{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:29:38Z","timestamp":1787974178282,"version":"build-2784847793"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012645","name":"Kentucky Spinal Cord and Head Injury Research Trust","doi-asserted-by":"publisher","award":["#OGMB210076"],"award-info":[{"award-number":["#OGMB210076"]}],"id":[{"id":"10.13039\/100012645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012645","name":"Kentucky Spinal Cord and Head Injury Research Trust","doi-asserted-by":"publisher","award":["#OGMB210076"],"award-info":[{"award-number":["#OGMB210076"]}],"id":[{"id":"10.13039\/100012645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012645","name":"Kentucky Spinal Cord and Head Injury Research Trust","doi-asserted-by":"publisher","award":["#G3435"],"award-info":[{"award-number":["#G3435"]}],"id":[{"id":"10.13039\/100012645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Scientific and Technological Development of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Paralysis is assumed permanent in persons with motor-complete spinal cord injury (SCI). However, spinal epidural stimulation combined with activity-based locomotor training (ABLT) and cognitive intent enabled two adults with motor-complete SCI to walk with a walker. Transcutaneous spinal stimulation (scTS), also capable of promoting a cyclic step-like pattern, might be a viable alternative in children with SCI. These findings prompted our investigation into multimodal neuromodulation training using ABLT (enhancing afferent input), spinal stimulation (scTS) and descending (intent) drive to restore voluntary stepping in children with chronic motor-complete SCI.<\/jats:p>\n               <jats:p>Five non-ambulatory children (9.6 \u00b1 2.5 years old, three female, four thoracic and one cervical injury) with chronic (&amp;gt;1 year, 5.2 \u00b1 2.5 years), complete SCI underwent 60 sessions of combined ABLT and scTS training with cognitive intent to step and returned for a 3- to 6-month follow-up.<\/jats:p>\n               <jats:p>During the first training session in a gravity-neutral position, all five children made small reciprocal cycles of the hips\/knees in a flexion\/extension step-like pattern with stimulation, with increased excursion at session 20 for five of five children (right hip excursion increased from 10.1\u00b0 \u00b1 15.1\u00b0 to 25.9\u00b0 \u00b1 21.3\u00b0 and right knee excursion increased from 9.3\u00b0 \u00b1 13.9\u00b0 to 39.6\u00b0 \u00b1 29.2\u00b0, P = 0.02). The children stepped overground at sessions 50 [Participant (P)15], 60 (P34) and 20 (P32, P14, P240), voluntarily initiating and alternating left\/right leg swings on the treadmill and overground with and without scTS. Three to six months post-training, all children maintained the capacity to step. The parents and children reported unanticipated improvements in sensation, bladder function, proprioception, assist to stand, transfers and dressing.<\/jats:p>\n               <jats:p>In children with chronic, motor-complete SCI, multimodal neuromodulation training can potentiate the intrinsic stepping capacity of the spinal locomotor centres to enable voluntary stepping. Remarkably, these enhancements are durable and observed even in the absence of spinal stimulation.<\/jats:p>","DOI":"10.1093\/brain\/awaf115","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T15:44:17Z","timestamp":1743781457000},"page":"3290-3299","source":"Crossref","is-referenced-by-count":9,"title":["Non-invasive spinal neuromodulation enables stepping in children with complete spinal cord injury"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1178-9492","authenticated-orcid":false,"given":"Kathryn","family":"Lucas","sequence":"first","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center , University of Louisville, Louisville, KY 40202 ,","place":["USA"]},{"name":"Department of Neurological Surgery, University of Louisville , Louisville, KY 40202 ,","place":["USA"]},{"name":"Department of Physical Therapy, Creighton University , Phoenix, AZ 85012 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,","place":["USA"]},{"name":"Department of Neurological Surgery, University of Louisville , Louisville, KY 40202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Stepp","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center , University of Louisville, Louisville, KY 40202 ,","place":["USA"]},{"name":"Department of Neurological Surgery, University of Louisville , Louisville, KY 40202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Parikh","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center , University of Louisville, Louisville, KY 40202 ,","place":["USA"]},{"name":"Department of Neurological Surgery, University of Louisville , Louisville, KY 40202 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