{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:28:18Z","timestamp":1790630898573,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["445569437"],"award-info":[{"award-number":["445569437"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"H.W.","award":["CRC128"],"award-info":[{"award-number":["CRC128"]}]},{"name":"C.C.G. and H.W.","award":["GR3946-3\/1"],"award-info":[{"award-number":["GR3946-3\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). Patients with MS have elevated titres of EBV-specific antibodies in serum and show signs of CNS damage only after EBV infection. Regarding CD8+ T cells, an elevated but ineffective response to EBV was suggested in MS patients, who present with a broader MHC-I-restricted EBV-specific T-cell receptor beta chain (TRB) repertoire compared to controls. It is not known whether this altered EBV response could be subject to dynamic changes, e.g. by approved MS therapies, and whether it is specific for MS.<\/jats:p>\n               <jats:p>Peripheral blood TRB repertoire samples (n = 1317) of healthy donors (n = 409), patients with MS (n = 710) before and after treatment, patients with neuromyelitis optica spectrum disorder (n = 87), MOG antibody-associated disease (MOGAD) (n = 64) and Susac\u2019s syndrome (n = 47) were analysed.<\/jats:p>\n               <jats:p>Apart from MS, none of the evaluated diseases presented with a broader anti-EBV TRB repertoire. In MS patients undergoing autologous haematopoietic stem-cell transplantation, EBV reactivation coincided with elevated MHC-I-restricted EBV-specific TRB sequence matches. Therapy with ocrelizumab, teriflunomide or dimethyl fumarate reduced EBV-specific, but not CMV-specific MHC-I-restricted TRB sequence matches.<\/jats:p>\n               <jats:p>Together, these data suggest that the aberrant MHC-I-restricted T-cell response directed against EBV is specific to MS with regard to neuromyelitis optica, MOGAD and Susac\u2019s syndrome and that it is specifically modified by MS treatments interfering with EBV host cells or activated lymphocytes.<\/jats:p>","DOI":"10.1093\/brain\/awae244","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T08:12:54Z","timestamp":1721290374000},"page":"933-940","source":"Crossref","is-referenced-by-count":38,"title":["Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-5176","authenticated-orcid":false,"given":"Tilman","family":"Schneider-Hohendorf","sequence":"first","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"W\u00fcnsch","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Falk","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Raposo","sequence":"additional","affiliation":[{"name":"F. Hoffmann-La Roche Ltd , 4070 Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rubelt","sequence":"additional","affiliation":[{"name":"Roche Sequencing Solutions , 4300 Pleasanton, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Mirebrahim","sequence":"additional","affiliation":[{"name":"Roche Sequencing Solutions , 4300 Pleasanton, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosseinali","family":"Asgharian","sequence":"additional","affiliation":[{"name":"Roche Sequencing Solutions , 4300 Pleasanton, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schlecht","sequence":"additional","affiliation":[{"name":"Roche Sequencing Solutions , 4300 Pleasanton, CA 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Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lauks","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Jarius","sequence":"additional","affiliation":[{"name":"Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Wildemann","sequence":"additional","affiliation":[{"name":"Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Havla","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, LMU Klinikum, Ludwig-Maximilians-Universi\u00e4t M\u00fcnchen , 80539 M\u00fcnchen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7509-5268","authenticated-orcid":false,"given":"Tania","family":"K\u00fcmpfel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, LMU Klinikum, Ludwig-Maximilians-Universi\u00e4t M\u00fcnchen , 80539 M\u00fcnchen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam-Carolina","family":"Schrot","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Du\u0308sseldorf, Medical Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Ringelstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Du\u0308sseldorf, Medical Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]},{"name":"Department of Neurology, LVR-Klinikum, Heinrich-Heine-University D\u00fcsseldorf , 40629 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Du\u0308sseldorf, Medical Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]},{"name":"Department of Neurology, Alfried Krupp Hospital , 45131 Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Schwake","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University Bochum , 44791 Bochum ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schmitter","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University Bochum , 44791 Bochum ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Ayzenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University Bochum , 44791 Bochum ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katinka","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Du\u0308sseldorf, Medical Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G","family":"Meuth","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Du\u0308sseldorf, Medical Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Du\u0308sseldorf, Medical Faculty, Heinrich Heine University , 40225 Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W","family":"H\u00fcmmert","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School , 30625 Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R","family":"Kretschmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School , 30625 Hannover 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,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyin","family":"Chen-Harris","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies , 98109 Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina C","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Klotz","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Wiendl","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University of Muenster , 48149 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