{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:40:34Z","timestamp":1780904434988,"version":"3.54.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH121657"],"award-info":[{"award-number":["K23MH121657"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH136248"],"award-info":[{"award-number":["R01MH136248"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009372","name":"Baszucki Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain & Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BrainsWay Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intense political behaviour is associated with brain regions involved in emotional and cognitive processing. However, it remains unclear if this neuroanatomy is causal, compensatory or otherwise correlated.<\/jats:p>\n               <jats:p>We employed lesion network mapping in a cross-sectional study of 124 male military veterans with penetrating head trauma. Approximately 40\u201345 years after the injury, participants reported current political behaviour and recollection of political behaviour pre-injury. Using a normative connectome database (n = 1000), we mapped the circuitry functionally connected to lesions associated with changes in intensity of political involvement, ideological polarity and party affiliation.<\/jats:p>\n               <jats:p>No significant neuroanatomical circuit was associated with political ideology or party affiliation, but a distinct circuit was associated with intensity of political involvement. Political involvement was more intense after lesions connected to the left dorsolateral prefrontal cortex and posterior precuneus, in the full sample and in conservative-leaning participants. Political involvement was less intense after lesions connected to the amygdala and anterior temporal lobe, in the full sample and in liberal-leaning participants. These effects survived cross-validation in the full sample (P = 0.01) and in both conservative-leaning and liberal-leaning participants.<\/jats:p>\n               <jats:p>These findings may inform cognitive mechanisms of political behaviour as well as clinical assessment after brain lesions.<\/jats:p>","DOI":"10.1093\/brain\/awaf101","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T04:28:29Z","timestamp":1742704109000},"page":"3280-3289","source":"Crossref","is-referenced-by-count":2,"title":["Effects of focal brain damage on political behaviour across different political ideologies"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-9289","authenticated-orcid":false,"given":"Shan H","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Center for Brain-Mind Medicine, and Department of Psychiatry, Mass General Brigham\/Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3106-3261","authenticated-orcid":false,"given":"Stephanie","family":"Balters","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine , Palo Alto, CA 94305 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-3373","authenticated-orcid":false,"given":"Giovanna","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia , Modena, MO 41121 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Cohen-Zimerman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan H","family":"Grafman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]},{"name":"Department of Psychiatry & Behavioral Sciences, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"2025090219572312300_awaf101-B1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/17470910902860308","article-title":"Individualism, conservatism, and radicalism as criteria for processing political beliefs: A parametric fMRI study","volume":"4","author":"Zamboni","year":"2009","journal-title":"Soc Neurosci."},{"key":"2025090219572312300_awaf101-B2","doi-asserted-by":"crossref","first-page":"20200137","DOI":"10.1098\/rstb.2020.0137","article-title":"Toward a neuropsychology of political orientation: Exploring ideology in patients with frontal and midbrain lesions","volume":"376","author":"Nam","year":"2021","journal-title":"Philos Trans R Soc B: Biol Sci"},{"key":"2025090219572312300_awaf101-B3","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1126\/science.288.5472.1835","article-title":"Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control","volume":"288","author":"MacDonald","year":"2000","journal-title":"Science"},{"key":"2025090219572312300_awaf101-B4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cub.2011.03.017","article-title":"Political orientations are correlated with brain structure in young adults","volume":"21","author":"Kanai","year":"2011","journal-title":"Curr Biol."},{"key":"2025090219572312300_awaf101-B5","doi-asserted-by":"crossref","first-page":"110532","DOI":"10.1016\/j.isci.2024.110532","article-title":"Is political ideology correlated with brain structure? 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