{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:13:28Z","timestamp":1789582408815,"version":"build-2803163510"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020090","name":"Fondation Neurodis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008211","name":"Association France Parkinson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM-FDM 40482"],"award-info":[{"award-number":["FRM-FDM 40482"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alexander von Humboldt fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Impulse control disorders (ICDs) are frequent and particularly distressing neuropsychiatric symptoms in patients with Parkinson\u2019s disease, which are related to impaired behavioural inhibition. Multiple PET imaging studies indicate that striatal dopaminergic abnormalities contribute to hyperdopaminergic functioning in Parkinson\u2019s disease patients with ICD (PDICD+) and to the dysregulation of the limbic fronto-striatal networks, which are critical for reward-related decision impulsivity. However, the serotonergic system is central to response inhibition and plays a critical role in neuropsychiatric symptoms in PD, but its role remains undetermined in PDICD. We hypothesized that PDICD+ patients exhibit serotonergic dysfunction within the cortico-striato-pallido-thalamic circuits involved in the inhibitory control of behaviour and decided to investigate the pre- and postsynaptic serotonergic innervation using two highly specific PET tracers for the serotonin transporter (SERT) using 11C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile (11C-DASB) and the 5-HT2A receptor using 18F-altanserin.<\/jats:p>\n                  <jats:p>In this prospective, case-control, double-tracer PET study, we recruited 15 PDICD+ patients, 15 PDICD\u2212 patients and 15 healthy controls, matched for age and sex, and compared the availability of 11C-DASB and 18F-altanserin using permutation-based analysis.<\/jats:p>\n                  <jats:p>PDICD+ patients had one (n = 9) or multiple ICDs (n = 6), consisting of hypersexuality (n = 8), compulsive eating (n = 6), compulsive shopping (n = 5) and pathological gambling (n = 4), and were characterized by greater choice impulsivity (impaired delay discounting for monetary rewards) and greater urgency with more severe depressive and anxious symptoms. We demonstrate that PDICD+ patients had greater 11C-DASB binding in the posterior putamen and pallidum in comparison to PDICD\u2212 patients, corresponding to relatively preserved presynaptic SERT availability within the subcortical sensorimotor network involved in response inhibition. In addition, cortical 18F-altanserin binding was greater in PDICD+ patients in the bilateral supplementary motor area, precentral gyrus and right dorsolateral prefrontal cortex, involving the sensorimotor and associative networks which regulate behavioural inhibition. Furthermore, we show that pre- and postsynaptic serotonergic dysfunction subserving action versus decision impulsivity in patients with Parkinson\u2019s disease specifically followed the distinctive functional organization of the sensorimotor and associative fronto-striatal networks.<\/jats:p>\n                  <jats:p>Altogether, we demonstrate that serotonergic dysfunction related to ICDs in Parkinson\u2019s disease specifically involve the sensorimotor and associative cortico-striato-pallido-thalamic circuits involved in inhibitory control. Thus, serotonergic dysfunction contributes to the mechanisms related to the vulnerability and development of ICDs in patients with Parkinson\u2019s disease, beyond the known dopaminergic abnormalities in the limbic fronto-striatal circuit.<\/jats:p>","DOI":"10.1093\/brain\/awaf087","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:24:23Z","timestamp":1740986663000},"page":"2108-2121","source":"Crossref","is-referenced-by-count":11,"title":["Serotonergic dysfunction in patients with impulse control disorders in Parkinson\u2019s disease"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-7634","authenticated-orcid":false,"given":"St\u00e9phane","family":"Prange","sequence":"first","affiliation":[{"name":"Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028 , Bron F- 69675 ,","place":["France"]},{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK\/FCRIN network , Bron F-69500 ,","place":["France"]},{"name":"Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, Facult\u00e9 de M\u00e9decine et de Ma\u00efeutique Lyon Sud Charles M\u00e9rieux , Oullins F-69600 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Metereau","sequence":"additional","affiliation":[{"name":"Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028 , Bron F- 69675 ,","place":["France"]},{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK\/FCRIN network , Bron F-69500 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Klinger","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK\/FCRIN network , Bron F-69500 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Huddlestone","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK\/FCRIN network , Bron F-69500 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK\/FCRIN network , Bron F-69500 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Duperrier","sequence":"additional","affiliation":[{"name":"Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR 5284, INSERM U1314, MeLiS , Lyon F-69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Courault","sequence":"additional","affiliation":[{"name":"Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028 , Bron F- 69675 ,","place":["France"]},{"name":"Hospices Civils de Lyon (HCL) , Lyon F-69002 ,","place":["France"]},{"name":"CERMEP-Imaging platform, Groupement Hospitalier Est , Bron F- 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Redoute","sequence":"additional","affiliation":[{"name":"Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028 , Bron F- 69675 ,","place":["France"]},{"name":"CERMEP-Imaging platform, Groupement Hospitalier Est , Bron F- 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Univ Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS UMR 5229 , Bron F- 69675 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-8586","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Sgambato","sequence":"additional","affiliation":[{"name":"Univ Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS UMR 5229 , Bron F- 69675 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lancelot","sequence":"additional","affiliation":[{"name":"Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028 , Bron F- 69675 ,","place":["France"]},{"name":"Hospices Civils de Lyon (HCL) , Lyon F-69002 ,","place":["France"]},{"name":"CERMEP-Imaging platform, Groupement Hospitalier Est , Bron F- 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Thobois","sequence":"additional","affiliation":[{"name":"Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028 , Bron F- 69675 ,","place":["France"]},{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK\/FCRIN network , Bron F-69500 ,","place":["France"]},{"name":"Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, Facult\u00e9 de M\u00e9decine et de Ma\u00efeutique Lyon Sud Charles M\u00e9rieux , Oullins F-69600 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"2025060300224758800_awaf087-B1","first-page":"679","volume-title":"International review of neurobiology","author":"Weintraub","year":"2017"},{"key":"2025060300224758800_awaf087-B2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/jnnp-2019-322453","article-title":"Spectrum of impulse control behaviours in Parkinson\u2019s disease: Pathophysiology and management","volume":"91","author":"Kelly","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025060300224758800_awaf087-B3","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1212\/WNL.0000000000005816","article-title":"Longitudinal analysis of impulse control disorders in Parkinson disease","volume":"91","author":"Corvol","year":"2018","journal-title":"Neurology"},{"key":"2025060300224758800_awaf087-B4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/archneurol.2009.294","article-title":"Dopamine agonist withdrawal syndrome in Parkinson disease","volume":"67","author":"Rabinak","year":"2010","journal-title":"Arch Neurol"},{"key":"2025060300224758800_awaf087-B5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/mds.29700","article-title":"Management of impulse control and related disorders in Parkinson\u2019s disease: An expert consensus","volume":"39","author":"Debove","year":"2024","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/mds.25291","article-title":"Prospective cohort study of impulse control disorders in Parkinson\u2019s disease","volume":"28","author":"Bastiaens","year":"2013","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1212\/WNL.0b013e3182840678","article-title":"Trial of CBT for impulse control behaviors affecting Parkinson patients and their caregivers","volume":"80","author":"Okai","year":"2013","journal-title":"Neurology"},{"key":"2025060300224758800_awaf087-B8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41531-023-00596-9","article-title":"Impulsive-compulsive behaviour in early Parkinson\u2019s disease is determined by apathy and dopamine receptor D3 polymorphism","volume":"9","author":"Theis","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"key":"2025060300224758800_awaf087-B9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/brain\/awz007","article-title":"Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control","volume":"142","author":"Hammes","year":"2019","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B10","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.neurol.2024.09.004","article-title":"Imaging of impulse control disorders in Parkinson\u2019s disease","volume":"180","author":"Prange","year":"2024","journal-title":"Rev Neurol (Paris)"},{"key":"2025060300224758800_awaf087-B11","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3390\/brainsci12091248","article-title":"Imaging the limbic system in Parkinson\u2019s disease\u2014A review of limbic pathology and clinical symptoms","volume":"12","author":"Banwinkler","year":"2022","journal-title":"Brain Sci"},{"key":"2025060300224758800_awaf087-B12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrn.2017.8","article-title":"Fractionating impulsivity: Neuropsychiatric implications","volume":"18","author":"Dalley","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"2025060300224758800_awaf087-B13","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1093\/brain\/awaa318","article-title":"Inhibitory control dysfunction in parkinsonian impulse control disorders","volume":"143","author":"Meyer","year":"2020","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00702-017-1693-z","article-title":"Dopamine and serotonin modulation of motor and non-motor functions of the non-human primate striato-pallidal circuits in normal and pathological states","volume":"125","author":"Sgambato-Faure","year":"2018","journal-title":"J Neural Transm (Vienna)"},{"key":"2025060300224758800_awaf087-B15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neubiorev.2011.06.001","article-title":"Serotonin and decision making processes","volume":"36","author":"Homberg","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"2025060300224758800_awaf087-B16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.biopsych.2021.05.016","article-title":"The modulatory role of serotonin on human impulsive aggression","volume":"90","author":"da Cunha-Bang","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2025060300224758800_awaf087-B17","first-page":"120","article-title":"A high-resolution in vivo atlas of the human brain\u2019s serotonin system","volume":"37","author":"Beliveau","year":"2017","journal-title":"J Neurosci"},{"key":"2025060300224758800_awaf087-B18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neubiorev.2016.02.008","article-title":"The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases","volume":"64","author":"Aznar","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"2025060300224758800_awaf087-B19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1017\/S1461145705005055","article-title":"Patients with obsessive\u2013compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei","volume":"8","author":"Adams","year":"2005","journal-title":"Int J Neuropsychopharm"},{"key":"2025060300224758800_awaf087-B20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S1461145706006559","article-title":"Cerebral 5-HT2A receptor binding is increased in patients with Tourette\u2019s syndrome","volume":"10","author":"Haugb\u00f8l","year":"2007","journal-title":"Int J Neuropsychopharm"},{"key":"2025060300224758800_awaf087-B21","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/mds.28722","article-title":"Serotonergic and dopaminergic lesions underlying parkinsonian neuropsychiatric signs","volume":"36","author":"Maillet","year":"2021","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.nbd.2010.05.028","article-title":"Staging of serotonergic dysfunction in Parkinson\u2019s disease: An in vivo 11C-DASB PET study","volume":"40","author":"Politis","year":"2010","journal-title":"Neurobiol Dis"},{"key":"2025060300224758800_awaf087-B23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ana.24859","article-title":"Serotonin transporter in Parkinson\u2019s disease: A meta-analysis of positron emission tomography studies","volume":"81","author":"Pagano","year":"2017","journal-title":"Ann Neurol"},{"key":"2025060300224758800_awaf087-B24","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/mds.22212","article-title":"Elevated serotonin transporter binding in depressed patients with Parkinson\u2019s disease: A preliminary PET study with [11C]DASB","volume":"23","author":"Boileau","year":"2008","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1001\/archneurol.2010.35","article-title":"Serotonin 2A receptors and visual hallucinations in Parkinson disease","volume":"67","author":"Ballanger","year":"2010","journal-title":"Arch Neurol"},{"issue":"Pt 9","key":"2025060300224758800_awaf087-B26","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1093\/brain\/aww162","article-title":"The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson\u2019s disease","volume":"139","author":"Maillet","year":"2016","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B27","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/mds.28971","article-title":"Limbic serotonergic plasticity contributes to the compensation of apathy in early Parkinson\u2019s disease","volume":"37","author":"Prange","year":"2022","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/mds.26223","article-title":"International validation of a behavioral scale in Parkinson\u2019s disease without dementia","volume":"30","author":"Rieu","year":"2015","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B29","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society-sponsored revision of the unified Parkinson\u2019s disease rating scale (MDS-UPDRS): Scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/mds.24023","article-title":"Questionnaire for impulsive-compulsive disorders in Parkinson\u2019s disease-rating scale","volume":"27","author":"Weintraub","year":"2012","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.comppsych.2011.09.001","article-title":"Validation of a short French version of the UPPS-P impulsive behavior scale","volume":"53","author":"Billieux","year":"2012","journal-title":"Compr Psychiatry"},{"key":"2025060300224758800_awaf087-B32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1176\/jnp.4.2.134","article-title":"Reliability, validity, and clinical correlates of apathy in Parkinson's disease","volume":"4","author":"Starkstein","year":"1992","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"2025060300224758800_awaf087-B33","first-page":"95","volume-title":"Stress and anxiety","author":"Spielberger","year":"1980"},{"key":"2025060300224758800_awaf087-B34","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: Psychometric properties","volume":"56","author":"Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"2025060300224758800_awaf087-B35","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/mds.21740","article-title":"The REM sleep behavior disorder screening questionnaire\u2014A new diagnostic instrument","volume":"22","author":"Stiasny-Kolster","year":"2007","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1037\/0096-3445.128.1.78","article-title":"Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls","volume":"128","author":"Kirby","year":"1999","journal-title":"J Exp Psychol Gen"},{"key":"2025060300224758800_awaf087-B37","doi-asserted-by":"crossref","first-page":"e46323","DOI":"10.7554\/eLife.46323","article-title":"A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task","volume":"8","author":"Verbruggen","year":"2019","journal-title":"Elife"},{"key":"2025060300224758800_awaf087-B38","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/npp.2013.351","article-title":"Serotonin depletion induces \u2018waiting impulsivity\u2019 on the human four-choice serial reaction time task: Cross-species translational significance","volume":"39","author":"Worbe","year":"2014","journal-title":"Neuropsychopharmacol"},{"key":"2025060300224758800_awaf087-B39","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/01.WCB.0000074092.59115.23","article-title":"Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus\/infusion approach","volume":"23","author":"Pinborg","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025060300224758800_awaf087-B40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuroimage.2010.01.072","article-title":"Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation","volume":"51","author":"Heckemann","year":"2010","journal-title":"Neuroimage"},{"key":"2025060300224758800_awaf087-B41","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.nucmedbio.2004.10.001","article-title":"Regional distribution of serotonin transporter protein in postmortem human brain: Is the cerebellum a SERT-free brain region?","volume":"32","author":"Kish","year":"2005","journal-title":"Nucl Med Biol"},{"key":"2025060300224758800_awaf087-B42","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"2025060300224758800_awaf087-B43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"2025060300224758800_awaf087-B44","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage"},{"key":"2025060300224758800_awaf087-B45","first-page":"120","article-title":"Preferential loss of serotonin markers in caudate versus putamen in Parkinson\u2019s disease","volume":"131","author":"Kish","year":"2008","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B46","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0969-8051(02)00316-5","article-title":"In vitro and in vivo characterisation of [11C]-DASB: A probe for in vivo measurements of the serotonin transporter by positron emission tomography","volume":"29","author":"Wilson","year":"2002","journal-title":"Nucl Med Biol"},{"key":"2025060300224758800_awaf087-B47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.parkreldis.2016.05.028","article-title":"Impulse control disorder in PD: A lateralized monoaminergic frontostriatal disconnection syndrome?","volume":"30","author":"Premi","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"2025060300224758800_awaf087-B48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/0891988721996802","article-title":"Bidirectional correlations between dopaminergic function and motivation in Parkinson\u2019s disease","volume":"35","author":"Hinkle","year":"2022","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"2025060300224758800_awaf087-B49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.2010.05906.x","article-title":"VMAT2: A dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse","volume":"1216","author":"Eiden","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"2025060300224758800_awaf087-B50","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/mds.24941","article-title":"Increased medial orbitofrontal [18F]fluorodopa uptake in parkinsonian impulse control disorders","volume":"27","author":"Joutsa","year":"2012","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B51","doi-asserted-by":"crossref","first-page":"e13264","DOI":"10.1111\/adb.13264","article-title":"Serotonergic and dopaminergic control of impulsivity in gambling disorder","volume":"28","author":"Kaasinen","year":"2023","journal-title":"Addict Biol"},{"key":"2025060300224758800_awaf087-B52","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1556\/2006.2023.00037","article-title":"Abnormal frontostriatal connectivity and serotonin function in gambling disorder: A preliminary exploratory study","volume":"12","author":"Bellmunt-Gil","year":"2023","journal-title":"J Behav Addict"},{"key":"2025060300224758800_awaf087-B53","doi-asserted-by":"crossref","first-page":"e84565","DOI":"10.1371\/journal.pone.0084565","article-title":"Increased functional connectivity between prefrontal cortex and reward system in pathological gambling","volume":"8","author":"Koehler","year":"2013","journal-title":"PLoS One"},{"key":"2025060300224758800_awaf087-B54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cortex.2017.06.008","article-title":"Resting-state brain networks in patients with Parkinson\u2019s disease and impulse control disorders","volume":"94","author":"Tessitore","year":"2017","journal-title":"Cortex"},{"key":"2025060300224758800_awaf087-B55","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.neurobiolaging.2007.04.011","article-title":"Reduced 5-HT2A receptor binding in patients with mild cognitive impairment","volume":"29","author":"Hasselbalch","year":"2008","journal-title":"Neurobiol Aging"},{"key":"2025060300224758800_awaf087-B56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neurobiolaging.2010.03.023","article-title":"Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer\u2019s disease: A combined [11C]DASB and [18F]altanserin-PET study","volume":"33","author":"Marner","year":"2012","journal-title":"Neurobiol Aging"},{"key":"2025060300224758800_awaf087-B57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0022-510X(91)90193-B","article-title":"Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"106","author":"Cheng","year":"1991","journal-title":"J Neurol Sci"},{"key":"2025060300224758800_awaf087-B58","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/mdc3.12466","article-title":"The relationship between serotonin-2A receptor and cognitive functions in nondemented Parkinson\u2019s disease patients with visual hallucinations","volume":"4","author":"Cho","year":"2017","journal-title":"Mov Disord Clin Pract"},{"key":"2025060300224758800_awaf087-B59","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/mds.27885","article-title":"Functional inhibitory control dynamics in impulse control disorders in Parkinson\u2019s disease","volume":"35","author":"Paz-Alonso","year":"2020","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B60","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.neuroimage.2012.07.023","article-title":"Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas","volume":"63","author":"Lanzenberger","year":"2012","journal-title":"Neuroimage"},{"key":"2025060300224758800_awaf087-B61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00213-006-0635-5","article-title":"Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT2A receptor binding in the rat","volume":"190","author":"Cahir","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"2025060300224758800_awaf087-B62","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/01.WCB.0000126233.08565.E7","article-title":"[18f]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge","volume":"24","author":"Pinborg","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025060300224758800_awaf087-B63","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1749-6632.1997.tb52365.x","article-title":"Postmortem findings in suicide victims. Implications for in vivo imaging studies","volume":"836","author":"Arango","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"2025060300224758800_awaf087-B64","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.bjp.0705328","article-title":"Evidence that central 5-HT2A and 5-HT2B\/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat","volume":"139","author":"Boothman","year":"2003","journal-title":"Br J Pharmacol"},{"key":"2025060300224758800_awaf087-B65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neuint.2014.01.005","article-title":"Serotonin-induced down-regulation of cell surface serotonin transporter","volume":"73","author":"J\u00f8rgensen","year":"2014","journal-title":"Neurochem Int"},{"key":"2025060300224758800_awaf087-B66","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1523\/JNEUROSCI.2852-09.2010","article-title":"A nonlinear relationship between cerebral serotonin transporter and 5-HT2A receptor binding: An in vivo molecular imaging study in humans","volume":"30","author":"Erritzoe","year":"2010","journal-title":"J Neurosci"},{"key":"2025060300224758800_awaf087-B67","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/syn.10266","article-title":"High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain","volume":"50","author":"Rothman","year":"2003","journal-title":"Synapse"},{"key":"2025060300224758800_awaf087-B68","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0006-8993(91)90553-8","article-title":"Serotonergic sprouting is induced by dopamine-lesion in substantia nigra of adult rat brain","volume":"556","author":"Zhou","year":"1991","journal-title":"Brain Res"},{"key":"2025060300224758800_awaf087-B69","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00230443","article-title":"Serotonergic sprouting in primate MTP-induced hemiparkinsonism","volume":"96","author":"Gaspar","year":"1993","journal-title":"Exp Brain Res"},{"issue":"Pt 9","key":"2025060300224758800_awaf087-B70","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1093\/brain\/awv183","article-title":"Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate","volume":"138","author":"Beaudoin-Gobert","year":"2015","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-3806(99)00066-8","article-title":"Serotonin 2A receptor mRNA levels in the neonatal dopamine-depleted rat striatum remain upregulated following suppression of serotonin hyperinnervation","volume":"116","author":"Basura","year":"1999","journal-title":"Brain Res Dev Brain Res"},{"key":"2025060300224758800_awaf087-B72","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0006-8993(94)91511-3","article-title":"Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase","volume":"667","author":"Arai","year":"1994","journal-title":"Brain Res"},{"key":"2025060300224758800_awaf087-B73","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00702-018-1871-7","article-title":"Pathophysiology of dyskinesia and behavioral disorders in non-human primates: The role of serotonergic fibers","volume":"125","author":"Sgambato","year":"2018","journal-title":"J Neural Transm (Vienna)"},{"key":"2025060300224758800_awaf087-B74","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1212\/WNL.0000000000002494","article-title":"Serotonin-to-dopamine transporter ratios in Parkinson disease: Relevance for dyskinesias","volume":"86","author":"Roussakis","year":"2016","journal-title":"Neurology"},{"key":"2025060300224758800_awaf087-B75","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/ana.22097","article-title":"Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia","volume":"68","author":"Rylander","year":"2010","journal-title":"Ann Neurol"},{"key":"2025060300224758800_awaf087-B76","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S1474-4422(17)30004-2","article-title":"Impulse control disorders and levodopa-induced dyskinesias in Parkinson\u2019s disease: An update","volume":"16","author":"Voon","year":"2017","journal-title":"Lancet Neurol"},{"key":"2025060300224758800_awaf087-B77","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.nbd.2010.03.013","article-title":"Reduced dopamine transporter density in the ventral striatum of patients with Parkinson\u2019s disease and pathological gambling","volume":"39","author":"Cilia","year":"2010","journal-title":"Neurobiol Dis"},{"key":"2025060300224758800_awaf087-B78","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/mds.25886","article-title":"Reduced dopamine transporter binding predates impulse control disorders in Parkinson\u2019s disease","volume":"29","author":"Vriend","year":"2014","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B79","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/jnnp-2013-305395","article-title":"Impulse control disorders in Parkinson\u2019s disease: Decreased striatal dopamine transporter levels","volume":"85","author":"Voon","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025060300224758800_awaf087-B80","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/jnnp-2015-311827","article-title":"Incident impulse control disorder symptoms and dopamine transporter imaging in Parkinson disease","volume":"87","author":"Smith","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025060300224758800_awaf087-B81","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/brain\/awp054","article-title":"Increased striatal dopamine release in parkinsonian patients with pathological gambling: A [11C] raclopride PET study","volume":"132","author":"Steeves","year":"2009","journal-title":"Brain"},{"issue":"Pt 4","key":"2025060300224758800_awaf087-B82","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/brain\/awr003","article-title":"Cue-induced striatal dopamine release in Parkinson\u2019s disease-associated impulsive-compulsive behaviours","volume":"134","author":"O\u2019Sullivan","year":"2011","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B83","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41531-021-00253-z","article-title":"Unlucky punches: The vulnerability-stress model for the development of impulse control disorders in Parkinson\u2019s disease","volume":"7","author":"Theis","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"2025060300224758800_awaf087-B84","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1162\/jocn.2008.20100","article-title":"The key locus of common response inhibition network for no-go and stop signals","volume":"20","author":"Zheng","year":"2008","journal-title":"J Cogn Neurosci"},{"key":"2025060300224758800_awaf087-B85","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/mds.27898","article-title":"The anterior caudate nucleus supports impulsive choices triggered by pramipexole","volume":"35","author":"Martinez","year":"2020","journal-title":"Mov Disord"},{"key":"2025060300224758800_awaf087-B86","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbr.2015.05.023","article-title":"Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency","volume":"291","author":"Yates","year":"2015","journal-title":"Behav Brain Res"},{"key":"2025060300224758800_awaf087-B87","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s11682-021-00609-2","article-title":"Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system","volume":"16","author":"Kojima","year":"2022","journal-title":"Brain Imaging Behav"},{"key":"2025060300224758800_awaf087-B88","doi-asserted-by":"crossref","first-page":"102330","DOI":"10.1016\/j.nicl.2020.102330","article-title":"Linking brain activity during sequential gambling to impulse control in Parkinson\u2019s disease","volume":"27","author":"Haagensen","year":"2020","journal-title":"Neuroimage Clin"},{"key":"2025060300224758800_awaf087-B89","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fnbeh.2015.00317","article-title":"Impulsivity is associated with increased metabolism in the fronto-insular network in Parkinson\u2019s disease","volume":"9:","author":"Tahmasian","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"2025060300224758800_awaf087-B90","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1212\/WNL.0b013e3181fc27fa","article-title":"Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD","volume":"75","author":"van Eimeren","year":"2010","journal-title":"Neurology"},{"issue":"Pt 4","key":"2025060300224758800_awaf087-B91","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/brain\/awu032","article-title":"Selective serotonin reuptake inhibition modulates response inhibition in Parkinson\u2019s disease","volume":"137","author":"Ye","year":"2014","journal-title":"Brain"},{"key":"2025060300224758800_awaf087-B92","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuron.2020.02.012","article-title":"Prefrontal-subthalamic hyperdirect pathway modulates movement inhibition in humans","volume":"106","author":"Chen","year":"2020","journal-title":"Neuron"},{"key":"2025060300224758800_awaf087-B93","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/npp.2012.264","article-title":"Serotonin 2A receptors, citalopram and tryptophan-depletion: A multimodal imaging study of their interactions during response inhibition","volume":"38","author":"Macoveanu","year":"2013","journal-title":"Neuropsychopharmacol"},{"key":"2025060300224758800_awaf087-B94","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/FBP.0b013e3283305e11","article-title":"Effects of acute systemic administration of serotonin2A\/C receptor ligands in a delay-based decision-making task in rats","volume":"20","author":"Hadamitzky","year":"2009","journal-title":"Behav Pharmacol"},{"key":"2025060300224758800_awaf087-B95","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1007\/s00415-015-7722-7","article-title":"Single versus multiple impulse control disorders in Parkinson\u2019s disease: An 11C-raclopride positron emission tomography study of reward cue-evoked striatal dopamine release","volume":"262","author":"Wu","year":"2015","journal-title":"J Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf087\/62278794\/awaf087.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/6\/2108\/62278794\/awaf087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/6\/2108\/62278794\/awaf087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:23:18Z","timestamp":1748910198000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/148\/6\/2108\/8052774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3,5]]},"published-print":{"date-parts":[[2025,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf087","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,3,5]]}}}