{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:53:12Z","timestamp":1793361192666,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100021790","name":"Fondation Recherche Alzheimer","doi-asserted-by":"publisher","award":["PDR T0236.20"],"award-info":[{"award-number":["PDR T0236.20"]}],"id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021790","name":"Fondation Recherche Alzheimer","doi-asserted-by":"publisher","award":["CDR J.0175.23"],"award-info":[{"award-number":["CDR J.0175.23"]}],"id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"FNRS","doi-asserted-by":"publisher","award":["0913351"],"award-info":[{"award-number":["0913351"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"FNRS","doi-asserted-by":"publisher","award":["F\/2022\/1967"],"award-info":[{"award-number":["F\/2022\/1967"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013845","name":"Foundation against Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022434","name":"WelBio","doi-asserted-by":"publisher","award":["40010035"],"award-info":[{"award-number":["40010035"]}],"id":[{"id":"10.13039\/501100022434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microtubules are essential components of the cytoskeleton. Dysfunctions of microtubules and microtubule-associated proteins are prominent features of neurodegenerative disorders. In Alzheimer's disease, changes in microtubule composition and hyperphosphorylation of Tau are more closely related to neurodegeneration than amyloid plaque formation. However, the accumulation of amyloid beta (A\u03b2) species is the earliest event in Alzheimer's disease pathology and induces Tau toxicity. KIF2A is a microtubule depolarizing kinesin with important roles during cortical development. KIF2A expression is maintained in the mature brain, where it is required for neuronal survival.<\/jats:p>\n                  <jats:p>Here, we used a conditional approach to ablate KIF2A specifically in the adult mouse cortex and hippocampus to assess the impact of KIF2A deletion on neuronal survival and Tau phosphorylation.<\/jats:p>\n                  <jats:p>We found that KIF2A deficiency leads to a reduction of dendritic spine density and maturation associated with cognitive decline, followed by an increase in Tau phosphorylation through MAPK ERK1\/2 upregulation. We also studied KIF2A expression in a 5xFAD mouse model and post-mortem human brain tissue. We report that A\u03b2 accumulation alters KIF2A expression in neurons and most importantly, KIF2A protein levels are drastically reduced in patients with Alzheimer's disease, but not in patients with other primary tauopathies.<\/jats:p>\n                  <jats:p>Our results shed light on the relationship between A\u03b2 accumulation, KIF2A deregulation, microtubule dysfunction and enhanced Tau phosphorylation in the context of Alzheimer's disease.<\/jats:p>","DOI":"10.1093\/brain\/awaf382","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:17:45Z","timestamp":1759925865000},"page":"1650-1662","source":"Crossref","is-referenced-by-count":3,"title":["KIF2A downregulation links amyloid-\u03b2 to Tau phosphorylation in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7008-7920","authenticated-orcid":false,"given":"Nuria","family":"Ruiz-Reig","sequence":"first","affiliation":[{"name":"Developmental Neurobiology Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Virosztek","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7007-9010","authenticated-orcid":false,"given":"Georges","family":"Chehade","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-2858","authenticated-orcid":false,"given":"Nuria","family":"Suelves","sequence":"additional","affiliation":[{"name":"Aging and Dementia Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-2305","authenticated-orcid":false,"given":"Nathalie","family":"Kyalu Ngoie Zola","sequence":"additional","affiliation":[{"name":"Louvain Aging Brain Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-5136","authenticated-orcid":false,"given":"Yasmine","family":"Salman","sequence":"additional","affiliation":[{"name":"Aging and Dementia Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Schakman","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Behavioral Analysis Platform, Universit\u00e9 Catholique de Louvain , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-2942","authenticated-orcid":false,"given":"Pascal","family":"Kienlen-Campard","sequence":"additional","affiliation":[{"name":"Aging and Dementia Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3102-6778","authenticated-orcid":false,"given":"Bernard","family":"Hanseeuw","sequence":"additional","affiliation":[{"name":"Louvain Aging Brain Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]},{"name":"Neurology Department, Cliniques Universitaires Saint-Luc , Brussels 1200 ,","place":["Belgium"]},{"name":"WELBIO Department, WEL Research Institute , Wavre 1300 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-6622","authenticated-orcid":false,"given":"Fadel","family":"Tissir","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology Laboratory, Universit\u00e9 Catholique de Louvain, Institute of Neuroscience , Brussels 1200 ,","place":["Belgium"]},{"name":"College of Health and Life Sciences, Hamad Bien Khalifa University (HBKU) , Doha 00000 ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2026050508320851100_awaf382-B1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4172\/2157-7412.1000203","article-title":"Microtubule defects & neurodegeneration","volume":"4","author":"Baird","year":"2013","journal-title":"J Genet Syndr Gene Ther"},{"key":"2026050508320851100_awaf382-B2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fncel.2018.00165","article-title":"The role of the microtubule cytoskeleton in neurodevelopmental disorders","volume":"12","author":"Lasser","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"2026050508320851100_awaf382-B3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fncel.2015.00343","article-title":"Neurodegeneration and microtubule dynamics: Death by a thousand cuts","volume":"9","author":"Dubey","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"2026050508320851100_awaf382-B4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/1673-5374.375298","article-title":"Connecting neurodevelopment to neurodegeneration: A spotlight on the role of kinesin superfamily protein 2A (KIF2A)","volume":"19","author":"Ruiz-Reig","year":"2023","journal-title":"Neural Regen Res"},{"key":"2026050508320851100_awaf382-B5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tcb.2019.02.007","article-title":"Tau: It\u2019s not what you think","volume":"29","author":"Baas","year":"2019","journal-title":"Trends Cell Biol"},{"key":"2026050508320851100_awaf382-B6","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1083\/jcb.201701045","article-title":"Stabilization of dynamic microtubules by mDia1 drives tau-dependent Abeta1\u201342 synaptotoxicity","volume":"216","author":"Qu","year":"2017","journal-title":"J Cell Biol"},{"key":"2026050508320851100_awaf382-B7","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.cub.2018.05.045","article-title":"Tau does not stabilize axonal microtubules but rather enables them to have long labile domains","volume":"28","author":"Qiang","year":"2018","journal-title":"Curr Biol"},{"key":"2026050508320851100_awaf382-B8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"2026050508320851100_awaf382-B9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-beta and tau: The trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"2026050508320851100_awaf382-B10","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-beta pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol Psychiatry"},{"key":"2026050508320851100_awaf382-B11","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1093\/brain\/awad159","article-title":"The amyloid cascade hypothesis: An updated critical review","volume":"146","author":"Kepp","year":"2023","journal-title":"Brain"},{"key":"2026050508320851100_awaf382-B12","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1038\/emboj.2013.207","article-title":"Amyloid-beta oligomers induce synaptic damage via tau-dependent microtubule severing by TTLL6 and spastin","volume":"32","author":"Zempel","year":"2013","journal-title":"EMBO J"},{"key":"2026050508320851100_awaf382-B13","doi-asserted-by":"crossref","first-page":"7781","DOI":"10.1038\/ncomms8781","article-title":"HDAC6 and RhoA are novel players in abeta-driven disruption of neuronal polarity","volume":"6","author":"Tsushima","year":"2015","journal-title":"Nat Commun"},{"key":"2026050508320851100_awaf382-B14","first-page":"1117","article-title":"The Abeta1-42 peptide regulates microtubule stability independently of tau","volume":"127","author":"Pianu","year":"2014","journal-title":"J Cell Sci"},{"key":"2026050508320851100_awaf382-B15","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1073\/pnas.1017033108","article-title":"Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration","volume":"108","author":"Jin","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050508320851100_awaf382-B16","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1038\/s41467-018-05025-7","article-title":"Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate","volume":"9","author":"Trofimova","year":"2018","journal-title":"Nat Commun"},{"key":"2026050508320851100_awaf382-B17","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1073\/pnas.1107808109","article-title":"Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches","volume":"109","author":"Noda","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050508320851100_awaf382-B18","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.celrep.2015.08.018","article-title":"Microtubule destabilizer KIF2A undergoes distinct site-specific phosphorylation cascades that differentially affect neuronal morphogenesis","volume":"12","author":"Ogawa","year":"2015","journal-title":"Cell Rep"},{"key":"2026050508320851100_awaf382-B19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.celrep.2013.03.005","article-title":"Axonal pruning is actively regulated by the microtubule-destabilizing protein kinesin superfamily protein 2A","volume":"3","author":"Maor-Nof","year":"2013","journal-title":"Cell Rep"},{"key":"2026050508320851100_awaf382-B20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(03)00522-1","article-title":"Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension","volume":"114","author":"Homma","year":"2003","journal-title":"Cell"},{"key":"2026050508320851100_awaf382-B21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/hmg\/ddx384","article-title":"Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development","volume":"27","author":"Broix","year":"2018","journal-title":"Hum Mol Genet"},{"key":"2026050508320851100_awaf382-B22","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/hmg\/ddz316","article-title":"Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny","volume":"29","author":"Gilet","year":"2020","journal-title":"Hum Mol Genet"},{"key":"2026050508320851100_awaf382-B23","doi-asserted-by":"crossref","first-page":"102177","DOI":"10.1016\/j.pneurobio.2021.102177","article-title":"The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain","volume":"208","author":"Hakanen","year":"2022","journal-title":"Prog Neurobiol"},{"key":"2026050508320851100_awaf382-B24","doi-asserted-by":"crossref","first-page":"1110986","DOI":"10.3389\/fnmol.2022.1110986","article-title":"Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons","volume":"15","author":"Ruiz-Reig","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"2026050508320851100_awaf382-B25","doi-asserted-by":"crossref","first-page":"e2209714119","DOI":"10.1073\/pnas.2209714119","article-title":"KIF2A deficiency causes early-onset neurodegeneration","volume":"119","author":"Ruiz-Reig","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050508320851100_awaf382-B26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat Neurosci"},{"key":"2026050508320851100_awaf382-B27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"2026050508320851100_awaf382-B28","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"2026050508320851100_awaf382-B29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"2026050508320851100_awaf382-B30","first-page":"55835","article-title":"Enrichment of detergent-insoluble protein aggregates from human postmortem brain","volume":"128","author":"Diner","year":"2017","journal-title":"J Vis Exp"},{"key":"2026050508320851100_awaf382-B31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/neuonc\/nop072","article-title":"Identification of valid endogenous control genes for determining gene expression in human glioma","volume":"12","author":"Kreth","year":"2010","journal-title":"Neuro Oncol"},{"key":"2026050508320851100_awaf382-B32","first-page":"2841","article-title":"Lateral thalamic eminence: A novel origin for mGluR1\/lot cells","volume":"27","author":"Ruiz-Reig","year":"2017","journal-title":"Cereb Cortex"},{"key":"2026050508320851100_awaf382-B33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-016-1558-9","article-title":"Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Abeta generation in Alzheimer\u2019s disease","volume":"132","author":"Sadleir","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2026050508320851100_awaf382-B34","doi-asserted-by":"crossref","first-page":"dev192674","DOI":"10.1242\/dev.192674","article-title":"Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation","volume":"148","author":"Akkaya","year":"2021","journal-title":"Development"},{"key":"2026050508320851100_awaf382-B35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1037\/a0025770","article-title":"Chronic stress and a cyclic regimen of estradiol administration separately facilitate spatial memory: Relationship with hippocampal CA1 spine density and dendritic complexity","volume":"126","author":"Conrad","year":"2012","journal-title":"Behav Neurosci"},{"key":"2026050508320851100_awaf382-B36","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1073\/pnas.91.26.12673","article-title":"An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses","volume":"91","author":"Moser","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050508320851100_awaf382-B37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0169-328X(02)00488-6","article-title":"Up-regulation of mitogen-activated protein kinases ERK1\/2 and MEK1\/2 is associated with the progression of neurofibrillary degeneration in Alzheimer\u2019s disease","volume":"109","author":"Pei","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"2026050508320851100_awaf382-B38","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","article-title":"Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms","volume":"86","author":"Andorfer","year":"2003","journal-title":"J Neurochem"},{"key":"2026050508320851100_awaf382-B39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnagi.2020.00011","article-title":"Differences between human and murine tau at the N-terminal end","volume":"12","author":"Hernandez","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"2026050508320851100_awaf382-B40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40035-015-0030-4","article-title":"Posttranslational modifications of alpha-tubulin in Alzheimer disease","volume":"4","author":"Zhang","year":"2015","journal-title":"Transl Neurodegener"},{"key":"2026050508320851100_awaf382-B41","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0002-9440(10)64296-4","article-title":"Microtubule reduction in Alzheimer\u2019s disease and aging is independent of tau filament formation","volume":"162","author":"Cash","year":"2003","journal-title":"Am J Pathol"},{"key":"2026050508320851100_awaf382-B42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41597-021-01054-y","article-title":"Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"8","author":"Forner","year":"2021","journal-title":"Sci Data"},{"key":"2026050508320851100_awaf382-B43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2007.12.073","article-title":"Activation of alpha 2A adrenoceptors alters dendritic spine development and the expression of spinophilin in cultured cortical neurones","volume":"1199","author":"Hu","year":"2008","journal-title":"Brain Res"},{"key":"2026050508320851100_awaf382-B44","doi-asserted-by":"crossref","first-page":"e27688","DOI":"10.1371\/journal.pone.0027688","article-title":"Dynamic microtubules promote synaptic NMDA receptor-dependent spine enlargement","volume":"6","author":"Merriam","year":"2011","journal-title":"PLoS One"},{"key":"2026050508320851100_awaf382-B45","doi-asserted-by":"crossref","first-page":"12120","DOI":"10.1523\/JNEUROSCI.2509-08.2008","article-title":"Microtubules in dendritic spine development","volume":"28","author":"Gu","year":"2008","journal-title":"J Neurosci"},{"key":"2026050508320851100_awaf382-B46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuron.2008.11.013","article-title":"Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity","volume":"61","author":"Jaworski","year":"2009","journal-title":"Neuron"},{"key":"2026050508320851100_awaf382-B47","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.3390\/ijms23042274","article-title":"Cytoskeleton protein EB3 contributes to dendritic spines enlargement and enhances their resilience to toxic effects of Beta-amyloid","volume":"23","author":"Pchitskaya","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026050508320851100_awaf382-B48","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.cub.2007.06.058","article-title":"EB3 regulates microtubule dynamics at the cell cortex and is required for myoblast elongation and fusion","volume":"17","author":"Straube","year":"2007","journal-title":"Curr Biol"},{"key":"2026050508320851100_awaf382-B49","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s00018-016-2168-3","article-title":"Microtubule plus-end tracking proteins in neuronal development","volume":"73","author":"van de Willige","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"2026050508320851100_awaf382-B50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1037\/a0025959","article-title":"Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats","volume":"126","author":"Eilam-Stock","year":"2012","journal-title":"Behav Neurosci"},{"key":"2026050508320851100_awaf382-B51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-pathol-012615-044216","article-title":"Dendritic spine pathology in neurodegenerative diseases","volume":"11","author":"Herms","year":"2016","journal-title":"Annu Rev Pathol"},{"key":"2026050508320851100_awaf382-B52","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1134\/S0006297918090080","article-title":"Dynamic microtubules in Alzheimer\u2019s disease: Association with dendritic spine pathology","volume":"83","author":"Pchitskaya","year":"2018","journal-title":"Biochemistry (Mosc)"},{"key":"2026050508320851100_awaf382-B53","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1093\/brain\/awab436","article-title":"Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer\u2019s disease","volume":"145","author":"Peris","year":"2022","journal-title":"Brain"},{"key":"2026050508320851100_awaf382-B54","doi-asserted-by":"crossref","first-page":"40205","DOI":"10.1038\/srep40205","article-title":"Increase in alpha-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer\u2019s disease","volume":"7","author":"Vu","year":"2017","journal-title":"Sci Rep"},{"key":"2026050508320851100_awaf382-B55","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3233\/JAD-130545","article-title":"Microtubule depolymerization and tau phosphorylation","volume":"37","author":"Hernandez","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"2026050508320851100_awaf382-B56","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0306-4522(94)90533-9","article-title":"Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons","volume":"63","author":"Brion","year":"1994","journal-title":"Neuroscience"},{"key":"2026050508320851100_awaf382-B57","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/j.1460-2075.1992.tb05272.x","article-title":"Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state","volume":"11","author":"Drewes","year":"1992","journal-title":"EMBO J"},{"key":"2026050508320851100_awaf382-B58","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.15252\/embj.201797724","article-title":"Somatodendritic accumulation of tau in Alzheimer\u2019s disease is promoted by Fyn-mediated local protein translation","volume":"36","author":"Li","year":"2017","journal-title":"EMBO J"},{"key":"2026050508320851100_awaf382-B59","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1523\/JNEUROSCI.17-10-03588.1997","article-title":"Aberrant expression of mitotic cdc2\/cyclin B1 kinase in degenerating neurons of Alzheimer\u2019s disease brain","volume":"17","author":"Vincent","year":"1997","journal-title":"J Neurosci"},{"key":"2026050508320851100_awaf382-B60","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/alz.12319","article-title":"Whole-genome sequencing reveals new Alzheimer\u2019s disease-associated rare variants in loci related to synaptic function and neuronal development","volume":"17","author":"Prokopenko","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2026050508320851100_awaf382-B61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2022.05.022","article-title":"Genetic architecture of primary tauopathies","volume":"518","author":"Gallo","year":"2023","journal-title":"Neuroscience"},{"key":"2026050508320851100_awaf382-B62","doi-asserted-by":"crossref","first-page":"607680","DOI":"10.3389\/fneur.2020.607680","article-title":"Similarities and differences in the pattern of tau hyperphosphorylation in physiological and pathological conditions: Impacts on the elaboration of therapies to prevent tau pathology","volume":"11","author":"Duquette","year":"2021","journal-title":"Front Neurol"},{"key":"2026050508320851100_awaf382-B63","doi-asserted-by":"crossref","first-page":"e1005917","DOI":"10.1371\/journal.pgen.1005917","article-title":"Stabilization of microtubule-unbound tau via tau phosphorylation at Ser262\/356 by par-1\/MARK contributes to augmentation of AD-related phosphorylation and Abeta42-induced tau toxicity","volume":"12","author":"Ando","year":"2016","journal-title":"PLoS Genet"},{"key":"2026050508320851100_awaf382-B64","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/hmg\/ddn326","article-title":"Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model","volume":"18","author":"Chatterjee","year":"2009","journal-title":"Hum Mol Genet"},{"key":"2026050508320851100_awaf382-B65","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.febslet.2010.06.014","article-title":"Microtubule destruction induces tau liberation and its subsequent phosphorylation","volume":"584","author":"Miyasaka","year":"2010","journal-title":"FEBS Lett"},{"key":"2026050508320851100_awaf382-B66","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1471-4159.2010.06663.x","article-title":"Drosophila models of human tauopathies indicate that tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein","volume":"113","author":"Feuillette","year":"2010","journal-title":"J Neurochem"},{"key":"2026050508320851100_awaf382-B67","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.4161\/cc.10.9.15478","article-title":"Alzheimer Abeta disrupts the mitotic spindle and directly inhibits mitotic microtubule motors","volume":"10","author":"Borysov","year":"2011","journal-title":"Cell Cycle"},{"key":"2026050508320851100_awaf382-B68","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.neuint.2007.10.020","article-title":"Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B)","volume":"52","author":"Gevorkian","year":"2008","journal-title":"Neurochem Int"},{"key":"2026050508320851100_awaf382-B69","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1074\/jbc.M507378200","article-title":"Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid beta-peptide-induced neuronal apoptosis. Synergistic involvement of calpain and caspase-3","volume":"281","author":"Fifre","year":"2006","journal-title":"J Biol Chem"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf382\/64619500\/awaf382.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/5\/1650\/64619500\/awaf382.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/5\/1650\/64619500\/awaf382.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:32:21Z","timestamp":1777984341000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/5\/1650\/8281741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":69,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,10]]},"published-print":{"date-parts":[[2026,5,5]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf382","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,10,10]]}}}