{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:09:14Z","timestamp":1792008554469,"version":"4.4.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is considerable evidence linking alterations in gut microbiome composition with Parkinson\u2019s disease, leading to several recent randomized controlled faecal microbiota transplantation (FMT) trials in patients with Parkinson\u2019s disease targeting gut dysbiosis with the aim to modulate the gut\u2013brain axis. Some FMT trials have observed motor and non-motor symptoms improvements in patients with Parkinson\u2019s disease, possibly through microbiota linked enhanced short-chain fatty acid or other metabolite effects and reduced systemic inflammation. While the findings are exciting and can potentially open a new treatment paradigm, crital questions on donor selection, the optimal screening and selection of the donor microbiome, delivery routes and the timing and frequency of transplantation need to be addressed. We suggest that future FMT trials should incorporate blood, metabolites, urine and functional neuroimaging biological markers and to control for dietary, lifestyle comorbidities, medication intake and\/or other potential variables to ensure optimal evaluation of interactions between the gut microbes and brain outcomes prospectively over a longer time frame.<\/jats:p>","DOI":"10.1093\/brain\/awaf419","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:20:58Z","timestamp":1762647658000},"page":"59-70","source":"Crossref","is-referenced-by-count":11,"title":["Faecal microbiota transplant for Parkinson\u2019s disease: promises and future directions"],"prefix":"10.1093","volume":"149","author":[{"given":"Eng King","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Duke NUS Medical School , 169857 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0400-6999","authenticated-orcid":false,"given":"Jia Dong James","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Duke NUS Medical School , 169857 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Duke NUS Medical School , 169857 ,","place":["Singapore"]},{"name":"Department of Dental Medicine, Karolinska Institutet , 171 77 Stockholm ,","place":["Sweden"]},{"name":"School of Medical and Life Sciences, Sunway University , Sunway City 47500 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