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People living with FM also experience tactile allodynia, cold-evoked pain, paraesthesia and dysaesthesia. There is evidence of small fibre neuropathy and hyperexcitability of nociceptors in FM; however, the presence of other sensory abnormalities suggests involvement of large diameter sensory fibres. The passive transfer of FM IgG to mice causes cold and mechanical hyperalgesia associated with changes in A- and C-nociceptor function. However, whether FM IgG also confers sensitivity to light touch and whether large diameter sensory fibres contribute to symptoms evoked by cold is unknown.<\/jats:p>\n                  <jats:p>Here we demonstrate that the presence of sensory abnormalities such as tingling, correlate with the impact of FM, and that people with FM describe the sensation of cutaneous cooling with neuropathic descriptors such as tingling\/pins and needles. We find a causal link between circulating FM IgG and the sensitization of large diameter, A\u03b2 low threshold mechanoreceptors (A\u03b2-LTMRs) to mechanical and cold stimuli in mice ex vivo and in vivo. In keeping with our experimental observations, a larger proportion of A\u03b2-LTMRs respond to cold stimulation in people with FM, but in contrast to our results ex vivo, the same fibres display reduced responses to mechanical stimuli.<\/jats:p>\n                  <jats:p>These results expand the pathophysiological role of IgG in FM and will inform future studies of sensory symptoms and pain in people with FM.<\/jats:p>","DOI":"10.1093\/brain\/awaf321","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:37:14Z","timestamp":1756813034000},"page":"4016-4029","source":"Crossref","is-referenced-by-count":11,"title":["A\u03b2 low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia"],"prefix":"10.1093","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-6036","authenticated-orcid":false,"given":"Mathilde R","family":"Israel","sequence":"first","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Berwick","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]},{"name":"Department of Pain Medicine, Walton Centre NHS Foundation Trust , Liverpool L9 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Vastani","sequence":"additional","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Moore","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]},{"name":"Department of Pain Medicine, Walton Centre NHS Foundation Trust , Liverpool L9 7AL ,","place":["UK"]},{"name":"Center for Social and Affective Neuroscience, Link\u00f6ping University , Link\u00f6ping SE-581 83 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Maurer","sequence":"additional","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Gentry","sequence":"additional","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Marshall","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]},{"name":"Center for Social and Affective Neuroscience, Link\u00f6ping University , Link\u00f6ping SE-581 83 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Sun","sequence":"additional","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Neiland","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Dunham","sequence":"additional","affiliation":[{"name":"School of Physiology, Pharmacology and Neuroscience, University of Bristol , Bristol BS8 1QU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otmane","family":"Bouchatta","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Link\u00f6ping University , Link\u00f6ping SE-581 83 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Plant","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-8232","authenticated-orcid":false,"given":"Saad S","family":"Nagi","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Link\u00f6ping University , Link\u00f6ping SE-581 83 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Olausson","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Link\u00f6ping University , Link\u00f6ping SE-581 83 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uazman","family":"Alam","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhong","family":"Dong","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]},{"name":"The Solomon H. Snyder Department of Neuroscience, Department of Neuroscience, Johns Hopkins University, School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Bevan","sequence":"additional","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-7089","authenticated-orcid":false,"given":"Andrew","family":"Marshall","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]},{"name":"Department of Pain Medicine, Walton Centre NHS Foundation Trust , Liverpool L9 7AL ,","place":["UK"]},{"name":"Center for Social and Affective Neuroscience, Link\u00f6ping University , Link\u00f6ping SE-581 83 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-8206","authenticated-orcid":false,"given":"Andreas","family":"Goebel","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool , Liverpool L9 7AL ,","place":["UK"]},{"name":"Department of Pain Medicine, Walton Centre NHS Foundation Trust , Liverpool L9 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-8548","authenticated-orcid":false,"given":"David A","family":"Andersson","sequence":"additional","affiliation":[{"name":"Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE1 1UL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"2025110519262772100_awaf321-B1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11916-013-0356-5","article-title":"Worldwide epidemiology of fibromyalgia","volume":"17","author":"Queiroz","year":"2013","journal-title":"Curr Pain Headache Rep"},{"key":"2025110519262772100_awaf321-B2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0304-3959(95)00112-3","article-title":"Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls","volume":"64","author":"Kosek","year":"1996","journal-title":"Pain"},{"key":"2025110519262772100_awaf321-B3","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/ejp.1252","article-title":"Comorbid fibromyalgia: A qualitative review of prevalence and importance","volume":"22","author":"Fitzcharles","year":"2018","journal-title":"Eur J Pain"},{"key":"2025110519262772100_awaf321-B4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00002508-200112000-00005","article-title":"Quantitative sensory testing in fibromyalgia patients and in healthy subjects: Identification of subgroups","volume":"17","author":"Hurtig","year":"2001","journal-title":"Clin J Pain"},{"key":"2025110519262772100_awaf321-B5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/art.1780310205","article-title":"Tenderness in 75 anatomic sites. 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