{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:09:07Z","timestamp":1791486547871,"version":"4.3.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"STI2030-Major Projects","award":["2021ZD0201001"],"award-info":[{"award-number":["2021ZD0201001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81827901"],"award-info":[{"award-number":["81827901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The basal forebrain is a critical brain region involved in various neurobiological processes, including learning, memory and attention. Basal forebrain cells undergo structural and functional changes during ageing, increasing their vulnerability to neurodegenerative diseases.<\/jats:p>\n               <jats:p>To reveal the molecular landscape of distinct cell types during development and early ageing, we constructed a comprehensive single-nucleus transcriptomic atlas spanning postnatal Days 4 and 14 and 3, 9 and 15 months of age. Distinct molecular regulatory patterns of basal forebrain subclasses and ageing-related pathways were unveiled. The transcriptional regulation analysis and pseudo-time analysis revealed the dynamic regulatory network of cholinergic neurons during postnatal development.<\/jats:p>\n               <jats:p>To gain insights into the relationship between ageing and Alzheimer\u2019s disease, we conducted an integrative analysis. We identified four potential regulatory networks involved in cholesterol\/lipid metabolism, DNA damage repair and death receptor signal in 5xFAD mice. The cholinergic subtype CN-2 exhibited heightened activity of regulons associated with Srebf2 and Zmiz1, which, in turn, target hub genes implicated in these networks. Meanwhile, CN-2 is the main cholinergic subtype contributing to the alteration of the NRXN signalling pathway.<\/jats:p>\n               <jats:p>This study offers a significant data source to elucidate the molecular underpinnings of ageing-related and pathological changes in the basal forebrain, paving the way for future research and therapeutic interventions that target specific basal forebrain subclasses and signalling pathways.<\/jats:p>","DOI":"10.1093\/brain\/awaf060","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:36:36Z","timestamp":1739360196000},"page":"2493-2508","source":"Crossref","is-referenced-by-count":6,"title":["Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2355-4643","authenticated-orcid":false,"given":"Jiale","family":"Chen","sequence":"first","affiliation":[{"name":"Britton Chance Center 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