{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:01:27Z","timestamp":1789837287522,"version":"4.0.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence National de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"Association Francaise contre les Myopathies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023851","name":"Association Institut de Myologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Muscleblind-like proteins (MBNLs) are a family of RNA-binding proteins that play essential roles in the regulation of RNA metabolism. Beyond their canonical role in RNA regulation, MBNL proteins have emerged as key players in the pathogenesis of myotonic dystrophy type 1. In myotonic dystrophy type 1, sequestration of MBNL proteins by expansion of the CUG repeat RNA leads to functional depletion of MBNL, resulting in deregulated alternative splicing and aberrant RNA processing, which underlie the clinical features of the disease.<\/jats:p>\n                  <jats:p>Although attention on MBNL proteins has focused on their functions in skeletal muscle, new evidence suggests that their importance extends to motor neurons (MNs), pivotal cellular components in the control of motor skills and movement. To address this question, we generated conditional double-knockout (dKO) mice, in which Mbnl1 and Mbnl2 were specifically deleted in motor neurons (MN-dKO). Adult MN-dKO mice develop gait coordination deficits associated with structural and ultrastructural defects in the neuromuscular junction, indicating that MBNL activity in MNs is crucial for the maintenance of the neuromuscular junction. In addition, transcriptome analysis performed on the spinal cord of MN-dKO mice identified mis-splicing events in genes associated with synaptic transmission and neuromuscular junction homeostasis.<\/jats:p>\n                  <jats:p>In summary, our results highlight the complex roles and regulatory mechanisms of MBNL proteins in MNs for muscle function and locomotion. This work provides valuable insights into fundamental aspects of RNA biology and offers promising avenues for therapeutic intervention in myotonic dystrophy type 1 and in a range of diseases associated with RNA dysregulation.<\/jats:p>","DOI":"10.1093\/brain\/awae336","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T15:25:06Z","timestamp":1729265106000},"page":"1180-1193","source":"Crossref","is-referenced-by-count":9,"title":["MBNL deficiency in motor neurons disrupts neuromuscular junction maintenance and gait coordination"],"prefix":"10.1093","volume":"148","author":[{"given":"Charles","family":"Frison-Roche","sequence":"first","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Martin","family":"Demier","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Cottin","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Lain\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Arandel","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Halliez","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9gane","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"UMS28, Ph\u00e9notypage du Petit Animal, Sorbonne Universit\u00e9 , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavi\u00e8re","family":"Lornage","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Strochlic","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice S","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine , Gainesville, FL 32610 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5234-1064","authenticated-orcid":false,"given":"C\u00e9cile","family":"Martinat","sequence":"additional","affiliation":[{"name":"Inserm, Paris Saclay University, I-STEM , 91100 Corbeil-Essonnes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mess\u00e9ant","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, Inserm, Institut de Myologie , 75013 Paris 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