{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:44:43Z","timestamp":1784861083905,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ventriculitis is a dreaded complication of central nervous system infections, which has been scarcely described in the literature. We aimed to present a contemporary picture of ventriculitis, describing its characteristics and outcomes across the spectrum of aetiologies that may lead to ventriculitis.<\/jats:p>\n                  <jats:p>VELCRO is an international retrospective multicentre cohort study conducted at 34 hospitals in six countries. Adult patients fulfilling the clinical, microbiological and imaging criteria for ventriculitis between 2010 and 2021 were included. Survival analyses were performed using a multivariable Cox proportional hazards regression model to identify risk factors for 1-year all-cause mortality.<\/jats:p>\n                  <jats:p>Overall, 436 patients with ventriculitis were included [274 (62.8%) males, median age 58 years (interquartile range 48\u201368); 68 (15.6%) had diabetes mellitus and 62 (14.2%) were immunocompromised]. The most common neuroimaging features of ventriculitis were ependymal enhancement (n = 310\/436, 71.1%), intraventricular pus (n = 286\/436, 65.6%) and intraventricular septations (n = 85\/436, 19.5%). To describe the cohort, patients were divided into three groups: ventriculitis with brain abscess(es) (V-BA, n = 181), community-acquired ventriculitis without brain abscess (CA-V, n = 88), and healthcare-associated ventriculitis without brain abscess (HCA-V, n = 167). Intensive care unit admission was required for 351 patients (80.5%), and the median hospital length of stay was 45 days (range 26\u201374). One-year mortality rate was 33.7% (n = 147\/436), with a lower rate in patients with V-BA (n = 50\/181, 27.6%) than in patients with CA-V (n = 30\/88, 34.1%) and HCA-V (n = 67\/167, 40.1%). On multivariable analysis, the predictive factors for 1-year mortality were: age &amp;gt; 60 years, immunosuppression, diabetes mellitus, Glasgow Coma Scale score &amp;lt; 13 at presentation, infection involving Enterobacterales or fungi, acute hydrocephalus, cerebral ischaemia and intraventricular septations. Staphylococcal ventriculitis was associated with a lower 1-year mortality. Long-term unfavourable outcome [modified Rankin score (mRS) &amp;gt;2 after 6 months of follow-up] occurred in 43.3% (n = 91\/210), considering that 26.7% (n = 56) had a mRS &amp;gt;2 before the onset of ventriculitis.<\/jats:p>\n                  <jats:p>Ventriculitis is associated with high mortality and neurological morbidity. Further large prospective studies are needed in this area of research.<\/jats:p>","DOI":"10.1093\/brain\/awaf178","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:50:21Z","timestamp":1747036221000},"page":"333-342","source":"Crossref","is-referenced-by-count":4,"title":["Ventriculitis characteristics and outcomes (VELCRO): an international retrospective cohort study"],"prefix":"10.1093","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-7305","authenticated-orcid":false,"given":"David","family":"Luque Paz","sequence":"first","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Rennes University Hospital , Rennes 35000 ,","place":["France"]},{"name":"ESCMID Study Group of Infections of the Brain (ESGIB) , Basel 4051 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"D\u00edaz-Poll\u00e1n","sequence":"additional","affiliation":[{"name":"ESCMID Study Group of Infections of the Brain (ESGIB) , Basel 4051 ,","place":["Switzerland"]},{"name":"Clinical Microbiology and Infectious Diseases Unit, Hospital Universitario La Paz, IdiPAZ Hospital La Paz Institute for Health Research, CIBERINFEC, Carlos III Health Institute , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Boyer-Besseyre","sequence":"additional","affiliation":[{"name":"Surgical Intensive Care Unit, University Hospital of Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Djanikian","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Lapeyronie University Hospital , Montpellier 34000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Munier","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Saint 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