{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:03:38Z","timestamp":1792785818796,"version":"4.5.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["NS136108"],"award-info":[{"award-number":["NS136108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["NS130138"],"award-info":[{"award-number":["NS130138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Health Technology R&D Project","award":["HI21C1062"],"award-info":[{"award-number":["HI21C1062"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022M3E5E8081191"],"award-info":[{"award-number":["NRF-2022M3E5E8081191"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson\u2019s disease is a progressive neurodegenerative disease with well-documented motor symptoms and less recognized, but significant, non-motor symptoms. These non-motor symptoms include prodromal pain and peripheral neuropathy, the causes of which are unknown.<\/jats:p>\n                  <jats:p>We investigated the role of DJ-1\/PARK7, a Parkinson\u2019s disease-associated gene, in prodromal pain and peripheral neuropathy. Using Dj-1-deficient mice, we conducted comprehensive sensory tests, cutaneous staining, molecular analyses and electrophysiological studies on mouse and human primary sensory neurons from dorsal root ganglia.<\/jats:p>\n                  <jats:p>We found that these mice exhibited cold hypersensitivity, oxidative stress, and neuropathy of the cutaneous fibres of primary sensory neurons before any motor impairments were observed. Mechanistically, DJ-1 in primary sensory neurons regulated this hypersensitivity and neuropathy via TRPA1 signalling. Interestingly, we discovered that DJ-1 also plays a role in the progression of chemotherapy-induced peripheral neuropathies. Pain and mechanisms associated with these neuropathies were exacerbated in Dj-1-deficient mice but were significantly reduced by the pharmacological activation of Dj-1. Importantly, we also confirmed the expression of DJ-1 and its therapeutic potential in human primary sensory neurons.<\/jats:p>\n                  <jats:p>Thus, we uncover a peripheral mechanism of DJ-1 and propose that it might serve as a new target for developing therapeutic approaches for Parkinson\u2019s disease-linked and other painful neuropathies.<\/jats:p>","DOI":"10.1093\/brain\/awae341","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T15:24:10Z","timestamp":1729783450000},"page":"1639-1651","source":"Crossref","is-referenced-by-count":15,"title":["The Parkinson\u2019s disease\n                    <i>DJ-1<\/i>\n                    \/\n                    <i>PARK7<\/i>\n                    gene controls peripheral neuronal excitability and painful neuropathy"],"prefix":"10.1093","volume":"148","author":[{"given":"Sang Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center , Cincinnati, OH 45267 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Tonello","sequence":"additional","affiliation":[{"name":"Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center , Cincinnati, OH 45267 ,","place":["USA"]},{"name":"Pain Research Center, Department of Molecular Pathobiology, College of Dentistry , New York, NY 10010 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kihwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Tooth-Periodontium Complex Medical Research Center, Seoul National University , Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jueun","family":"Roh","sequence":"additional","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University , Incheon 21999 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Silveira","family":"Prudente","sequence":"additional","affiliation":[{"name":"Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center , Cincinnati, OH 45267 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University , Incheon 21999 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University , Incheon 21999 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-8288","authenticated-orcid":false,"given":"Temugin","family":"Berta","sequence":"additional","affiliation":[{"name":"Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center , Cincinnati, OH 45267 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"2025052317033698300_awae341-B1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"2025052317033698300_awae341-B2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat Rev 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