{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:03:50Z","timestamp":1785942230006,"version":"3.56.0"},"reference-count":119,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100014156","name":"RUB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017118","name":"FoRUM","doi-asserted-by":"publisher","award":["F1008N-20"],"award-info":[{"award-number":["F1008N-20"]}],"id":[{"id":"10.13039\/100017118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017118","name":"FoRUM","doi-asserted-by":"publisher","award":["IF-027N-22"],"award-info":[{"award-number":["IF-027N-22"]}],"id":[{"id":"10.13039\/100017118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017118","name":"FoRUM","doi-asserted-by":"publisher","award":["TU432\/3-1"],"award-info":[{"award-number":["TU432\/3-1"]}],"id":[{"id":"10.13039\/100017118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017118","name":"FoRUM","doi-asserted-by":"publisher","award":["TU432\/6-1"],"award-info":[{"award-number":["TU432\/6-1"]}],"id":[{"id":"10.13039\/100017118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["GRK2862\/1\/492434978"],"award-info":[{"award-number":["GRK2862\/1\/492434978"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The evolutionarily conserved RNA exosome complex modulates gene expression during development. Mutations in RNA exosome complex subunits have been implicated in various human brain disorders, suggesting that defects in RNA decay are linked to impaired neural development. In our study, we identified de novo variants of EXOSC10 in microcephalic individuals. The patient\u2019s phenotype can be replicated by heterozygous conditional knockout of Exosc10 in the developing mouse forebrain.<\/jats:p>\n                  <jats:p>The heterozygous loss of Exosc10 in the developing mouse cortex leads to increased cell cycle exit, with a premature differentiation of radial glial cells to intermediate progenitors and neurons in the embryonic cortex. This premature neurogenesis at the expense of neural stem cell proliferation coincides with a smaller cortical size. RNA sequencing and RNA immunoprecipitation sequencing revealed upregulation of many Sonic hedgehog (Shh) signalling genes. We further show the direct degradation of Shh pathway transcripts such as Scube1 and Scube3 by Exosc10. In Exosc10 mouse mutants, the reduced cortical size could be largely rescued by reducing Shh activity.<\/jats:p>\n                  <jats:p>We propose that increased Shh activity due to Exosc10 deficiency leads to premature neurogenesis and ultimately to microcephaly. These observations offer new insights into the neurodevelopmental role of Exosc10 and highlight the dosage-dependent regulation of Shh signalling by Exosc10 in cortical development.<\/jats:p>","DOI":"10.1093\/brain\/awaf405","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:54:39Z","timestamp":1761134079000},"page":"2072-2090","source":"Crossref","is-referenced-by-count":2,"title":["<i>EXOSC10<\/i>\n                    haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling"],"prefix":"10.1093","volume":"149","author":[{"given":"Pauline Antonie","family":"Ulmke","sequence":"first","affiliation":[{"name":"Department of Human Genetics, University of Bochum , Bochum 44801 ,","place":["Germany"]},{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Sadman","family":"Sakib","sequence":"additional","affiliation":[{"name":"Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE) , Goettingen 37075 ,","place":["Germany"]},{"name":"Evotec SE , Hamburg 22419 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang Ton","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Genome Research, Vietnam Academy of Science and Technology , Hanoi 122000 ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asisa","family":"Muchamedin","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Bochum , Bochum 44801 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin","family":"Sokpor","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Bochum , Bochum 44801 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Bochum , Bochum 44801 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbin","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Abbas","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]},{"name":"Department of Neuro- and Sensory Physiology, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37073 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Castro Hernandez","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanathan","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Wincent","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, and Clinical Genetics and Genomics, Karolinska University Hospital , Stockholm 17176 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne","family":"Lied\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, and Clinical Genetics and Genomics, Karolinska University Hospital , Stockholm 17176 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Harris","sequence":"additional","affiliation":[{"name":"Northern Genetics Service, Institute of Genetic Medicine, International Centre for Life , Newcastle Upon Tyne NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelagh","family":"Joss","sequence":"additional","affiliation":[{"name":"West of Scotland Regional Genetics Service, Queen Elizabeth University Hospital , Glasgow G51 4TF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE) , Goettingen 37075 ,","place":["Germany"]},{"name":"Cluster of Excellence \u2018Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells\u2019 (MBExC), University of Goettingen , Goettingen 37073 ,","place":["Germany"]},{"name":"Department of Psychiatry and Psychotherapy, University Medical Center Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-9723","authenticated-orcid":false,"given":"Jochen F","family":"Staiger","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-788X","authenticated-orcid":false,"given":"Huu Phuc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Bochum , Bochum 44801 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Tuoc","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Bochum , Bochum 44801 ,","place":["Germany"]},{"name":"Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen , Goettingen 37075 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"2026060317001531400_awaf405-B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cell.2011.06.030","article-title":"Development and evolution of the human neocortex. Research support, N.I.H., extramural research support, non-U.S. Gov't review","volume":"146","author":"Lui","year":"2011","journal-title":"Cell"},{"key":"2026060317001531400_awaf405-B2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/joa.13055","article-title":"New insights into the development of the human cerebral cortex","volume":"235","author":"Molnar","year":"2019","journal-title":"J Anat"},{"key":"2026060317001531400_awaf405-B3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-cellbio-101011-155801","article-title":"The cell biology of neurogenesis: Toward an understanding of the development and evolution of the neocortex","volume":"30","author":"Taverna","year":"2014","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2026060317001531400_awaf405-B4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-genom-083117-021441","article-title":"The genetics of primary microcephaly","volume":"19","author":"Jayaraman","year":"2018","journal-title":"Annu Rev Genomics Hum Genet."},{"key":"2026060317001531400_awaf405-B5","doi-asserted-by":"crossref","first-page":"eaba4517","DOI":"10.1126\/science.aba4517","article-title":"Mapping the molecular and cellular complexity of cortical malformations","volume":"371","author":"Klingler","year":"2021","journal-title":"Science"},{"key":"2026060317001531400_awaf405-B6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-0037-1601448","article-title":"Autosomal recessive primary microcephaly (MCPH): An update","volume":"48","author":"Zaqout","year":"2017","journal-title":"Neuropediatrics"},{"key":"2026060317001531400_awaf405-B7","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41594-022-00882-9","article-title":"A critical period of translational control during brain development at codon resolution","volume":"29","author":"Harnett","year":"2022","journal-title":"Nat Struct Mol Biol"},{"key":"2026060317001531400_awaf405-B8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fncel.2014.00396","article-title":"Neurogenesis in the embryonic and adult brain: Same regulators, different roles","volume":"8","author":"Urban","year":"2014","journal-title":"Front Cell Neurosci."},{"key":"2026060317001531400_awaf405-B9","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1038\/s41593-024-01827-9","article-title":"Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system","volume":"27","author":"Adameyko","year":"2024","journal-title":"Nat Neurosci"},{"key":"2026060317001531400_awaf405-B10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41593-021-01002-4","article-title":"Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler","volume":"25","author":"Noack","year":"2022","journal-title":"Nat Neurosci"},{"key":"2026060317001531400_awaf405-B11","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aap8809","article-title":"Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex","volume":"358","author":"Nowakowski","year":"2017","journal-title":"Science"},{"key":"2026060317001531400_awaf405-B12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cell.2015.09.004","article-title":"Molecular identity of human outer radial glia during cortical development. Research support, N.I.H., extramural research support, non-U.S. Gov't","volume":"163","author":"Pollen","year":"2015","journal-title":"Cell"},{"key":"2026060317001531400_awaf405-B13","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.aad8361","article-title":"Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex","volume":"351","author":"Telley","year":"2016","journal-title":"Science"},{"key":"2026060317001531400_awaf405-B14","doi-asserted-by":"crossref","first-page":"e3003031","DOI":"10.1371\/journal.pbio.3003031","article-title":"mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis","volume":"23","author":"Serdar","year":"2025","journal-title":"PLoS Biol"},{"key":"2026060317001531400_awaf405-B15","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2017.09.003","article-title":"Temporal control of mammalian cortical neurogenesis by m6A methylation","volume":"171","author":"Yoon","year":"2017","journal-title":"Cell"},{"key":"2026060317001531400_awaf405-B16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.sbi.2014.01.011","article-title":"The eukaryotic RNA exosome","volume":"24","author":"Januszyk","year":"2014","journal-title":"Curr Opin Struct Biol"},{"key":"2026060317001531400_awaf405-B17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrm.2015.15","article-title":"The regulation and functions of the nuclear RNA exosome complex","volume":"17","author":"Kilchert","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026060317001531400_awaf405-B18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-030-31434-7_4","article-title":"The nuclear RNA exosome and its cofactors","volume":"1203","author":"Schmid","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"2026060317001531400_awaf405-B19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.molcel.2011.06.028","article-title":"Interaction profiling identifies the human nuclear exosome targeting complex","volume":"43","author":"Lubas","year":"2011","journal-title":"Mol Cell"},{"key":"2026060317001531400_awaf405-B20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2017.03.043","article-title":"Nuclear proximity of Mtr4 to RNA exosome restricts DNA mutational asymmetry","volume":"169","author":"Lim","year":"2017","journal-title":"Cell"},{"key":"2026060317001531400_awaf405-B21","doi-asserted-by":"crossref","first-page":"E5506","DOI":"10.1073\/pnas.1803530115","article-title":"Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex","volume":"115","author":"Puno","year":"2018","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026060317001531400_awaf405-B22","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/ng.2254","article-title":"Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration","volume":"44","author":"Wan","year":"2012","journal-title":"Nat Genet."},{"key":"2026060317001531400_awaf405-B23","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1038\/ncomms5287","article-title":"EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia","volume":"5","author":"Boczonadi","year":"2014","journal-title":"Nat Commun"},{"key":"2026060317001531400_awaf405-B24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jmedgenet-2015-103511","article-title":"Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt","volume":"53","author":"Di Donato","year":"2016","journal-title":"J Med Genet."},{"key":"2026060317001531400_awaf405-B25","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.ajhg.2018.03.011","article-title":"Variants in EXOSC9 disrupt the RNA exosome and result in cerebellar atrophy with spinal motor neuronopathy","volume":"102","author":"Burns","year":"2018","journal-title":"Am J Hum Genet"},{"key":"2026060317001531400_awaf405-B26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1261\/rna.064626.117","article-title":"The RNA exosome and RNA exosome-linked disease","volume":"24","author":"Morton","year":"2018","journal-title":"RNA"},{"key":"2026060317001531400_awaf405-B27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-9822-7_1","article-title":"The RNA exosome and human disease","volume":"2062","author":"Fasken","year":"2020","journal-title":"Methods Mol Biol"},{"key":"2026060317001531400_awaf405-B28","doi-asserted-by":"crossref","first-page":"E3179","DOI":"10.1073\/pnas.1217812110","article-title":"Conditionals by inversion provide a universal method for the generation of conditional alleles","volume":"110","author":"Economides","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026060317001531400_awaf405-B29","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2015.04.034","article-title":"RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity","volume":"161","author":"Pefanis","year":"2015","journal-title":"Cell"},{"key":"2026060317001531400_awaf405-B30","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.22-15-06309.2002","article-title":"Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage","volume":"22","author":"Gorski","year":"2002","journal-title":"J Neurosci"},{"key":"2026060317001531400_awaf405-B31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.devcel.2013.04.005","article-title":"Chromatin regulation by BAF170 controls cerebral cortical size and thickness","volume":"25","author":"Tuoc","year":"2013","journal-title":"Dev Cell"},{"key":"2026060317001531400_awaf405-B32","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1101\/gad.471708","article-title":"Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Research support, non-U.S. Gov't","volume":"22","author":"Tuoc","year":"2008","journal-title":"Genes Dev"},{"key":"2026060317001531400_awaf405-B33","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.celrep.2015.10.046","article-title":"Loss of BAF (mSWI\/SNF) complexes causes global transcriptional and chromatin state changes in forebrain development","volume":"13","author":"Narayanan","year":"2015","journal-title":"Cell Rep"},{"key":"2026060317001531400_awaf405-B34","doi-asserted-by":"crossref","first-page":"619538","DOI":"10.3389\/fcell.2021.619538","article-title":"Conditional loss of BAF (mSWI\/SNF) scaffolding subunits affects specification and proliferation of oligodendrocyte precursors in developing mouse forebrain","volume":"9","author":"Abbas","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026060317001531400_awaf405-B35","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1523\/JNEUROSCI.5669-08.2009","article-title":"Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice","volume":"29","author":"Tuoc","year":"2009","journal-title":"J Neurosci"},{"key":"2026060317001531400_awaf405-B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/002215540104900101","article-title":"Sensitive nonradioactive detection of mRNA in tissue sections: Novel application of the whole-mount in situ hybridization protocol","volume":"49","author":"Moorman","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"2026060317001531400_awaf405-B37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbrc.2010.07.035","article-title":"Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization","volume":"399","author":"An","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"2026060317001531400_awaf405-B38","doi-asserted-by":"crossref","first-page":"e15240","DOI":"10.1371\/journal.pone.0015240","article-title":"Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis","volume":"5","author":"Qiu","year":"2010","journal-title":"PLoS One"},{"key":"2026060317001531400_awaf405-B39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2202-15-12","article-title":"New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development","volume":"15","author":"Paes de Faria","year":"2014","journal-title":"BMC Neurosci"},{"key":"2026060317001531400_awaf405-B40","doi-asserted-by":"crossref","first-page":"dev188276","DOI":"10.1242\/dev.188276","article-title":"Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling","volume":"148","author":"Ulmke","year":"2021","journal-title":"Development"},{"key":"2026060317001531400_awaf405-B41","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.stemcr.2018.04.014","article-title":"Epigenetic regulation by BAF complexes limits neural stem cell proliferation by suppressing Wnt signaling in late embryonic development","volume":"10","author":"Nguyen","year":"2018","journal-title":"Stem Cell Reports"},{"key":"2026060317001531400_awaf405-B42","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1007\/s12035-019-1595-1","article-title":"RBM15 modulates the function of chromatin remodeling factor BAF155 through RNA methylation in developing cortex","volume":"56","author":"Xie","year":"2019","journal-title":"Mol Neurobiol."},{"key":"2026060317001531400_awaf405-B43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"W1","key":"2026060317001531400_awaf405-B44","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"2026060317001531400_awaf405-B45","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: Gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"2026060317001531400_awaf405-B46","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: An integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2026060317001531400_awaf405-B47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"2026060317001531400_awaf405-B48","doi-asserted-by":"crossref","first-page":"e2018866118","DOI":"10.1073\/pnas.2018866118","article-title":"Progenitor cell diversity in the developing mouse neocortex","volume":"118","author":"Ruan","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026060317001531400_awaf405-B49","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1261\/rna.057760.116","article-title":"Purification and analysis of endogenous human RNA exosome complexes","volume":"22","author":"Domanski","year":"2016","journal-title":"RNA"},{"key":"2026060317001531400_awaf405-B50","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.0609699104","article-title":"Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists","volume":"104","author":"Lauth","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026060317001531400_awaf405-B51","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1158\/1078-0432.CCR-13-2195","article-title":"Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer","volume":"20","author":"Huang","year":"2014","journal-title":"Clin Cancer Res"},{"key":"2026060317001531400_awaf405-B52","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature14957","article-title":"Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination","volume":"526","author":"Samanta","year":"2015","journal-title":"Nature"},{"key":"2026060317001531400_awaf405-B53","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"Database issue","key":"2026060317001531400_awaf405-B54","doi-asserted-by":"crossref","first-page":"D552","DOI":"10.1093\/nar\/gkh029","article-title":"Org: An atlas of gene expression patterns in the mouse embryo","volume":"32","author":"Visel","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2026060317001531400_awaf405-B55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuron.2007.12.012","article-title":"Satb2 regulates callosal projection neuron identity in the developing cerebral cortex","volume":"57","author":"Alcamo","year":"2008","journal-title":"Neuron"},{"key":"2026060317001531400_awaf405-B56","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.neuron.2007.12.028","article-title":"Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex","volume":"57","author":"Britanova","year":"2008","journal-title":"Neuron"},{"key":"2026060317001531400_awaf405-B57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2013.05.006","article-title":"Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex. Research support, non-U.S. Gov't","volume":"547","author":"Komada","year":"2013","journal-title":"Neurosci Lett"},{"key":"2026060317001531400_awaf405-B58","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1242\/dev.015891","article-title":"Hedgehog signaling is involved in development of the neocortex","volume":"135","author":"Komada","year":"2008","journal-title":"Development"},{"key":"2026060317001531400_awaf405-B59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ydbio.2010.10.014","article-title":"Ptch1-mediated dosage-dependent action of shh signaling regulates neural progenitor development at late gestational stages","volume":"349","author":"Shikata","year":"2011","journal-title":"Dev Biol"},{"key":"2026060317001531400_awaf405-B60","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1242\/dev.01349","article-title":"Temporal requirement for hedgehog signaling in ventral telencephalic patterning","volume":"131","author":"Fuccillo","year":"2004","journal-title":"Development"},{"key":"2026060317001531400_awaf405-B61","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0896-6273(03)00561-0","article-title":"Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches","volume":"39","author":"Machold","year":"2003","journal-title":"Neuron"},{"key":"2026060317001531400_awaf405-B62","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1242\/dev.02090","article-title":"Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon","volume":"132","author":"Xu","year":"2005","journal-title":"Development"},{"key":"2026060317001531400_awaf405-B63","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1242\/jcs.137695","article-title":"Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells","volume":"127","author":"Jakobs","year":"2014","journal-title":"J Cell Sci."},{"key":"2026060317001531400_awaf405-B64","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3727\/096504016X14747335734344","article-title":"Overexpression of SCUBE2 inhibits proliferation, migration, and invasion in glioma cells","volume":"25","author":"Guo","year":"2017","journal-title":"Oncol Res."},{"key":"2026060317001531400_awaf405-B65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2018.06.012","article-title":"SCUBE2 inhibits the proliferation, migration and invasion of human non-small cell lung cancer cells through regulation of the sonic hedgehog signaling pathway","volume":"672","author":"Yang","year":"2018","journal-title":"Gene"},{"key":"2026060317001531400_awaf405-B66","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0925-4773(99)00014-3","article-title":"SWiP-1: Novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development","volume":"82","author":"Vasiliauskas","year":"1999","journal-title":"Mech Dev."},{"key":"2026060317001531400_awaf405-B67","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"2026060317001531400_awaf405-B68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0896-6273(00)80897-1","article-title":"Sonic hedgehog\u2013regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system","volume":"25","author":"Lu","year":"2000","journal-title":"Neuron"},{"key":"2026060317001531400_awaf405-B69","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fncel.2015.00030","article-title":"Morphological and functional aspects of progenitors perturbed in cortical malformations","volume":"9","author":"Bizzotto","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"2026060317001531400_awaf405-B70","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1472-6947-15-S1-S6","article-title":"Identification of genomic features in the classification of loss- and gain-of-function mutation","volume":"15","author":"Jung","year":"2015","journal-title":"BMC Med Inform Decis Mak"},{"key":"2026060317001531400_awaf405-B71","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ydbio.2021.12.010","article-title":"EXOSC10\/Rrp6 is essential for the eight-cell embryo\/morula transition","volume":"483","author":"Petit","year":"2022","journal-title":"Dev Biol"},{"key":"2026060317001531400_awaf405-B72","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/brv.12693","article-title":"Regulation of the conserved 3\u2032-5\u2032 exoribonuclease EXOSC10\/Rrp6 during cell division, development and cancer","volume":"96","author":"Stuparevic","year":"2021","journal-title":"Biol Rev Camb Philos Soc"},{"key":"2026060317001531400_awaf405-B73","doi-asserted-by":"crossref","first-page":"e74132","DOI":"10.1371\/journal.pone.0074132","article-title":"Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates","volume":"9","author":"Pereira","year":"2014","journal-title":"PLoS One"},{"key":"2026060317001531400_awaf405-B74","doi-asserted-by":"crossref","first-page":"a001198","DOI":"10.1101\/cshperspect.a001198","article-title":"The origins and evolution of the p53 family of genes","volume":"2","author":"Belyi","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026060317001531400_awaf405-B75","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1007\/s00429-018-1621-5","article-title":"Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution","volume":"223","author":"Memi","year":"2018","journal-title":"Brain Struct Funct"},{"key":"2026060317001531400_awaf405-B76","first-page":"285","article-title":"A glance of p53 functions in brain development, neural stem cells, and brain cancer","volume":"9","author":"Xiong","year":"2020","journal-title":"Biology (Basel)"},{"key":"2026060317001531400_awaf405-B77","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/BPL-180064","article-title":"Sonic Hedgehog signaling rises to the surface: Emerging roles in neocortical development","volume":"3","author":"Yabut","year":"2018","journal-title":"Brain Plasticity"},{"key":"2026060317001531400_awaf405-B78","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1741-4520.2012.00368.x","article-title":"Sonic hedgehog signaling coordinates the proliferation and differentiation of neural stem\/progenitor cells by regulating cell cycle kinetics during development of the neocortex","volume":"52","author":"Komada","year":"2012","journal-title":"Congenit Anom (Kyoto)."},{"key":"2026060317001531400_awaf405-B79","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrn704","article-title":"Hedgehog-Gli signalling and the growth of the brain","volume":"3","author":"Ruiz i Altaba","year":"2002","journal-title":"Nat Rev Neurosci."},{"key":"2026060317001531400_awaf405-B80","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000507113","article-title":"Acute lengthening of progenitor mitosis influences progeny fate during cortical development in vivo","volume":"41","author":"Mitchell-Dick","year":"2019","journal-title":"Dev Neurosci"},{"key":"2026060317001531400_awaf405-B81","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuron.2015.12.007","article-title":"Prolonged mitosis of neural progenitors alters cell fate in the developing brain","volume":"89","author":"Pilaz","year":"2016","journal-title":"Neuron"},{"key":"2026060317001531400_awaf405-B82","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nn.2527","article-title":"The exon junction complex component Magoh controls brain size by regulating neural stem cell division","volume":"13","author":"Silver","year":"2010","journal-title":"Nat Neurosci"},{"key":"2026060317001531400_awaf405-B83","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/geno.2000.6370","article-title":"Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1)","volume":"70","author":"Grimmond","year":"2000","journal-title":"Genomics"},{"key":"2026060317001531400_awaf405-B84","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0925-4773(00)00586-4","article-title":"Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development","volume":"102","author":"Grimmond","year":"2001","journal-title":"Mech Dev."},{"key":"2026060317001531400_awaf405-B85","doi-asserted-by":"crossref","first-page":"37485","DOI":"10.1074\/jbc.M405912200","article-title":"A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones","volume":"279","author":"Wu","year":"2004","journal-title":"J Biol Chem"},{"key":"2026060317001531400_awaf405-B86","doi-asserted-by":"crossref","first-page":"46364","DOI":"10.1074\/jbc.M207410200","article-title":"Identification of a novel family of cell-surface proteins expressed in human vascular endothelium","volume":"277","author":"Yang","year":"2002","journal-title":"J Biol Chem"},{"key":"2026060317001531400_awaf405-B87","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2012.05.007","article-title":"Scube activity is necessary for Hedgehog signal transduction in vivo","volume":"368","author":"Johnson","year":"2012","journal-title":"Dev Biol"},{"key":"2026060317001531400_awaf405-B88","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ydbio.2006.02.032","article-title":"Scube2 mediates Hedgehog signalling in the zebrafish embryo","volume":"294","author":"Hollway","year":"2006","journal-title":"Dev Biol"},{"key":"2026060317001531400_awaf405-B89","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.celrep.2012.07.010","article-title":"Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand","volume":"2","author":"Tukachinsky","year":"2012","journal-title":"Cell Rep"},{"key":"2026060317001531400_awaf405-B90","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/s12967-022-03689-w","article-title":"CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh\/Gli1 pathway in hepatocellular carcinoma","volume":"20","author":"Zhao","year":"2022","journal-title":"J Transl Med"},{"key":"2026060317001531400_awaf405-B91","doi-asserted-by":"crossref","first-page":"e24671","DOI":"10.1097\/MD.0000000000024671","article-title":"A novel biomarker for predicting sepsis mortality: SCUBE-1","volume":"100","author":"Erdogan","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"2026060317001531400_awaf405-B92","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12020-023-03444-1","article-title":"Can signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) be used as an indicator of endothelial dysfunction in acromegaly patients?","volume":"82","author":"Tufekci","year":"2023","journal-title":"Endocrine"},{"key":"2026060317001531400_awaf405-B93","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3233\/CBM-2012-00285","article-title":"Is SCUBE 1 a new biomarker for gastric cancer?","volume":"11","author":"Mentese","year":"2012","journal-title":"Cancer Biomark"},{"key":"2026060317001531400_awaf405-B94","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/08869634.2021.2005917","article-title":"Can we use serum SCUBE 1 levels as a biomarker in obstructive sleep apnea hypopnea syndrome?","volume":"42","author":"Selcuk","year":"2024","journal-title":"Cranio"},{"key":"2026060317001531400_awaf405-B95","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/09513590.2019.1683537","article-title":"Evaluation of SCUBE-1 levels as a placental dysfunction marker at gestational diabetes mellitus","volume":"36","author":"Tekin Y","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"2026060317001531400_awaf405-B96","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ajhg.2020.11.015","article-title":"SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling","volume":"108","author":"Lin","year":"2021","journal-title":"Am J Hum Genet"},{"key":"2026060317001531400_awaf405-B97","first-page":"264","article-title":"SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer","volume":"7","author":"Zhao","year":"2013","journal-title":"Biosci Trends"},{"key":"2026060317001531400_awaf405-B98","first-page":"120","article-title":"Activation of TGF-beta1 pathway by SCUBE3 regulates TWIST1 expression and promotes breast cancer progression","volume":"35","author":"Yang","year":"2020","journal-title":"Cancer Biother Radiopharm"},{"key":"2026060317001531400_awaf405-B99","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1196-357","article-title":"Mutations in the human Sonic Hedgehog gene cause holoprosencephaly","volume":"14","author":"Roessler","year":"1996","journal-title":"Nat Genet."},{"key":"2026060317001531400_awaf405-B100","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/8.13.2479","article-title":"The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly","volume":"8","author":"Nanni","year":"1999","journal-title":"Hum Mol Genet"},{"key":"2026060317001531400_awaf405-B101","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1196-353","article-title":"Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly","volume":"14","author":"Belloni","year":"1996","journal-title":"Nat Genet."},{"key":"2026060317001531400_awaf405-B102","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ejhg.2008.176","article-title":"PTCH1 duplication in a family with microcephaly and mild developmental delay","volume":"17","author":"Derwinska","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"2026060317001531400_awaf405-B103","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ajmg.a.30070","article-title":"A retrospective survey of perinatal risk factors of 104 living children with holoprosencephaly","volume":"128A","author":"Stashinko","year":"2004","journal-title":"Am J Med Genet A"},{"key":"2026060317001531400_awaf405-B104","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ajmg.a.30110","article-title":"Phenotypic and molecular variability of the holoprosencephalic spectrum","volume":"129A","author":"Lazaro","year":"2004","journal-title":"Am J Med Genet A"},{"key":"2026060317001531400_awaf405-B105","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/hmg\/6.11.1847","article-title":"Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly","volume":"6","author":"Roessler","year":"1997","journal-title":"Hum Mol Genet"},{"key":"2026060317001531400_awaf405-B106","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1073\/pnas.91.17.8102","article-title":"Linkage of a human brain malformation, familial holoprosencephaly, to chromosome 7 and evidence for genetic heterogeneity","volume":"91","author":"Muenke","year":"1994","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026060317001531400_awaf405-B107","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nature00989","article-title":"Patched acts catalytically to suppress the activity of smoothened","volume":"418","author":"Taipale","year":"2002","journal-title":"Nature"},{"key":"2026060317001531400_awaf405-B108","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(00)81268-4","article-title":"Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome","volume":"85","author":"Hahn","year":"1996","journal-title":"Cell"},{"key":"2026060317001531400_awaf405-B109","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.272.5268.1668","article-title":"Human homolog of patched, a candidate gene for the basal cell nevus syndrome","volume":"272","author":"Johnson","year":"1996","journal-title":"Science"},{"key":"2026060317001531400_awaf405-B110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/humu.20296","article-title":"PTCH mutations: Distribution and analyses","volume":"27","author":"Lindstrom","year":"2006","journal-title":"Hum Mutat"},{"key":"2026060317001531400_awaf405-B111","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00439-002-0695-5","article-title":"Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly","volume":"110","author":"Ming","year":"2002","journal-title":"Hum Genet"},{"key":"2026060317001531400_awaf405-B112","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tcb.2008.08.001","article-title":"Apoptosis-induced compensatory proliferation. The cell is dead. Long live the cell!","volume":"18","author":"Fan","year":"2008","journal-title":"Trends Cell Biol"},{"key":"2026060317001531400_awaf405-B113","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s10495-024-01958-1","article-title":"Understanding the molecular mechanism of regeneration through apoptosis-induced compensatory proliferation studies\u2014Updates and future aspects","volume":"29","author":"Rajagopalan","year":"2024","journal-title":"Apoptosis"},{"key":"2026060317001531400_awaf405-B114","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.3145re8","article-title":"Apoptosis, stem cells, and tissue regeneration","volume":"3","author":"Bergmann","year":"2010","journal-title":"Sci Signal"},{"key":"2026060317001531400_awaf405-B115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.devcel.2009.07.014","article-title":"Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration","volume":"17","author":"Chera","year":"2009","journal-title":"Dev Cell"},{"key":"2026060317001531400_awaf405-B116","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ydbio.2009.09.015","article-title":"Cell death and tissue remodeling in planarian regeneration","volume":"338","author":"Pellettieri","year":"2010","journal-title":"Dev Biol"},{"key":"2026060317001531400_awaf405-B117","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jphysparis.2008.10.007","article-title":"Adult neurogenesis and neuronal regeneration in the brain of teleost fish","volume":"102","author":"Zupanc","year":"2008","journal-title":"J Physiol Paris"},{"key":"2026060317001531400_awaf405-B118","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.devcel.2008.01.003","article-title":"Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye","volume":"14","author":"Fan","year":"2008","journal-title":"Dev Cell"},{"key":"2026060317001531400_awaf405-B119","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.expneurol.2015.08.010","article-title":"Apoptotic neurons induce proliferative responses of progenitor cells in the postnatal neocortex","volume":"273","author":"Petrenko","year":"2015","journal-title":"Exp Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf405\/64912397\/awaf405.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/6\/2072\/64912397\/awaf405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/6\/2072\/64912397\/awaf405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:00:34Z","timestamp":1780520434000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/6\/2072\/8300602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":119,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,10,24]]},"published-print":{"date-parts":[[2026,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf405","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2025,10,24]]}}}