{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:01:11Z","timestamp":1789837271875,"version":"4.0.1"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009879","name":"Emilia-Romagna Region health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009879","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of University and Research"},{"name":"PRIN","award":["2022BNE97C"],"award-info":[{"award-number":["2022BNE97C"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Considering the growing age of the world population, the incidence of epilepsy in older adults is expected to increase significantly. It has been suggested that late-onset temporal lobe epilepsy (LO-TLE) may be neurodegenerative in origin and overlap with Alzheimer\u2019s disease (AD). Herein, we aimed to characterize the pattern of cortical atrophy and CSF biomarkers of AD (total and phosphorylated tau and amyloid-\u03b2) in a selected population of LO-TLE of unknown origin.<\/jats:p>\n               <jats:p>We prospectively enrolled individuals with temporal lobe epilepsy onset after the age of 50 and no cognitive impairment. They underwent a structural MRI scan and CSF biomarkers measurement. Imaging and biomarkers data were compared to three retrospectively collected groups: (i) age-sex-matched healthy controls; (ii) patients with mild cognitive impairment (MCI) and abnormal CSF AD biomarkers (MCI-AD); and (iii) patients with MCI and normal CSF AD biomarkers (MCI-noAD).<\/jats:p>\n               <jats:p>From a pool of 52 patients, 20 consecutive eligible LO-TLE patients with a mean disease duration of 1.8\u2005years were recruited. As control populations, 25 patients with MCI-AD, 25 patients with MCI-noAD and 25 healthy controls were enrolled. CSF biomarkers returned normal values in LO-TLE, significantly different from patients with MCI due to AD. There were no differences in cortico-subcortical atrophy between epilepsy patients and healthy controls, while patients with MCI demonstrated widespread injuries of cortico-subcortical structures.<\/jats:p>\n               <jats:p>Individuals with LO-TLE, characterized by short disease duration and normal CSF amyloid-\u03b2 and tau protein levels, showed patterns of cortical thickness and subcortical volumes not significantly different from healthy controls, but highly different from patients with MCI, either due to AD or not.<\/jats:p>","DOI":"10.1093\/brain\/awae207","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T07:46:50Z","timestamp":1719301610000},"page":"185-198","source":"Crossref","is-referenced-by-count":21,"title":["Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer\u2019s disease biomarkers"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-1599","authenticated-orcid":false,"given":"Alice","family":"Ballerini","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Biagioli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiari","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Neurology Unit, OCB Hospital, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tondelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]},{"name":"Neuroscience Department, Neurology Unit, OCB Hospital, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Vinceti","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Neurology Unit, OCB Hospital, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bedin","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Malagoli","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Neuroradiology Unit, OCB Hospital, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Genovese","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Neuroradiology Unit, OCB Hospital, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Scolastico","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Neurophysiology Unit and Epilepsy Centre, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pugnaghi","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Neurophysiology Unit and Epilepsy Centre, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]},{"name":"Neuroscience Department, Neurophysiology Unit and Epilepsy Centre, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-539X","authenticated-orcid":false,"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]},{"name":"Neuroscience Department, Neurophysiology Unit and Epilepsy Centre, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-3373","authenticated-orcid":false,"given":"Giovanna","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]},{"name":"Neuroscience Department, Neurology Unit, OCB Hospital, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-7526","authenticated-orcid":false,"given":"Anna Elisabetta","family":"Vaudano","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , 41125 Modena ,","place":["Italy"]},{"name":"Neuroscience Department, Neurophysiology Unit and Epilepsy Centre, AOU Modena , 41126 Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2025010718525851500_awae207-B1","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/S0140-6736(98)04512-7","article-title":"Age-specific incidence 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