{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:27:14Z","timestamp":1790807234102,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009017","name":"ALS Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009017","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Barry Barrett Foundation"},{"name":"Rose Family Foundation"},{"DOI":"10.13039\/100009003","name":"Hotchkiss Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Brain Canada Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons in the brain and spinal cord. Accumulation of misfolded proteins is central to the pathogenesis of ALS and the glymphatic system is emerging as a potential therapeutic target to reduce proteinopathy. Using diffusion tensor imaging analysis along the perivascular spaces (DTI-ALPS) to assess glymphatic function, we performed a longitudinal analysis of glymphatic function in ALS and compared it to a disorder in the motor neuron disease spectrum, primary lateral sclerosis (PLS).<\/jats:p>\n                  <jats:p>From a cohort of 45 participants from the Calgary site in the CALSNIC study (Canadian ALS Neuroimaging Consortium), including 18 ALS, 5 PLS and 22 control participants, DTI-ALPS was analysed and correlated to clinical features (age, sex, disease presentation, disease severity and progression rate) and white matter hyperintensity burden. This included longitudinal measurements at three time points, 4\u2005months apart.<\/jats:p>\n                  <jats:p>The DTI-ALPS index was reduced in ALS participants compared with PLS and control participants across all three time points. There was no association with clinical factors; however, the index tended to decline with advancing age. Our study suggests heterogeneity in glymphatic dysfunction in motor neuron diseases that may be related to the underlying pathogenesis.<\/jats:p>","DOI":"10.1093\/brain\/awae288","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T21:17:58Z","timestamp":1725657478000},"page":"4026-4032","source":"Crossref","is-referenced-by-count":30,"title":["Longitudinal analysis of glymphatic function in amyotrophic lateral sclerosis and primary lateral sclerosis"],"prefix":"10.1093","volume":"147","author":[{"given":"Rachel J","family":"Sharkey","sequence":"first","affiliation":[{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Seaman Family MR Research Centre, Foothills Medical Centre , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomeno","family":"Cortese","sequence":"additional","affiliation":[{"name":"Seaman Family MR Research Centre, Foothills Medical Centre , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-7126","authenticated-orcid":false,"given":"Bradley G","family":"Goodyear","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Seaman Family MR Research Centre, Foothills Medical Centre , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence W","family":"Korngut","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Jacob","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kalra","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Alberta , Edmonton, AB T6G 2G3 ,","place":["Canada"]},{"name":"Neuroscience and Mental Health Institute, University of Alberta , Edmonton, AB T6G 2G3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-8617","authenticated-orcid":false,"given":"Minh Dang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Frayne","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Seaman Family MR Research Centre, Foothills Medical Centre , Calgary, AB T2N 4N1 ,","place":["Canada"]},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 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