{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:01:14Z","timestamp":1785160874344,"version":"3.55.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013790","name":"Brain Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013790","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Science"},{"name":"Migraine Trust UK Fellowship","award":["MR\/N013700\/1"],"award-info":[{"award-number":["MR\/N013700\/1"]}]},{"name":"Migraine Trust UK Fellowship"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104612\/Z\/14\/Z"],"award-info":[{"award-number":["104612\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020536","name":"Eli Lilly","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020536","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kallyope"},{"DOI":"10.13039\/100008021","name":"Bristol Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022606","name":"Almirall","doi-asserted-by":"publisher","award":["MR\/P006264\/1"],"award-info":[{"award-number":["MR\/P006264\/1"]}],"id":[{"id":"10.13039\/501100022606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","award":["NIHR-CS-011-028"],"award-info":[{"award-number":["NIHR-CS-011-028"]}],"id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K015184\/1"],"award-info":[{"award-number":["MR\/K015184\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Raised intracranial pressure (ICP) is associated with altered cerebral haemodynamics and cephalic pain. The relationship between the algetic response and cortical neurovascular changes in raised ICP is unclear. This study aimed to evaluate this relationship and determine whether lowering ICP (using a glucagon-like peptide-1 receptor agonist) could ameliorate the algetic response. We also sought to explore the role of calcitonin gene-related peptide in cephalic pain driven by raised ICP by inhibiting calcitonin gene-related peptide signalling and quantifying changes in the algetic response.<\/jats:p>\n               <jats:p>In a rat model of raised ICP, created by intracisternal kaolin injection, mechanical thresholds were measured alongside steady-state potential and cerebral blood flow responses to spreading depolarization. Nuclear magnetic resonance spectroscopy evaluated energetic substrates in animals with raised ICP ex vivo. The glucagon-like peptide-1 receptor (GLP-1R) agonist exenatide and the calcitonin gene-related peptide receptor (CGRP-R) antagonist olcegepant were injected daily, and measurements were repeated.<\/jats:p>\n               <jats:p>Kaolin increased ICP [median (range) 15.96 (8.97)\u2005mmHg, n = 8] versus controls [6.02 (1.79)\u2005mmHg, n = 6, P = 0.0007]. Animals with raised ICP exhibited reduced mechanical thresholds [mean (standard deviation) hind paw baseline: 5.78 (2.81)\u2005g, Day\u20057: 3.34 (2.22)\u2005g, P &amp;lt; 0.001; periorbital baseline: 6.13 (2.07)\u2005g, Day\u20057: 2.35 (1.91)\u2005g, n = 12, P &amp;lt; 0.001]. Depolarization and repolarization durations were increased [depolarization, raised ICP: 108.81 (222.12)\u2005s, n = 11, controls: 37.54 (108.38)\u2005s, n = 9, P = 0.038; repolarization, raised ICP: 1824.26 (3499.54)\u2005s, n = 12, controls: 86.96 (140.05)\u2005s, n = 9, P &amp;lt; 0.0001]. Cerebral blood flow change was also reduced [85.55 (30.84)%, n = 9] compared with controls [217.64 (37.70)%, n = 8, P &amp;lt; 0.0001]. Substrates for cellular energetics (ADP, ATP and NAD+) were depleted in rodent brains with raised ICP (P = 0.009, P = 0.018 and P = 0.011, respectively).<\/jats:p>\n               <jats:p>Exenatide significantly lowered ICP [exenatide: 9.74 (6.09)\u2005mmHg, n = 19, vehicle: 18.27 (6.67)\u2005mmHg, n = 16, P = 0.004] and rescued changes in mechanical withdrawal. Exenatide recovered characteristic spreading depolarization responses [depolarization duration, exenatide: 56.46 (25.10)\u2005s, n = 7, vehicle: 115.98 (58.80)\u2005s, n = 6, P = 0.033; repolarization duration, exenatide: 177.55 (562.88)\u2005s, n = 7, vehicle: 800.85 (1988.67)\u2005s, n = 6, P = 0.002]. In the setting of raised ICP, olcegepant prevented changes in periorbital mechanical thresholds.<\/jats:p>\n               <jats:p>We conclude that raised ICP disrupted the cortical neurovascular responses, reduced algetic thresholds and depleted crucial energetic substrates. Exenatide reduced ICP, improving algetic thresholds and cortical neurovascular changes. Importantly, olcegepant alleviated the cerebral algesia, suggesting a role for calcitonin gene-related peptide in driving pain responses in elevated ICP.<\/jats:p>\n               <jats:p>These studies support the rationale that reducing ICP improves cephalic pain in conditions of raised ICP. Furthermore, the data suggest that headache pain in diseases associated with raised ICP could be ameliorated therapeutically though blockade of the calcitonin gene-related peptide pathway.<\/jats:p>","DOI":"10.1093\/brain\/awae415","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T19:07:36Z","timestamp":1741460856000},"page":"2163-2177","source":"Crossref","is-referenced-by-count":4,"title":["Raised intracranial pressure alters cortical vascular function and cephalic allodynia"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-802X","authenticated-orcid":false,"given":"Olivia","family":"Grech","sequence":"first","affiliation":[{"name":"Metabolism and Systems Science, College of Medicine and Health, University of Birmingham , Birmingham B15 2TT ,","place":["UK"]},{"name":"Biomedical Sciences, College of Medicine and Health, University of Birmingham , Birmingham B15 2TT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-3632","authenticated-orcid":false,"given":"Eloisa","family":"Rubio-Beltran","sequence":"additional","affiliation":[{"name":"Headache Group, Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London SE1 3RB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C","family":"Stanyer","sequence":"additional","affiliation":[{"name":"Headache Group, Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London SE1 3RB ,","place":["UK"]},{"name":"Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford OX3 9DU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Labastida-Ramirez","sequence":"additional","affiliation":[{"name":"Headache Group, Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London SE1 3RB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth G","family":"Lavery","sequence":"additional","affiliation":[{"name":"Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Clifton Campus , Nottingham NG11 8NS ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-7029","authenticated-orcid":false,"given":"Lisa J","family":"Hill","sequence":"additional","affiliation":[{"name":"Metabolism and Systems Science, College of Medicine and Health, University of Birmingham , Birmingham B15 2TT ,","place":["UK"]},{"name":"Biomedical Sciences, College of Medicine and Health, University of Birmingham , Birmingham B15 2TT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3345-4853","authenticated-orcid":false,"given":"Philip R","family":"Holland","sequence":"additional","affiliation":[{"name":"Headache Group, Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London SE1 3RB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-5132","authenticated-orcid":false,"given":"Alexandra J","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Metabolism and Systems Science, College of Medicine and Health, University of Birmingham , Birmingham B15 2TT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"key":"2025060300223306800_awae415-B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3171\/jns.1999.91.1.0011","article-title":"Hemodynamic characterization of intracranial pressure plateau waves in head-injury patients","volume":"91","author":"Czosnyka","year":"1999","journal-title":"J Neurosurg"},{"key":"2025060300223306800_awae415-B2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3171\/jns.1997.86.4.0633","article-title":"Cerebral blood flow as a predictor of outcome following traumatic brain injury","volume":"86","author":"Kelly","year":"1997","journal-title":"J Neurosurg"},{"key":"2025060300223306800_awae415-B3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s10194-021-01321-8","article-title":"Intracranial pressure directly predicts headache morbidity in idiopathic intracranial hypertension","volume":"22","author":"Mollan","year":"2021","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B4","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.apmr.2004.12.042","article-title":"Headache after moderate and severe traumatic brain injury: A longitudinal analysis","volume":"86","author":"Walker","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"key":"2025060300223306800_awae415-B5","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1089\/neu.2009.0961","article-title":"Spreading depolarizations and late secondary insults after traumatic brain injury","volume":"26","author":"Hartings","year":"2009","journal-title":"J Neurotrauma"},{"key":"2025060300223306800_awae415-B6","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1093\/brain\/awp102","article-title":"Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage","volume":"132","author":"Dreier","year":"2009","journal-title":"Brain"},{"key":"2025060300223306800_awae415-B7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/jcbfm.2010.191","article-title":"Clinical relevance of cortical spreading depression in neurological disorders: Migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury","volume":"31","author":"Lauritzen","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025060300223306800_awae415-B8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s101940170043","article-title":"Headache associated with acute ischemic stroke","volume":"2","author":"Paciaroni","year":"2001","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ana.410330109","article-title":"The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats","volume":"33","author":"Goadsby","year":"1993","journal-title":"Ann Neurol"},{"key":"2025060300223306800_awae415-B10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s10194-022-01499-5","article-title":"CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury","volume":"23","author":"Ashina","year":"2022","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ana.410280213","article-title":"Vasoactive peptide release in the extracerebral circulation of humans during migraine headache","volume":"28","author":"Goadsby","year":"1990","journal-title":"Ann Neurol"},{"key":"2025060300223306800_awae415-B12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","article-title":"CGRP may play a causative role in migraine","volume":"22","author":"Lassen","year":"2002","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B13","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1177\/0333102418759786","article-title":"ARISE: A phase 3 randomized trial of erenumab for episodic migraine","volume":"38","author":"Dodick","year":"2018","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B14","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1056\/NEJMoa1705848","article-title":"A controlled trial of erenumab for episodic migraine","volume":"377","author":"Goadsby","year":"2017","journal-title":"N Engl J Med"},{"key":"2025060300223306800_awae415-B15","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(08)61626-8","article-title":"Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: A randomised, placebo-controlled, parallel-treatment trial","volume":"372","author":"Ho","year":"2008","journal-title":"Lancet"},{"key":"2025060300223306800_awae415-B16","doi-asserted-by":"crossref","first-page":"3331024231159366","DOI":"10.1177\/03331024231159366","article-title":"Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials","volume":"43","author":"Haghdoost","year":"2023","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/head.14026","article-title":"Erenumab for headaches in idiopathic intracranial hypertension: A prospective open-label evaluation","volume":"61","author":"Yiangou","year":"2021","journal-title":"Headache"},{"key":"2025060300223306800_awae415-B18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s10194-020-01182-7","article-title":"Calcitonin gene related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension","volume":"21","author":"Yiangou","year":"2020","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s10194-020-01136-z","article-title":"Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: An open-label study","volume":"21","author":"Ashina","year":"2020","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/nbm.1428","article-title":"NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases \u2013 a diagnostic tool?","volume":"23","author":"Sinclair","year":"2010","journal-title":"NMR Biomed"},{"key":"2025060300223306800_awae415-B21","doi-asserted-by":"crossref","first-page":"e1702","DOI":"10.1212\/WNL.0000000000201007","article-title":"Nuclear magnetic resonance spectroscopy metabolomics in idiopathic intracranial hypertension to identify markers of disease and headache","volume":"99","author":"Grech","year":"2022","journal-title":"Neurology"},{"key":"2025060300223306800_awae415-B22","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/brain\/awad003","article-title":"The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: A randomized clinical trial","volume":"146","author":"Mitchell","year":"2023","journal-title":"Brain"},{"key":"2025060300223306800_awae415-B23","doi-asserted-by":"crossref","first-page":"eaan0972","DOI":"10.1126\/scitranslmed.aan0972","article-title":"A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus","volume":"9","author":"Botfield","year":"2017","journal-title":"Sci Transl Med"},{"key":"2025060300223306800_awae415-B24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ana.21138","article-title":"Reduced threshold for cortical spreading depression in female mice","volume":"61","author":"Brennan","year":"2007","journal-title":"Ann Neurol"},{"key":"2025060300223306800_awae415-B25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s10194-023-01598-x","article-title":"Estrogen modulation of cortical spreading depression","volume":"24","author":"Kudo","year":"2023","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B26","first-page":"e125348","article-title":"A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics","volume":"4","author":"O\u2019Reilly","year":"2019","journal-title":"JCI Insight"},{"key":"2025060300223306800_awae415-B27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/CBO9780511541742.026","volume-title":"Handbook of experimental neurology: Methods and techniques in animal research","author":"Khan","year":"2006"},{"key":"2025060300223306800_awae415-B28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2045-8118-11-23","article-title":"Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus","volume":"11","author":"Di Curzio","year":"2014","journal-title":"Fluids Barriers CNS"},{"key":"2025060300223306800_awae415-B29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.expneurol.2008.03.026","article-title":"The impact of anesthetics and hyperoxia on cortical spreading depression","volume":"212","author":"Kudo","year":"2008","journal-title":"Exp Neurol"},{"key":"2025060300223306800_awae415-B30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"2025060300223306800_awae415-B31","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/brain\/awaa211","article-title":"Differential medication overuse risk of novel anti-migraine therapeutics","volume":"143","author":"Saengjaroentham","year":"2020","journal-title":"Brain"},{"key":"2025060300223306800_awae415-B32","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1177\/0333102419861726","article-title":"Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain","volume":"39","author":"Christensen","year":"2019","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B33","first-page":"9.60.1","article-title":"Animal model of chronic migraine-associated pain","volume":"80","author":"Moye","year":"2017","journal-title":"Curr Protoc Neurosci"},{"key":"2025060300223306800_awae415-B34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ana.23653","article-title":"Acid-sensing ion channel 1: A novel therapeutic target for migraine with aura","volume":"72","author":"Holland","year":"2012","journal-title":"Ann Neurol"},{"key":"2025060300223306800_awae415-B35","doi-asserted-by":"crossref","first-page":"e633","DOI":"10.1097\/CCM.0000000000001625","article-title":"High intracranial pressure induced injury in the healthy rat brain","volume":"44","author":"Dai","year":"2016","journal-title":"Crit Care Med"},{"key":"2025060300223306800_awae415-B36","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1089\/089771503322686111","article-title":"Relationship between intracranial pressure and cortical spreading depression following fluid percussion brain injury in rats","volume":"20","author":"Rogatsky","year":"2003","journal-title":"J Neurotrauma"},{"key":"2025060300223306800_awae415-B37","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1177\/0271678X221076566","article-title":"Changes in neurovascular coupling with cerebral perfusion pressure indicate a link to cerebral autoregulation","volume":"42","author":"Acharya","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025060300223306800_awae415-B38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3940(93)90759-E","article-title":"Rats do not experience cortical or hippocampal spreading depression as aversive","volume":"149","author":"Koroleva","year":"1993","journal-title":"Neurosci Lett."},{"key":"2025060300223306800_awae415-B39","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/jnnp.2004.042838","article-title":"Brain energy metabolism and intracranial pressure in idiopathic adult hydrocephalus syndrome","volume":"76","author":"Agren-Wilsson","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025060300223306800_awae415-B40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0032-1304500","article-title":"Elevated intracranial pressure, low cerebral perfusion pressure, and impaired brain metabolism correlate with fatal outcome after severe brain injury","volume":"73","author":"Hej\u010dl","year":"2012","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"2025060300223306800_awae415-B41","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1097\/00001756-199807130-00006","article-title":"Suppression of cortical spreading depressions after magnesium treatment in the rat","volume":"9","author":"van der Hel","year":"1998","journal-title":"Neuroreport"},{"key":"2025060300223306800_awae415-B42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1212\/01.WNL.0000151975.03598.ED","article-title":"Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial","volume":"64","author":"S\u00e2ndor","year":"2005","journal-title":"Neurology"},{"key":"2025060300223306800_awae415-B43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1468-2982.2002.00335.x","article-title":"Open label trial of coenzyme Q10 as a migraine preventive","volume":"22","author":"Rozen","year":"2002","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/iub.1017","article-title":"Glucose-6-phosphate dehydrogenase, NADPH, and cell survival","volume":"64","author":"Stanton","year":"2012","journal-title":"IUBMB Life"},{"key":"2025060300223306800_awae415-B45","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1001\/jama.2021.23619","article-title":"Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: The STEP 8 randomized clinical trial","volume":"327","author":"Rubino","year":"2022","journal-title":"JAMA"},{"key":"2025060300223306800_awae415-B46","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1042\/CS20130708","article-title":"GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans","volume":"127","author":"Subaran","year":"2014","journal-title":"Clin Sci"},{"key":"2025060300223306800_awae415-B47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00395-021-00873-9","article-title":"Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke","volume":"116","author":"Nizari","year":"2021","journal-title":"Basic Res Cardiol"},{"key":"2025060300223306800_awae415-B48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1468-2982.1990.1006331.x","article-title":"The headache profile of idiopathic intracranial hypertension","volume":"10","author":"Wall","year":"1990","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B49","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1227\/01.NEU.0000372092.96124.E6","article-title":"Brain tumor headaches: From bedside to bench. Review","volume":"67","author":"Goffaux","year":"2010","journal-title":"Neurosurgery"},{"key":"2025060300223306800_awae415-B50","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.2147\/JPR.S186878","article-title":"The link between idiopathic intracranial hypertension, fibromyalgia, and chronic fatigue syndrome: Exploration of a shared pathophysiology","volume":"11","author":"Hulens","year":"2018","journal-title":"J Pain Res"},{"key":"2025060300223306800_awae415-B51","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jamaneurol.2014.133","article-title":"The idiopathic intracranial hypertension treatment trial: Clinical profile at baseline","volume":"71","author":"Wall","year":"2014","journal-title":"JAMA Neurol"},{"key":"2025060300223306800_awae415-B52","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/head.13153","article-title":"Headache in idiopathic intracranial hypertension: Findings from the idiopathic intracranial hypertension treatment trial","volume":"57","author":"Friedman","year":"2017","journal-title":"Headache"},{"key":"2025060300223306800_awae415-B53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10194-019-0968-1","article-title":"Migraine-provoking substances evoke periorbital allodynia in mice","volume":"20","author":"De Logu","year":"2019","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s10194-022-01496-8","article-title":"A c-Fos activation map in nitroglycerin\/levcromakalim-induced models of migraine","volume":"23","author":"Wu","year":"2022","journal-title":"J Headache Pain"},{"key":"2025060300223306800_awae415-B55","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41598-018-19901-1","article-title":"A unique inbred rat strain with sustained cephalic hypersensitivity as a model of chronic migraine-like pain","volume":"8","author":"Munro","year":"2018","journal-title":"Sci Rep"},{"issue":"Suppl 1","key":"2025060300223306800_awae415-B56","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12028-022-01474-7","article-title":"Cortical spreading depolarization, blood flow, and cognitive outcomes in a closed head injury mouse model of traumatic brain injury","volume":"37","author":"Mosley","year":"2022","journal-title":"Neurocrit Care"},{"key":"2025060300223306800_awae415-B57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/jcbfm.1983.11","article-title":"The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 1. Topography of changes in blood flow, potassium ion activity, and EEG","volume":"3","author":"Strong","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025060300223306800_awae415-B58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/mrm.1910310316","article-title":"Transient cell depolarization after permanent middle cerebral artery occlusion: An observation by diffusion-weighted MRI and localized 1H-MRS","volume":"31","author":"Gyngell","year":"1994","journal-title":"Magn Reson Med"},{"issue":"Suppl 1","key":"2025060300223306800_awae415-B59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12028-021-01397-9","article-title":"Cortical spreading depolarizations in a mouse model of subarachnoid hemorrhage","volume":"37","author":"Lai","year":"2022","journal-title":"Neurocrit Care"},{"key":"2025060300223306800_awae415-B60","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/1522-2594(200007)44:1<110::AID-MRM16>3.0.CO;2-N","article-title":"Spreading waves of transient and prolonged decreases in water diffusion after subarachnoid hemorrhage in rats","volume":"44","author":"Beaulieu","year":"2000","journal-title":"Magn Reson Med"},{"key":"2025060300223306800_awae415-B61","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1038\/s41598-022-05187-x","article-title":"Characterization of persistent post-traumatic headache and management strategies in adolescents and young adults following mild traumatic brain injury","volume":"12","author":"Kothari","year":"2022","journal-title":"Sci Rep"},{"key":"2025060300223306800_awae415-B62","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/0333102413505236","article-title":"Chronic post-traumatic headache after mild head injury: A descriptive study","volume":"34","author":"Kjeldgaard","year":"2014","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B63","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/0333102420909865","article-title":"Persistent post-traumatic headache attributed to mild traumatic brain injury: Deep phenotyping and treatment patterns","volume":"40","author":"Ashina","year":"2020","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B64","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1177\/0333102416651285","article-title":"Headache in military service members with a history of mild traumatic brain injury: A cohort study of diagnosis and classification","volume":"37","author":"Finkel","year":"2017","journal-title":"Cephalalgia"},{"key":"2025060300223306800_awae415-B65","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1212\/WNL.0000000000003428","article-title":"Ischemic stroke subtypes and migraine with visual aura in the ARIC study","volume":"87","author":"Androulakis","year":"2016","journal-title":"Neurology"},{"key":"2025060300223306800_awae415-B66","doi-asserted-by":"crossref","first-page":"1004058","DOI":"10.3389\/fneur.2022.1004058","article-title":"Migraine aura-like symptoms at onset of stroke and stroke-like symptoms in migraine with aura","volume":"13","author":"Scutelnic","year":"2022","journal-title":"Front Neurol"},{"key":"2025060300223306800_awae415-B67","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/ane.12341","article-title":"Prevalence of migraine headache in an in-patient stroke population","volume":"131","author":"Lantz","year":"2015","journal-title":"Acta Neurol Scand"},{"key":"2025060300223306800_awae415-B68","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1526-4610.2011.01882.x","article-title":"Sex differences in behavior and expression of CGRP-related genes in a rodent model of chronic migraine","volume":"51","author":"Stucky","year":"2011","journal-title":"Headache"},{"key":"2025060300223306800_awae415-B69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2012.02.058","article-title":"Propofol hemisuccinate suppresses cortical spreading depression","volume":"514","author":"Dhir","year":"2012","journal-title":"Neurosci Lett"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae415\/62350216\/awae415.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/6\/2163\/62350216\/awae415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/6\/2163\/62350216\/awae415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T04:22:55Z","timestamp":1748924575000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/148\/6\/2163\/8064584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":69,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3,8]]},"published-print":{"date-parts":[[2025,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae415","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,3,8]]}}}