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Although foundational studies in monkeys have identified neural correlates of vergence in the midbrain, a translational gap persists, leaving the neural basis of vergence dysfunction in humans poorly understood.<\/jats:p>\n                  <jats:p>Through voxel-wise analyses in 66 humans and 19 monkeys with midbrain lesions, we link vergence dysfunction causally to a region rostral to the superior colliculus and centred on the nucleus of the posterior commissure (NPC). Connectivity analyses across species identified a brain circuit linking the NPC to the visual pretectum and midbrain premotor hubs, regions capable of integrating the visual input and motor output necessary for vergence control.<\/jats:p>\n                  <jats:p>Collectively, these findings provide a neuroanatomical basis for vergence dysfunction and demonstrate how lesion mapping can bridge fundamental insights from animal models with clinical observations in humans.<\/jats:p>","DOI":"10.1093\/brain\/awaf316","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:39:25Z","timestamp":1756467565000},"page":"302-316","source":"Crossref","is-referenced-by-count":0,"title":["Cross-species lesion mapping links a midbrain circuit to vergence dysfunction"],"prefix":"10.1093","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-1268","authenticated-orcid":false,"given":"Maximilian 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