{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:34:08Z","timestamp":1791588848694,"version":"4.3.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 AG085980"],"award-info":[{"award-number":["F31 AG085980"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 AG074855"],"award-info":[{"award-number":["U24 AG074855"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG059716"],"award-info":[{"award-number":["R01 AG059716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG073439"],"award-info":[{"award-number":["R01 AG073439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Up to 30% of older adults meet pathological criteria for a diagnosis of Alzheimer\u2019s disease at autopsy yet never show signs of cognitive impairment. Recent work has highlighted genetic drivers of this resilience, or better-than-expected cognitive performance given a level of neuropathology, that allow the aged brain to protect itself from the downstream consequences of amyloid and tau deposition. However, models of resilience have been constrained by reliance on measures of neuropathology, substantially limiting the number of participants available for analysis. We sought to determine whether new approaches using APOE allele status, age and other demographic variables as a proxy for neuropathology could still effectively quantify resilience and uncover novel genetic drivers associated with better-than-expected cognitive performance while vastly expanding sample size and statistical power.<\/jats:p>\n               <jats:p>Leveraging 20 513 participants from eight well-characterized cohort studies of ageing, we determined the effects of genetic variants on resilience metrics using mixed-effects regressions. The outcome of interest was residual cognitive resilience, quantified from residuals in three cognitive domains (memory, executive function and language) and built within two frameworks: \u2018silver\u2019 models, which obviate the requirement for neuropathological data (n = 17 241), and \u2018gold\u2019 models, which include post-mortem neuropathological assessments (n = 3272). We then performed cross-ancestry genome-wide association studies (European ancestry, n = 18 269; African ancestry, n = 2244), gene- and pathway-based tests and genetic correlation analyses. All analyses were conducted across all participants and repeated when restricted to those with unimpaired cognition at baseline.<\/jats:p>\n               <jats:p>Despite different modelling approaches, the silver and gold phenotypes were highly correlated (R = 0.77\u20130.88) and displayed comparable performance in quantifying better- or worse-than-expected cognition, enabling silver\u2013gold meta-analyses. Genetic correlation analyses highlighted associations of resilience with multiple neuropsychiatric and cardiovascular traits [false discovery rate-corrected P (PFDR) values &amp;lt; 5.0 \u00d7 10\u22122]. In pathway-level tests, we observed three significant associations with resilience: metabolism of amino acids and derivatives (PFDR = 4.1 \u00d7 10\u22122), negative regulation of transforming growth factor beta (TGF-\u03b2) production (PFDR = 1.9 \u00d7 10\u22122) and severe acute respiratory syndrome (PFDR = 3.9 \u00d7 10\u22124). Finally, in single-variant analyses, we identified a locus on chromosome 17 approaching genome-wide significance among cognitively unimpaired participants (index single nucleotide polymorphism: rs757022, minor allele frequency = 0.18, \u03b2=0.08, P = 1.1 \u00d7 10\u22127). The top variant at this locus (rs757022) was significantly associated with expression of numerous ATP-binding cassette genes in brain.<\/jats:p>\n               <jats:p>Overall, through validating a novel modelling approach, we demonstrate the utility of silver models of resilience to increase statistical power and participant diversity.<\/jats:p>","DOI":"10.1093\/brain\/awaf106","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T16:14:49Z","timestamp":1742573689000},"page":"2714-2729","source":"Crossref","is-referenced-by-count":5,"title":["Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-970X","authenticated-orcid":false,"given":"Jared M","family":"Phillips","sequence":"first","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Department of Pharmacology, Vanderbilt University School of Medicine , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9782-9944","authenticated-orcid":false,"given":"Logan C","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-0785","authenticated-orcid":false,"given":"Derek B","family":"Archer","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra N","family":"Regelson","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhabrata","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-1214","authenticated-orcid":false,"given":"Michael L","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Scollard","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily H","family":"Trittschuh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavior Sciences, University of Washington School of Medicine , Seattle, WA 98195 ,","place":["USA"]},{"name":"VA Puget Sound Health Care System, Geriatric Research Education and Clinical Center , Seattle, WA 98108 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A","family":"Kukull","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Biber","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Mez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University Chobanian & Avedisian School of Medicine , Boston, MA 02118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Clifton","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia B","family":"Libby","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skylar","family":"Walters","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-6519","authenticated-orcid":false,"given":"William S","family":"Bush","sequence":"additional","affiliation":[{"name":"Cleveland Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine , Cleveland, OH 44106 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne D","family":"Engelman","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison , Madison, WI 53726 ,","place":["USA"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin-Madison , Madison, WI 53726 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-0969","authenticated-orcid":false,"given":"Qiongshi","family":"Lu","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin-Madison , Madison, WI 53726 ,","place":["USA"]},{"name":"Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706 ,","place":["USA"]},{"name":"Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI 53706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Fardo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]},{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith F","family":"Widaman","sequence":"additional","affiliation":[{"name":"Graduate School of Education, University of California at Riverside , Riverside, CA 92521 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-5537","authenticated-orcid":false,"given":"Rachel F","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Center of Alzheimer\u2019s Research and Treatment, Department of Neurology, Brigham and Women\u2019s Hospital\/Harvard Medical School , Boston, MA 02115 ,","place":["USA"]},{"name":"Melbourne School of Psychological Sciences, University of Melbourne , Melbourne, VIC 3010 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C","family":"Mormino","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford University , Stanford, CA 94305 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Elizabeth","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R","family":"Clark","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin-Madison , Madison, WI 53726 ,","place":["USA"]},{"name":"Geriatric Research and Education Center, William S. Middleton Memorial Veteran\u2019s Hospital , Madison, WI 53705 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Gifford","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badri","family":"Vardarajan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"The Taub Institute for Research on Alzheimer\u2019s Disease and The Aging Brain, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"The Institute of Genomic Medicine, Columbia University Medical Center and The New York Presbyterian Hospital , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L","family":"Cuccaro","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami School of Medicine , Miami, FL 33136 ,","place":["USA"]},{"name":"Dr John T. Macdonald Foundation, Department of Human Genetics, University of Miami , Miami, FL 33136 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A","family":"Pericak-Vance","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, University of Miami School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-4225","authenticated-orcid":false,"given":"Lindsay A","family":"Farrer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University Chobanian & Avedisian School of Medicine , Boston, MA 02118 ,","place":["USA"]},{"name":"Department of Biostatistics, Boston University School of Public Health , Boston, MA 02118 ,","place":["USA"]},{"name":"Department of Medicine (Biomedical Genetics), Boston University School of Medicine , Boston, MA 02118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-San","family":"Wang","sequence":"additional","affiliation":[{"name":"Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard D","family":"Schellenberg","sequence":"additional","affiliation":[{"name":"Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L","family":"Haines","sequence":"additional","affiliation":[{"name":"Cleveland Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine , Cleveland, OH 44106 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford University , Stanford, CA 94305 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn S","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Saykin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine , Indianapolis, IN 46202 ,","place":["USA"]},{"name":"Indiana Alzheimer\u2019s Disease Research Center, Indiana University School of Medicine , Indianapolis, IN 46202 ,","place":["USA"]},{"name":"Stark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN 46202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-7943","authenticated-orcid":false,"given":"Shannon L","family":"Risacher","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine , Indianapolis, IN 46202 ,","place":["USA"]},{"name":"Indiana Alzheimer\u2019s Disease Research Center, Indiana University School of Medicine , Indianapolis, IN 46202 ,","place":["USA"]},{"name":"Stark Neurosciences Research Institute, Indiana University School of Medicine , Indianapolis, IN 46202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]},{"name":"Kaiser Permanente Washington Health Research Institute , Seattle, WA 98101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Center of Alzheimer\u2019s Research and Treatment, Department of Neurology, Brigham and Women\u2019s Hospital\/Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"The Taub Institute for Research on Alzheimer\u2019s Disease and The Aging Brain, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M","family":"Goate","sequence":"additional","affiliation":[{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E","family":"Renton","sequence":"additional","affiliation":[{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Marcora","sequence":"additional","affiliation":[{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fulton-Howard","sequence":"additional","affiliation":[{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulsi","family":"Patel","sequence":"additional","affiliation":[{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-554X","authenticated-orcid":false,"given":"David A","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, IL 60612 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Schneider","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, IL 60612 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0072-9817","authenticated-orcid":false,"given":"Lisa L","family":"Barnes","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, IL 60612 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-689X","authenticated-orcid":false,"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Washington University School of Medicine , St Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hassenstab","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Belloy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-9470","authenticated-orcid":false,"given":"Shea J","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California , San Francisco, CA 94143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Resnick","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bilgel","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"An","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-6270","authenticated-orcid":false,"given":"Lori L","family":"Beason-Held","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-9853","authenticated-orcid":false,"given":"Keenan A","family":"Walker","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Duggan","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon S","family":"Klinedinst","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-7465","authenticated-orcid":false,"given":"Paul K","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3377-7014","authenticated-orcid":false,"given":"Timothy J","family":"Hohman","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Department of Pharmacology, Vanderbilt University School of Medicine , Nashville, TN 37232 ,","place":["USA"]},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"2025080112523897800_awaf106-B1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2174\/156720511795745348","article-title":"Asymptomatic Alzheimer\u2019s disease: A prodrome or a state of resilience?","volume":"8","author":"Driscoll","year":"2011","journal-title":"Curr Alzheimer Res"},{"key":"2025080112523897800_awaf106-B2","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1093\/brain\/awaa209","article-title":"Genetic variants and functional pathways associated with resilience to Alzheimer\u2019s disease","volume":"143","author":"Dumitrescu","year":"2020","journal-title":"Brain"},{"key":"2025080112523897800_awaf106-B3","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/brain\/awac177","article-title":"Sex differences in the genetic architecture of cognitive resilience to Alzheimer\u2019s disease","volume":"145","author":"Eissman","year":"2022","journal-title":"Brain"},{"key":"2025080112523897800_awaf106-B4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11682-016-9615-5","article-title":"Genetic resilience to amyloid related cognitive decline","volume":"11","author":"Hohman","year":"2017","journal-title":"Brain Imaging Behav."},{"key":"2025080112523897800_awaf106-B5","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1212\/WNL.0000000000003397","article-title":"Asymptomatic Alzheimer disease: Defining resilience","volume":"87","author":"Hohman","year":"2016","journal-title":"Neurology"},{"issue":"S11","key":"2025080112523897800_awaf106-B6","doi-asserted-by":"crossref","first-page":"e067846","DOI":"10.1002\/alz.067846","article-title":"Attitudes and beliefs about brain donation among black Americans","volume":"18","author":"Caban-Holt","year":"2022","journal-title":"Alzheimers Dement"},{"key":"2025080112523897800_awaf106-B7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/alz.13507","article-title":"Sex-specific genetic architecture of late-life memory performance","volume":"20","author":"Eissman","year":"2024","journal-title":"Alzheimers Dement"},{"key":"2025080112523897800_awaf106-B8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jamaneurol.2023.2169","article-title":"Associations of sex, race, and apolipoprotein E alleles with multiple domains of cognition among older adults","volume":"80","author":"Walters","year":"2023","journal-title":"JAMA Neurol"},{"key":"2025080112523897800_awaf106-B9","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/alz.13508","article-title":"Longitudinal change in memory performance as a strong endophenotype for Alzheimer\u2019s disease","volume":"20","author":"Archer","year":"2024","journal-title":"Alzheimers Dement"},{"key":"2025080112523897800_awaf106-B10","doi-asserted-by":"crossref","first-page":"e1010208","DOI":"10.1371\/journal.pgen.1010208","article-title":"Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer\u2019s disease outside of the APOE region","volume":"18","author":"De La Fuente","year":"2022","journal-title":"PLoS Genet"},{"key":"2025080112523897800_awaf106-B11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"2025080112523897800_awaf106-B12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1001\/jamaneurol.2020.3780","article-title":"Association between apolipoprotein E \u025b2 vs \u025b4, age, and \u03b2-amyloid in adults without cognitive impairment","volume":"78","author":"Insel","year":"2021","journal-title":"JAMA Neurol"},{"key":"2025080112523897800_awaf106-B13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1212\/WNL.0000000000004336","article-title":"APOE genotype and early \u03b2-amyloid accumulation in older adults without dementia","volume":"89","author":"Lim","year":"2017","journal-title":"Neurology"},{"key":"2025080112523897800_awaf106-B14","doi-asserted-by":"crossref","first-page":"15181","DOI":"10.1523\/JNEUROSCI.1542-12.2012","article-title":"Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid \u03b2 peptide","volume":"32","author":"Hashimoto","year":"2012","journal-title":"J Neurosci"},{"key":"2025080112523897800_awaf106-B15","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1001\/archneur.59.11.1737","article-title":"Dementia and Alzheimer disease incidence: A prospective cohort study","volume":"59","author":"Kukull","year":"2002","journal-title":"Arch Neurol"},{"key":"2025080112523897800_awaf106-B16","first-page":"270","article-title":"The National Alzheimer\u2019s Coordinating Center (NACC) database: An Alzheimer disease database","volume":"18","author":"Beekly","year":"2004","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"s1","key":"2025080112523897800_awaf106-B17","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders study and rush memory and aging project","volume":"64","author":"Bennett","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2025080112523897800_awaf106-B18","doi-asserted-by":"crossref","first-page":"734","DOI":"10.2174\/156720512801322627","article-title":"The minority aging research study: Ongoing efforts to obtain brain donation in African Americans without dementia","volume":"9","author":"Barnes","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"2025080112523897800_awaf106-B19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.dadm.2017.11.007","article-title":"The Wisconsin registry for Alzheimer\u2019s prevention: A review of findings and current directions","volume":"10","author":"Johnson","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"key":"2025080112523897800_awaf106-B20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"2025080112523897800_awaf106-B21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"2025080112523897800_awaf106-B22","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.jalz.2017.04.011","article-title":"Incidence of cognitively defined late-onset Alzheimer\u2019s dementia subgroups from a prospective cohort study","volume":"13","author":"Crane","year":"2017","journal-title":"Alzheimers Dement"},{"key":"2025080112523897800_awaf106-B23","volume-title":"Mplus user\u2019s guide","author":"Muth\u00e9n","year":"1998","edition":"7th ed"},{"key":"2025080112523897800_awaf106-B24","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat Genet"},{"key":"2025080112523897800_awaf106-B25","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/bioinformatics\/btu704","article-title":"Minimac2: Faster genotype imputation","volume":"31","author":"Fuchsberger","year":"2015","journal-title":"Bioinformatics"},{"key":"2025080112523897800_awaf106-B26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-03205-y","article-title":"Sequencing of 53,831 diverse genomes from the NHLBI TOPMed program","volume":"590","author":"Taliun","year":"2021","journal-title":"Nature"},{"key":"2025080112523897800_awaf106-B27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.paid.2016.06.069","article-title":"Effect size guidelines for individual differences researchers","volume":"102","author":"Gignac","year":"2016","journal-title":"Pers Individ Dif"},{"key":"2025080112523897800_awaf106-B28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"2025080112523897800_awaf106-B29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2105-11-288","article-title":"GWAMA: Software for genome-wide association meta-analysis","volume":"11","author":"M\u00e4gi","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2025080112523897800_awaf106-B30","doi-asserted-by":"crossref","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: Generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"2025080112523897800_awaf106-B31","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025080112523897800_awaf106-B32","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ajhg.2017.11.001","article-title":"A powerful approach to estimating annotation-stratified genetic covariance via GWAS summary statistics","volume":"101","author":"Lu","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"10","key":"2025080112523897800_awaf106-B33","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/nn.4632","article-title":"An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome","volume":"20","author":"Ng","year":"2017","journal-title":"Nat Neurosci"},{"key":"2025080112523897800_awaf106-B34","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1001\/jamaneurol.2023.3599","article-title":"APOE genotype and Alzheimer disease risk across age, sex, and population ancestry","volume":"80","author":"Belloy","year":"2023","journal-title":"JAMA Neurol"},{"key":"2025080112523897800_awaf106-B35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ng.3766","article-title":"Case\u2013control association mapping by proxy using family history of disease","volume":"49","author":"Liu","year":"2017","journal-title":"Nat Genet"},{"key":"2025080112523897800_awaf106-B36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"key":"2025080112523897800_awaf106-B37","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.3390\/cells11213523","article-title":"Branched-chain amino acids are linked with Alzheimer\u2019s disease-related pathology and cognitive deficits","volume":"11","author":"Siddik","year":"2022","journal-title":"Cells"},{"key":"2025080112523897800_awaf106-B38","doi-asserted-by":"crossref","first-page":"BSR20180127","DOI":"10.1042\/BSR20180127","article-title":"Defect of branched-chain amino acid metabolism promotes the development of Alzheimer\u2019s disease by targeting the mTOR signaling","volume":"38","author":"Li","year":"2018","journal-title":"Biosci Rep"},{"key":"2025080112523897800_awaf106-B39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jchromb.2017.03.015","article-title":"Metabolic profiling of tyrosine, tryptophan, and glutamate in human urine using gas chromatography\u2013tandem mass spectrometry combined with single SPE cleanup","volume":"1051","author":"Shin","year":"2017","journal-title":"J Chromatogr B"},{"key":"2025080112523897800_awaf106-B40","doi-asserted-by":"crossref","first-page":"1237469","DOI":"10.3389\/fnagi.2023.1237469","article-title":"Several dementia subtypes and mild cognitive impairment share brain reduction of neurotransmitter precursor amino acids, impaired energy metabolism, and lipid hyperoxidation","volume":"15","author":"Aquilani","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"2025080112523897800_awaf106-B41","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.3390\/ijms23084325","article-title":"Role of branched-chain amino acid metabolism in type 2 diabetes, obesity, cardiovascular disease and non-alcoholic fatty liver disease","volume":"23","author":"Cuomo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025080112523897800_awaf106-B42","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/biomedicines10040778","article-title":"Type 2 diabetes mellitus as a risk factor for Alzheimer\u2019s disease: Review and meta-analysis","volume":"10","author":"Athanasaki","year":"2022","journal-title":"Biomedicines"},{"key":"2025080112523897800_awaf106-B43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1755-5949.2009.00115.x","article-title":"TGF-\u03b21 pathway as a new target for neuroprotection in Alzheimer\u2019s disease","volume":"17","author":"Caraci","year":"2011","journal-title":"CNS Neurosci Ther"},{"key":"2025080112523897800_awaf106-B44","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/jcb.240530408","article-title":"TGF-\u03b21 is an organizer of responses to neurodgeneration","volume":"53","author":"Finch","year":"1993","journal-title":"J Cell Biochem"},{"key":"2025080112523897800_awaf106-B45","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1523\/JNEUROSCI.3351-16.2017","article-title":"Astrocyte transforming growth factor Beta 1 protects synapses against A\u03b2 oligomers in Alzheimer\u2019s disease model","volume":"37","author":"Pereira Diniz","year":"2017","journal-title":"J Neurosci"},{"key":"2025080112523897800_awaf106-B46","doi-asserted-by":"crossref","first-page":"e200097","DOI":"10.1212\/NXI.0000000000200097","article-title":"Deep phenotyping of neurologic postacute sequelae of SARS-CoV-2 infection","volume":"10","author":"Mina","year":"2023","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"2025080112523897800_awaf106-B47","doi-asserted-by":"crossref","first-page":"2050312120957925","DOI":"10.1177\/2050312120957925","article-title":"Neurological manifestations in COVID-19: A narrative review","volume":"8","author":"Rahman","year":"2020","journal-title":"SAGE Open Med"},{"key":"2025080112523897800_awaf106-B48","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"2025080112523897800_awaf106-B49","first-page":"160","article-title":"Epstein-Barr virus as a leading cause of multiple sclerosis: Mechanisms and implications","volume":"19","author":"Bjornevik","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"2025080112523897800_awaf106-B50","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1073\/pnas.022301899","article-title":"Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice","volume":"99","author":"Feldman","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025080112523897800_awaf106-B51","doi-asserted-by":"crossref","first-page":"e00241-19","DOI":"10.1128\/JVI.00241-19","article-title":"Immune-mediated control of a dormant neurotropic RNA virus infection","volume":"93","author":"Miller","year":"2019","journal-title":"J Virol"},{"key":"2025080112523897800_awaf106-B52","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3390\/cells10071836","article-title":"The influence of virus infection on microglia and accelerated brain aging","volume":"10","author":"Filgueira","year":"2021","journal-title":"Cells"},{"key":"2025080112523897800_awaf106-B53","doi-asserted-by":"crossref","first-page":"235.e1","DOI":"10.1016\/j.neurobiolaging.2016.04.004","article-title":"ABCA7 p.G215S as potential protective factor for Alzheimer\u2019s disease","volume":"46","author":"Sassi","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2025080112523897800_awaf106-B54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fpsyt.2012.00017","article-title":"A-Subclass ATP-binding cassette proteins in brain lipid homeostasis and neurodegeneration","volume":"3","author":"Piehler","year":"2012","journal-title":"Front Psychiatry"},{"key":"2025080112523897800_awaf106-B55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41531-024-00632-2","article-title":"A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson\u2019s disease","volume":"10","author":"Fu","year":"2024","journal-title":"NPJ Parkinsons Dis"},{"key":"2025080112523897800_awaf106-B56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/BJ20121764","article-title":"ABCA8 stimulates sphingomyelin production in oligodendrocytes","volume":"452","author":"Kim","year":"2013","journal-title":"Biochem J"},{"key":"2025080112523897800_awaf106-B57","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3233\/JAD-141320","article-title":"ABCA5 regulates amyloid-\u03b2 peptide production and is associated with Alzheimer\u2019s disease neuropathology","volume":"43","author":"Fu","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"2025080112523897800_awaf106-B58","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1523\/JNEUROSCI.2572-06.2006","article-title":"Functional genomic analysis of oligodendrocyte differentiation","volume":"26","author":"Dugas","year":"2006","journal-title":"J Neurosci"},{"key":"2025080112523897800_awaf106-B59","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cne.23866","article-title":"Transcriptional and epigenetic mechanisms of early cortical development: An examination of how pax6 coordinates cortical development","volume":"524","author":"Ypsilanti","year":"2016","journal-title":"J Comp Neurol"},{"key":"2025080112523897800_awaf106-B60","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/brain\/awab134","article-title":"Amyloid-\u03b2 toxicity modulates tau phosphorylation through the PAX6 signalling pathway","volume":"144","author":"Zhang","year":"2021","journal-title":"Brain"},{"key":"2025080112523897800_awaf106-B61","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1326-2-12","article-title":"Tau phosphorylation by GSK-3\u03b2 promotes tangle-like filament morphology","volume":"2","author":"Rankin","year":"2007","journal-title":"Mol Neurodegener"},{"key":"2025080112523897800_awaf106-B62","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41392-024-01812-5","article-title":"A positive feedback inhibition of isocitrate dehydrogenase 3\u03b2 on paired-box gene 6 promotes Alzheimer-like pathology","volume":"9","author":"Wang","year":"2024","journal-title":"Sig Transduct Target Ther"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf106\/62493355\/awaf106.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/8\/2714\/62493355\/awaf106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/148\/8\/2714\/62493355\/awaf106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T16:52:56Z","timestamp":1754067176000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/148\/8\/2714\/8088222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,3,20]]},"published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf106","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,3,20]]}}}