{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:50:23Z","timestamp":1789023023340,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["DFD-181599"],"award-info":[{"award-number":["DFD-181599"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS134805"],"award-info":[{"award-number":["R01NS134805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21NS128604"],"award-info":[{"award-number":["R21NS128604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM007814-40"],"award-info":[{"award-number":["T32GM007814-40"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS107404"],"award-info":[{"award-number":["R01NS107404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03NS135450"],"award-info":[{"award-number":["R03NS135450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["W81XWH2110908"],"award-info":[{"award-number":["W81XWH2110908"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Program of the National Human Genome Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson's disease is a common multisystem movement disorder characterized by accumulation of neurotoxic Lewy body aggregates, neuronal loss and gliosis of vulnerable populations. The gene encoding \u03b1-synuclein (SNCA) is the greatest genetic risk factor for sporadic Parkinson's disease. Misfolding and overexpression of SNCA (\u03b1-Syn) underlie pathognomonic features of Parkinson's disease, including insoluble Lewy body aggregates and midbrain dopaminergic (mbDA) neurodegeneration. We recently identified an SNCA intronic sequence that harbours variation associated with Parkinson's disease risk and demonstrated its role as a neuronal cis-regulatory element (CRE).<\/jats:p>\n                  <jats:p>CRISPR-mediated engineering was used to establish a mouse model lacking this intronic CRE sequence (SncaEnh+37). Single molecule fluorescent in situ hybridization (smFISH) was used to assess changes on Snca transcription in mbDA neurons. Intrastriatal injection of \u03b1-Syn preformed fibrils was used to seed Parkinson's disease pathology (or PBS vehicle) in these mice. Cohorts of mice harbouring two, one or zero CRE deleted alleles of SncaEnh+37 were evaluated for motor deficits in standard assays (pole descent, rotarod, grip strength). Immunohistochemistry, unbiased stereology and western blotting were employed to evaluate the impact of neuronal integrity, Lewy body acquisition and glial activation in the substantia nigra.<\/jats:p>\n                  <jats:p>Mice deficient in SncaEnh+37 exhibit significantly reduced Snca transcription in mbDA neurons. In animals challenged with intrastriatal delivery of \u03b1-Syn preformed fibrils, SncaEnh+37 deficient animals are largely protected from motor deficits. Further, we demonstrate that mice lacking this Snca enhancer are protected against Parkinson's disease-relevant histopathology, including DA neurodegeneration, Lewy body acquisition and evidence of neuroinflammatory response.<\/jats:p>\n                  <jats:p>By targeting a cell-dependent Snca CRE, we directly reduced the onset, severity and progression of Parkinson's disease pathology in mice. The demonstration that cell-type-dependent modulation of key genes in disease progression can be leveraged to mitigate risk introduces a potentially powerful therapeutic avenue for Parkinson's disease.<\/jats:p>","DOI":"10.1093\/brain\/awag007","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:31:50Z","timestamp":1767702710000},"page":"2668-2679","source":"Crossref","is-referenced-by-count":1,"title":["Neuronal titration of\n                    <i>Snca<\/i>\n                    via enhancer disruption mitigates disease onset in a Parkinson's disease mouse model"],"prefix":"10.1093","volume":"149","author":[{"given":"Rachel J","family":"Boyd","sequence":"first","affiliation":[{"name":"McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Ra","family":"Kho","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]},{"name":"Department of Neurology, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A","family":"McClymont","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie K","family":"Loftus","sequence":"additional","affiliation":[{"name":"Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]},{"name":"Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Seok","family":"Ko","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]},{"name":"Department of Neurology, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S","family":"McCallion","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]},{"name":"Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"2026081101572581100_awag007-B1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","article-title":"The Parkinson pandemic\u2014A call to action","volume":"75","author":"Dorsey","year":"2018","journal-title":"JAMA Neurol"},{"key":"2026081101572581100_awag007-B2","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson\u2019s disease: Substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"2026081101572581100_awag007-B3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2012","journal-title":"Nat Rev 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