{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:59:37Z","timestamp":1789790377371,"version":"4.0.1"},"reference-count":273,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"M\u00e4xi-Stiftung Foundation"},{"name":"3R Competence Centre","award":["OC-2020-002"],"award-info":[{"award-number":["OC-2020-002"]}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSK-3_195902"],"award-info":[{"award-number":["CRSK-3_195902"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PZ00P3_216225"],"award-info":[{"award-number":["PZ00P3_216225"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cell-based therapies hold great promise for brain repair after stroke. While accumulating evidence confirms the preclinical and clinical benefits of cell therapies, the underlying mechanisms by which they promote brain repair remain unclear. Here, we briefly review endogenous mechanisms of brain repair after ischaemic stroke and then focus on how different stem and progenitor cell sources can promote brain repair.<\/jats:p>\n                  <jats:p>Specifically, we examine how transplanted cell grafts contribute to improved functional recovery either through direct cell replacement or by stimulating endogenous repair pathways. Additionally, we discuss recently implemented preclinical refinement methods, such as preconditioning, microcarriers, genetic safety switches and universal (immune evasive) cell transplants, as well as the therapeutic potential of these pharmacologic and genetic manipulations to further enhance the efficacy and safety of cell therapies.<\/jats:p>\n                  <jats:p>By gaining a deeper understanding of post-ischaemic repair mechanisms, prospective clinical trials may be further refined to advance post-stroke cell therapy to the clinic.<\/jats:p>","DOI":"10.1093\/brain\/awae204","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T17:47:35Z","timestamp":1719078455000},"page":"3286-3305","source":"Crossref","is-referenced-by-count":67,"title":["Brain repair mechanisms after cell therapy for stroke"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-3453","authenticated-orcid":false,"given":"Ruslan","family":"Rust","sequence":"first","affiliation":[{"name":"Department of Physiology and Neuroscience, University of Southern California , Los Angeles, CA 90033 ,","place":["USA"]},{"name":"Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["USA"]},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina R","family":"Nih","sequence":"additional","affiliation":[{"name":"Department of Brain Health, University of Nevada , Las Vegas, NV 89154 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Liberale","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Genoa , 16132 Genova ,","place":["Italy"]},{"name":"IRCCS Ospedale Policlinico San Martino , 16132 Genova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yin","sequence":"additional","affiliation":[{"name":"Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University , London, ON N6A 3K7 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"El Amki","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital and University of Zurich , 8091 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Kooi","family":"Ong","sequence":"additional","affiliation":[{"name":"School of Health and Medical Sciences & Centre for Health Research, University of Southern Queensland , Toowoomba, QLD 4350 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-8232","authenticated-orcid":false,"given":"Berislav V","family":"Zlokovic","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience, University of Southern California , Los Angeles, CA 90033 ,","place":["USA"]},{"name":"Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2024100318022907700_awae204-B1","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics-2023 update: A report from the American Heart 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Is the aged brain microenvironment refractory to cell therapy?","volume":"94","author":"Sandu","year":"2017","journal-title":"Exp Gerontol"},{"key":"2024100318022907700_awae204-B9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fneur.2019.00332","article-title":"Cell-based therapies for stroke: Promising solution or dead end? Mesenchymal stem cells and comorbidities in preclinical stroke research","volume":"10","author":"Laso-Garc\u00eda","year":"2019","journal-title":"Front Neurol"},{"key":"2024100318022907700_awae204-B10","doi-asserted-by":"crossref","first-page":"628908","DOI":"10.3389\/fncel.2021.628908","article-title":"Stem cell-based therapy for experimental ischemic stroke: A preclinical systematic review","volume":"15","author":"Zhang","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"2024100318022907700_awae204-B11","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/sctm.19-0076","article-title":"Concise review: Stem cell therapy for stroke patients: Are we there yet?","volume":"8","author":"Borlongan","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"2024100318022907700_awae204-B12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3389\/fneur.2019.00656","article-title":"Cell-based therapies for stroke: Are we there 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