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Using mouse genetics, we show that expression of mutant TDP-43 in astrocytes is necessary to cause gliosis and behavioural abnormalities. Mechanistically, we show that glial MYC gain-of-function drives neurodegeneration by promoting the release of astrocyte-derived extracellular vesicles that nonetheless fail to provide trophic support to surrounding neurons.<\/jats:p>\n                  <jats:p>Our research reveals a novel functional role for MYC in glia-to-neuron miscommunication in ALS.<\/jats:p>","DOI":"10.1093\/brain\/awaf360","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:22:09Z","timestamp":1758716529000},"page":"1604-1622","source":"Crossref","is-referenced-by-count":6,"title":["MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"149","author":[{"given":"Paolo V","family":"Fioretti","sequence":"first","affiliation":[{"name":"Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento , Trento 38123 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