"Department of Nuclear Medicine, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Gn\u00f6rich","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge , Cambridge CB2 1TN , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirlind","family":"Zaganjori","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Magna Graecia University , 88100 Catanzaro , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattes","family":"Gross","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"Department of Nuclear Medicine, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Steward","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-196X","authenticated-orcid":false,"given":"Anna","family":"Dewenter","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Dehsarvi","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ferschmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Wall","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Palleis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) , 81377 Munich , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris S","family":"Rauchmann","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich , 80336 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Katzdobler","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"J\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stockbauer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban M","family":"Fietzek","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endy","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-8398","authenticated-orcid":false,"given":"Andreas","family":"Zwergal","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"German Center for Vertigo and Balance Disorders (DSGZ), University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-4674","authenticated-orcid":false,"given":"Sophia","family":"St\u00f6cklein","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, LMU Munich , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Perneczky","sequence":"additional","affiliation":[{"name":"Munich Cluster for Systems Neurology (SyNergy) , 81377 Munich , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , 81377 Munich , Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich , 80336 Munich , Germany"},{"name":"Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London , London SW7 2BX , UK"},{"name":"Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield , Sheffield S10 2HQ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk","family":"Barthel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Leipzig , 04103 Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Sabri","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Leipzig , 04103 Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) , 81377 Munich , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-2283","authenticated-orcid":false,"given":"Nicolai","family":"Franzmeier","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich , 81377 Munich , Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) , 81377 Munich , Germany"},{"name":"Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology , SE 413 90 M\u00f6lndal and Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"2024070507220263100_awae174-B1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12208","article-title":"Invited review: Neuropathology of tauopathies: Principles and practice","volume":"41","author":"Kovacs","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2024070507220263100_awae174-B2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria","volume":"32","author":"Hoglinger","year":"2017","journal-title":"Mov Disord"},{"key":"2024070507220263100_awae174-B3","doi-asserted-by":"crossref","first-page":"101644","DOI":"10.1016\/j.pneurobio.2019.101644","article-title":"Four-repeat tauopathies","volume":"180","author":"Rosler","year":"2019","journal-title":"Prog Neurobiol"},{"key":"2024070507220263100_awae174-B4","first-page":"66","article-title":"Corticobasal degeneration and corticobasal syndrome: A review","volume":"1","author":"Constantinides","year":"2019","journal-title":"Clin Park Relat Disord"},{"key":"2024070507220263100_awae174-B5","doi-asserted-by":"crossref","first-page":"fcac108","DOI":"10.1093\/braincomms\/fcac108","article-title":"Histologic lesion type correlates of magnetic resonance imaging biomarkers in four-repeat tauopathies","volume":"4","author":"Carlos","year":"2022","journal-title":"Brain Commun"},{"key":"2024070507220263100_awae174-B6","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1212\/WNL.0000000000003305","article-title":"Progression of brain atrophy in PSP and CBS over 6 months and 1 year","volume":"87","author":"Dutt","year":"2016","journal-title":"Neurology"},{"issue":"Pt 6","key":"2024070507220263100_awae174-B7","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/brain\/awh508","article-title":"Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy","volume":"128","author":"Cordato","year":"2005","journal-title":"Brain"},{"key":"2024070507220263100_awae174-B8","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/mds.26973","article-title":"Longitudinal magnetic resonance imaging in progressive supranuclear palsy: A new combined score for clinical trials","volume":"32","author":"Hoglinger","year":"2017","journal-title":"Mov Disord. Jun"},{"key":"2024070507220263100_awae174-B9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol"},{"key":"2024070507220263100_awae174-B10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-022-00533-z","article-title":"Tauopathies: New perspectives and challenges","volume":"17","author":"Zhang","year":"2022","journal-title":"Mol Neurodegener"},{"key":"2024070507220263100_awae174-B11","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s41380-022-01875-2","article-title":"Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains","volume":"28","author":"Malarte","year":"2023","journal-title":"Mol Psychiatry"},{"key":"2024070507220263100_awae174-B12","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1007\/s00259-019-04397-2","article-title":"Discovery and preclinical characterization of [(18)F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies","volume":"46","author":"Kroth","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2024070507220263100_awae174-B13","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/acschemneuro.2c00291","article-title":"Molecular simulations reveal distinct energetic and kinetic binding properties of [(18)F]PI-2620 on tau filaments from 3R\/4R and 4R tauopathies","volume":"13","author":"Kunze","year":"2022","journal-title":"ACS Chem Neurosci"},{"key":"2024070507220263100_awae174-B14","first-page":"1754","article-title":"(18)F-PI-2620 tau PET improves the imaging diagnosis of progressive supranuclear palsy","volume":"63","author":"Messerschmidt","year":"2022","journal-title":"J Nucl Med"},{"key":"2024070507220263100_awae174-B15","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1007\/s00259-021-05391-3","article-title":"Feasibility of short imaging protocols for [(18)F]PI-2620 tau-PET in progressive supranuclear palsy","volume":"48","author":"Song","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2024070507220263100_awae174-B16","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41467-022-28896-3","article-title":"Tau deposition patterns are associated with functional connectivity in primary tauopathies","volume":"13","author":"Franzmeier","year":"2022","journal-title":"Nat Commun"},{"key":"2024070507220263100_awae174-B17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00259-022-05964-w","article-title":"Additive value of [(18)F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome","volume":"50","author":"Katzdobler","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2024070507220263100_awae174-B18","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1001\/jamaneurol.2020.2526","article-title":"Assessment of 18F-PI-2620 as a biomarker in progressive supranuclear palsy","volume":"77","author":"Brendel","year":"2020","journal-title":"JAMA Neurol"},{"key":"2024070507220263100_awae174-B19","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1002\/mds.28624","article-title":"Cortical [(18) F]PI-2620 binding differentiates corticobasal syndrome subtypes","volume":"36","author":"Palleis","year":"2021","journal-title":"Mov Disord"},{"key":"2024070507220263100_awae174-B20","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.2967\/jnumed.116.186403","article-title":"(18)F-FDG PET in parkinsonism: Differential diagnosis and evaluation of cognitive impairment","volume":"58","author":"Meyer","year":"2017","journal-title":"J Nucl Med"},{"key":"2024070507220263100_awae174-B21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fneur.2018.00483","article-title":"Clinical routine FDG-PET imaging of suspected progressive supranuclear palsy and corticobasal degeneration: A gatekeeper for subsequent tau-PET imaging?","volume":"9","author":"Beyer","year":"2018","journal-title":"Front Neurol"},{"key":"2024070507220263100_awae174-B22","doi-asserted-by":"crossref","first-page":"e1121","DOI":"10.1212\/WNL.0000000000007038","article-title":"FDG-PET patterns associated with underlying pathology in corticobasal syndrome","volume":"92","author":"Pardini","year":"2019","journal-title":"Neurology"},{"key":"2024070507220263100_awae174-B23","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.neuroimage.2005.03.012","article-title":"FDG PET in the differential diagnosis of parkinsonian disorders","volume":"26","author":"Eckert","year":"2005","journal-title":"Neuroimage"},{"key":"2024070507220263100_awae174-B24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(10)70002-8","article-title":"Differential diagnosis of parkinsonism: A metabolic imaging study using pattern analysis","volume":"9","author":"Tang","year":"2010","journal-title":"Lancet Neurol"},{"issue":"Pt 9","key":"2024070507220263100_awae174-B25","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/brain\/awu101","article-title":"Diaschisis: Past, present, future","volume":"137","author":"Carrera","year":"2014","journal-title":"Brain"},{"key":"2024070507220263100_awae174-B26","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.STR.17.5.817","article-title":"Diaschisis","volume":"17","author":"Feeney","year":"1986","journal-title":"Stroke"},{"key":"2024070507220263100_awae174-B27","first-page":"92","article-title":"Vascular and neuronal factors in diaschisis with focal cerebral ischemia","volume":"41","author":"Kempinsky","year":"1966","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"2024070507220263100_awae174-B28","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1177\/0271678X211001216","article-title":"Crossed cerebellar diaschisis on (18)F-FDG PET: Frequency across neurodegenerative syndromes and association with (11)C-PIB and (18)F-flortaucipir","volume":"41","author":"Provost","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"2024070507220263100_awae174-B29","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00259-020-04788-w","article-title":"Early-phase [(18)F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury","volume":"47","author":"Beyer","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2024070507220263100_awae174-B30","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s00259-022-06087-y","article-title":"Assessment of perfusion deficit with early phases of [(18)F]PI-2620 tau-PET versus [(18)F]flutemetamol-amyloid-PET recordings","volume":"50","author":"Volter","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2024070507220263100_awae174-B31","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1038\/s41467-022-34129-4","article-title":"Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease","volume":"13","author":"Binette","year":"2022","journal-title":"Nat Commun"},{"key":"2024070507220263100_awae174-B32","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1038\/s41467-022-32592-7","article-title":"Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading","volume":"13","author":"Frontzkowski","year":"2022","journal-title":"Nat Commun"},{"key":"2024070507220263100_awae174-B33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"key":"2024070507220263100_awae174-B34","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"2024070507220263100_awae174-B35","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41593-020-00711-6","article-title":"Topographic organization of the human subcortex unveiled with functional connectivity gradients","volume":"23","author":"Tian","year":"2020","journal-title":"Nat Neurosci"},{"key":"2024070507220263100_awae174-B36","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-Global parcellation of the human cerebral Cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex"},{"key":"2024070507220263100_awae174-B37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41467-023-44374-w","article-title":"Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease","volume":"15","author":"Franzmeier","year":"2024","journal-title":"Nat Commun"},{"key":"2024070507220263100_awae174-B38","doi-asserted-by":"crossref","first-page":"eabd1327","DOI":"10.1126\/sciadv.abd1327","article-title":"Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease","volume":"6","author":"Franzmeier","year":"2020","journal-title":"Sci Adv"},{"key":"2024070507220263100_awae174-B39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41467-019-14159-1","article-title":"Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease","volume":"11","author":"Franzmeier","year":"2020","journal-title":"Nat Commun"},{"key":"2024070507220263100_awae174-B40","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/awz026","article-title":"Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease","volume":"142","author":"Franzmeier","year":"2019","journal-title":"Brain"},{"key":"2024070507220263100_awae174-B41","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/alz.12867","article-title":"Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease","volume":"19","author":"Steward","year":"2023","journal-title":"Alzheimers Dement"},{"key":"2024070507220263100_awae174-B42","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jamaneurol.2023.4038","article-title":"Apoe4 and connectivity-mediated spreading of tau pathology at lower amyloid levels","volume":"80","author":"Steward","year":"2023","journal-title":"JAMA Neurol"},{"key":"2024070507220263100_awae174-B43","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41583-023-00731-8","article-title":"Connectome-based modelling of neurodegenerative diseases: Towards precision medicine and mechanistic insight","volume":"24","author":"Vogel","year":"2023","journal-title":"Nat Rev Neurosci"},{"key":"2024070507220263100_awae174-B44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12021-018-9384-y","article-title":"QModeling: A multiplatform, easy-to-use and open-source toolbox for PET kinetic analysis","volume":"17","author":"Lopez-Gonzalez","year":"2019","journal-title":"Neuroinformatics"},{"key":"2024070507220263100_awae174-B45","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ana.23650","article-title":"Amyloid deposition, hypometabolism, and longitudinal cognitive decline","volume":"72","author":"Landau","year":"2012","journal-title":"Ann Neurol"},{"key":"2024070507220263100_awae174-B46","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.neuroimage.2017.05.058","article-title":"Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease","volume":"157","author":"Maass","year":"2017","journal-title":"Neuroimage"},{"key":"2024070507220263100_awae174-B47","doi-asserted-by":"crossref","first-page":"eabd1327","DOI":"10.1126\/sciadv.abd1327","article-title":"Patient-centered connectivity-based prediction of tau patholog spread in Alzheimer\u2019s disease","volume":"6","author":"Franzmeier","year":"2020","journal-title":"Sci Adv"},{"key":"2024070507220263100_awae174-B48","volume-title":"A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"2024070507220263100_awae174-B49","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jocn.2020.06.008","article-title":"MRI and 18F-FDG-PET\/CT analysis of progressive supranuclear palsy","volume":"80","author":"Zhao","year":"2020","journal-title":"J Clin Neurosci"},{"key":"2024070507220263100_awae174-B50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00401-016-1650-1","article-title":"Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy","volume":"133","author":"Smith","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2024070507220263100_awae174-B51","doi-asserted-by":"crossref","first-page":"a009621","DOI":"10.1101\/cshperspect.a009621","article-title":"Functional neuroanatomy ofthe basal ganglia","volume":"2","author":"Lanciego","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2024070507220263100_awae174-B52","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat Neurosci"},{"key":"2024070507220263100_awae174-B53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1326-4-13","article-title":"The role of tau in neurodegeneration","volume":"4","author":"Gendron","year":"2009","journal-title":"Mol Neurodegener"},{"key":"2024070507220263100_awae174-B54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00259-022-05952-0","article-title":"Interplay of tau and functional network connectivity in progressive supranuclear palsy: A [(18)F]PI-2620 PET\/MRI study","volume":"50","author":"Aghakhanyan","year":"2022","journal-title":"Eur J Nuclear Med Mol Imaging"},{"key":"2024070507220263100_awae174-B55","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archneur.56.7.809","article-title":"Effects of subcortical cerebral infarction on cortical glucose metabolism and cognitive function","volume":"56","author":"Kwan","year":"1999","journal-title":"Arch Neurol"},{"issue":"Pt 5","key":"2024070507220263100_awae174-B56","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/brain\/110.5.1211","article-title":"Aphasia and neglect after subcortical stroke. A clinical\/cerebral perfusion correlation study","volume":"110","author":"Perani","year":"1987","journal-title":"Brain"},{"issue":"Pt 5","key":"2024070507220263100_awae174-B57","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/brain\/awf113","article-title":"Subcortical aphasia and neglect in acute stroke: The role of cortical hypoperfusion","volume":"125","author":"Hillis","year":"2002","journal-title":"Brain"},{"key":"2024070507220263100_awae174-B58","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamaneurol.2023.1067","article-title":"Comparison of group-level and individualized brain regions for measuring change in longitudinal tau positron emission tomography in Alzheimer disease","volume":"80","author":"Leuzy","year":"2023","journal-title":"JAMA Neurol"},{"key":"2024070507220263100_awae174-B59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrneurol.2011.43","article-title":"Corticobasal degeneration: A pathologically distinct 4R tauopathy","volume":"7","author":"Kouri","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"2024070507220263100_awae174-B60","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nn.4328","article-title":"Neuronal activity enhances tau propagation and tau pathology in vivo","volume":"19","author":"Wu","year":"2016","journal-title":"Nat Neurosci"},{"key":"2024070507220263100_awae174-B61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-016-0143-y","article-title":"The release and trans-synaptic transmission of tau via exosomes","volume":"12","author":"Wang","year":"2017","journal-title":"Mol Neurodegener"},{"key":"2024070507220263100_awae174-B62","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1177\/0271678X211018904","article-title":"Binding characteristics of [(18)F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET","volume":"41","author":"Song","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"2024070507220263100_awae174-B63","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1073\/pnas.0811168106","article-title":"Predicting human resting-state functional connectivity from structural connectivity","volume":"106","author":"Honey","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024070507220263100_awae174-B64","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.bbadis.2014.08.002","article-title":"Advanced diffusion MRI fiber tracking in neurosurgical and neurodegenerative disorders and neuroanatomical studies: A review","volume":"1842","author":"Abhinav","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2024070507220263100_awae174-B65","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroimage.2018.10.006","article-title":"Mapping the human brain's cortical-subcortical functional network organization","volume":"185","author":"Ji","year":"2019","journal-title":"Neuroimage"},{"key":"2024070507220263100_awae174-B66","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/nn.4135","article-title":"Functional connectome fingerprinting: Identifying individuals using patterns of brain connectivity","volume":"18","author":"Finn","year":"2015","journal-title":"Nat Neurosci"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae174\/58385650\/awae174.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/7\/2428\/58447124\/awae174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/7\/2428\/58447124\/awae174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T07:23:44Z","timestamp":1720164224000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/7\/2428\/7688961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":66,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,6,6]]},"published-print":{"date-parts":[[2024,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae174","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,6,6]]}}}