{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:16:23Z","timestamp":1792062983442,"version":"4.4.0"},"reference-count":159,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000627","name":"Guarantors of Brain","doi-asserted-by":"publisher","award":["G101149"],"award-info":[{"award-number":["G101149"]}],"id":[{"id":"10.13039\/501100000627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017506","name":"Alzheimer\u2019s Society","doi-asserted-by":"publisher","award":["602"],"award-info":[{"award-number":["602"]}],"id":[{"id":"10.13039\/501100017506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC-1215-20014"],"award-info":[{"award-number":["BRC-1215-20014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017751","name":"NIHR BioResource","doi-asserted-by":"publisher","award":["RG94028"],"award-info":[{"award-number":["RG94028"]}],"id":[{"id":"10.13039\/100017751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017751","name":"NIHR BioResource","doi-asserted-by":"publisher","award":["RG85445"],"award-info":[{"award-number":["RG85445"]}],"id":[{"id":"10.13039\/100017751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220258"],"award-info":[{"award-number":["220258"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["SUAG\/010 RG91365"],"award-info":[{"award-number":["SUAG\/010 RG91365"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["SUAG\/051G101400"],"award-info":[{"award-number":["SUAG\/051G101400"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Holt Fellowship"},{"name":"Addenbrookes Charitable Trust, Cambridge University Hospitals"},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK-RADF2021A-010"],"award-info":[{"award-number":["ARUK-RADF2021A-010"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Frontotemporal dementia (FTD) shows autosomal dominant transmission in up to a third of families, enabling the study of presymptomatic and prodromal phases. Despite self-reported well-being and normal daily cognitive functioning, brain structural changes are evident a decade or more before the expected onset of disease. This divergence between cognitive function and brain structure contrasts with the coupling of structural and functional decline after symptom onset. In healthy ageing, it has been shown that functional connectivity is a better predictor of cognitive function than volumetric structural imaging. We previously proposed that in the presymptomatic phase of genetic FTD, the maintenance of brain functional network integrity enables carriers of pathogenic variants to sustain cognitive performance. However, prior work has focused on a small number of, often predefined, networks. This provides a limited and potentially biased characterization of the substrates and moderators of brain network integration.<\/jats:p>\n                  <jats:p>Here, we test the hypothesis that brain-wide functional integration in FTD determines resilience to progressive pathology before symptom onset. We assess functional connectome integration in 289 presymptomatic carriers of pathogenic variants associated with FTD using functional MRI in relation to cognition and contrast with 271 family members without pathogenic variants. Because structural atrophy, functional integration and cognitive profiles are multivariate, we used canonical correlation models, supplemented by multiple linear regression models for each imaging modality.<\/jats:p>\n                  <jats:p>We confirmed progressive atrophy and normal cognitive function in presymptomatic carriers compared to non-carriers. Notably, functional integration was preserved in presymptomatic carriers across age, while it declined in familial non-carriers. The strongest effects were observed in cognitive control networks. The changes in functional integration in presymptomatic carriers were behaviourally relevant and independent of the severity of atrophy, suggesting a resilience mechanism in those at risk of dementia. To generate hypotheses about the genetic and neurometabolic basis of resilience, we assessed the spatial overlap between behaviourally-relevant functional integration maps and gene transcription profiles. These spatial correlations suggested resilience signatures to glial cell composition (astrocytes, microglia, oligodendrocytes), revealing cellular mechanisms inaccessible to standard neuroimaging.<\/jats:p>\n                  <jats:p>Our findings suggest that resilience to atrophy is associated with enhanced functional integration, protecting against clinical conversion for many years in individuals at risk of dementia. This result has implications for the design of presymptomatic disease-modifying therapy trials and gives hope for therapeutic strategies aimed at enhancing resilience and ability to maintain function despite the presence of genetically determined neuropathology.<\/jats:p>","DOI":"10.1093\/brain\/awaf443","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:17:45Z","timestamp":1763731065000},"page":"2831-2849","source":"Crossref","is-referenced-by-count":2,"title":["Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia"],"prefix":"10.1093","volume":"149","author":[{"given":"Kamen A","family":"Tsvetanov","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]},{"name":"Department of Psychology, University of Cambridge , Cambridge CB2 1NF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-9656","authenticated-orcid":false,"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]},{"name":"UK Dementia Research Institute, University of Cambridge , Cambridge CB2 0AH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Simon","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1063-6937","authenticated-orcid":false,"given":"Timothy","family":"Rittman","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-9220","authenticated-orcid":false,"given":"David J","family":"Whiteside","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-0670","authenticated-orcid":false,"given":"Alexander G","family":"Murley","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-0685","authenticated-orcid":false,"given":"Richard","family":"Bethlehem","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge , Cambridge CB2 8AH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Paquola","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Medicine, INM-7, Forschungszentrum J\u00fclich , J\u00fclich 52428 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4342-6963","authenticated-orcid":false,"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[{"name":"Neurology, Department of Neurological and Vision Sciences, ASST Spedali Civili , Brescia 25123 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8590","authenticated-orcid":false,"given":"Arabella","family":"Bouzigues","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy L","family":"Russell","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe H","family":"Foster","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Ferry-Bolder","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre , Rotterdam 3015 GD ,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lize C","family":"Jiskoot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre , Rotterdam 3015 GD ,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-7527","authenticated-orcid":false,"given":"Harro","family":"Seelaar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre , Rotterdam 3015 GD ,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-896X","authenticated-orcid":false,"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Institut d\u2019Investigaci\u00f3ns Biom\u00e8diques August Pi I Sunyer, University of Barcelona , Barcelona 08036 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Laforce","sequence":"additional","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire, D\u00e9partement des Sciences Neurologiques, CHU de Qu\u00e9bec, and Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-2951","authenticated-orcid":false,"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society; Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet , Solna 171 65 ,","place":["Sweden"]},{"name":"Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital , Solna SE-17176 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico , Milan 20122 ,","place":["Italy"]},{"name":"University of Milan, Centro Dino Ferrari , Milan 20122 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2502","authenticated-orcid":false,"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven , Leuven 3001 ,","place":["Belgium"]},{"name":"Neurology Service, University Hospitals Leuven , Leuven 3000 ,","place":["Belgium"]},{"name":"Leuven Brain Institute, KU Leuven , Leuven 3000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon , Lisbon 1649-028 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta , Milano 20133 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"University Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra , Coimbra 3004-531 ,","place":["Portugal"]},{"name":"Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra , Coimbra 3004-531 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-6062","authenticated-orcid":false,"given":"Alexander","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester , Manchester M20 3LJ ,","place":["UK"]},{"name":"Department of Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen , Essen 45147 ,","place":["Germany"]},{"name":"Department of Geriatric Medicine, Klinikum Hochsauerland , Arnsberg 59755 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen , Munich 80802 ,","place":["Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) , Munich 81377 ,","place":["Germany"]},{"name":"Munich Cluster of Systems Neurology (SyNergy) , Munich 81377 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Department of Neurofarba, University of Florence , Florence 50139 ,","place":["Italy"]},{"name":"IRCCS Fondazione Don Carlo Gnocchi , Florence 50139 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm , Ulm 89081 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-503X","authenticated-orcid":false,"given":"Maxime","family":"Bertoux","sequence":"additional","affiliation":[{"name":"Lille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Lebouvier","sequence":"additional","affiliation":[{"name":"Lille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-1113","authenticated-orcid":false,"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Department of Psychiatry, McGill University , Montreal, QC H4H 1R3 ,","place":["Canada"]},{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , Montreal, QC H4H 1R3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris R","family":"Butler","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford , Oxford OX3 7JX ,","place":["UK"]},{"name":"Department of Brain Sciences, Imperial College London , London SW7 2AZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Le Ber","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute \u2013 Institut du Cerveau \u2013 ICM, Inserm U1127, CNRS UMR 7225, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris 75013 ,","place":["France"]},{"name":"Centre de r\u00e9f\u00e9rence des d\u00e9mences rares ou pr\u00e9coces, IM2A, D\u00e9partement de Neurologie, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris 75013 ,","place":["France"]},{"name":"D\u00e9partement de Neurologie, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-7427","authenticated-orcid":false,"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, University of Western Ontario , London, ON , N6A 3K7","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto , Toronto, ON , M5T 0S8","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-2096","authenticated-orcid":false,"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto , Toronto, ON , M5T 2S8","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of T\u00fcbingen , T\u00fcbingen 72076 ,","place":["Germany"]},{"name":"Center for Neurodegenerative Diseases (DZNE) , T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia , San Sebastian 20014 ,","place":["Spain"]},{"name":"Neurosciences Area, Group of Neurodegenerative Diseases, Biogipuzkoa Health Research Institute , San Sebastian 20014 ,","place":["Spain"]},{"name":"Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Carlos III Health Institute , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia , Brescia 15-25121 ,","place":["Italy"]},{"name":"Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli , Brescia 15-25121 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB23 3EB ,","place":["UK"]},{"name":"MRC Cognition and Brain Science Unit, Department of Psychiatry, University of Cambridge , Cambridge CB2 7EF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Genetic FTD Initiative, GENFI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian","family":"Convery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Samra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Alberici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Buratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Borracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Serpente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Carandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Rotondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giaccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Fede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tang-Wai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen","family":"Shoesmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robart","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Poos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M","family":"Papma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liset","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"de Houwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fainardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Chiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Viklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Taheri","family":"Rydell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"\u00d6ijerstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Langheinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Antonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Bargall\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Borrego-Ecija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Costa-Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Miltenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Sim\u00f5es do","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alazne","family":"Gabilondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Croitoru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Tainta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Barandiaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Vogels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Poesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Montembault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaella Lara","family":"Migliaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninon","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Sch\u00f6necker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Maximilian","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stockbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolina","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Anderl-Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Rollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Dur\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jo\u00e3o","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosario","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"T\u00e1buas-Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3nia","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2026080312464596900_awaf443-B1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuroimage.2016.04.047","article-title":"Functional connectivity and structural covariance between regions of interest can be measured more accurately using multivariate distance correlation","volume":"135","author":"Geerligs","year":"2016","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neurobiolaging.2023.06.001","article-title":"Cognition\u2019s dependence on functional network integrity with age is conditional on structural network integrity","volume":"129","author":"Liu","year":"2023","journal-title":"Neurobiol Aging."},{"key":"2026080312464596900_awaf443-B3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/cercor\/bhj036","article-title":"Structure-function correlates of cognitive decline in aging","volume":"16","author":"Persson","year":"2006","journal-title":"Cereb Cortex"},{"key":"2026080312464596900_awaf443-B4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neurobiolaging.2018.12.009","article-title":"Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia","volume":"77","author":"Rittman","year":"2019","journal-title":"Neurobiol Aging."},{"key":"2026080312464596900_awaf443-B5","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/alz.12209","article-title":"Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia","volume":"17","author":"Tsvetanov","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41583-018-0068-2","article-title":"Maintenance, reserve and compensation: The cognitive neuroscience of healthy ageing","volume":"19","author":"Cabeza","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2026080312464596900_awaf443-B7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/brain\/awx347","article-title":"Tau burden and the functional connectome in Alzheimer\u2019s disease and progressive supranuclear palsy","volume":"141","author":"Cope","year":"2018","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B8","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","article-title":"A network diffusion model of disease progression in dementia","volume":"73","author":"Raj","year":"2012","journal-title":"Neuron"},{"key":"2026080312464596900_awaf443-B9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"2026080312464596900_awaf443-B10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1017\/S1355617713000507","article-title":"Cognitive reserve and brain reserve in prodromal Huntington\u2019s disease","volume":"19","author":"Bonner-Jackson","year":"2013","journal-title":"J Int Neuropsychol Soc."},{"key":"2026080312464596900_awaf443-B11","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/brain\/awy122","article-title":"Testing a longitudinal compensation model in premanifest Huntington\u2019s disease","volume":"141","author":"Gregory","year":"2018","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jalz.2017.06.2268","article-title":"Presymptomatic atrophy in autosomal dominant Alzheimer\u2019s disease: A serial magnetic resonance imaging study","volume":"14","author":"Kinnunen","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B13","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ebiom.2015.08.002","article-title":"Compensation in preclinical Huntington\u2019s disease: Evidence from the track-on HD study","volume":"2","author":"Kl\u00f6ppel","year":"2015","journal-title":"EBioMedicine"},{"key":"2026080312464596900_awaf443-B14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the genetic frontotemporal dementia initiative (GENFI) study: A cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol."},{"key":"2026080312464596900_awaf443-B15","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1093\/brain\/aww250","article-title":"Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia","volume":"139","author":"Vatsavayai","year":"2016","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/B978-0-444-64076-5.00027-2","article-title":"Frontotemporal dementia","volume":"148","author":"Deleon","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"2026080312464596900_awaf443-B17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(19)30394-1","article-title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: An international retrospective cohort study","volume":"19","author":"Moore","year":"2020","journal-title":"Lancet Neurol."},{"key":"2026080312464596900_awaf443-B18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/21678421.2015.1074700","article-title":"Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations","volume":"16","author":"Snowden","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"2026080312464596900_awaf443-B19","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/s41598-017-02364-1","article-title":"Age-related penetrance of the C9orf72 repeat expansion","volume":"7","author":"Murphy","year":"2017","journal-title":"Sci Rep"},{"key":"2026080312464596900_awaf443-B20","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/brain\/awx103","article-title":"Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: A GENFI study","volume":"140","author":"Premi","year":"2017","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2017.10.008","article-title":"Patterns of gray matter atrophy in genetic frontotemporal dementia: Results from the GENFI study","volume":"62","author":"Cash","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2026080312464596900_awaf443-B22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/jnnp-2017-316799","article-title":"Longitudinal diffusion imaging across the C9orf72 clinical spectrum","volume":"89","author":"Floeter","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026080312464596900_awaf443-B23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/brain\/awy288","article-title":"Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia","volume":"142","author":"Jiskoot","year":"2019","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.nicl.2018.05.017","article-title":"Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers","volume":"19","author":"Olm","year":"2018","journal-title":"Neuroimage Clin"},{"key":"2026080312464596900_awaf443-B25","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1523\/JNEUROSCI.2733-15.2016","article-title":"Extrinsic and intrinsic brain network connectivity maintains cognition across the lifespan despite accelerated decay of regional brain activation","volume":"36","author":"Tsvetanov","year":"2016","journal-title":"J Neurosci"},{"key":"2026080312464596900_awaf443-B26","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.1002\/alz.14299","article-title":"Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion","volume":"20","author":"Liu","year":"2024","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B27","doi-asserted-by":"crossref","first-page":"7218\u2013","DOI":"10.1523\/JNEUROSCI.2574-18.2019","article-title":"Neuroinflammation and functional connectivity in Alzheimer\u2019s disease: Interactive influences on cognitive performance","volume":"39","author":"Passamonti","year":"2019","journal-title":"J Neurosci"},{"key":"2026080312464596900_awaf443-B28","doi-asserted-by":"crossref","first-page":"13771","DOI":"10.1038\/s41598-019-50254-5","article-title":"Perceptual and conceptual processing of visual objects across the adult lifespan","volume":"9","author":"Bruffaerts","year":"2019","journal-title":"Sci Rep"},{"key":"2026080312464596900_awaf443-B29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neurobiolaging.2021.01.035","article-title":"Transient neural network dynamics in cognitive ageing","volume":"105","author":"Tibon","year":"2021","journal-title":"Neurobiol Aging"},{"key":"2026080312464596900_awaf443-B30","doi-asserted-by":"crossref","first-page":"746236","DOI":"10.3389\/fnagi.2021.746236","article-title":"The \u201cneural shift\u201d of sleep quality and cognitive aging: A resting-state MEG study of transient neural dynamics","volume":"13","author":"Tibon","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"2026080312464596900_awaf443-B31","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1523\/JNEUROSCI.1361-21.2022","article-title":"Prefrontal cortical connectivity mediates locus Coeruleus noradrenergic regulation of inhibitory control in older adults","volume":"42","author":"Tomassini","year":"2022","journal-title":"J Neurosci"},{"key":"2026080312464596900_awaf443-B32","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1523\/JNEUROSCI.2919-17.2018","article-title":"Activity and connectivity differences underlying inhibitory control across the adult life span","volume":"38","author":"Tsvetanov","year":"2018","journal-title":"J Neurosci"},{"key":"2026080312464596900_awaf443-B33","doi-asserted-by":"crossref","first-page":"117299","DOI":"10.1016\/j.neuroimage.2020.117299","article-title":"Dispersion of functional gradients across the adult lifespan","volume":"222","author":"Bethlehem","year":"2020","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B34","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1002\/hbm.23653","article-title":"Challenges in measuring individual differences in functional connectivity using fMRI: The case of healthy aging","volume":"38","author":"Geerligs","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"2026080312464596900_awaf443-B35","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1073\/pnas.1608282113","article-title":"Situating the default-mode network along a principal gradient of macroscale cortical organization","volume":"113","author":"Margulies","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080312464596900_awaf443-B36","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/brain\/121.6.1013","article-title":"From sensation to cognition","volume":"121","author":"Mesulam","year":"1998","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B37","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia","volume":"266","author":"Greaves","year":"2019","journal-title":"J Neurol"},{"key":"2026080312464596900_awaf443-B38","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1038\/s41380-024-02847-4","article-title":"Disruption of macroscale functional network organisation in patients with frontotemporal dementia","volume":"30","author":"Bouzigues","year":"2025","journal-title":"Mol Psychiatry"},{"key":"2026080312464596900_awaf443-B39","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/brain\/awaa082","article-title":"Editorial","volume":"143","author":"Kullmann","year":"2020","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/23273798.2016.1227858","article-title":"Ageing and the resting state: Is cognition obsolete?","volume":"32","author":"Campbell","year":"2017","journal-title":"Lang Cogn Neurosci"},{"key":"2026080312464596900_awaf443-B41","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neubiorev.2019.09.005","article-title":"A neural-vascular complex of age-related changes in the human brain: Anatomy, physiology, and implications for neurocognitive aging","volume":"107","author":"Abdelkarim","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"2026080312464596900_awaf443-B42","doi-asserted-by":"crossref","first-page":"RP93327","DOI":"10.7554\/eLife.93327","article-title":"Neural evidence of functional compensation for fluid intelligence in healthy ageing","volume":"13","author":"Knights","year":"2024","journal-title":"Elife"},{"key":"2026080312464596900_awaf443-B43","doi-asserted-by":"crossref","first-page":"20190631","DOI":"10.1098\/rstb.2019.0631","article-title":"Separating vascular and neuronal effects of age on fMRI BOLD signals","volume":"376","author":"Tsvetanov","year":"2021","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2026080312464596900_awaf443-B44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2022.09.006","article-title":"Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan","volume":"121","author":"Wu","year":"2023","journal-title":"Neurobiol Aging"},{"key":"2026080312464596900_awaf443-B45","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1080\/23273798.2016.1251600","article-title":"The use of resting state data in an integrative approach to studying neurocognitive ageing \u2013 commentary on Campbell and Schacter (2016)","volume":"32","author":"Geerligs","year":"2016","journal-title":"Lang Cogn Neurosci"},{"key":"2026080312464596900_awaf443-B46","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1523\/JNEUROSCI.0900-18.2018","article-title":"Unique mapping of structural and functional connectivity on cognition","volume":"38","author":"Zimmermann","year":"2018","journal-title":"J Neurosci"},{"key":"2026080312464596900_awaf443-B47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data","volume":"189","author":"Arnatkevic\u0306i\u016bt\u0117","year":"2019","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.biopsych.2022.10.016","article-title":"Toward best practices for imaging transcriptomics of the human brain","volume":"93","author":"Arnatkeviciute","year":"2023","journal-title":"Biol Psychiatry"},{"key":"2026080312464596900_awaf443-B49","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bpsgos.2021.10.002","article-title":"Imaging transcriptomics of brain disorders","volume":"2","author":"Arnatkeviciute","year":"2022","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"2026080312464596900_awaf443-B50","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"2026080312464596900_awaf443-B51","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.wad.0000213865.09806.92","article-title":"The uniform data set (UDS): Clinical and cognitive variables and descriptive data from Alzheimer disease centers","volume":"20","author":"Morris","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2026080312464596900_awaf443-B52","first-page":"1","article-title":"Mice: Multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2011","journal-title":"J Stat Softw"},{"key":"2026080312464596900_awaf443-B53","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1037\/h0071325","article-title":"Analysis of a complex of statistical variables into principal components","volume":"24","author":"Hotelling","year":"1933","journal-title":"J Educ Psychol."},{"key":"2026080312464596900_awaf443-B54","author":"van der Maaten"},{"key":"2026080312464596900_awaf443-B55","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/14786440109462720","article-title":"On lines and planes of closest fit to systems of points in space","volume":"2","author":"Pearson","year":"1901","journal-title":"Lond Edinb Dubl Phil Mag J Sci"},{"key":"2026080312464596900_awaf443-B56","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1214\/19-AOS1907","article-title":"Permutation methods for factor analysis and PCA","volume":"48","author":"Dobriban","year":"2020","journal-title":"Ann Stat"},{"key":"2026080312464596900_awaf443-B57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF02289447","article-title":"A rationale and test for the number of factors in factor analysis","volume":"30","author":"Horn","year":"1965","journal-title":"Psychometrika"},{"key":"2026080312464596900_awaf443-B58","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"Fsl","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"issue":"Suppl 2","key":"2026080312464596900_awaf443-B59","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1259\/bjr\/33553595","article-title":"Overview of fMRI analysis","volume":"77","author":"Smith","year":"2004","journal-title":"Br J Radiol"},{"key":"2026080312464596900_awaf443-B60","doi-asserted-by":"crossref","DOI":"10.1016\/B978-012372560-8\/50002-4","volume-title":"Statistical parametric mapping: The analysis of functional brain images","author":"Friston","year":"2007"},{"key":"2026080312464596900_awaf443-B61","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B62","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/alz.12252","article-title":"Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes","volume":"17","author":"Malpetti","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B63","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","article-title":"ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data","volume":"112","author":"Pruim","year":"2015","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B64","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B65","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature"},{"key":"2026080312464596900_awaf443-B66","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuroimage.2012.08.052","article-title":"An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data","volume":"64","author":"Satterthwaite","year":"2013","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B67","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI","volume":"37","author":"Behzadi","year":"2007","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B68","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroimage.2016.12.027","article-title":"Potential pitfalls when denoising resting state fMRI data using nuisance regression","volume":"154","author":"Bright","year":"2017","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B69","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2013.05.116","article-title":"The nuisance of nuisance regression: Spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity","volume":"82","author":"Hallquist","year":"2013","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B70","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1002\/hbm.24528","article-title":"Modular preprocessing pipelines can reintroduce artifacts into fMRI data","volume":"40","author":"Lindquist","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"2026080312464596900_awaf443-B71","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s42003-020-0794-7","article-title":"BrainSpace: A toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets","volume":"3","author":"de Wael","year":"2020","journal-title":"Commun Biol"},{"key":"2026080312464596900_awaf443-B72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.acha.2006.04.006","article-title":"Diffusion maps","volume":"21","author":"Coifman","year":"2006","journal-title":"Appl Comput Harmon Anal"},{"key":"2026080312464596900_awaf443-B73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tics.2017.11.002","article-title":"Large-scale gradients in human cortical organization","volume":"22","author":"Huntenburg","year":"2018","journal-title":"Trends Cogn Sci"},{"key":"2026080312464596900_awaf443-B74","doi-asserted-by":"crossref","first-page":"117322","DOI":"10.1016\/j.neuroimage.2020.117322","article-title":"Toward a connectivity gradient-based framework for reproducible biomarker discovery","volume":"223","author":"Hong","year":"2020","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B75","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s42003-023-05629-w","article-title":"Mapping and comparing fMRI connectivity networks across species","volume":"6","author":"Pagani","year":"2023","journal-title":"Commun Biol"},{"key":"2026080312464596900_awaf443-B76","doi-asserted-by":"crossref","first-page":"117346","DOI":"10.1016\/j.neuroimage.2020.117346","article-title":"Cross-species functional alignment reveals evolutionary hierarchy within the connectome","volume":"223","author":"Xu","year":"2020","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B77","doi-asserted-by":"crossref","first-page":"e3000284","DOI":"10.1371\/journal.pbio.3000284","article-title":"Microstructural and functional gradients are increasingly dissociated in transmodal cortices","volume":"17","author":"Paquola","year":"2019","journal-title":"PLoS Biol."},{"key":"2026080312464596900_awaf443-B78","doi-asserted-by":"crossref","first-page":"e70119","DOI":"10.7554\/eLife.70119","article-title":"The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging","volume":"10","author":"Paquola","year":"2021","journal-title":"Elife"},{"key":"2026080312464596900_awaf443-B79","doi-asserted-by":"crossref","first-page":"106821","DOI":"10.1016\/j.nbd.2025.106821","article-title":"Aberrant functional connectome gradient and its neurotransmitter basis in Parkinson\u2019s disease","volume":"206","author":"Guo","year":"2025","journal-title":"Neurobiol Dis."},{"key":"2026080312464596900_awaf443-B80","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jad.2024.11.003","article-title":"Cognition-related connectome gradient dysfunctions of thalamus and basal ganglia in drug-na\u00efve first-episode major depressive disorder","volume":"370","author":"Zhang","year":"2025","journal-title":"J Affect Disord"},{"key":"2026080312464596900_awaf443-B81","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/s41380-022-01519-5","article-title":"Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes","volume":"27","author":"Xia","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2026080312464596900_awaf443-B82","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1038\/s41467-024-49300-2","article-title":"Tau follows principal axes of functional and structural brain organization in Alzheimer\u2019s disease","volume":"15","author":"Ottoy","year":"2024","journal-title":"Nat Commun"},{"key":"2026080312464596900_awaf443-B83","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12883-014-0204-1","article-title":"The Cambridge centre for ageing and neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing","volume":"14","author":"Shafto","year":"2014","journal-title":"BMC Neurol."},{"key":"2026080312464596900_awaf443-B84","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.neuroimage.2015.09.018","article-title":"The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository: Structural and functional MRI, MEG, and cognitive data from a cross-sectional adult lifespan sample","volume":"144","author":"Taylor","year":"2017","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B85","doi-asserted-by":"crossref","first-page":"12641","DOI":"10.1073\/pnas.1717374114","article-title":"Converging evidence for the role of transmodal cortex in cognition","volume":"114","author":"Margulies","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026080312464596900_awaf443-B86","doi-asserted-by":"crossref","first-page":"12821","DOI":"10.1073\/pnas.1710521114","article-title":"Default mode contributions to automated information processing","volume":"114","author":"Vatansever","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026080312464596900_awaf443-B87","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1073\/pnas.1705120114","article-title":"Brain network dynamics are hierarchically organized in time","volume":"114","author":"Vidaurre","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026080312464596900_awaf443-B88","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The brain\u2019s default mode network","volume":"38","author":"Raichle","year":"2015","journal-title":"Annu Rev Neurosci."},{"key":"2026080312464596900_awaf443-B89","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026080312464596900_awaf443-B90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cortex.2020.06.013","article-title":"Activity in the fronto-parietal multiple-demand network is robustly associated with individual differences in working memory and fluid intelligence","volume":"131","author":"Assem","year":"2020","journal-title":"Cortex"},{"key":"2026080312464596900_awaf443-B91","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tics.2010.01.004","article-title":"The multiple-demand (MD) system of the primate brain: Mental programs for intelligent behaviour","volume":"14","author":"Duncan","year":"2010","journal-title":"Trends Cogn Sci."},{"key":"2026080312464596900_awaf443-B92","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41562-017-0282-3","article-title":"Fluid intelligence is supported by the multiple-demand system not the language system","volume":"2","author":"Woolgar","year":"2018","journal-title":"Nat Hum Behav"},{"key":"2026080312464596900_awaf443-B93","author":"Wang"},{"key":"2026080312464596900_awaf443-B94","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"key":"2026080312464596900_awaf443-B95","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jneumeth.2014.04.023","article-title":"Exploration of scanning effects in multi-site structural MRI studies","volume":"230","author":"Chen","year":"2014","journal-title":"J Neurosci Methods"},{"key":"2026080312464596900_awaf443-B96","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B97","first-page":"392","article-title":"Symbolic description of factorial models for analysis of variance","volume":"22","author":"Wilkinson","year":"1973","journal-title":"J R Stat Soc Ser C Appl Stat"},{"key":"2026080312464596900_awaf443-B98","doi-asserted-by":"crossref","first-page":"103253","DOI":"10.1016\/j.nicl.2022.103253","article-title":"Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study","volume":"36","author":"Tsvetanov","year":"2022","journal-title":"Neuroimage Clin"},{"key":"2026080312464596900_awaf443-B99","volume-title":"Multiple regression: Testing and interpreting interactions","author":"Aiken","year":"1991"},{"key":"2026080312464596900_awaf443-B100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10869-013-9308-7","article-title":"Moderation in management research: What, why, when, and how","volume":"29","author":"Dawson","year":"2014","journal-title":"J Bus Psychol"},{"key":"2026080312464596900_awaf443-B101","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1037\/0021-9010.91.4.917","article-title":"Probing three-way interactions in moderated multiple regression: Development and application of a slope difference test","volume":"91","author":"Dawson","year":"2006","journal-title":"J Appl Psychol"},{"key":"2026080312464596900_awaf443-B102","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/s41562-021-01082-z","article-title":"Mapping gene transcription and neurocognition across human neocortex","volume":"5","author":"Hansen","year":"2021","journal-title":"Nat Hum Behav"},{"key":"2026080312464596900_awaf443-B103","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1038\/s41467-020-17051-5","article-title":"Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders","volume":"11","author":"Seidlitz","year":"2020","journal-title":"Nat Commun"},{"key":"2026080312464596900_awaf443-B104","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.neuroimage.2018.05.070","article-title":"On testing for spatial correspondence between maps of human brain structure and function","volume":"178","author":"Alexander-Bloch","year":"2018","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B105","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1038\/s41467-021-22862-1","article-title":"Overcoming false-positive gene-category enrichment in the analysis of spatially resolved transcriptomic brain atlas data","volume":"12","author":"Fulcher","year":"2021","journal-title":"Nat Commun"},{"key":"2026080312464596900_awaf443-B106","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41583-022-00601-9","article-title":"Null models in network neuroscience","volume":"23","author":"V\u00e1\u0161a","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"2026080312464596900_awaf443-B107","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41586-021-04369-3","article-title":"A human brain vascular atlas reveals diverse mediators of Alzheimer\u2019s risk","volume":"603","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"2026080312464596900_awaf443-B108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cortex.2014.11.019","article-title":"A purely confirmatory replication study of structural brain-behavior correlations","volume":"66","author":"Boekel","year":"2015","journal-title":"Cortex"},{"key":"2026080312464596900_awaf443-B109","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.neubiorev.2006.07.001","article-title":"Differential aging of the brain: Patterns, cognitive correlates and modifiers","volume":"30","author":"Raz","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"2026080312464596900_awaf443-B110","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jalz.2018.07.219","article-title":"Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance","volume":"16","author":"Stern","year":"2020","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B111","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1002\/hbm.26025","article-title":"Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects","volume":"43","author":"Liu","year":"2022","journal-title":"Hum Brain Mapp"},{"key":"2026080312464596900_awaf443-B112","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.1002\/alz.14299","article-title":"Frontoparietal network integrity supports cognitive function despite atrophy and hypoperfusion in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure and perfusion","volume":"20","author":"Liu","year":"2024","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B113","volume-title":"Neuroglia: Function and pathology","author":"Verkhratsky","year":"2023"},{"key":"2026080312464596900_awaf443-B114","doi-asserted-by":"crossref","first-page":"106054","DOI":"10.1016\/j.nbd.2023.106054","article-title":"Astroglia support, regulate and reinforce brain barriers","volume":"179","author":"Verkhratsky","year":"2023","journal-title":"Neurobiol Dis"},{"key":"2026080312464596900_awaf443-B115","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.tins.2024.02.008","article-title":"Astrocytes in selective vulnerability to neurodegenerative disease","volume":"47","author":"Zimmer","year":"2024","journal-title":"Trends Neurosci"},{"key":"2026080312464596900_awaf443-B116","doi-asserted-by":"crossref","first-page":"742065","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: From understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front Neurosci"},{"key":"2026080312464596900_awaf443-B117","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/brain\/awaa088","article-title":"Microglial activation and tau burden predict cognitive decline in Alzheimer\u2019s disease","volume":"143","author":"Malpetti","year":"2020","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B118","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1093\/brain\/awad078","article-title":"Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia","volume":"146","author":"Malpetti","year":"2023","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B119","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13024-024-00719-7","article-title":"The concept of resilience to Alzheimer\u2019s disease: Current definitions and cellular and molecular mechanisms","volume":"19","author":"de Vries","year":"2024","journal-title":"Mol Neurodegener"},{"key":"2026080312464596900_awaf443-B120","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1038\/s41380-024-02644-z","article-title":"Neuroglia in cognitive reserve","volume":"29","author":"Verkhratsky","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2026080312464596900_awaf443-B121","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.3390\/cells11213405","article-title":"A resilience related glial-neurovascular network is transcriptionally activated after chronic social defeat in male mice","volume":"11","author":"Vennin","year":"2022","journal-title":"Cells"},{"key":"2026080312464596900_awaf443-B122","doi-asserted-by":"crossref","first-page":"17757","DOI":"10.1073\/pnas.1010459107","article-title":"Regional aerobic glycolysis in the human brain","volume":"107","author":"Vaishnavi","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026080312464596900_awaf443-B123","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41593-022-01186-3","article-title":"Mapping neurotransmitter systems to the structural and functional organization of the human neocortex","volume":"25","author":"Hansen","year":"2022","journal-title":"Nat Neurosci"},{"key":"2026080312464596900_awaf443-B124","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/alz.12004","article-title":"Tracking disease progression in familial and sporadic frontotemporal lobar degeneration: Recent findings from ARTFL and LEFFTDS","volume":"16","author":"Rosen","year":"2020","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B126","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/s41591-022-01942-9","article-title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia","volume":"28","author":"Staffaroni","year":"2022","journal-title":"Nat Med"},{"key":"2026080312464596900_awaf443-B127","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41380-023-02324-4","article-title":"Clarity on the blazing trail: Clearing the way for amyloid-removing therapies for Alzheimer\u2019s disease","volume":"29","author":"Lian","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2026080312464596900_awaf443-B128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.conb.2019.06.004","article-title":"Vascular and neural basis of the BOLD signal","volume":"58","author":"Drew","year":"2019","journal-title":"Curr Opin Neurobiol"},{"key":"2026080312464596900_awaf443-B129","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature06976","article-title":"What we can do and what we cannot do with fMRI","volume":"453","author":"Logothetis","year":"2008","journal-title":"Nature"},{"key":"2026080312464596900_awaf443-B130","doi-asserted-by":"crossref","first-page":"e70043","DOI":"10.1002\/hbm.70043","article-title":"Evaluating models of the ageing BOLD response","volume":"45","author":"Henson","year":"2024","journal-title":"Hum Brain Mapp"},{"key":"2026080312464596900_awaf443-B131","volume-title":"Psychophysiology","author":"Tsvetanov","year":"2021"},{"key":"2026080312464596900_awaf443-B132","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/hbm.22768","article-title":"The effect of ageing on fMRI: Correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG in 335 adults","volume":"36","author":"Tsvetanov","year":"2015","journal-title":"Hum Brain Mapp."},{"key":"2026080312464596900_awaf443-B133","doi-asserted-by":"crossref","first-page":"e213677","DOI":"10.1212\/WNL.0000000000213677","article-title":"Cerebrovascular reactivity at rest and its association with cognitive function in people with genetic frontotemporal dementia","volume":"106","author":"Kancheva","year":"2025","journal-title":"Neurology"},{"key":"2026080312464596900_awaf443-B134","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neurobiolaging.2020.08.007","article-title":"Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer\u2019s disease","volume":"96","author":"Millar","year":"2020","journal-title":"Neurobiol Aging."},{"key":"2026080312464596900_awaf443-B135","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.neuroimage.2019.01.041","article-title":"Patterns of functional connectivity in an aging population: The Rotterdam study","volume":"189","author":"Zonneveld","year":"2019","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B136","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroimage.2014.07.067","article-title":"Changes in structural and functional connectivity among resting-state networks across the human lifespan","volume":"102","author":"Betzel","year":"2014","journal-title":"Neuroimage"},{"key":"2026080312464596900_awaf443-B137","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1073\/pnas.1415122111","article-title":"Decreased segregation of brain systems across the healthy adult lifespan","volume":"111","author":"Chan","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080312464596900_awaf443-B138","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhu012","article-title":"A brain-wide study of age-related changes in functional connectivity","volume":"25","author":"Geerligs","year":"2015","journal-title":"Cerebral Cortex"},{"key":"2026080312464596900_awaf443-B139","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/hbm.22175","article-title":"Reduced specificity of functional connectivity in the aging brain during task performance","volume":"35","author":"Geerligs","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"2026080312464596900_awaf443-B140","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neurobiolaging.2023.11.009","article-title":"Does functional system segregation mediate the effects of lifestyle on cognition in older adults?","volume":"134","author":"Raykov","year":"2024","journal-title":"Neurobiol Aging"},{"key":"2026080312464596900_awaf443-B141","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1016\/j.neurobiolaging.2015.07.028","article-title":"Idiosyncratic responding during movie-watching predicted by age differences in attentional control","volume":"36","author":"Campbell","year":"2015","journal-title":"Neurobiol Aging"},{"key":"2026080312464596900_awaf443-B142","doi-asserted-by":"crossref","first-page":"14743","DOI":"10.1038\/ncomms14743","article-title":"Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity","volume":"8","author":"Samu","year":"2017","journal-title":"Nat Commun."},{"key":"2026080312464596900_awaf443-B143","first-page":"e12208","article-title":"A profile of brain reserve in adults at genetic risk of Alzheimer\u2019s disease","volume":"13","author":"Coughlan","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B144","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/jnnp-2019-320439","article-title":"Education modulates brain maintenance in presymptomatic frontotemporal dementia","volume":"90","author":"Gazzina","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026080312464596900_awaf443-B145","doi-asserted-by":"crossref","first-page":"881","DOI":"10.14283\/jpad.2024.140","article-title":"Left frontoparietal control network connectivity moderates the effect of amyloid on cognitive decline in preclinical Alzheimer\u2019s disease: The A4 study","volume":"11","author":"Boyle","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"2026080312464596900_awaf443-B146","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/cercor\/bhm155","article-title":"Que PASA? The posterior-anterior shift in aging","volume":"18","author":"Davis","year":"2008","journal-title":"Cerebral Cortex"},{"key":"2026080312464596900_awaf443-B147","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1037\/0882-7974.17.1.85","article-title":"Hemispheric asymmetry reduction in older adults: The HAROLD model","volume":"17","author":"Cabeza","year":"2002","journal-title":"Psychol Aging"},{"key":"2026080312464596900_awaf443-B148","first-page":"391","article-title":"Neuroplasticity and cognitive aging: The scaffolding theory of aging and cognition","volume":"27","author":"Goh","year":"2009","journal-title":"Restor Neurol Neurosci"},{"key":"2026080312464596900_awaf443-B149","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.psych.59.103006.093656","article-title":"The adaptive brain: Aging and neurocognitive scaffolding","volume":"60","author":"Park","year":"2009","journal-title":"Annu Rev Psychol"},{"key":"2026080312464596900_awaf443-B150","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/cercor\/bhr025","article-title":"Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging","volume":"21","author":"Mormino","year":"2011","journal-title":"Cereb Cortex"},{"key":"2026080312464596900_awaf443-B151","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/archneurol.2011.202","article-title":"Divergent network connectivity changes in healthy APOE \u03b54 carriers: Disinhibition or compensation?","volume":"68","author":"Seeley","year":"2011","journal-title":"Arch Neurol"},{"key":"2026080312464596900_awaf443-B152","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer\u2019s disease: What are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2026080312464596900_awaf443-B153","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1038\/s41467-021-22742-8","article-title":"Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer\u2019s disease","volume":"12","author":"Lauterborn","year":"2021","journal-title":"Nat Commun"},{"key":"2026080312464596900_awaf443-B154","doi-asserted-by":"crossref","first-page":"e77745","DOI":"10.7554\/eLife.77745","article-title":"Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer\u2019s disease continuum","volume":"11","author":"Ng","year":"2022","journal-title":"Elife"},{"key":"2026080312464596900_awaf443-B155","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/brain\/awx022","article-title":"Operationalizing compensation over time in neurodegenerative disease","volume":"140","author":"Gregory","year":"2017","journal-title":"Brain"},{"key":"2026080312464596900_awaf443-B156","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer\u2019s disease","volume":"11","author":"Stern","year":"2012","journal-title":"Lancet Neurol."},{"key":"2026080312464596900_awaf443-B157","doi-asserted-by":"crossref","first-page":"e063263","DOI":"10.1002\/alz.063263","article-title":"International collaboration and the FTD prevention initiative","volume":"18","author":"Russell","year":"2022","journal-title":"Alzheimers Dement"},{"key":"2026080312464596900_awaf443-B158","author":"R Core Team"},{"key":"2026080312464596900_awaf443-B159","author":"Wickham"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf443\/65489601\/awaf443.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/8\/2831\/65489601\/awaf443.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/8\/2831\/65489601\/awaf443.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:47:09Z","timestamp":1785775629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/8\/2831\/8341081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":159,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,11,24]]},"published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf443","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2025,11,24]]}}}