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No studies have compared the clinical performance of p-tau217 as assessed by the fully automated Lumipulse and single molecule array (SIMOA) AlZpath p-tau217.<\/jats:p>\n                  <jats:p>The study included 392 participants, 162 with Alzheimer\u2019s disease, 70 with other neurodegenerative diseases with CSF biomarkers and 160 healthy controls. Plasma p-tau217 levels were measured using the Lumipulse and ALZpath SIMOA assays. The ability of p-tau217 assessed by both techniques to discriminate Alzheimer\u2019s disease from other neurodegenerative diseases and controls was investigated using receiver operating characteristic analyses.<\/jats:p>\n                  <jats:p>The p-tau217 levels measured by the two techniques demonstrated a strong correlation, showing a consistent relationship with CSF p-tau181 levels. In head-to-head comparison, Lumipulse and SIMOA showed similar diagnostic accuracy for differentiating Alzheimer\u2019s disease from other neurodegenerative diseases [area under the curve (AUC) 0.952, 95% confidence interval (CI) 0.927\u20130.978 versus 0.955, 95% CI 0.928\u20130.982, respectively] and healthy controls (AUC 0.938, 95% CI 0.910\u20130.966 and 0.937, 95% CI 0.907\u20130.967 for both assays).<\/jats:p>\n                  <jats:p>This study demonstrated the high precision and diagnostic accuracy of p-tau217 for the clinical diagnosis of Alzheimer\u2019s disease using fully automated or semi-automated techniques.<\/jats:p>","DOI":"10.1093\/brain\/awae368","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T23:34:02Z","timestamp":1730936042000},"page":"408-415","source":"Crossref","is-referenced-by-count":72,"title":["Plasma p-tau217 in Alzheimer\u2019s disease: Lumipulse and ALZpath SIMOA head-to-head 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