{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:42:27Z","timestamp":1790991747236,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011542","name":"Mayo Clinic Center for Clinical and Translational Science","doi-asserted-by":"publisher","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100011542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vasculitic neuropathy is caused by inflammatory destruction of nerve blood vessels resulting in nerve ischaemia. Nerve vasculitis can be divided into two categories based on vessel size: large-arteriole vasculitis (\u226575\u2005\u00b5m) and microvasculitis (&amp;lt;75\u2005\u00b5m). Herein, we characterize the clinical features of nerve large-arteriole vasculitis in comparison to nerve microvasculitis.<\/jats:p>\n                  <jats:p>This is a retrospective cohort study of patients evaluated and biopsied at Mayo sites between 2001 and 2020. We collected clinical and histopathological data from patients whose nerve biopsies were either diagnostic or highly suggestive of nerve vasculitis.<\/jats:p>\n                  <jats:p>Two hundred and seventy-eight cases were identified: 125 cases of large-arteriole vasculitis and 153 cases of microvasculitis. Nerve large-arteriole vasculitis presented with a more acute (50.4% versus 26.8%) versus chronic onset (33.6% versus 57.5%) than nerve microvasculitis (P = 0.0001). Nerve microvasculitis had longer mean time to diagnosis (10.5 versus 4.3 months; P &amp;lt; 0.0001) and longer time to plateau (8.9 versus 3.5 months; P &amp;lt; 0.0001). Nerve large-arteriole vasculitis typically presented as distal asymmetric polyneuropathy (48.0%), whereas nerve microvasculitis typically presented as radiculoplexus neuropathy\/polyradiculoneuropathy (more proximal involvement of shoulder and thigh) (43.8%) (P &amp;lt; 0.0001). Systemic autoimmune disease was more common in nerve large-arteriole vasculitis (70.4% versus 22.9%, odds ratio, 8.0; 95% confidence interval, 4.7\u201313.7; P &amp;lt; 0.0001). Nerve microvasculitis was significantly related to non-systemic vasculitis (71% versus 23%, odds ratio, 7.9; 95% confidence interval, 4.6\u201313.6; P &amp;lt; 0.0001). Nerve microvasculitis had more autonomic involvement (24.2% versus 7.2%, odds ratio, 4.1; 95% confidence interval, 1.9\u20138.9; P = 0.0002).<\/jats:p>\n                  <jats:p>Nerve large-arteriole vasculitis and nerve microvasculitis have different but overlapping clinical features. Nerve large-arteriole vasculitis usually presents with acute onset, distal asymmetric polyneuropathy, associated with other autoimmune diseases and systemic involvement. In contrast, nerve microvasculitis usually presents with a subacute\/chronic onset, as radiculoplexus neuropathy\/polyradiculopathy (distal and proximal pattern) with autonomic involvement, and is more often a form of non-systemic vasculitis.<\/jats:p>","DOI":"10.1093\/brain\/awae406","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:31:41Z","timestamp":1734679901000},"page":"1031-1042","source":"Crossref","is-referenced-by-count":5,"title":["Distinctive clinical features in biopsy-proven nerve large-arteriole vasculitis and microvasculitis"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-0021","authenticated-orcid":false,"given":"Pannathat","family":"Soontrapa","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]},{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok 10700 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-6657","authenticated-orcid":false,"given":"Marcus V","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Shouman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Quantitative Health Sciences, Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaNean K","family":"Engelstad","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Aragon Pinto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Dalhousie University , Halifax, NS B3H 4R2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L","family":"Mauermann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E","family":"Berini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Peter","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Phoenix, AZ 85259 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon I","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Koster","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M","family":"Weyand","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Warrington","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Dyck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P James B","family":"Dyck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 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A current survey and recommendation","volume":"10","author":"Dyck","year":"2005","journal-title":"J Peripher Nerv Syst"},{"key":"2026032301121182300_awae406-B22","doi-asserted-by":"crossref","first-page":"116424","DOI":"10.1016\/j.jns.2019.116424","article-title":"Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS+7","volume":"405","author":"Dyck","year":"2019","journal-title":"J Neurol Sci"},{"key":"2026032301121182300_awae406-B23","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/01.STR.0000258355.23810.c6","article-title":"Outcomes validity and reliability of the modified Rankin scale: Implications for stroke clinical trials","volume":"38","author":"Banks","year":"2007","journal-title":"Stroke"},{"key":"2026032301121182300_awae406-B24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/mus.24207","article-title":"INCAT disability score: A critical analysis of its measurement properties","volume":"50","author":"Breiner","year":"2014","journal-title":"Muscle Nerve"},{"key":"2026032301121182300_awae406-B25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/mus.26479","article-title":"The utility of nerve biopsy in carefully selected patients in modern neuromuscular practice","volume":"59","author":"Berini","year":"2019","journal-title":"Muscle Nerve"},{"key":"2026032301121182300_awae406-B26","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1474-4422(05)70249-0","article-title":"An update on the classification and treatment of vasculitic neuropathy","volume":"4","author":"Schaublin","year":"2005","journal-title":"Lancet Neurol"},{"key":"2026032301121182300_awae406-B27","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1136\/jnnp.2008.151126","article-title":"The use of nerve and muscle biopsy in the diagnosis of vasculitis: A 5 year retrospective study","volume":"79","author":"Bennett","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026032301121182300_awae406-B28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1212\/01.WNL.0000082715.48844.3E","article-title":"Nonsystemic vasculitic neuropathy: Insights from a clinical cohort","volume":"61","author":"Collins","year":"2003","journal-title":"Neurology"},{"key":"2026032301121182300_awae406-B29","first-page":"102","article-title":"Vasculitic neuropathy","volume":"36","author":"Sampaio","year":"2011","journal-title":"Acta Reumatol Port"},{"key":"2026032301121182300_awae406-B30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/aian.AIAN_47_18","article-title":"Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center","volume":"22","author":"Hui","year":"2019","journal-title":"Ann Indian Acad Neurol"},{"issue":"Suppl 3","key":"2026032301121182300_awae406-B31","doi-asserted-by":"crossref","first-page":"iii55","DOI":"10.1093\/rheumatology\/keaa075","article-title":"Vasculitis and the peripheral nervous system","volume":"59","author":"Ginsberg","year":"2020","journal-title":"Rheumatology"},{"key":"2026032301121182300_awae406-B32","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/ana.22334","article-title":"Painless diabetic motor neuropathy: A variant of diabetic lumbosacral radiculoplexus neuropathy?","volume":"69","author":"Garces-Sanchez","year":"2011","journal-title":"Ann Neurol"},{"key":"2026032301121182300_awae406-B33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1468-1331.2010.03041.x","article-title":"The additional yield of combined nerve\/muscle biopsy in vasculitic neuropathy","volume":"18","author":"Vrancken","year":"2011","journal-title":"Eur J Neurol"},{"key":"2026032301121182300_awae406-B34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1085-9489.2006.00060.x","article-title":"Combined nerve and muscle biopsy in the diagnosis of vasculitic neuropathy. 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