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However, their relation to striatal dopaminergic denervation and PD progression remains uncertain. Research on \u03b2 oscillations is limited to advanced PD stages undergoing DBS, prohibiting insights into early-stage progression and compensatory mechanisms. We therefore investigated \u03b2 dynamics, correlation with motor performance, and nigrostriatal neurodegeneration in a progressive PD rat model overexpressing AAV1\/2-A53T \u03b1-synuclein, mimicking PD pathology.<\/jats:p>\n                  <jats:p>Over 8 weeks, we longitudinally conducted behavioural assessments using the cylinder test and recorded local field potentials (LFP) from the STN and motor cortex (MCx) in the AAV-A53T-\u03b1Syn PD rat model.<\/jats:p>\n                  <jats:p>Increased \u03b2 power and burst parameters accompanied early motor deficits in the AAV-A53T-\u03b1Syn PD rat model. Changes were observed in the STN and MCx versus empty vector controls; alterations intensified with pathology progression. Increased high \u03b2 power and burst parameters (e.g. long burst probability in the STN but not MCx) were associated with motor impairment and nigrostriatal dopaminergic neurodegeneration. Multivariate analyses from these rat-derived data demonstrated that combined \u03b2 parameters in the cortico-subthalamic pathway and striatal dopaminergic fibre density predicted motor performance and neurodegeneration. Additional multivariate analyses confirmed the translational relevance of the A53T PD model, linking \u03b2 activity and dopamine uptake to motor impairment (UPDRS III Med-OFF) in human PD patients. Our data support the pathophysiological significance of \u03b2 oscillations as a progression marker of PD for motor symptoms and neurodegeneration. Our predictive models carry translational relevance, with the prospect of monitoring disease progression and neuroprotective outcomes in PD based on LFP recordings.<\/jats:p>","DOI":"10.1093\/brain\/awaf063","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T07:14:44Z","timestamp":1739603684000},"page":"4058-4071","source":"Crossref","is-referenced-by-count":10,"title":["Low \u03b2 predicts motor output and cell degeneration in the A53T Parkinson\u2019s disease rat model"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-0519","authenticated-orcid":false,"given":"Katarina","family":"Hofman","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmoy","family":"Sil","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-1597","authenticated-orcid":false,"given":"Franziska","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Uncertainty, Inverse Modeling and Machine Learning Group , Technische Universit\u00e4t Berlin, 10623 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Haufe","sequence":"additional","affiliation":[{"name":"Uncertainty, Inverse Modeling and Machine Learning Group , Technische Universit\u00e4t Berlin, 10623 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolo","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-5144","authenticated-orcid":false,"given":"Ioannis U","family":"Isaias","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Koprich","sequence":"additional","affiliation":[{"name":"Atuka Inc., Toronto, Ontario, Canada M5X 1C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Brotchie","sequence":"additional","affiliation":[{"name":"Atuka Inc., Toronto, Ontario, Canada M5X 1C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-9060","authenticated-orcid":false,"given":"Andrea A","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Movement Disorder and Neuromodulation Unit, Charit\u00e9\u2014Universit\u00e4tsmedizin , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Matthies","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthuraman","family":"Muthuraman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]},{"name":"Informatics for Medical Technology, Institute of Computer Science, University Augsburg , 86159 Augsburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Volkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-385X","authenticated-orcid":false,"given":"Chi Wang","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of 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