{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:24:16Z","timestamp":1788121456154,"version":"build-2803163510"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 NS116872"],"award-info":[{"award-number":["R35 NS116872"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS090390"],"award-info":[{"award-number":["R01 NS090390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54NS091046-01"],"award-info":[{"award-number":["1U54NS091046-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001671","name":"Hereditary Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001671","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HD CARE"},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007223","name":"CIRM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020414","name":"NSF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020414","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cedars-Sinai Proteomics and Metabolomics Core"},{"name":"Erika Glazer Endowed Chair in Women\u2019s Heart Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Huntington\u2019s disease is a neurodegenerative disorder caused by an expanded CAG repeat mutation in the Huntingtin (HTT) gene. The mutation impacts neuronal protein homeostasis and cortical\/striatal circuitry. SUMOylation is a post-translational modification with broad cellular effects including via modification of synaptic proteins.<\/jats:p>\n               <jats:p>Here, we used an optimized SUMO protein-enrichment and mass spectrometry method to identify the protein SUMOylation\/SUMO interaction proteome in the context of Huntington\u2019s disease using R6\/2 transgenic and non-transgenic mice.<\/jats:p>\n               <jats:p>Significant changes in the enrichment of SUMOylated and SUMO-interacting proteins were observed, including those involved in presynaptic function, cytomatrix at the active zone, cytoskeleton organization and glutamatergic signalling. Mitochondrial and RNA-binding proteins also showed altered enrichment. Modified SUMO-associated pathways in Huntington\u2019s disease tissue include clathrin-mediated endocytosis signalling, synaptogenesis signalling, synaptic long-term potentiation and SNARE signalling. To evaluate how modulation of SUMOylation might influence functional measures of neuronal activity in Huntington\u2019s disease cells in vitro, we used primary neuronal cultures from R6\/2 and non-transgenic mice. A receptor internalization assay for the metabotropic glutamate receptor 7 (mGLUR7), a SUMO-enriched protein in the mass spectrometry, showed decreased internalization in R6\/2 neurons compared to non-transgenic neurons. SiRNA-mediated knockdown of the E3 SUMO ligase protein inhibitor of activated STAT1 (Pias1), which can SUMO modify mGLUR7, reduced this Huntington\u2019s disease phenotype. In addition, microelectrode array analysis of primary neuronal cultures indicated early hyperactivity in Huntington\u2019s disease cells, while later time points demonstrated deficits in several measurements of neuronal activity within cortical neurons. Huntington\u2019s disease phenotypes were rescued at selected time points following knockdown of Pias1.<\/jats:p>\n               <jats:p>Collectively, our results provide a mouse brain SUMOome resource and show that significant alterations occur within the post-translational landscape of SUMO-protein interactions of synaptic proteins in Huntington\u2019s disease mice, suggesting that targeting of synaptic SUMO networks may provide a proteostatic systems-based therapeutic approach for Huntington\u2019s disease and other neurological disorders.<\/jats:p>","DOI":"10.1093\/brain\/awae319","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:25:45Z","timestamp":1728635145000},"page":"1212-1227","source":"Crossref","is-referenced-by-count":9,"title":["Dysregulation of protein SUMOylation networks in Huntington\u2019s disease R6\/2 mouse striatum"],"prefix":"10.1093","volume":"148","author":[{"given":"Marketta","family":"Kachemov","sequence":"first","affiliation":[{"name":"Neurobiology and Behavior, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Vaibhav","sequence":"additional","affiliation":[{"name":"Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of California Irvine , Irvine, CA 92868 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niveda","family":"Sundararaman","sequence":"additional","affiliation":[{"name":"Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Heath","sequence":"additional","affiliation":[{"name":"Neurobiology and Behavior, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon F","family":"Pendlebury","sequence":"additional","affiliation":[{"name":"Neurobiology and Behavior, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Matlock","sequence":"additional","affiliation":[{"name":"Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Lau","sequence":"additional","affiliation":[{"name":"Sue and Bill Gross Stem Cell Center, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Morozko","sequence":"additional","affiliation":[{"name":"Neurobiology and Behavior, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Memory Impairments and Neurological Disorders, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Reidling","sequence":"additional","affiliation":[{"name":"Institute of Memory Impairments and Neurological Disorders, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan S","family":"Steffan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of California Irvine , Irvine, CA 92868 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E","family":"Van Eyk","sequence":"additional","affiliation":[{"name":"Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-9514","authenticated-orcid":false,"given":"Leslie M","family":"Thompson","sequence":"additional","affiliation":[{"name":"Neurobiology and Behavior, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]},{"name":"Department of Psychiatry and Human Behavior, University of California Irvine , Irvine, CA 92868 ,","place":["USA"]},{"name":"Sue and Bill Gross Stem Cell Center, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]},{"name":"Institute of Memory Impairments and Neurological Disorders, University of California Irvine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"2025040316594768500_awae319-B1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"Huntington\u2019s Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"2025040316594768500_awae319-B2","doi-asserted-by":"crossref","first-page":"689332","DOI":"10.3389\/fncel.2021.689332","article-title":"Huntingtin and the Synapse","volume":"15","author":"Barron","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"2025040316594768500_awae319-B3","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1093\/hmg\/ddg218","article-title":"Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release","volume":"12","author":"Li","year":"2003","journal-title":"Hum Mol Genet"},{"key":"2025040316594768500_awae319-B4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.conb.2020.04.001","article-title":"Traffic signaling: New functions of huntingtin and axonal transport in neurological disease","volume":"63","author":"Vitet","year":"2020","journal-title":"Curr Opin Neurobiol"},{"key":"2025040316594768500_awae319-B5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/aps.2018.11","article-title":"Proteostasis in Huntington\u2019s disease: Disease mechanisms and therapeutic opportunities","volume":"39","author":"Harding","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"2025040316594768500_awae319-B6","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington\u2019s disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"2025040316594768500_awae319-B7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025040316594768500_awae319-B8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.neuro.051508.135422","article-title":"Physiology and pharmacology of striatal neurons","volume":"32","author":"Kreitzer","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"2025040316594768500_awae319-B9","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1523\/JNEUROSCI.2630-18.2019","article-title":"Glutamatergic innervation onto striatal neurons potentiates GABAergic synaptic output","volume":"39","author":"Paraskevopoulou","year":"2019","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/263517a0","article-title":"Duplication of biochemical changes of Huntington\u2019s chorea by intrastriatal injections of glutamic and kainic acids","volume":"263","author":"McGeer","year":"1976","journal-title":"Nature"},{"key":"2025040316594768500_awae319-B11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0024-3205(84)90148-6","article-title":"II. Excitotoxic models for neurodegenerative disorders","volume":"35","author":"Schwarcz","year":"1984","journal-title":"Life Sci"},{"key":"2025040316594768500_awae319-B12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1755-5949.2010.00134.x","article-title":"Dopamine and glutamate in Huntington\u2019s disease: A balancing act","volume":"16","author":"Andre","year":"2010","journal-title":"CNS Neurosci Ther"},{"key":"2025040316594768500_awae319-B13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1523\/JNEUROSCI.4974-09.2010","article-title":"Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington\u2019s disease","volume":"30","author":"Ribeiro","year":"2010","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B14","doi-asserted-by":"crossref","first-page":"12916","DOI":"10.1038\/s41598-019-49356-x","article-title":"Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: An in vivo PET imaging study","volume":"9","author":"Crabbe","year":"2019","journal-title":"Sci Rep"},{"key":"2025040316594768500_awae319-B15","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0028-3908(99)00102-1","article-title":"Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection","volume":"38","author":"Nicoletti","year":"1999","journal-title":"Neuropharmacology"},{"key":"2025040316594768500_awae319-B16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0166-2236(96)20019-0","article-title":"Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?","volume":"19","author":"Nicoletti","year":"1996","journal-title":"Trends Neurosci"},{"key":"2025040316594768500_awae319-B17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.phrs.2016.11.013","article-title":"Metabotropic glutamate receptors and neurodegenerative diseases","volume":"115","author":"Ribeiro","year":"2017","journal-title":"Pharmacol Res"},{"key":"2025040316594768500_awae319-B18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2004.06.005","article-title":"The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington\u2019s disease","volume":"1019","author":"Schiefer","year":"2004","journal-title":"Brain Res"},{"key":"2025040316594768500_awae319-B19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuropharm.2015.11.021","article-title":"Regulation of mGluR7 trafficking by SUMOylation in neurons","volume":"102","author":"Choi","year":"2016","journal-title":"Neuropharmacology"},{"key":"2025040316594768500_awae319-B20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/jnc.15103","article-title":"SUMOylation of synaptic and synapse-associated proteins: An update","volume":"156","author":"Henley","year":"2021","journal-title":"J Neurochem"},{"key":"2025040316594768500_awae319-B21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.conb.2011.10.017","article-title":"Protein SUMOylation in spine structure and function","volume":"22","author":"Craig","year":"2012","journal-title":"Curr Opin Neurobiol"},{"key":"2025040316594768500_awae319-B22","doi-asserted-by":"crossref","first-page":"22781","DOI":"10.1074\/jbc.M112.356337","article-title":"Homeostatic synaptic scaling is regulated by protein SUMOylation","volume":"287","author":"Craig","year":"2012","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B23","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1152\/physrev.00008.2014","article-title":"Neuronal SUMOylation: Mechanisms, physiology, and roles in neuronal dysfunction","volume":"94","author":"Henley","year":"2014","journal-title":"Physiol Rev"},{"key":"2025040316594768500_awae319-B24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature05736","article-title":"SUMOylation regulates kainate-receptor-mediated synaptic transmission","volume":"447","author":"Martin","year":"2007","journal-title":"Nature"},{"key":"2025040316594768500_awae319-B25","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrn2276","article-title":"Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction","volume":"8","author":"Martin","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"2025040316594768500_awae319-B26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-biochem-061909-093311","article-title":"Sumoylation: A regulatory protein modification in health and disease","volume":"82","author":"Flotho","year":"2013","journal-title":"Annu Rev Biochem"},{"key":"2025040316594768500_awae319-B27","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrm3011","article-title":"The SUMO pathway: Emerging mechanisms that shape specificity, conjugation and recognition","volume":"11","author":"Gareau","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025040316594768500_awae319-B28","doi-asserted-by":"crossref","first-page":"26509","DOI":"10.1038\/srep26509","article-title":"SUMO5, a novel poly-SUMO isoform, regulates PML nuclear bodies","volume":"6","author":"Liang","year":"2016","journal-title":"Sci Rep"},{"key":"2025040316594768500_awae319-B29","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1111\/febs.15319","article-title":"Sumoylation on its 25th anniversary: Mechanisms, pathology, and emerging concepts","volume":"287","author":"Celen","year":"2020","journal-title":"FEBS J"},{"key":"2025040316594768500_awae319-B30","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1007\/s00018-009-0061-z","article-title":"PIAS proteins: Pleiotropic interactors associated with SUMO","volume":"66","author":"Rytinki","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"2025040316594768500_awae319-B31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nri1667","article-title":"Regulation of gene-activation pathways by PIAS proteins in the immune system","volume":"5","author":"Shuai","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"2025040316594768500_awae319-B32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tips.2008.07.008","article-title":"Targeting the PIAS1 SUMO ligase pathway to control inflammation","volume":"29","author":"Liu","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"2025040316594768500_awae319-B33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of huntingtin and Huntington\u2019s disease pathology","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"key":"2025040316594768500_awae319-B34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1073\/pnas.0235361100","article-title":"Positive and negative regulation of APP amyloidogenesis by sumoylation","volume":"100","author":"Li","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025040316594768500_awae319-B35","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1074\/jbc.M510127200","article-title":"Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein","volume":"281","author":"Dorval","year":"2006","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B36","doi-asserted-by":"crossref","first-page":"14145","DOI":"10.1073\/pnas.97.26.14145","article-title":"Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)","volume":"97","author":"Poukka","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025040316594768500_awae319-B37","doi-asserted-by":"crossref","first-page":"dmm036145","DOI":"10.1242\/dmm.036145","article-title":"SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models","volume":"12","author":"Marinello","year":"2019","journal-title":"Dis Model Mech"},{"key":"2025040316594768500_awae319-B38","doi-asserted-by":"crossref","first-page":"21942","DOI":"10.1074\/jbc.M501677200","article-title":"SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal","volume":"280","author":"Riley","year":"2005","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B39","doi-asserted-by":"crossref","first-page":"e2107187119","DOI":"10.1073\/pnas.2107187119","article-title":"Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in huntington disease","volume":"119","author":"Ramirez-Jarquin","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025040316594768500_awae319-B40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.celrep.2013.06.034","article-title":"SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation","volume":"4","author":"O'Rourke","year":"2013","journal-title":"Cell Rep"},{"key":"2025040316594768500_awae319-B41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neuron.2016.03.016","article-title":"PIAS1 regulates mutant huntingtin accumulation and Huntington\u2019s disease-associated phenotypes in vivo","volume":"90","author":"Ochaba","year":"2016","journal-title":"Neuron"},{"key":"2025040316594768500_awae319-B42","doi-asserted-by":"crossref","first-page":"e2021836118","DOI":"10.1073\/pnas.2021836118","article-title":"PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington\u2019s disease","volume":"118","author":"Morozko","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025040316594768500_awae319-B43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"2025040316594768500_awae319-B44","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nn.4332","article-title":"The mouse cortico-striatal projectome","volume":"19","author":"Hintiryan","year":"2016","journal-title":"Nat Neurosci"},{"key":"2025040316594768500_awae319-B45","doi-asserted-by":"crossref","first-page":"e1004879","DOI":"10.1371\/journal.pcbi.1004879","article-title":"Network-Based interpretation of diverse high-throughput datasets through the omics integrator software package","volume":"12","author":"Tuncbag","year":"2016","journal-title":"PLoS Comput Biol"},{"key":"2025040316594768500_awae319-B46","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1021\/jasms.0c00032","article-title":"PINE: An automation tool to extract and visualize protein-centric functional networks","volume":"31","author":"Sundararaman","year":"2020","journal-title":"J Am Soc Mass Spectrom"},{"key":"2025040316594768500_awae319-B47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington\u2019s disease in attempts to develop novel therapeutic strategies","volume":"2","author":"Li","year":"2005","journal-title":"NeuroRx"},{"key":"2025040316594768500_awae319-B48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/JHD-210491","article-title":"HDinHD: A rich data portal for Huntington\u2019s disease research","volume":"10","author":"Aaronson","year":"2021","journal-title":"J Huntingtons Dis"},{"key":"2025040316594768500_awae319-B49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fnhum.2016.00317","article-title":"Corticostriatal dysfunction in Huntington\u2019s disease: The basics","volume":"10","author":"Bunner","year":"2016","journal-title":"Front Hum Neurosci"},{"key":"2025040316594768500_awae319-B50","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3390\/cells10112825","article-title":"SUMO interacting motifs: Structure and function","volume":"10","author":"Yau","year":"2021","journal-title":"Cells"},{"key":"2025040316594768500_awae319-B51","doi-asserted-by":"crossref","first-page":"17669","DOI":"10.1038\/srep17669","article-title":"SUMOylation of Syntaxin1A regulates presynaptic endocytosis","volume":"5","author":"Craig","year":"2015","journal-title":"Sci Rep"},{"key":"2025040316594768500_awae319-B52","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1038\/ncomms8728","article-title":"SUMOylation of synapsin ia maintains synaptic vesicle availability and is reduced in an autism mutation","volume":"6","author":"Tang","year":"2015","journal-title":"Nat Commun"},{"key":"2025040316594768500_awae319-B53","doi-asserted-by":"crossref","first-page":"780535","DOI":"10.3389\/fnmol.2021.780535","article-title":"Proteomic identification of an endogenous synaptic SUMOylome in the developing rat brain","volume":"14","author":"Pronot","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"2025040316594768500_awae319-B54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12192-019-00974-4","article-title":"P38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells","volume":"24","author":"Chowdhury","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"2025040316594768500_awae319-B55","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1097-2765(03)00265-X","article-title":"Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity","volume":"12","author":"Yang","year":"2003","journal-title":"Mol Cell"},{"key":"2025040316594768500_awae319-B56","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-60761-795-2_21","article-title":"MAP kinase: SUMO pathway interactions","volume":"661","author":"Yang","year":"2010","journal-title":"Methods Mol Biol"},{"key":"2025040316594768500_awae319-B57","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1128\/MCB.16.3.1189","article-title":"Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression","volume":"16","author":"Bennett","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2025040316594768500_awae319-B58","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0896-6273(00)00127-6","article-title":"Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site","volume":"28","author":"Boudin","year":"2000","journal-title":"Neuron"},{"key":"2025040316594768500_awae319-B59","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2009.07.027","article-title":"Synaptotagmin-1 docks secretory vesicles to syntaxin-1\/SNAP-25 acceptor complexes","volume":"138","author":"de Wit","year":"2009","journal-title":"Cell"},{"key":"2025040316594768500_awae319-B60","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1523\/JNEUROSCI.0473-17.2017","article-title":"ERK\/MAPK signaling is required for pathway-specific striatal motor functions","volume":"37","author":"Hutton","year":"2017","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnsyn.2017.00008","article-title":"Dynamic arc SUMOylation and selective interaction with F-actin-binding protein drebrin A in LTP consolidation in vivo","volume":"9","author":"Nair","year":"2017","journal-title":"Front Synaptic Neurosci"},{"key":"2025040316594768500_awae319-B62","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.celrep.2015.08.037","article-title":"PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs","volume":"12","author":"Prahallad","year":"2015","journal-title":"Cell Rep"},{"key":"2025040316594768500_awae319-B63","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.cr.7290055","article-title":"The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological functions","volume":"10","author":"Qu","year":"2000","journal-title":"Cell Res"},{"key":"2025040316594768500_awae319-B64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuron.2013.05.003","article-title":"The small GTPase Arf1 modulates Arp2\/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity","volume":"79","author":"Rocca","year":"2013","journal-title":"Neuron"},{"key":"2025040316594768500_awae319-B65","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1128\/MCB.20.5.1526-1536.2000","article-title":"Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity","volume":"20","author":"Shi","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2025040316594768500_awae319-B66","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.neuron.2008.03.028","article-title":"Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7","volume":"58","author":"Suh","year":"2008","journal-title":"Neuron"},{"key":"2025040316594768500_awae319-B67","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuroscience.2016.11.036","article-title":"Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice","volume":"343","author":"Zhang","year":"2017","journal-title":"Neuroscience"},{"key":"2025040316594768500_awae319-B68","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/STROKEAHA.113.004315","article-title":"Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: Putative protective proteins\/pathways","volume":"45","author":"Yang","year":"2014","journal-title":"Stroke"},{"key":"2025040316594768500_awae319-B69","doi-asserted-by":"crossref","first-page":"21122","DOI":"10.1073\/pnas.1215366110","article-title":"In vivo localization and identification of SUMOylated proteins in the brain of his6-HA-SUMO1 knock-in mice","volume":"109","author":"Tirard","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025040316594768500_awae319-B70","doi-asserted-by":"crossref","first-page":"rs2","DOI":"10.1126\/scisignal.2005146","article-title":"Proteome-wide identification of SUMO2 modification sites","volume":"7","author":"Tammsalu","year":"2014","journal-title":"Sci Signal"},{"key":"2025040316594768500_awae319-B71","doi-asserted-by":"crossref","first-page":"108691","DOI":"10.1016\/j.celrep.2021.108691","article-title":"Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex","volume":"34","author":"Gonzalez-Prieto","year":"2021","journal-title":"Cell Rep"},{"key":"2025040316594768500_awae319-B72","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.psychres.2015.08.021","article-title":"Low expression of gria1 and grin1 glutamate receptors in the nucleus accumbens of spontaneously hypertensive rats (SHR)","volume":"229","author":"Diana","year":"2015","journal-title":"Psychiatry Res"},{"key":"2025040316594768500_awae319-B73","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1523\/JNEUROSCI.23-05-01667.2003","article-title":"Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting","volume":"23","author":"Ko","year":"2003","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B74","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1093\/hmg\/ddt598","article-title":"Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington\u2019s disease","volume":"23","author":"Ribeiro","year":"2014","journal-title":"Hum Mol Genet"},{"key":"2025040316594768500_awae319-B75","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2174\/1570159X13666150716165323","article-title":"Metabotropic glutamate receptor 7: From synaptic function to therapeutic implications","volume":"14","author":"Palazzo","year":"2016","journal-title":"Curr Neuropharmacol"},{"key":"2025040316594768500_awae319-B76","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neulet.2011.01.032","article-title":"Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation","volume":"491","author":"Wilkinson","year":"2011","journal-title":"Neurosci Lett"},{"key":"2025040316594768500_awae319-B77","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1096-9861(19991213)415:2<266::AID-CNE9>3.0.CO;2-7","article-title":"Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia","volume":"415","author":"Kosinski","year":"1999","journal-title":"J Comp Neurol"},{"key":"2025040316594768500_awae319-B78","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1523\/JNEUROSCI.20-19-07252.2000","article-title":"PICK1 interacts with and regulates PKC phosphorylation of mGLUR7","volume":"20","author":"Dev","year":"2000","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B79","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1083\/jcb.201701034","article-title":"PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 alpha-appendage and dynamin","volume":"216","author":"Fiuza","year":"2017","journal-title":"J Cell Biol"},{"key":"2025040316594768500_awae319-B80","doi-asserted-by":"crossref","first-page":"38153","DOI":"10.1074\/jbc.M508168200","article-title":"Pias1 interaction and sumoylation of metabotropic glutamate receptor 8","volume":"280","author":"Tang","year":"2005","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B81","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1074\/jbc.M109.080838","article-title":"The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals","volume":"285","author":"Martin","year":"2010","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B82","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1038\/ncomms6113","article-title":"Mglu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of ubc9 into spines","volume":"5","author":"Loriol","year":"2014","journal-title":"Nat Commun"},{"key":"2025040316594768500_awae319-B83","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1523\/JNEUROSCI.1592-09.2009","article-title":"Alterations in cortical excitation and inhibition in genetic mouse models of Huntington\u2019s disease","volume":"29","author":"Cummings","year":"2009","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B84","doi-asserted-by":"crossref","first-page":"e00036","DOI":"10.1042\/AN20100007","article-title":"Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington\u2019s disease","volume":"2","author":"Cummings","year":"2010","journal-title":"ASN Neuro"},{"key":"2025040316594768500_awae319-B85","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003","article-title":"Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington\u2019s disease","volume":"23","author":"Cepeda","year":"2003","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B86","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1523\/JNEUROSCI.5687-08.2009","article-title":"Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease","volume":"29","author":"Joshi","year":"2009","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B87","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.nbd.2015.11.020","article-title":"Differential changes in thalamic and cortical excitatory synapses onto striatal spiny projection neurons in a Huntington disease mouse model","volume":"86","author":"Kolodziejczyk","year":"2016","journal-title":"Neurobiol Dis"},{"key":"2025040316594768500_awae319-B88","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1523\/JNEUROSCI.2804-08.2008","article-title":"Altered information processing in the prefrontal cortex of Huntington\u2019s disease mouse models","volume":"28","author":"Walker","year":"2008","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B89","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1039\/D1MO00440A","article-title":"Spatial proteomic alterations detected via MALDI-MS imaging implicate neuronal loss in a Huntington\u2019s disease mouse (YAC128) brain","volume":"18","author":"Karayel-Basar","year":"2022","journal-title":"Mol Omics"},{"key":"2025040316594768500_awae319-B90","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41467-020-14581-w","article-title":"Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"2025040316594768500_awae319-B91","doi-asserted-by":"crossref","first-page":"100164","DOI":"10.1016\/j.mcpro.2021.100164","article-title":"Identification of SUMO targets associated with the pluripotent state in human stem cells","volume":"20","author":"Mojsa","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"2025040316594768500_awae319-B92","doi-asserted-by":"crossref","first-page":"27573","DOI":"10.1074\/jbc.274.39.27573","article-title":"A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7","volume":"274","author":"Nakajima","year":"1999","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B93","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.286.5442.1180","article-title":"Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling","volume":"286","author":"O'Connor","year":"1999","journal-title":"Science"},{"key":"2025040316594768500_awae319-B94","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1093\/emboj\/cdf313","article-title":"PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7","volume":"21","author":"Perroy","year":"2002","journal-title":"EMBO J"},{"key":"2025040316594768500_awae319-B95","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nn.2142","article-title":"PICK1 uncoupling from mGluR7a causes absence-like seizures","volume":"11","author":"Bertaso","year":"2008","journal-title":"Nat Neurosci"},{"key":"2025040316594768500_awae319-B96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-319-50044-7_20","article-title":"Coordination of cellular localization-dependent effects of sumoylation in regulating cardiovascular and neurological diseases","volume":"963","author":"Abe","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"2025040316594768500_awae319-B97","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1038\/s41467-022-35388-x","article-title":"Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation","volume":"13","author":"Lim","year":"2022","journal-title":"Nat Commun"},{"key":"2025040316594768500_awae319-B98","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnmol.2012.00052","article-title":"Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins","volume":"5","author":"Enz","year":"2012","journal-title":"Front Mol Neurosci"},{"key":"2025040316594768500_awae319-B99","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuropharm.2012.06.005","article-title":"Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning","volume":"66","author":"Mukherjee","year":"2013","journal-title":"Neuropharmacology"},{"key":"2025040316594768500_awae319-B100","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: Physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2025040316594768500_awae319-B101","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4615-0123-7_7","article-title":"Neuroprotective activity of metabotropic glutamate receptor ligands","volume":"513","author":"Flor","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"2025040316594768500_awae319-B102","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biocel.2016.03.003","article-title":"Inside story of group I metabotropic glutamate receptors (mGluRs)","volume":"77","author":"Bhattacharyya","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"2025040316594768500_awae319-B103","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pharmthera.2005.01.008","article-title":"Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis","volume":"111","author":"Dhami","year":"2006","journal-title":"Pharmacol Ther"},{"key":"2025040316594768500_awae319-B104","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1523\/JNEUROSCI.1037-21.2021","article-title":"Regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis by the postsynaptic protein norbin","volume":"42","author":"Ojha","year":"2022","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B105","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1096\/fj.00-0072com","article-title":"The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1","volume":"14","author":"Sallese","year":"2000","journal-title":"FASEB J"},{"key":"2025040316594768500_awae319-B106","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1523\/JNEUROSCI.0454-18.2018","article-title":"A critical role for sorting nexin 1 in the trafficking of metabotropic glutamate receptors","volume":"38","author":"Sharma","year":"2018","journal-title":"J Neurosci"},{"key":"2025040316594768500_awae319-B107","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1074\/jbc.M116.752105","article-title":"A critical role for ubiquitination in the endocytosis of glutamate receptors","volume":"292","author":"Gulia","year":"2017","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B108","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnmol.2019.00020","article-title":"Role of metabotropic glutamate receptors in neurological disorders","volume":"12","author":"Crupi","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"2025040316594768500_awae319-B109","doi-asserted-by":"crossref","first-page":"109050","DOI":"10.1016\/j.celrep.2021.109050","article-title":"Mechanisms of differential desensitization of metabotropic glutamate receptors","volume":"35","author":"Abreu","year":"2021","journal-title":"Cell Rep"},{"key":"2025040316594768500_awae319-B110","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/cercor\/12.9.961","article-title":"Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex","volume":"12","author":"Dalezios","year":"2002","journal-title":"Cereb Cortex"},{"key":"2025040316594768500_awae319-B111","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.08.031","article-title":"Differential effects of protein phosphatases in the recycling of metabotropic glutamate receptor 5","volume":"306","author":"Mahato","year":"2015","journal-title":"Neuroscience"},{"key":"2025040316594768500_awae319-B112","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/jnc.12930","article-title":"Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A-dependent manner in non-neuronal and neuronal cell lines","volume":"131","author":"Pandey","year":"2014","journal-title":"J Neurochem"},{"key":"2025040316594768500_awae319-B113","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1038\/ncomms11459","article-title":"Altered mGluR5-homer scaffolds and corticostriatal connectivity in a shank3 complete knockout model of autism","volume":"7","author":"Wang","year":"2016","journal-title":"Nat Commun"},{"key":"2025040316594768500_awae319-B114","doi-asserted-by":"crossref","first-page":"e70415","DOI":"10.1371\/journal.pone.0070415","article-title":"Mglur5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion","volume":"8","author":"Jew","year":"2013","journal-title":"PLoS One"},{"key":"2025040316594768500_awae319-B115","doi-asserted-by":"crossref","first-page":"34840","DOI":"10.1074\/jbc.M504508200","article-title":"Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin","volume":"280","author":"Anborgh","year":"2005","journal-title":"J Biol Chem"},{"key":"2025040316594768500_awae319-B116","doi-asserted-by":"crossref","first-page":"e20054","DOI":"10.7554\/eLife.20054","article-title":"SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons","volume":"5","author":"Plant","year":"2016","journal-title":"Elife"},{"key":"2025040316594768500_awae319-B117","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1085\/jgp.201110604","article-title":"SUMO modification of cell surface kv2.1 potassium channels regulates the activity of rat hippocampal neurons","volume":"137","author":"Plant","year":"2011","journal-title":"J Gen Physiol"},{"key":"2025040316594768500_awae319-B118","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1093\/cercor\/bhz245","article-title":"Cortical network dynamics is altered in mouse models of Huntington\u2019s disease","volume":"30","author":"Donzis","year":"2020","journal-title":"Cereb Cortex"},{"key":"2025040316594768500_awae319-B119","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fncir.2013.00019","article-title":"Role of cerebral cortex in the neuropathology of Huntington\u2019s disease","volume":"7","author":"Estrada-Sanchez","year":"2013","journal-title":"Front Neural Circuits"},{"key":"2025040316594768500_awae319-B120","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/jnr.24503","article-title":"Developmental origins of cortical hyperexcitability in Huntington\u2019s disease: Review and new observations","volume":"97","author":"Cepeda","year":"2019","journal-title":"J Neurosci Res"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae319\/59718031\/awae319.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/4\/1212\/59718031\/awae319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/4\/1212\/59718031\/awae319.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T22:51:54Z","timestamp":1743720714000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/148\/4\/1212\/7818204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":120,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10,11]]},"published-print":{"date-parts":[[2025,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae319","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2024,10,11]]}}}