{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:31:22Z","timestamp":1792071082158,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute for Health and Care Research"},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SGL027\\1016"],"award-info":[{"award-number":["SGL027\\1016"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["227217\/Z\/23\/Z"],"award-info":[{"award-number":["227217\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["222426\/Z\/21\/Z"],"award-info":[{"award-number":["222426\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["104079\/Z\/14\/Z"],"award-info":[{"award-number":["104079\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Infinitopes"},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021686","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2021025S"],"award-info":[{"award-number":["A2021025S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001641","name":"Glaucoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"National","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institutes of Health"},{"DOI":"10.13039\/501100023864","name":"National","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012736","name":"Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["P30 AG062677"],"award-info":[{"award-number":["P30 AG062677"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["1RF1AG080556-01A1"],"award-info":[{"award-number":["1RF1AG080556-01A1"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2023-00356"],"award-info":[{"award-number":["#2023-00356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101053962"],"award-info":[{"award-number":["101053962"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish State Support for Clinical Research","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"DOI":"10.13039\/100002565","name":"Alzheimer\u2019s Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-24-1284328-C"],"award-info":[{"award-number":["#ADSF-24-1284328-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield Project"},{"DOI":"10.13039\/501100021720","name":"Olav Thon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Erling-Persson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}],"id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["860197"],"award-info":[{"award-number":["860197"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU Joint Programme\u2014Neurodegenerative Disease Research","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"DOI":"10.13039\/501100012317","name":"University College London Hospitals Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V007173\/1"],"award-info":[{"award-number":["MR\/V007173\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011950","name":"BMA Foundation for Medical Research\u2014","doi-asserted-by":"crossref","award":["2013"],"award-info":[{"award-number":["2013"]}],"id":[{"id":"10.13039\/501100011950","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011950","name":"BMA Foundation for Medical Research\u2014","doi-asserted-by":"crossref","award":["2017"],"award-info":[{"award-number":["2017"]}],"id":[{"id":"10.13039\/501100011950","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oxford Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In animal models, brain neurodegeneration biomarkers drain into cervical lymph nodes (CLNs), and this drainage function is reduced with ageing. If this occurred in humans, CLNs may provide a readily accessible measure of this aspect of protein clearance. We tested this hypothesis in people using ultrasound-guided fine needle aspiration.<\/jats:p>\n                  <jats:p>We measured amyloid-beta 40 and 42, phosphorylated tau 181 (pTau181), glial fibrillary acidic protein and neurofilament light using single molecule array in CLN aspirates and plasma from: (i) a discovery cohort of 25 autoimmune patients; and (ii) plasma, CLNs and capillary blood in four healthy volunteers, an optimization cohort.<\/jats:p>\n                  <jats:p>Ultrasound-guided fine needle aspiration was well-tolerated by all participants. In both cohorts, all biomarkers were detected in all plasma and CLN samples, other than neurofilament light (8\/17 of discovery cohort). CLN biomarker concentrations were significantly greater than plasma concentrations for all except neurofilament light, most markedly for pTau181 (266-fold; P &amp;lt; 0.02), whose CLN concentrations decreased with age (Spearman r = \u22120.66, P = 0.001).<\/jats:p>\n                  <jats:p>This study presents the first evidence that neurodegenerative biomarkers are detectable in human CLNs. Raised CLN:plasma biomarker ratios suggest their concentration in CLNs may offer a distinct compartment for minimally-invasive measurement of brain clearance and lymphatic drainage, with potential applicability to study of ageing and future clinical trials.<\/jats:p>","DOI":"10.1093\/brain\/awae329","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T15:21:20Z","timestamp":1729264880000},"page":"394-400","source":"Crossref","is-referenced-by-count":37,"title":["Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-7579","authenticated-orcid":false,"given":"Adam","family":"Al-Diwani","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford OX3 7JX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M","family":"Provine","sequence":"additional","affiliation":[{"name":"Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford , Oxford OX3 7DQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Murchison","sequence":"additional","affiliation":[{"name":"Department of Radiology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust , Oxford OX3 9DU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhiannon","family":"Laban","sequence":"additional","affiliation":[{"name":"Fluid Biomarker Laboratory , UK Dementia Research Institute at UCL, London W1T 7NF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen J","family":"Swann","sequence":"additional","affiliation":[{"name":"Fluid Biomarker Laboratory , UK Dementia Research Institute at UCL, London W1T 7NF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8493","authenticated-orcid":false,"given":"Ivan","family":"Koychev","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford OX3 7JX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fintan","family":"Sheerin","sequence":"additional","affiliation":[{"name":"Department of Radiology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust , Oxford OX3 9DU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Da Mesquita","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Heslegrave","sequence":"additional","affiliation":[{"name":"Fluid Biomarker Laboratory , UK Dementia Research Institute at UCL, London W1T 7NF ,","place":["UK"]},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Fluid Biomarker Laboratory , UK Dementia Research Institute at UCL, London W1T 7NF ,","place":["UK"]},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square , London WC1N 3BG ,","place":["UK"]},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , M\u00f6lndal 431 39 ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , M\u00f6lndal 431 39 ,","place":["Sweden"]},{"name":"Hong Kong Center for Neurodegenerative Diseases , Clear Water Bay ,","place":["Hong Kong"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison , Madison, WI 53792 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-9161","authenticated-orcid":false,"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[{"name":"Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford , Oxford OX3 7DQ ,","place":["UK"]},{"name":"Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford , Oxford OX3 9DU ,","place":["UK"]},{"name":"Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford , Oxford OX1 3SY ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-9748","authenticated-orcid":false,"given":"Sarosh R","family":"Irani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic , Jacksonville, FL 32224 ,","place":["USA"]},{"name":"Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford OX3 9DU ,","place":["UK"]},{"name":"Department of Neurology, Mayo Clinic , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"2025020305065215700_awae329-B1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research framework: Toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2025020305065215700_awae329-B2","doi-asserted-by":"crossref","first-page":"147ra11","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"key":"2025020305065215700_awae329-B3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"2025020305065215700_awae329-B4","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41593-018-0227-9","article-title":"CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature","volume":"21","author":"Louveau","year":"2018","journal-title":"Nat Neurosci"},{"key":"2025020305065215700_awae329-B5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"key":"2025020305065215700_awae329-B6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-5728(89)90136-7","article-title":"Role of cervical lymph node in the systemic humoral response to human serum albumin microinfused into rat cerebrospinal fluid","volume":"25","author":"Harling-Berg","year":"1989","journal-title":"J Neuroimmunol"},{"key":"2025020305065215700_awae329-B7","doi-asserted-by":"crossref","first-page":"e20211275","DOI":"10.1084\/jem.20211275","article-title":"Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration","volume":"219","author":"Ishida","year":"2022","journal-title":"J Exp Med"},{"key":"2025020305065215700_awae329-B8","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1038\/s41598-018-25666-4","article-title":"Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes","volume":"8","author":"Eide","year":"2018","journal-title":"Sci Rep"},{"key":"2025020305065215700_awae329-B9","doi-asserted-by":"crossref","first-page":"e20220035","DOI":"10.1084\/jem.20220035","article-title":"Conserved meningeal lymphatic drainage circuits in mice and humans","volume":"219","author":"Jacob","year":"2022","journal-title":"J Exp Med"},{"key":"2025020305065215700_awae329-B10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-019-0312-x","article-title":"Dural lymphatics regulate clearance of extracellular tau from the CNS","volume":"14","author":"Patel","year":"2019","journal-title":"Mol Neurodegener"},{"key":"2025020305065215700_awae329-B11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41586-021-03489-0","article-title":"Meningeal lymphatics affect microglia responses and anti-Abeta immunotherapy","volume":"593","author":"Da Mesquita","year":"2021","journal-title":"Nature"},{"key":"2025020305065215700_awae329-B12","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41586-023-06737-7","article-title":"Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema","volume":"623","author":"Hussain","year":"2023","journal-title":"Nature"},{"key":"2025020305065215700_awae329-B13","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1093\/brain\/awac199","article-title":"Aqp4 stop codon readthrough facilitates amyloid-beta clearance from the brain","volume":"145","author":"Sapkota","year":"2022","journal-title":"Brain"},{"key":"2025020305065215700_awae329-B14","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1093\/brain\/awac088","article-title":"Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis","volume":"145","author":"Al-Diwani","year":"2022","journal-title":"Brain"},{"key":"2025020305065215700_awae329-B15","doi-asserted-by":"crossref","first-page":"e2121804119","DOI":"10.1073\/pnas.2121804119","article-title":"Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders","volume":"119","author":"Damato","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025020305065215700_awae329-B16","doi-asserted-by":"crossref","first-page":"e2350872","DOI":"10.1002\/eji.202350872","article-title":"Fine needle aspiration of human lymph nodes reveals cell populations and soluble interactors pivotal to immunological priming","volume":"54","author":"Provine","year":"2024","journal-title":"Eur J Immunol"},{"key":"2025020305065215700_awae329-B17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s40478-019-0848-6","article-title":"Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies","volume":"7","author":"Pires","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"2025020305065215700_awae329-B18","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/brain\/awaa104","article-title":"Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms","volume":"143","author":"Ramberger","year":"2020","journal-title":"Brain"},{"key":"2025020305065215700_awae329-B19","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cell.2020.07.013","article-title":"TREM2 modulation remodels the tumor myeloid landscape enhancing anti-PD-1 immunotherapy","volume":"182","author":"Molgora","year":"2020","journal-title":"Cell"},{"key":"2025020305065215700_awae329-B20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/JAD-150859","article-title":"The presence of select tau species in human peripheral tissues and their relation to Alzheimer\u2019s disease","volume":"51","author":"Dugger","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"2025020305065215700_awae329-B21","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1038\/s41598-019-41429-1","article-title":"Amyloid beta in nasal secretions may be a potential biomarker of Alzheimer's disease","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"key":"2025020305065215700_awae329-B22","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.1102289","article-title":"Brain-derived antigens in lymphoid tissue of patients with acute stroke","volume":"188","author":"Planas","year":"2012","journal-title":"J Immunol"},{"key":"2025020305065215700_awae329-B23","doi-asserted-by":"crossref","first-page":"114311","DOI":"10.1016\/j.celrep.2024.114311","article-title":"Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load","volume":"43","author":"Nanaware","year":"2024","journal-title":"Cell Rep."},{"key":"2025020305065215700_awae329-B24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","article-title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: A diagnostic performance and prediction modelling study using data from four prospective cohorts","volume":"19","author":"Karikari","year":"2020","journal-title":"Lancet Neurol"},{"key":"2025020305065215700_awae329-B25","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.neuron.2023.04.020","article-title":"Synaptic oligomeric tau in Alzheimer\u2019s disease\u2014A potential culprit in the spread of tau pathology through the brain","volume":"111","author":"Colom-Cadena","year":"2023","journal-title":"Neuron"},{"key":"2025020305065215700_awae329-B26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s40478-017-0488-7","article-title":"What is the evidence that tau pathology spreads through prion-like propagation?","volume":"5","author":"Mudher","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"2025020305065215700_awae329-B27","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat Neurosci"},{"key":"2025020305065215700_awae329-B28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-021-00440-9","article-title":"Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model","volume":"16","author":"Clayton","year":"2021","journal-title":"Mol Neurodegener"},{"key":"2025020305065215700_awae329-B29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-023-03003-5","article-title":"Peripheral blood amyloid-beta involved in the pathogenesis of Alzheimer\u2019s disease via impacting on peripheral innate immune cells","volume":"21","author":"Shi","year":"2024","journal-title":"J Neuroinflammation"},{"key":"2025020305065215700_awae329-B30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/alz.12385","article-title":"Amyloid-beta is present in human lymph nodes and greatly enriched in those of the cervical region","volume":"18","author":"Nauen","year":"2022","journal-title":"Alzheimers Dement"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae329\/61019125\/awae329.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/2\/394\/61019125\/awae329.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/2\/394\/61019125\/awae329.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:08:06Z","timestamp":1738541286000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/148\/2\/394\/7829162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,10,21]]},"published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae329","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.26.591238","asserted-by":"object"}]},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,10,21]]}}}