{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:48:53Z","timestamp":1772981333506,"version":"3.50.1"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006084","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL126559"],"award-info":[{"award-number":["HL126559"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH128022"],"award-info":[{"award-number":["MH128022"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH072567"],"award-info":[{"award-number":["MH072567"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA050528"],"award-info":[{"award-number":["DA050528"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA044579"],"award-info":[{"award-number":["DA044579"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA059849"],"award-info":[{"award-number":["DA059849"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS141704"],"award-info":[{"award-number":["R21NS141704"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30AI073961"],"award-info":[{"award-number":["P30AI073961"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20POST35211181"],"award-info":[{"award-number":["20POST35211181"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute of Aging","doi-asserted-by":"publisher","award":["NS125905"],"award-info":[{"award-number":["NS125905"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Specific cell types of the blood\u2013brain barrier (BBB), such as pericytes, can be infected by HIV-1. Importantly, alterations of the expression of tight junction protein occludin (OCLN) have been linked to regulation of HIV-1 infection. In the present study, we hypothesized that OCLN can influence HIV-1 infection via modulating innate immunity responses.<\/jats:p>\n                  <jats:p>Unbiased transcriptome analysis was conducted on wild-type and OCLN-silenced primary human BBB pericytes. The role of differentially expressed innate-immunity pathways was then evaluated in the context of mitochondrial dysfunction and HIV-1 infection. Using a model of ischaemic stroke and OCLN-deficient mice, we elucidated the functional role of OCLN in cerebrovascular health in the presence of HIV-1 infection.<\/jats:p>\n                  <jats:p>OCLN silencing resulted in alterations of the gene expression signatures of interferon-stimulated genes and the antiviral retinoic acid-inducible gene-1 (RIG-I) pathway, which functions as a regulator of the cytoplasmic sensors upstream of the mitochondrial antiviral signalling protein. Indeed, we observed dysfunctional mitochondrial bioenergetics, dynamics and autophagy following OCLN silencing. Alterations of mitochondrial bioenergetics and innate immune protection translated into worsened ischaemic stroke outcomes in EcoHIV-infected OCLN-deficient mice. Animal studies also confirmed that OCLN\u2212\/\u2212 mice had higher EcoHIV load in plasma, spleen and brain.<\/jats:p>\n                  <jats:p>Our results allow for a better understanding of the molecular mechanisms of viral infection in the brain and describe a previously unrecognized role of occludin as a key factor in the control of innate immune responses and mitochondrial dynamics at the BBB level, which influence cerebral vascular disease outcomes such as ischaemic stroke.<\/jats:p>","DOI":"10.1093\/brain\/awaf262","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T13:16:26Z","timestamp":1752585386000},"page":"934-950","source":"Crossref","is-referenced-by-count":2,"title":["Occludin modulates HIV and ischaemic stroke response via the mitochondrial antiviral signalling pathway"],"prefix":"10.1093","volume":"149","author":[{"given":"Silvia","family":"Torices","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaidy","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, UCSF , San Francisco, CA 94143 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia M","family":"Osborne","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sita","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oandy","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timea","family":"Teglas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minseon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enze","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Toborek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"2026030512072262000_awaf262-B1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.coi.2011.08.001","article-title":"Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter","volume":"23","author":"Belgnaoui","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"2026030512072262000_awaf262-B2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat Immunol"},{"key":"2026030512072262000_awaf262-B3","doi-asserted-by":"crossref","first-page":"152102","DOI":"10.1016\/j.anndiagpath.2022.152102","article-title":"The differential expression of toll like receptors and RIG-1 correlates to the severity of infectious diseases","volume":"63","author":"Rice","year":"2023","journal-title":"Ann Diagn Pathol."},{"key":"2026030512072262000_awaf262-B4","doi-asserted-by":"crossref","first-page":"1146457","DOI":"10.3389\/fmed.2023.1146457","article-title":"Crosstalk between TLR8 and RIG-I-like receptors enhances antiviral immune responses","volume":"10","author":"Vlaming","year":"2023","journal-title":"Front Med (Lausanne)."},{"key":"2026030512072262000_awaf262-B5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cell.2011.06.041","article-title":"MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response","volume":"146","author":"Hou","year":"2011","journal-title":"Cell"},{"key":"2026030512072262000_awaf262-B6","doi-asserted-by":"crossref","first-page":"15676","DOI":"10.1038\/ncomms15676","article-title":"Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling","volume":"8","author":"Qi","year":"2017","journal-title":"Nat Commun"},{"key":"2026030512072262000_awaf262-B7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41392-020-00438-7","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I\/MDA-5 signaling","volume":"5","author":"Zheng","year":"2020","journal-title":"Signal Transduct Target Ther."},{"key":"2026030512072262000_awaf262-B8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.celrep.2013.01.033","article-title":"Structure and ubiquitination-dependent activation of TANK-binding kinase 1","volume":"3","author":"Tu","year":"2013","journal-title":"Cell Rep"},{"key":"2026030512072262000_awaf262-B9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","article-title":"Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3","volume":"122","author":"Seth","year":"2005","journal-title":"Cell"},{"key":"2026030512072262000_awaf262-B10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-065X.2011.01038.x","article-title":"Mitoxosome: A mitochondrial platform for cross-talk between cellular stress and antiviral signaling","volume":"243","author":"Tal","year":"2011","journal-title":"Immunol Rev"},{"key":"2026030512072262000_awaf262-B11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2006.04.004","article-title":"The specific and essential role of MAVS in antiviral innate immune responses","volume":"24","author":"Sun","year":"2006","journal-title":"Immunity"},{"key":"2026030512072262000_awaf262-B12","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258910","article-title":"AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS","volume":"135","author":"Lin","year":"2022","journal-title":"J Cell Sci."},{"key":"2026030512072262000_awaf262-B13","doi-asserted-by":"crossref","first-page":"109596","DOI":"10.1016\/j.vetmic.2022.109596","article-title":"Porcine epidemic diarrhea virus 3CL(pro) causes apoptosis and collapse of mitochondrial membrane potential requiring its protease activity and signaling through MAVS","volume":"275","author":"Liang","year":"2022","journal-title":"Vet Microbiol."},{"key":"2026030512072262000_awaf262-B14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.STR.0000105393.57853.11","article-title":"Acquired immunodeficiency syndrome and the risk of stroke","volume":"35","author":"Cole","year":"2004","journal-title":"Stroke"},{"key":"2026030512072262000_awaf262-B15","doi-asserted-by":"crossref","first-page":"e0217147","DOI":"10.1371\/journal.pone.0217147","article-title":"Incidence of stroke in patients with HIV infection: A population-based study in Taiwan","volume":"14","author":"Lin","year":"2019","journal-title":"PLoS One"},{"key":"2026030512072262000_awaf262-B16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/QAI.0000000000003382","article-title":"Risk of stroke among HIV patients: A systematic review and meta-analysis of global studies and associated comorbidities","volume":"95","author":"Moawad","year":"2024","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026030512072262000_awaf262-B17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1742-4690-10-146","article-title":"Relative resistance of HIV-1 founder viruses to control by interferon-alpha","volume":"10","author":"Fenton-May","year":"2013","journal-title":"Retrovirology"},{"key":"2026030512072262000_awaf262-B18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cytogfr.2012.06.001","article-title":"HIV-1, interferon and the interferon regulatory factor system: An interplay between induction, antiviral responses and viral evasion","volume":"23","author":"Marsili","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026030512072262000_awaf262-B19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/cmi.2017.168","article-title":"Interferon-beta induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier","volume":"16","author":"Nazli","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"2026030512072262000_awaf262-B20","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3390\/vaccines11050930","article-title":"You shall not pass: MX2 proteins are Versatile viral inhibitors","volume":"11","author":"Betancor","year":"2023","journal-title":"Vaccines (Basel)."},{"key":"2026030512072262000_awaf262-B21","first-page":"e01342","article-title":"ISG15 deficiency enhances HIV-1 infection by accumulating misfolded p53","volume":"10","author":"Kuffour","year":"2019","journal-title":"mBio"},{"key":"2026030512072262000_awaf262-B22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3389\/fimmu.2018.01135","article-title":"A positive feedback amplifier circuit that regulates interferon (IFN)-stimulated gene expression and controls type I and type II IFN responses","volume":"9","author":"Michalska","year":"2018","journal-title":"Front Immunol."},{"key":"2026030512072262000_awaf262-B23","first-page":"e01285","article-title":"Human MxB inhibits the replication of hepatitis C virus","volume":"93","author":"Yi","year":"2018","journal-title":"J Virol."},{"key":"2026030512072262000_awaf262-B24","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1007\/s12035-023-03381-0","article-title":"Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family","volume":"60","author":"Torices","year":"2023","journal-title":"Mol Neurobiol."},{"key":"2026030512072262000_awaf262-B25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neuron.2010.09.043","article-title":"Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging","volume":"68","author":"Bell","year":"2010","journal-title":"Neuron"},{"key":"2026030512072262000_awaf262-B26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10571-010-9605-x","article-title":"Brain pericytes: Emerging concepts and functional roles in brain homeostasis","volume":"31","author":"Kamouchi","year":"2011","journal-title":"Cell Mol Neurobiol"},{"key":"2026030512072262000_awaf262-B27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2023.01.037","article-title":"Senescence in brain pericytes attenuates blood\u2013brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains","volume":"645","author":"Iwao","year":"2023","journal-title":"Biochem Biophys Res Commun."},{"issue":"Suppl 1","key":"2026030512072262000_awaf262-B28","first-page":"S29","article-title":"Importance of pericytes in the pathophysiology of cerebral ischemia","volume":"59","author":"Gurler","year":"2022","journal-title":"Noro Psikiyatr Ars."},{"key":"2026030512072262000_awaf262-B29","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1111\/j.1582-4934.2012.01622.x","article-title":"Infection of human pericytes by HIV-1 disrupts the integrity of the blood\u2013brain barrier","volume":"16","author":"Nakagawa","year":"2012","journal-title":"J Cell Mol Med"},{"key":"2026030512072262000_awaf262-B30","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1096\/fj.15-277673","article-title":"Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation","volume":"30","author":"Castro","year":"2016","journal-title":"FASEB J"},{"key":"2026030512072262000_awaf262-B31","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/0271678X15606149","article-title":"Dysfunction of brain pericytes in chronic neuroinflammation","volume":"36","author":"Persidsky","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026030512072262000_awaf262-B32","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/brain\/awy339","article-title":"Blood\u2013brain barrier pericytes as a target for HIV-1 infection","volume":"142","author":"Bertrand","year":"2019","journal-title":"Brain"},{"key":"2026030512072262000_awaf262-B33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12974-019-1463-y","article-title":"Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection","volume":"16","author":"Bohannon","year":"2019","journal-title":"J Neuroinflammation"},{"key":"2026030512072262000_awaf262-B34","doi-asserted-by":"crossref","first-page":"16319","DOI":"10.1096\/fj.202001562R","article-title":"Occludin, caveolin-1, and alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes","volume":"34","author":"Torices","year":"2020","journal-title":"FASEB J"},{"key":"2026030512072262000_awaf262-B35","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3389\/fnmol.2017.00410","article-title":"HIV alters gap junction-mediated intercellular communication in human brain pericytes","volume":"10","author":"Cho","year":"2017","journal-title":"Front Mol Neurosci."},{"issue":"6 Pt 2","key":"2026030512072262000_awaf262-B36","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1083\/jcb.123.6.1777","article-title":"Occludin: A novel integral membrane protein localizing at tight junctions","volume":"123","author":"Furuse","year":"1993","journal-title":"J Cell Biol."},{"key":"2026030512072262000_awaf262-B37","doi-asserted-by":"crossref","first-page":"109485","DOI":"10.1016\/j.cellsig.2019.109485","article-title":"Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease","volume":"66","author":"Cong","year":"2020","journal-title":"Cell Signal"},{"key":"2026030512072262000_awaf262-B38","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.addr.2005.01.009","article-title":"Occludin: Structure, function and regulation","volume":"57","author":"Feldman","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"2026030512072262000_awaf262-B39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/0271678X17720816","article-title":"Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity","volume":"38","author":"Castro","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026030512072262000_awaf262-B40","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1038\/s41598-023-29894-1","article-title":"The tight junction protein occludin modulates blood\u2013brain barrier integrity and neurological function after ischemic stroke in mice","volume":"13","author":"Sugiyama","year":"2023","journal-title":"Sci Rep"},{"key":"2026030512072262000_awaf262-B41","doi-asserted-by":"crossref","first-page":"114472","DOI":"10.1016\/j.bbr.2023.114472","article-title":"Ramelteon improves blood\u2013brain barrier of focal cerebral ischemia rats to prevent post-stroke depression via upregulating occludin","volume":"449","author":"Qi","year":"2023","journal-title":"Behav Brain Res."},{"key":"2026030512072262000_awaf262-B42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12987-020-00182-8","article-title":"Autophagy-mediated occludin degradation contributes to blood\u2013brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models","volume":"17","author":"Kim","year":"2020","journal-title":"Fluids Barriers CNS."},{"key":"2026030512072262000_awaf262-B43","first-page":"388","article-title":"Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCbeta phosphorylation of occludin","volume":"140","author":"Goncalves","year":"2022","journal-title":"Blood"},{"key":"2026030512072262000_awaf262-B44","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/jnc.15102","article-title":"Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro","volume":"156","author":"Zhang","year":"2021","journal-title":"J Neurochem."},{"key":"2026030512072262000_awaf262-B45","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.3390\/ijms20215472","article-title":"The blood\u2013brain barrier and its intercellular junctions in age-related brain disorders","volume":"20","author":"Costea","year":"2019","journal-title":"Int J Mol Sci."},{"key":"2026030512072262000_awaf262-B46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood\u2013brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol."},{"key":"2026030512072262000_awaf262-B47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00018-023-04716-9","article-title":"Mfsd2a attenuated hypoxic-ischemic brain damage via protection of the blood\u2013brain barrier in mfat-1 transgenic mice","volume":"80","author":"Li","year":"2023","journal-title":"Cell Mol Life Sci."},{"key":"2026030512072262000_awaf262-B48","doi-asserted-by":"crossref","first-page":"133664","DOI":"10.1016\/j.neulet.2018.06.033","article-title":"Blood\u2013brain barrier regulation in psychiatric disorders","volume":"726","author":"Kealy","year":"2020","journal-title":"Neurosci Lett."},{"key":"2026030512072262000_awaf262-B49","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1073\/pnas.0500649102","article-title":"A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness","volume":"102","author":"Potash","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026030512072262000_awaf262-B50","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1038\/s41467-019-10046-x","article-title":"Targeting the HIV-infected brain to improve ischemic stroke outcome","volume":"10","author":"Bertrand","year":"2019","journal-title":"Nat Commun"},{"key":"2026030512072262000_awaf262-B51","first-page":"54804","article-title":"Mouse microsurgery infusion technique for targeted substance delivery into the CNS via the internal carotid artery","volume":"119","author":"Leda","year":"2017","journal-title":"J Vis Exp."},{"key":"2026030512072262000_awaf262-B52","doi-asserted-by":"crossref","first-page":"e0614242024","DOI":"10.1523\/JNEUROSCI.0614-24.2024","article-title":"Microvascular dysfunction, mitochondrial reprogramming, and inflammasome activation as critical regulators of ischemic stroke severity induced by chronic exposure to prescription opioids","volume":"45","author":"Sun","year":"2025","journal-title":"J Neurosci"},{"key":"2026030512072262000_awaf262-B53","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1212\/WNL.42.9.1707","article-title":"The diagnostic utility of elevation in cerebrospinal fluid beta 2-microglobulin in HIV-1 dementia. Multicenter AIDS cohort study","volume":"42","author":"McArthur","year":"1992","journal-title":"Neurology"},{"key":"2026030512072262000_awaf262-B54","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1161\/STROKEAHA.107.488486","article-title":"Antithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia","volume":"38","author":"Cuomo","year":"2007","journal-title":"Stroke"},{"key":"2026030512072262000_awaf262-B55","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026030512072262000_awaf262-B56","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"2026030512072262000_awaf262-B57","doi-asserted-by":"crossref","first-page":"e13984","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: A network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"key":"2026030512072262000_awaf262-B58","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"key":"2026030512072262000_awaf262-B59","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","article-title":"GOplot: An R package for visually combining expression data with functional analysis","volume":"31","author":"Walter","year":"2015","journal-title":"Bioinformatics"},{"key":"2026030512072262000_awaf262-B60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol Biol"},{"key":"2026030512072262000_awaf262-B61","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.acthis.2017.03.001","article-title":"A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture","volume":"119","author":"Valente","year":"2017","journal-title":"Acta Histochem."},{"key":"2026030512072262000_awaf262-B62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s11033-022-07981-2","article-title":"Retinoic acid-inducible gene 1 (RIG-1) and IFN-beta promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19)","volume":"50","author":"Nahavandi-Parizi","year":"2023","journal-title":"Mol Biol Rep."},{"key":"2026030512072262000_awaf262-B63","doi-asserted-by":"crossref","first-page":"e1004041","DOI":"10.1371\/journal.ppat.1004041","article-title":"HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1","volume":"10","author":"Peng","year":"2014","journal-title":"PLoS Pathog."},{"key":"2026030512072262000_awaf262-B64","doi-asserted-by":"crossref","first-page":"108631","DOI":"10.1016\/j.celrep.2020.108631","article-title":"The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling","volume":"34","author":"Li","year":"2021","journal-title":"Cell Rep."},{"key":"2026030512072262000_awaf262-B65","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/embor.2009.258","article-title":"Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway","volume":"11","author":"Castanier","year":"2010","journal-title":"EMBO Rep."},{"key":"2026030512072262000_awaf262-B66","doi-asserted-by":"crossref","first-page":"ra47","DOI":"10.1126\/scisignal.2000287","article-title":"Mitofusin 2 inhibits mitochondrial antiviral signaling","volume":"2","author":"Yasukawa","year":"2009","journal-title":"Sci Signal."},{"key":"2026030512072262000_awaf262-B67","doi-asserted-by":"crossref","first-page":"e0255721","DOI":"10.1128\/mBio.02557-21","article-title":"Herpes Simplex virus type 1 infection disturbs the mitochondrial network, leading to type I interferon production through the RNA polymerase III\/RIG-I pathway","volume":"12","author":"Berry","year":"2021","journal-title":"mBio"},{"key":"2026030512072262000_awaf262-B68","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/bse0470053","article-title":"Mitochondrial proton and electron leaks","volume":"47","author":"Jastroch","year":"2010","journal-title":"Essays Biochem"},{"key":"2026030512072262000_awaf262-B69","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semcdb.2019.05.022","article-title":"Mitochondria as playmakers of apoptosis, autophagy and senescence","volume":"98","author":"Abate","year":"2020","journal-title":"Semin Cell Dev Biol."},{"key":"2026030512072262000_awaf262-B70","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1080\/15548627.2022.2155368","article-title":"Mitochondria and peroxisomes: Partners in autophagy","volume":"19","author":"Wilhelm","year":"2023","journal-title":"Autophagy"},{"key":"2026030512072262000_awaf262-B71","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41418-022-01094-w","article-title":"Mitochondria and cell death-associated inflammation","volume":"30","author":"Vringer","year":"2023","journal-title":"Cell Death Differ."},{"key":"2026030512072262000_awaf262-B72","doi-asserted-by":"crossref","first-page":"154528","DOI":"10.1016\/j.phymed.2022.154528","article-title":"Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway","volume":"108","author":"Hu","year":"2023","journal-title":"Phytomedicine."},{"key":"2026030512072262000_awaf262-B73","doi-asserted-by":"crossref","first-page":"16024","DOI":"10.1038\/celldisc.2016.24","article-title":"MAVS maintains mitochondrial homeostasis via autophagy","volume":"2","author":"Sun","year":"2016","journal-title":"Cell Discov"},{"key":"2026030512072262000_awaf262-B74","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4161\/auto.25239","article-title":"PRKCB\/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy","volume":"9","author":"Patergnani","year":"2013","journal-title":"Autophagy"},{"key":"2026030512072262000_awaf262-B75","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/1440-1681.13764","article-title":"Thioredoxin-1 regulates the autophagy induced by oxidative stress through LC3-II in human lens epithelial cells","volume":"50","author":"Hu","year":"2023","journal-title":"Clin Exp Pharmacol Physiol."},{"key":"2026030512072262000_awaf262-B76","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"P62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J Biol Chem"},{"key":"2026030512072262000_awaf262-B77","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/abbs\/gmy091","article-title":"LC3-II may mediate ATR-induced mitophagy in dopaminergic neurons through SQSTM1\/p62 pathway","volume":"50","author":"Ma","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)."},{"key":"2026030512072262000_awaf262-B78","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.tcb.2018.01.003","article-title":"Novel insights into NDP52 autophagy receptor functioning","volume":"28","author":"Viret","year":"2018","journal-title":"Trends Cell Biol"},{"key":"2026030512072262000_awaf262-B79","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3390\/antiox12051075","article-title":"PGC-1alpha Is a master regulator of mitochondrial lifecycle and ROS stress response","volume":"12","author":"Shelbayeh","year":"2023","journal-title":"Antioxidants"},{"key":"2026030512072262000_awaf262-B80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11010-022-04477-2","article-title":"PGC-1alpha participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function","volume":"478","author":"Li","year":"2023","journal-title":"Mol Cell Biochem."},{"key":"2026030512072262000_awaf262-B81","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.molimm.2013.06.018","article-title":"Mx1, Mx2 and Mx3 proteins from the gilthead seabream (Sparus aurata) show in vitro antiviral activity against RNA and DNA viruses","volume":"56","author":"Fernandez-Trujillo","year":"2013","journal-title":"Mol Immunol."},{"key":"2026030512072262000_awaf262-B82","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF03033823","article-title":"The role of monocytes and perivascular macrophages in HIV and SIV neuropathogenesis: Information from non-human primate models","volume":"8","author":"Kim","year":"2005","journal-title":"Neurotox Res."},{"key":"2026030512072262000_awaf262-B83","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/glia.23081","article-title":"Fate of microglia during HIV-1 infection: From activation to senescence?","volume":"65","author":"Chen","year":"2017","journal-title":"Glia"},{"key":"2026030512072262000_awaf262-B84","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12981-023-00511-5","article-title":"Role of microglia in HIV-1 infection","volume":"20","author":"Bai","year":"2023","journal-title":"AIDS Res Ther."},{"key":"2026030512072262000_awaf262-B85","doi-asserted-by":"crossref","first-page":"152","DOI":"10.14336\/AD.2022.0712","article-title":"HIV nef expression down-modulated GFAP expression and altered glutamate uptake and release and proliferation in astrocytes","volume":"14","author":"Wilson","year":"2023","journal-title":"Aging Dis."},{"key":"2026030512072262000_awaf262-B86","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1359-6101(00)00027-7","article-title":"The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion","volume":"12","author":"Levy","year":"2001","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026030512072262000_awaf262-B87","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1128\/MMBR.00024-13","article-title":"Mx proteins: Antiviral gatekeepers that restrain the uninvited","volume":"77","author":"Verhelst","year":"2013","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026030512072262000_awaf262-B88","doi-asserted-by":"crossref","first-page":"154776","DOI":"10.1016\/j.cyto.2019.154776","article-title":"IL-22 suppresses HSV-2 replication in human cervical epithelial cells","volume":"123","author":"Xu","year":"2019","journal-title":"Cytokine"},{"key":"2026030512072262000_awaf262-B89","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.celrep.2019.10.009","article-title":"The GTPase domain of MX2 interacts with the HIV-1 capsid, enabling its short isoform to moderate antiviral restriction","volume":"29","author":"Betancor","year":"2019","journal-title":"Cell Rep"},{"key":"2026030512072262000_awaf262-B90","doi-asserted-by":"crossref","first-page":"e1007408","DOI":"10.1371\/journal.ppat.1007408","article-title":"Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction","volume":"14","author":"Dicks","year":"2018","journal-title":"PLoS Pathog"},{"key":"2026030512072262000_awaf262-B91","doi-asserted-by":"crossref","first-page":"e00193","DOI":"10.1128\/JVI.00193-19","article-title":"Mx1 in hematopoietic cells protects against thogoto virus infection","volume":"93","author":"Spitaels","year":"2019","journal-title":"J Virol"},{"key":"2026030512072262000_awaf262-B92","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/hep.25608","article-title":"Mxa inhibits hepatitis B virus replication by interaction with hepatitis B core antigen","volume":"56","author":"Li","year":"2012","journal-title":"Hepatology"},{"key":"2026030512072262000_awaf262-B93","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00439-019-02092-8","article-title":"Mx genes: Host determinants controlling influenza virus infection and trans-species transmission","volume":"139","author":"Haller","year":"2020","journal-title":"Hum Genet"},{"key":"2026030512072262000_awaf262-B94","doi-asserted-by":"crossref","first-page":"e00709","DOI":"10.1128\/JVI.00709-18","article-title":"Human MX2\/MxB: A potent interferon-induced postentry inhibitor of herpesviruses and HIV-1","volume":"92","author":"Staeheli","year":"2018","journal-title":"J Virol"},{"key":"2026030512072262000_awaf262-B95","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12974-021-02210-2","article-title":"Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: Implications for HIV-1 infection","volume":"18","author":"Torices","year":"2021","journal-title":"J Neuroinflammation"},{"key":"2026030512072262000_awaf262-B96","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/v16020288","article-title":"Macrophages: Key cellular players in HIV infection and pathogenesis","volume":"16","author":"Woottum","year":"2024","journal-title":"Viruses"},{"key":"2026030512072262000_awaf262-B97","doi-asserted-by":"crossref","first-page":"C343","DOI":"10.1152\/ajpcell.00095.2018","article-title":"Blood\u2013brain barrier dysfunction in ischemic stroke: Targeting tight junctions and transporters for vascular protection","volume":"315","author":"Abdullahi","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026030512072262000_awaf262-B98","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1007\/s12035-021-02577-6","article-title":"Correction to: Methamphetamine enhances HIV-induced aberrant proliferation of neural progenitor cells via the FOXO3-mediated mechanism","volume":"58","author":"Park","year":"2021","journal-title":"Mol Neurobiol"},{"key":"2026030512072262000_awaf262-B99","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s13365-018-0629-1","article-title":"Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice","volume":"24","author":"Olson","year":"2018","journal-title":"J Neurovirol"},{"key":"2026030512072262000_awaf262-B100","doi-asserted-by":"crossref","first-page":"22608","DOI":"10.1021\/acsnano.4c09363","article-title":"Correction to \u2018Brain-accumulating nanoparticles for assisting astrocytes to reduce human immunodeficiency virus and drug abuse-induced neuroinflammation and oxidative stress\u2019","volume":"18","author":"Surnar","year":"2024","journal-title":"ACS Nano"},{"key":"2026030512072262000_awaf262-B101","doi-asserted-by":"crossref","first-page":"149256","DOI":"10.1016\/j.brainres.2024.149256","article-title":"A reproducible murine model of studying HIV-associated brain damage in stroke","volume":"1846","author":"Salman","year":"2025","journal-title":"Brain Res"},{"key":"2026030512072262000_awaf262-B102","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-4886(95)90066-7","article-title":"Gp120, an HIV-1 protein, increases susceptibility to hypoglycemic and ischemic brain injury in perinatal rats","volume":"132","author":"Barks","year":"1995","journal-title":"Exp Neurol"},{"key":"2026030512072262000_awaf262-B103","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1742-2094-11-107","article-title":"Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood\u2013brain barrier disruption","volume":"11","author":"Liu","year":"2014","journal-title":"J Neuroinflammation"},{"key":"2026030512072262000_awaf262-B104","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.expneurol.2012.11.018","article-title":"Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia","volume":"240","author":"Jin","year":"2013","journal-title":"Exp Neurol"},{"key":"2026030512072262000_awaf262-B105","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jnr.23190","article-title":"3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation","volume":"91","author":"Yoon","year":"2013","journal-title":"J Neurosci Res"},{"key":"2026030512072262000_awaf262-B106","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/jnc.14894","article-title":"Cystatin C improves blood\u2013brain barrier integrity after ischemic brain injury in mice","volume":"153","author":"Yang","year":"2020","journal-title":"J Neurochem"},{"key":"2026030512072262000_awaf262-B107","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/s41590-022-01269-0","article-title":"Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3\/IRF7 in innate antiviral immunity","volume":"23","author":"Qin","year":"2022","journal-title":"Nat Immunol."},{"key":"2026030512072262000_awaf262-B108","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/gene.2011.21","article-title":"IRF7: Activation, regulation, modification and function","volume":"12","author":"Ning","year":"2011","journal-title":"Genes Immun"},{"key":"2026030512072262000_awaf262-B109","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3389\/fimmu.2018.03047","article-title":"IRF and STAT transcription factors\u2014From basic biology to roles in infection, protective immunity, and primary immunodeficiencies","volume":"9","author":"Mogensen","year":"2019","journal-title":"Front Immunol"},{"key":"2026030512072262000_awaf262-B110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu Rev Pathol."},{"key":"2026030512072262000_awaf262-B111","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Loson","year":"2013","journal-title":"Mol Biol Cell."},{"key":"2026030512072262000_awaf262-B112","doi-asserted-by":"crossref","first-page":"117084","DOI":"10.1016\/j.biopha.2024.117084","article-title":"New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026030512072262000_awaf262-B113","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ecco-jcc\/jjac148","article-title":"Autophagy reduces the degradation and promotes membrane localization of occludin to enhance the intestinal epithelial tight junction barrier against paracellular macromolecule flux","volume":"17","author":"Saha","year":"2023","journal-title":"J Crohns Colitis."},{"key":"2026030512072262000_awaf262-B114","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s11010-023-04806-z","article-title":"IL-22 promotes occludin expression by activating autophagy and treats ulcerative colitis","volume":"479","author":"Nong","year":"2024","journal-title":"Mol Cell Biochem."},{"key":"2026030512072262000_awaf262-B115","doi-asserted-by":"crossref","first-page":"9822157","DOI":"10.1155\/2022\/9822157","article-title":"Role of autophagy inducers and inhibitors in intestinal barrier injury induced by intestinal ischemia-reperfusion (I\/R)","volume":"2022","author":"Li","year":"2022","journal-title":"J Immunol Res."},{"key":"2026030512072262000_awaf262-B116","doi-asserted-by":"crossref","first-page":"e55116","DOI":"10.1371\/journal.pone.0055116","article-title":"Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: Implications for tumorigenesis","volume":"8","author":"Rachow","year":"2013","journal-title":"PLoS One"},{"key":"2026030512072262000_awaf262-B117","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2019.07.058","article-title":"Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression","volume":"157","author":"Kuo","year":"2019","journal-title":"Gastroenterology"},{"key":"2026030512072262000_awaf262-B118","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1242\/bio.20147799","article-title":"Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells","volume":"3","author":"Kitajiri","year":"2014","journal-title":"Biol Open."},{"key":"2026030512072262000_awaf262-B119","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1111\/j.1742-4658.2008.06467.x","article-title":"A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion","volume":"275","author":"Gu","year":"2008","journal-title":"FEBS J."},{"key":"2026030512072262000_awaf262-B120","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1158\/0008-5472.CAN-06-1864","article-title":"Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes","volume":"66","author":"Osanai","year":"2006","journal-title":"Cancer Res."}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf262\/63772021\/awaf262.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/3\/934\/63772021\/awaf262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/3\/934\/63772021\/awaf262.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:07:42Z","timestamp":1772730462000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/3\/934\/8202977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":120,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,7,15]]},"published-print":{"date-parts":[[2026,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf262","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,7,15]]}}}