{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:48:04Z","timestamp":1790790484744,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002986","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UK DRI-3002"],"award-info":[{"award-number":["UK DRI-3002"]}],"id":[{"id":"10.13039\/501100002986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["520488"],"award-info":[{"award-number":["520488"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["UKRI-MRC"],"award-info":[{"award-number":["UKRI-MRC"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004727","name":"Vlaams Instituut voor Biotechnologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Complement activation is implicated in driving brain inflammation, self-cell damage and progression of injury in Alzheimer\u2019s disease and other neurodegenerative diseases. Here, we investigate the impact of brain delivery of a complement-blocking antibody on neurodegeneration in an Alzheimer\u2019s mouse model. We engineered a brain-penetrant recombinant antibody targeting the pro-inflammatory membrane attack complex.<\/jats:p>\n                  <jats:p>Systemic administration of this antibody in APPNL-G-F mice reduced brain levels of complement activation products, demonstrating successful brain entry and target engagement. Prolonged treatment decreased synapse loss, amyloid burden and brain inflammatory cytokine levels, concomitant with cognitive improvement compared to controls. These results underscore the potential of brain-penetrant complement-inhibiting drugs as promising therapeutics, targeting downstream of amyloid plaques in Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/brain\/awae278","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T17:59:27Z","timestamp":1724954367000},"page":"941-954","source":"Crossref","is-referenced-by-count":21,"title":["Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer\u2019s disease mouse model"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2230-3550","authenticated-orcid":false,"given":"Wioleta M","family":"Zelek","sequence":"first","affiliation":[{"name":"School of Medicine, UK Dementia Research Institute Cardiff, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J","family":"Bevan","sequence":"additional","affiliation":[{"name":"School of Medicine, UK Dementia Research Institute Cardiff, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqui","family":"Nimmo","sequence":"additional","affiliation":[{"name":"School of Medicine, UK Dementia Research Institute Cardiff, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Dewilde","sequence":"additional","affiliation":[{"name":"Therapeutic and Diagnostic Antibodies, Pharmaceutical and Pharmacological Sciences , KU Leuven, Leuven 3000 ,","place":["Belgium"]},{"name":"PharmAbs, The KU Leuven Antibody Center , KU Leuven, Leuven 3000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"De Strooper","sequence":"additional","affiliation":[{"name":"Centre for Brain and Disease Research, KU Leuven and VIB Leuven , Leuven 3000 ,","place":["Belgium"]},{"name":"UK Dementia Research Institute, University College London , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan Paul","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Medicine, UK Dementia Research Institute Cardiff, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"2025030619372332200_awae278-B1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/pharmaceutics14061117","article-title":"Therapeutic approach to Alzheimer's disease: Current treatments and new perspectives","volume":"14","author":"Pardo-Moreno","year":"2022","journal-title":"Pharmaceutics"},{"key":"2025030619372332200_awae278-B2","doi-asserted-by":"crossref","first-page":"106549","DOI":"10.1016\/j.cct.2021.106549","article-title":"Current druggable targets for therapeutic control of Alzheimer's disease","volume":"109","author":"Gupta","year":"2021","journal-title":"Contemp Clin Trials"},{"key":"2025030619372332200_awae278-B3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/13543784.2021.2017881","article-title":"What have we learned from past failures of investigational drugs for Alzheimer's disease?","volume":"30","author":"Imbimbo","year":"2021","journal-title":"Expert Opin Investig Drugs"},{"key":"2025030619372332200_awae278-B4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: New insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"2025030619372332200_awae278-B5","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.3390\/vaccines10091527","article-title":"Immunotherapies for Alzheimer's disease-A review","volume":"10","author":"Valiukas","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"2025030619372332200_awae278-B6","first-page":"31925","article-title":"Aducanumab, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer's disease: A comprehensive review","volume":"10","author":"Haddad","year":"2022","journal-title":"Health Psychol Res"},{"key":"2025030619372332200_awae278-B7","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/alz.12286","article-title":"ENGAGE and EMERGE: Truth and consequences?","volume":"17","author":"Kuller","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2025030619372332200_awae278-B8","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1001\/jama.2021.3854","article-title":"Evaluation of aducanumab for Alzheimer disease: Scientific evidence and regulatory review involving efficacy, safety, and futility","volume":"325","author":"Alexander","year":"2021","journal-title":"JAMA"},{"key":"2025030619372332200_awae278-B9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.trci.2019.06.005","article-title":"Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials","volume":"5","author":"Andrews","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"key":"2025030619372332200_awae278-B10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JAD-160889","article-title":"The correlation between inflammatory biomarkers and polygenic risk score in Alzheimer's disease","volume":"56","author":"Morgan","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"2025030619372332200_awae278-B11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11357-018-0010-6","article-title":"Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia","volume":"40","author":"Cervellati","year":"2018","journal-title":"Geroscience"},{"issue":"Suppl 1","key":"2025030619372332200_awae278-B12","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2025030619372332200_awae278-B13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.molimm.2019.07.030","article-title":"Compendium of current complement therapeutics","volume":"114","author":"Zelek","year":"2019","journal-title":"Mol Immunol"},{"key":"2025030619372332200_awae278-B14","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"2025030619372332200_awae278-B15","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"2025030619372332200_awae278-B16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13195-023-01377-5","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative. Associations of cerebrospinal fluid complement proteins with Alzheimer's pathology, cognition, and brain structure in non-dementia elderly","volume":"16","author":"Li","year":"2024","journal-title":"Alzheimers Res Ther."},{"key":"2025030619372332200_awae278-B17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12974-023-02850-6","article-title":"Alzheimer's disease-associated complement gene variants influence plasma complement protein levels","volume":"20","author":"Veteleanu","year":"2023","journal-title":"J Neuroinflammation"},{"key":"2025030619372332200_awae278-B18","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4049\/jimmunol.1901068","article-title":"Complement-Mediated events in Alzheimer's disease: Mechanisms and potential therapeutic targets","volume":"204","author":"Tenner","year":"2020","journal-title":"J Immunol"},{"key":"2025030619372332200_awae278-B19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fimmu.2019.00362","article-title":"Therapeutic inhibition of the complement system in diseases of the central nervous system","volume":"10","author":"Carpanini","year":"2019","journal-title":"Front Immunol"},{"key":"2025030619372332200_awae278-B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.07.003","article-title":"Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models","volume":"61","author":"Spangenberg","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2025030619372332200_awae278-B21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: Systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J Neuroinflammation"},{"key":"2025030619372332200_awae278-B22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.tips.2022.02.006","article-title":"Targeting complement in neurodegeneration: Challenges, risks, and strategies","volume":"43","author":"Zelek","year":"2022","journal-title":"Trends Pharmacol Sci"},{"key":"2025030619372332200_awae278-B23","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12974-020-02024-8","article-title":"The good, the bad, and the opportunities of the complement system in neurodegenerative disease","volume":"17","author":"Schartz","year":"2020","journal-title":"J Neuroinflammation"},{"key":"2025030619372332200_awae278-B24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.smim.2013.04.003","article-title":"The role of the complement system in metabolic organs and metabolic diseases","volume":"25","author":"Phieler","year":"2013","journal-title":"Semin Immunol"},{"key":"2025030619372332200_awae278-B25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: An unexpected role in synaptic pruning during development and disease","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu Rev Neurosci"},{"key":"2025030619372332200_awae278-B26","first-page":"1017","article-title":"Eculizumab (Alexion)","volume":"3","author":"Kaplan","year":"2002","journal-title":"Curr Opin Investig Drugs"},{"key":"2025030619372332200_awae278-B27","doi-asserted-by":"crossref","first-page":"612402","DOI":"10.3389\/fimmu.2020.612402","article-title":"Monoclonal antibodies capable of inhibiting complement downstream of C5 in multiple Species","volume":"11","author":"Zelek","year":"2020","journal-title":"Front Immunol"},{"key":"2025030619372332200_awae278-B28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12987-020-00226-z","article-title":"Identification and in vivo characterization of a brain-penetrating nanobody","volume":"17","author":"Wouters","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"2025030619372332200_awae278-B29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12987-022-00374-4","article-title":"VHHs as tools for therapeutic protein delivery to the central nervous system","volume":"19","author":"Wouters","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"2025030619372332200_awae278-B30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single app knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat Neurosci"},{"key":"2025030619372332200_awae278-B31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molimm.2016.06.004","article-title":"Sex matters: Systemic complement activity of female C57BL\/6J and BALB\/cJ mice is limited by serum terminal pathway components","volume":"76","author":"Kotimaa","year":"2016","journal-title":"Mol Immunol"},{"key":"2025030619372332200_awae278-B32","doi-asserted-by":"crossref","first-page":"e4175","DOI":"10.21769\/BioProtoc.4175","article-title":"Measuring total classical pathway and activities of individual components of the mouse complement pathway","volume":"11","author":"Zelek","year":"2021","journal-title":"Bio Protoc"},{"key":"2025030619372332200_awae278-B33","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.4049\/jimmunol.181.9.6664","article-title":"Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b fc-associated effector functions","volume":"181","author":"Baudino","year":"2008","journal-title":"J Immunol"},{"key":"2025030619372332200_awae278-B34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1385\/159259056X","volume-title":"Complement methods and protocols","author":"Morgan","year":"2000"},{"key":"2025030619372332200_awae278-B35","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.imbio.2018.07.016","article-title":"Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers","volume":"223","author":"Zelek","year":"2018","journal-title":"Immunobiology"},{"key":"2025030619372332200_awae278-B36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/jcp.56.2.86","article-title":"Micropurification techniques in the analysis of amyloid proteins","volume":"56","author":"Kaplan","year":"2003","journal-title":"J Clin Pathol"},{"key":"2025030619372332200_awae278-B37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s40478-020-01094-2","article-title":"Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease","volume":"8","author":"Bevan","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"2025030619372332200_awae278-B38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s40478-022-01404-w","article-title":"Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models","volume":"10","author":"Carpanini","year":"2022","journal-title":"Acta Neuropathol Commun"},{"key":"2025030619372332200_awae278-B39","first-page":"e2607","article-title":"Assessing burrowing, nest construction, and hoarding in mice","volume":"59","author":"Deacon","year":"2012","journal-title":"J Vis Exp"},{"key":"2025030619372332200_awae278-B40","doi-asserted-by":"crossref","first-page":"e1857","DOI":"10.21769\/BioProtoc.1857","article-title":"Locomotion activity measurement in an open field for mice","volume":"6","author":"Gell\u00e9rt","year":"2016","journal-title":"Bio Protoc."},{"key":"2025030619372332200_awae278-B41","doi-asserted-by":"crossref","first-page":"e1249","DOI":"10.21769\/BioProtoc.1249","article-title":"Novel object recognition for studying memory in mice","volume":"4","author":"Huang","year":"2014","journal-title":"Bio Protoc."},{"key":"2025030619372332200_awae278-B42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbr.2017.09.006","article-title":"Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease","volume":"336","author":"Whyte","year":"2018","journal-title":"Behav Brain Res"},{"key":"2025030619372332200_awae278-B43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.imbio.2015.04.006","article-title":"The membrane attack complex as an inflammatory trigger","volume":"221","author":"Morgan","year":"2016","journal-title":"Immunobiology"},{"key":"2025030619372332200_awae278-B44","first-page":"2903","article-title":"The complement membrane attack complex triggers intracellular Ca2+fluxes leading to NLRP3 inflammasome activation","volume":"126","author":"Triantafilou","year":"2013","journal-title":"J Cell Sci"},{"key":"2025030619372332200_awae278-B45","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.4049\/jimmunol.152.9.4624","article-title":"Complement component C7. Assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7","volume":"152","author":"W\u00fcrzner","year":"1994","journal-title":"J Immunol"},{"key":"2025030619372332200_awae278-B46","doi-asserted-by":"crossref","first-page":"110081","DOI":"10.1016\/j.intimp.2023.110081","article-title":"The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics","volume":"118","author":"Ghosh","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2025030619372332200_awae278-B47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/cei\/uxad088","article-title":"Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model","volume":"214","author":"Kamegai","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"2025030619372332200_awae278-B48","doi-asserted-by":"crossref","first-page":"e165142","DOI":"10.1172\/jci.insight.165142","article-title":"Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies","volume":"8","author":"Chen","year":"2023","journal-title":"JCI Insight"},{"key":"2025030619372332200_awae278-B49","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.celrep.2017.12.019","article-title":"Brain shuttle antibody for Alzheimer's disease with attenuated peripheral effector function due to an inverted binding mode","volume":"22","author":"Weber","year":"2018","journal-title":"Cell Rep"},{"key":"2025030619372332200_awae278-B50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.7150\/thno.17155","article-title":"Bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor","volume":"7","author":"Hultqvist","year":"2017","journal-title":"Theranostics"},{"key":"2025030619372332200_awae278-B51","doi-asserted-by":"crossref","first-page":"eaay1359","DOI":"10.1126\/scitranslmed.aay1359","article-title":"Brain delivery of therapeutic proteins using an fc fragment blood-brain barrier transport vehicle in mice and monkeys","volume":"12","author":"Kariolis","year":"2020","journal-title":"Sci Transl Med"},{"key":"2025030619372332200_awae278-B52","doi-asserted-by":"crossref","first-page":"e21172","DOI":"10.1096\/fj.202001787R","article-title":"Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1","volume":"35","author":"Stocki","year":"2021","journal-title":"FASEB J"},{"key":"2025030619372332200_awae278-B53","doi-asserted-by":"crossref","first-page":"261ra154","DOI":"10.1126\/scitranslmed.3009835","article-title":"Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates","volume":"6","author":"Yu","year":"2014","journal-title":"Sci Transl Med"},{"key":"2025030619372332200_awae278-B54","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.nucmedbio.2015.03.003","article-title":"Fusion of hIgG1-fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP\/PS1 mice but does not increase brain uptake","volume":"42","author":"Rotman","year":"2015","journal-title":"Nucl Med Biol"},{"key":"2025030619372332200_awae278-B55","doi-asserted-by":"crossref","first-page":"458","DOI":"10.4049\/jimmunol.168.1.458","article-title":"The membrane attack complex of complement causes severe demyelination associated with acute axonal injury","volume":"168","author":"Mead","year":"2002","journal-title":"J Immunol"},{"key":"2025030619372332200_awae278-B56","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nrn3200","article-title":"The ageing cortical synapse: Hallmarks and implications for cognitive decline","volume":"13","author":"Morrison","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"2025030619372332200_awae278-B57","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1523\/JNEUROSCI.6142-10.2011","article-title":"Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease","volume":"31","author":"Perez-Cruz","year":"2011","journal-title":"J Neurosci"},{"key":"2025030619372332200_awae278-B58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40478-022-01356-1","article-title":"The amyloid plaque proteome in early onset Alzheimer's disease and down syndrome","volume":"10","author":"Drummond","year":"2022","journal-title":"Acta Neuropathol Commun"},{"key":"2025030619372332200_awae278-B59","doi-asserted-by":"crossref","first-page":"eaaf6295","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci Transl Med"},{"key":"2025030619372332200_awae278-B60","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1038\/s41380-023-02239-0","article-title":"Targeting NLRP3 inflammasome for neurodegenerative disorders","volume":"28","author":"Yao","year":"2023","journal-title":"Mol Psychiatry"},{"key":"2025030619372332200_awae278-B61","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2990.1995.tb01063.x","article-title":"Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: Correlation with neuritic plaque distribution","volume":"21","author":"Sheng","year":"1995","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2025030619372332200_awae278-B62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbi.2024.03.017","article-title":"Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia","volume":"118","author":"Zelek","year":"2024","journal-title":"Brain Behav Immun"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae278\/58982834\/awae278.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/3\/941\/58982834\/awae278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/3\/941\/58982834\/awae278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:45:03Z","timestamp":1741272303000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/148\/3\/941\/7746456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,31]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,8,31]]},"published-print":{"date-parts":[[2025,3,6]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae278","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2024,8,31]]}}}