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Neonatal intranasal oxytocin supplementation prevented the appearance of sensorimotor gating, social behaviour and immune system deficits in 22q11.2DS mice. This was related to an early and long-lasting effect of oxytocin in upregulating tight junction molecules claudin-5 and claudin-1, with claudin-5 leading to reduced permeability of the blood\u2013brain barrier. Consequently, myeloid cell infiltration into the brains of 22q11.2DS mice was reduced.<\/jats:p>\n                  <jats:p>Our findings elucidate a genetic\u2013immune interplay in the aberrant development associated with 22q11.2DS, supporting a novel therapeutic potential for oxytocin in sealing a critical brain barrier.<\/jats:p>","DOI":"10.1093\/brain\/awaf112","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T19:55:58Z","timestamp":1742673358000},"page":"3184-3198","source":"Crossref","is-referenced-by-count":8,"title":["Oxytocin seals the blood\u2013brain barrier, improving 22q11.2 deletion syndrome trajectories"],"prefix":"10.1093","volume":"148","author":[{"given":"Giulia","family":"Castellani","sequence":"first","affiliation":[{"name":"Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia (IIT) , Genova 16163 ,","place":["Italy"]},{"name":"Department of Pharmaceutical and Pharmacological Sciences, University 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\u201cCharles Darwin\u201d, Sapienza University of Rome , Rome 00185 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Trigilio","sequence":"additional","affiliation":[{"name":"Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia (IIT) , Genova 16163 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Barcik","sequence":"additional","affiliation":[{"name":"Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia (IIT) , Genova 16163 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Busnelli","sequence":"additional","affiliation":[{"name":"National Research Council (CNR), Institute of Neuroscience , Vedano al Lambro 20854, MB ,","place":["Italy"]},{"name":"NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca , Milan 20126 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Rodriguez","family":"Aburto","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland, University College Cork , Cork T12 CY82 ,","place":["Ireland"]},{"name":"Department of Anatomy and Neuroscience, University College Cork , Cork T12 CY82 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cucinelli","sequence":"additional","affiliation":[{"name":"Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia (IIT) , Genova 16163 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia (IIT) , Genova 16163 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Maltese","sequence":"additional","affiliation":[{"name":"Genetics of Cognition Laboratory, 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