{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:08:05Z","timestamp":1791529685400,"version":"4.3.4"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["WE.03-2022-07"],"award-info":[{"award-number":["WE.03-2022-07"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["WE.09-2022-05"],"award-info":[{"award-number":["WE.09-2022-05"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010573","name":"Dioraphte Foundation","doi-asserted-by":"publisher","award":["09-02-03-00"],"award-info":[{"award-number":["09-02-03-00"]}],"id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association for Frontotemporal Dementia","award":["2009"],"award-info":[{"award-number":["2009"]}]},{"DOI":"10.13039\/501100003246","name":"Netherlands Organization for Scientific Research","doi-asserted-by":"publisher","award":["HCMI 056-13-018"],"award-info":[{"award-number":["HCMI 056-13-018"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"crossref","award":["733051109"],"award-info":[{"award-number":["733051109"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013278","name":"Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"crossref","award":["2019-02248"],"award-info":[{"award-number":["2019-02248"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100022722","name":"Gieskes Strijbis Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022722","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield Project"},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK-CRF2017B-2"],"award-info":[{"award-number":["ARUK-CRF2017B-2"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["20143810"],"award-info":[{"award-number":["20143810"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["529-2014-7504"],"award-info":[{"award-number":["529-2014-7504"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["2019-02248"],"award-info":[{"award-number":["2019-02248"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019-0224"],"award-info":[{"award-number":["2019-0224"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015-02926"],"award-info":[{"award-number":["2015-02926"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02754"],"award-info":[{"award-number":["2018-02754"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish FTD Initiative"},{"name":"Sch\u00f6rling Foundation"},{"DOI":"10.13039\/501100008599","name":"Alzheimer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028950","name":"Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100028950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dementia Foundation"},{"name":"Region Stockholm"},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["733051042"],"award-info":[{"award-number":["733051042"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mady Browaeys Fund"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020951","name":"Fonds de recherche du Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tannenbaum Institute for Science in Sport"},{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["103838"],"award-info":[{"award-number":["103838"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220258"],"award-info":[{"award-number":["220258"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield Project"},{"name":"Cambridge Centre for Frontotemporal Dementia"},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00030\/14"],"award-info":[{"award-number":["MC_UU_00030\/14"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T033371\/1"],"award-info":[{"award-number":["MR\/T033371\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"National Institute for Health Research Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016948","name":"Tau Consortium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI19\/01637"],"award-info":[{"award-number":["PI19\/01637"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2023-00356"],"award-info":[{"award-number":["#2023-00356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Swedish State Support for Clinical Research","doi-asserted-by":"publisher","award":["(#ALFGBG-71320"],"award-info":[{"award-number":["(#ALFGBG-71320"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer Drug Discovery Foundation","doi-asserted-by":"publisher","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AD Strategic Fund"},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-24-1284328-C"],"award-info":[{"award-number":["#ADSF-24-1284328-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019599","name":"European Partnership on Metrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["#22HLT07"],"award-info":[{"award-number":["#22HLT07"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield Project"},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Erling-Persson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Familjen R\u00f6nstr\u00f6ms Stiftelse"},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme"},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield Project"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M008525\/1"],"award-info":[{"award-number":["MR\/M008525\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013790","name":"Brain Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fluid biomarkers to diagnose frontotemporal lobar degeneration (FTLD) are currently lacking. In this study, we aimed to identify proteomic changes in CSF associated with FTLD pathogenesis, focusing on signatures unique to different genetic groups. Additionally, we sought proteins distinguishing FTLD-spectrum disorders from controls.<\/jats:p>\n                  <jats:p>To this end, we measured a comprehensive library of over 2900 proteins in CSF using proximity extension assay technology in two well-characterized FTLD cohorts. The discovery cohort, selected from the GENFI cohort, included 47 symptomatic pathogenic variant carriers (22 C9orf72, 14 GRN, 10 MAPT and 1 TARDBP), 124 presymptomatic pathogenic variant carriers (55 C9orf72, 44 GRN, 24 MAPT and 1 TARDBP) and 57 healthy non-carriers. The validation cohort comprised individuals clinically diagnosed with an FTLD-spectrum disorder (n = 132) and cognitively intact controls (n = 32). We assessed differentially abundant proteins using linear regression, adjusting for age and sex. Over-representation analysis was conducted for the three genetic groups using Gene Ontology Biological Processes as the ontology source. To develop diagnostic tools, we applied a LASSO regression, establishing two types of panels: one to distinguish individuals with an FTLD-spectrum disorder from controls (FTLD panel) and another to differentiate individuals with underlying TDP pathology from controls (TDP panel).<\/jats:p>\n                  <jats:p>We observed 23 dysregulated proteins in symptomatic carriers. Of these, four were also significantly dysregulated (NEFL, TPM3, MSLN and DNM3) in the validation cohort. When focusing on genetic subgroups, 63 upregulated proteins were observed in symptomatic MAPT carriers, with enriched biological pathways linked to immune function. In symptomatic C9orf72 carriers, four proteins\u2014related to energy metabolism\u2014were upregulated. When limiting symptomatic carriers to GRN, six proteins were dysregulated, with enriched pathways involved in neuronal development and projection. Notably, NEFL and TPM3 were consistently significant in all comparisons across both cohorts. We developed two diagnostic panels: one for FTLD and one for FTLD-TDP. The FTLD panel consisted of six proteins (NEFL, RBFOX3, NPTX1, TFF1, ENTPD5 and CNP). The TDP panel was made up of seven proteins (NEFL, RBFOX3, CBLN4, ENTPD5, CCL25, CNP and MMP1). Both panels were successfully replicated in the validation cohort (AUC of 0.94 and 0.96, respectively).<\/jats:p>\n                  <jats:p>This study highlights distinct proteomic signatures across FTLD genetic subgroups and their associated pathologies using a targeted proteomic approach. Additionally, we present two diagnostic panels\u2014comprising both established and novel proteins\u2014that effectively differentiate individuals with FTLD-spectrum disorders from healthy controls, offering promising avenues for improved clinical diagnosis.<\/jats:p>","DOI":"10.1093\/brain\/awaf457","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:50:48Z","timestamp":1764679848000},"page":"2816-2830","source":"Crossref","is-referenced-by-count":2,"title":["Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration"],"prefix":"10.1093","volume":"149","author":[{"given":"Julie F H","family":"De Houwer","sequence":"first","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise G","family":"Dopper","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"van Buuren","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Stokkel","sequence":"additional","affiliation":[{"name":"Neurodegeneration, Amsterdam Neuroscience , Amsterdam 1081 HV ,","place":["The Netherlands"]},{"name":"Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam 1081 HV ,","place":["The Netherlands"]},{"name":"Alzheimer Center Amsterdam, Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam 1081 HV ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liset","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Swartenbroekx","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam A","family":"Boesjes","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6399-8170","authenticated-orcid":false,"given":"Ana","family":"Rajicic","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitana","family":"Sogorb-Esteve","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]},{"name":"UK Dementia Research Institute at University College London , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8590","authenticated-orcid":false,"given":"Arabella","family":"Bouzigues","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy L","family":"Russell","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe H","family":"Foster","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Ferry-Bolder","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-1858","authenticated-orcid":false,"given":"Lize C","family":"Jiskoot","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-896X","authenticated-orcid":false,"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Institut d\u2019Investigaci\u00f3ns Biom\u00e8diques August Pi I Sunyer, University of Barcelona , Barcelona 08036 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Laforce","sequence":"additional","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire, D\u00e9partement des Sciences Neurologiques, CHU de Qu\u00e9bec, and Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Qu\u00e9bec, QC , G1V 4G2","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-2951","authenticated-orcid":false,"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet , Solna 171 65 ,","place":["Sweden"]},{"name":"Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital , Solna 171 76 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan , Milan 20122 ,","place":["Italy"]},{"name":"Neurodegenerative Diseases Unit, Fondazione IRCCS Ospedale Maggiore Policlinico , Milan 20122 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2502","authenticated-orcid":false,"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven , Leuven 3000 ,","place":["Belgium"]},{"name":"Neurology Service, University Hospitals Leuven , Leuven 3000 ,","place":["Belgium"]},{"name":"Leuven Brain Institute, KU Leuven , Leuven 3000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon , Lisbon 1649-028 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta , Milano 20133 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"Neurology Service, Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra , Coimbra 3004-531 ,","place":["Portugal"]},{"name":"Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra , Coimbra 3004-504 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-6062","authenticated-orcid":false,"given":"Alexander","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester , Manchester M20 3LJ ,","place":["UK"]},{"name":"Department of Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen , Essen 45147 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen , Munich 80802 ,","place":["Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) , Munich 81377 ,","place":["Germany"]},{"name":"Munich Cluster of Systems Neurology (SyNergy) , Munich 81377 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[{"name":"Department of Neurofarba, University of Florence , Florence 50139 ,","place":["Italy"]},{"name":"IRCCS Fondazione Don Carlo Gnocchi , Florence 50139 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm , Ulm 45 89081 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-503X","authenticated-orcid":false,"given":"Maxime","family":"Bertoux","sequence":"additional","affiliation":[{"name":"Lille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Lebouvier","sequence":"additional","affiliation":[{"name":"Lille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-1113","authenticated-orcid":false,"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Department of Psychiatry, McGill University , Montreal, QC , H4H 1R3","place":["Canada"]},{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , Montreal, QC , H4H 1R3","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-9284","authenticated-orcid":false,"given":"Chris R","family":"Butler","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford , Oxford OX3 7JX ,","place":["UK"]},{"name":"Department of Brain Sciences, Imperial College London , London SW7 2AZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Le Ber","sequence":"additional","affiliation":[{"name":"Paris Brain Institute \u2013 Institut du Cerveau \u2013 ICM, Inserm U1127, CNRS UMR 7225, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9 , Paris 75013 ,","place":["France"]},{"name":"Centre de r\u00e9f\u00e9rence des d\u00e9mences rares ou pr\u00e9coces, IM2A, D\u00e9partement de Neurologie, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris 75013 ,","place":["France"]},{"name":"D\u00e9partement de Neurologie, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-7427","authenticated-orcid":false,"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, University of Western Ontario , London, ON , N6A 3K7","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto , Toronto, ON , M5G 1E8","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto , Toronto, ON , M4N 3M5","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB2 3EB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of T\u00fcbingen , T\u00fcbingen 72076 ,","place":["Germany"]},{"name":"Center for Neurodegenerative Diseases (DZNE) , T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia , San Sebastian 20014 ,","place":["Spain"]},{"name":"Neurosciences Area, Group of Neurodegenerative Diseases, Biogipuzkoa Health Research Institute , San Sebastian 20014 ,","place":["Spain"]},{"name":"Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Carlos III Health Institute , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9814","authenticated-orcid":false,"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia , Brescia 15-25121 ,","place":["Italy"]},{"name":"Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli , Brescia 15-25125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , M\u00f6lndal 405 30 ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , M\u00f6lndal 413 45 ,","place":["Sweden"]},{"name":"Hong Kong Center for Neurodegenerative Diseases , Clear Water Bay, Hong Kong 999 077 ,","place":["China"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison , Madison, WI 53726 ,","place":["USA"]},{"name":"Centre for Brain Research, Indian Institute of Science , Bangalore 560012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London , London WC1N 3AR ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-1797","authenticated-orcid":false,"given":"Betty M","family":"Tijms","sequence":"additional","affiliation":[{"name":"Neurodegeneration, Amsterdam Neuroscience , Amsterdam 1081 HV ,","place":["The Netherlands"]},{"name":"Alzheimer Center Amsterdam, Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam 1081 HV ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A L","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Neurodegeneration, Amsterdam Neuroscience , Amsterdam 1081 HV ,","place":["The Netherlands"]},{"name":"Alzheimer Center Amsterdam, Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam 1081 HV ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurodegeneration, Amsterdam Neuroscience , Amsterdam 1081 HV ,","place":["The Netherlands"]},{"name":"Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam 1081 HV ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-7527","authenticated-orcid":false,"given":"Harro","family":"Seelaar","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GENFI Consortium Members","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian","family":"Convery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Samra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Alberici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Buratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Borracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Serpente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Carandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Rotondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giaccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Di","family":"Fede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tang-Wai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen","family":"Shoesmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robart","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Poos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M","family":"Papma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fainardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Chiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Viklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Taheri","family":"Rydell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbe","family":"Ullgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rodriguez-Vieitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Langheinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Antonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Bargall\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Borrego-Ecija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Costa-Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Miltenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Sim\u00f5es do","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alazne","family":"Gabilondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Croitoru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Tainta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Barandiaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Vogels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Poesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Montembault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella Lara","family":"Migliaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninon","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Sch\u00f6necker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Maximilian","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stockbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolina","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Anderl-Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Rollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Dur\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jo\u00e3o","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosario","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"T\u00e1buas-Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3nia","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"2026080312470283600_awaf457-B1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nrneurol.2017.75","article-title":"Imaging and fluid biomarkers in frontotemporal dementia","volume":"13","author":"Meeter","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"2026080312470283600_awaf457-B2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41572-023-00447-0","article-title":"Frontotemporal lobar degeneration","volume":"9","author":"Grossman","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"2026080312470283600_awaf457-B3","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"2026080312470283600_awaf457-B4","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"2026080312470283600_awaf457-B5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"key":"2026080312470283600_awaf457-B6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria","volume":"32","author":"H\u00f6glinger","year":"2017","journal-title":"Mov Disord"},{"key":"2026080312470283600_awaf457-B7","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/nrdp.2017.71","article-title":"Amyotrophic lateral sclerosis","volume":"3","author":"Hardiman","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"Suppl 1","key":"2026080312470283600_awaf457-B8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/jnc.13588","article-title":"Molecular neuropathology of frontotemporal dementia: Insights into disease mechanisms from postmortem studies","volume":"138","author":"Mackenzie","year":"2016","journal-title":"J Neurochem"},{"key":"2026080312470283600_awaf457-B9","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia","volume":"266","author":"Greaves","year":"2019","journal-title":"J Neurol"},{"key":"2026080312470283600_awaf457-B10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/acn3.325","article-title":"Neurofilament light chain: A biomarker for genetic frontotemporal dementia","volume":"3","author":"Meeter","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"key":"2026080312470283600_awaf457-B11","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S1474-4422(19)30354-0","article-title":"Serum neurofilament light chain in genetic frontotemporal dementia: A longitudinal, multicentre cohort study","volume":"18","author":"van der Ende","year":"2019","journal-title":"Lancet Neurol"},{"key":"2026080312470283600_awaf457-B12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00415-019-09567-8","article-title":"Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders","volume":"267","author":"Katisko","year":"2020","journal-title":"J Neurol"},{"key":"2026080312470283600_awaf457-B13","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1038\/s41467-021-23620-z","article-title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","volume":"12","author":"Ashton","year":"2021","journal-title":"Nat Commun"},{"key":"2026080312470283600_awaf457-B14","doi-asserted-by":"crossref","first-page":"e2296","DOI":"10.1212\/WNL.0000000000011848","article-title":"Plasma neurofilament light for prediction of disease progression in familial frontotemporal lobar degeneration","volume":"96","author":"Rojas","year":"2021","journal-title":"Neurology"},{"key":"2026080312470283600_awaf457-B15","doi-asserted-by":"crossref","first-page":"e1069","DOI":"10.1212\/WNL.0000000000207581","article-title":"Clinical value of longitudinal serum neurofilament light chain in prodromal genetic frontotemporal dementia","volume":"101","author":"Giannini","year":"2023","journal-title":"Neurology"},{"key":"2026080312470283600_awaf457-B16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jamaneurol.2019.1534","article-title":"Diagnostic value of cerebrospinal fluid neurofilament light protein in neurology: A systematic review and meta-analysis","volume":"76","author":"Bridel","year":"2019","journal-title":"JAMA Neurol"},{"key":"2026080312470283600_awaf457-B17","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/s41591-024-02937-4","article-title":"Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS","volume":"30","author":"Chatterjee","year":"2024","journal-title":"Nat Med"},{"key":"2026080312470283600_awaf457-B18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40035-020-00198-y","article-title":"Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers","volume":"9","author":"Remnest\u00e5l","year":"2020","journal-title":"Transl Neurodegener"},{"key":"2026080312470283600_awaf457-B19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13024-021-00499-4","article-title":"A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: A GENFI study","volume":"16","author":"Bergstr\u00f6m","year":"2021","journal-title":"Mol Neurodegener"},{"key":"2026080312470283600_awaf457-B20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13024-023-00677-6","article-title":"Altered plasma protein profiles in genetic FTD - a GENFI study","volume":"18","author":"Ullgren","year":"2023","journal-title":"Mol Neurodegener"},{"key":"2026080312470283600_awaf457-B21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/acn3.745","article-title":"Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics","volume":"6","author":"van der Ende","year":"2019","journal-title":"Ann Clin Transl Neurol"},{"key":"2026080312470283600_awaf457-B22","doi-asserted-by":"crossref","first-page":"eadm9654","DOI":"10.1126\/scitranslmed.adm9654","article-title":"Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia subtypes","volume":"17","author":"Sogorb-Esteve","year":"2025","journal-title":"Sci Transl Med"},{"key":"2026080312470283600_awaf457-B23","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/jnnp-2019-322493","article-title":"Neuronal pentraxin 2: A synapse-derived CSF biomarker in genetic frontotemporal dementia","volume":"91","author":"van der Ende","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026080312470283600_awaf457-B24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13195-022-01042-3","article-title":"Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia","volume":"14","author":"Sogorb-Esteve","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"2026080312470283600_awaf457-B25","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/s43587-022-00300-1","article-title":"CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels","volume":"2","author":"Del Campo","year":"2022","journal-title":"Nat Aging"},{"key":"2026080312470283600_awaf457-B26","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1093\/brain\/awad213","article-title":"CSF proteomics in autosomal dominant Alzheimer's disease highlights parallels with sporadic disease","volume":"146","author":"van der Ende","year":"2023","journal-title":"Brain"},{"key":"2026080312470283600_awaf457-B27","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s43587-025-00878-2","article-title":"Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration","volume":"5","author":"Saloner","year":"2025","journal-title":"Nat Aging"},{"key":"2026080312470283600_awaf457-B28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13024-025-00882-5","article-title":"Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia","volume":"20","author":"Hok","year":"2025","journal-title":"Mol Neurodegener"},{"key":"2026080312470283600_awaf457-B29","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3233\/JAD-170850","article-title":"Amsterdam dementia cohort: Performing research to optimize care","volume":"62","author":"van der Flier","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2026080312470283600_awaf457-B30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2217\/bmm.12.46","article-title":"Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: An update","volume":"6","author":"del Campo","year":"2012","journal-title":"Biomark Med"},{"key":"2026080312470283600_awaf457-B31"},{"key":"2026080312470283600_awaf457-B32","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/s41593-024-01737-w","article-title":"Proteomic changes in Alzheimer's disease associated with progressive A\u03b2 plaque and tau tangle pathologies","volume":"27","author":"Pichet Binette","year":"2024","journal-title":"Nat Neurosci"},{"key":"2026080312470283600_awaf457-B33","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s43587-023-00478-y","article-title":"DOPA decarboxylase is an emerging biomarker for parkinsonian disorders including preclinical Lewy body disease","volume":"3","author":"Pereira","year":"2023","journal-title":"Nat Aging"},{"key":"2026080312470283600_awaf457-B34","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1093\/bioinformatics\/btab501","article-title":"Stable iterative variable selection","volume":"37","author":"Mahmoudian","year":"2021","journal-title":"Bioinformatics"},{"key":"2026080312470283600_awaf457-B35","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/acr2.11709","article-title":"Prediction of early adverse events after THA: A comparison of different machine-learning strategies based on 262,356 observations from the nordic arthroplasty register association (NARA) dataset","volume":"6","author":"Ven\u00e4l\u00e4inen","year":"2024","journal-title":"ACR Open Rheumatol"},{"key":"2026080312470283600_awaf457-B36","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"2026080312470283600_awaf457-B37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: An open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2026080312470283600_awaf457-B38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13395-023-00327-x","article-title":"Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy","volume":"13","author":"Lambert","year":"2023","journal-title":"Skelet Muscle"},{"key":"2026080312470283600_awaf457-B39","doi-asserted-by":"crossref","first-page":"2371970","DOI":"10.1155\/2016\/2371970","article-title":"Regulation of the postsynaptic compartment of excitatory synapses by the actin cytoskeleton in health and its disruption in disease","volume":"2016","author":"Stefen","year":"2016","journal-title":"Neural Plast"},{"key":"2026080312470283600_awaf457-B40","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3390\/cells10030715","article-title":"Deletion of the actin-associated tropomyosin Tpm3 leads to reduced cell complexity in cultured hippocampal neurons-new insights into the role of the C-terminal region of Tpm3.1","volume":"10","author":"Tomani\u0107","year":"2021","journal-title":"Cells"},{"key":"2026080312470283600_awaf457-B41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13024-023-00657-w","article-title":"A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls","volume":"18","author":"Pes\u00e4maa","year":"2023","journal-title":"Mol Neurodegener"},{"key":"2026080312470283600_awaf457-B42","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41582-019-0231-z","article-title":"Neuroinflammation in frontotemporal dementia","volume":"15","author":"Bright","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"2026080312470283600_awaf457-B43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/jnnp-2020-323698","article-title":"In vivo PET imaging of neuroinflammation in familial frontotemporal dementia","volume":"92","author":"Malpetti","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026080312470283600_awaf457-B44","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s12035-024-04315-0","article-title":"The link between matrix metalloproteinases and Alzheimer's disease pathophysiology","volume":"62","author":"Radosinska","year":"2024","journal-title":"Mol Neurobiol"},{"key":"2026080312470283600_awaf457-B45","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3233\/JAD-143186","article-title":"Matrix metalloproteinases in Alzheimer's disease and concurrent cerebral microbleeds","volume":"48","author":"Duits","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"2026080312470283600_awaf457-B46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3233\/JAD-201565","article-title":"Different inflammatory signatures in Alzheimer's disease and frontotemporal dementia cerebrospinal fluid","volume":"81","author":"Bostr\u00f6m","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"2026080312470283600_awaf457-B47","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1093\/brain\/awac024","article-title":"Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type","volume":"145","author":"Martino Adami","year":"2022","journal-title":"Brain"},{"key":"2026080312470283600_awaf457-B48","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/jnnp-2018-320151","article-title":"Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes","volume":"90","author":"Jabbari","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026080312470283600_awaf457-B49","doi-asserted-by":"crossref","first-page":"14606","DOI":"10.3390\/ijms232314606","article-title":"Emerging roles for the RNA-binding protein HuD (ELAVL4) in nervous system diseases","volume":"23","author":"Silvestri","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026080312470283600_awaf457-B50","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41431-023-01456-z","article-title":"The molecular genetics of nELAVL in brain development and disease","volume":"31","author":"Mulligan","year":"2023","journal-title":"Eur J Hum Genet"},{"key":"2026080312470283600_awaf457-B51","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1016\/j.celrep.2019.05.085","article-title":"Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in amyotrophic lateral sclerosis","volume":"27","author":"De Santis","year":"2019","journal-title":"Cell Rep"},{"key":"2026080312470283600_awaf457-B52","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s42003-021-02538-8","article-title":"ALS-related FUS mutations alter axon growth in motoneurons and affect HuD\/ELAVL4 and FMRP activity","volume":"4","author":"Garone","year":"2021","journal-title":"Commun Biol"},{"key":"2026080312470283600_awaf457-B53","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1038\/s41467-024-54004-8","article-title":"Hud impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models","volume":"15","author":"Silvestri","year":"2024","journal-title":"Nat Commun"},{"key":"2026080312470283600_awaf457-B54","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1016\/j.cell.2021.07.003","article-title":"ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids","volume":"184","author":"Bowles","year":"2021","journal-title":"Cell"},{"key":"2026080312470283600_awaf457-B55","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s12035-015-9122-5","article-title":"Novel insights into NeuN: From neuronal marker to splicing regulator","volume":"53","author":"Duan","year":"2016","journal-title":"Mol Neurobiol"},{"key":"2026080312470283600_awaf457-B56","doi-asserted-by":"crossref","first-page":"672891","DOI":"10.3389\/fnsyn.2021.672891","article-title":"Semaphorins in adult nervous system plasticity and disease","volume":"13","author":"Carulli","year":"2021","journal-title":"Front Synaptic Neurosci"},{"key":"2026080312470283600_awaf457-B57","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.neuron.2018.12.036","article-title":"Endothelium-derived semaphorin 3G regulates hippocampal synaptic structure and plasticity via neuropilin-2\/PlexinA4","volume":"101","author":"Tan","year":"2019","journal-title":"Neuron"},{"key":"2026080312470283600_awaf457-B58","doi-asserted-by":"crossref","first-page":"E10235","DOI":"10.1073\/pnas.1811086115","article-title":"Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs","volume":"115","author":"Seigneur","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080312470283600_awaf457-B59","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.aau8977","article-title":"Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits","volume":"363","author":"Favuzzi","year":"2019","journal-title":"Science"},{"key":"2026080312470283600_awaf457-B60","doi-asserted-by":"crossref","first-page":"e2123421119","DOI":"10.1073\/pnas.2123421119","article-title":"Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus","volume":"119","author":"Liakath-Ali","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080312470283600_awaf457-B61","doi-asserted-by":"crossref","first-page":"340","DOI":"10.14740\/wjon1655","article-title":"Biology of mesothelin and clinical implications: A review of existing literature","volume":"14","author":"Hagerty","year":"2023","journal-title":"World J Oncol"},{"key":"2026080312470283600_awaf457-B62","doi-asserted-by":"crossref","first-page":"6822","DOI":"10.1038\/s41467-021-27164-0","article-title":"Synergistic insights into human health from aptamer- and antibody-based proteomic profiling","volume":"12","author":"Pietzner","year":"2021","journal-title":"Nat Commun"},{"key":"2026080312470283600_awaf457-B63","doi-asserted-by":"crossref","first-page":"eabm5164","DOI":"10.1126\/sciadv.abm5164","article-title":"Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods","volume":"8","author":"Katz","year":"2022","journal-title":"Sci Adv"},{"key":"2026080312470283600_awaf457-B64","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41593-022-01124-3","article-title":"Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex","volume":"25","author":"Gerrits","year":"2022","journal-title":"Nat Neurosci"},{"key":"2026080312470283600_awaf457-B65","doi-asserted-by":"crossref","first-page":"e12326","DOI":"10.1002\/trc2.12326","article-title":"Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort study","volume":"8","author":"Benussi","year":"2022","journal-title":"Alzheimers Dement (N Y)"},{"key":"2026080312470283600_awaf457-B66","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1038\/s41467-025-59216-0","article-title":"Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing","volume":"16","author":"Pottier","year":"2025","journal-title":"Nat Commun"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaf457\/65752716\/awaf457.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/8\/2816\/65752716\/awaf457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/8\/2816\/65752716\/awaf457.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:47:26Z","timestamp":1785775646000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/8\/2816\/8367784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,12,4]]},"published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaf457","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2025,12,4]]}}}