{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:34:48Z","timestamp":1787726088444,"version":"build-2784847793"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","award":["RR191051"],"award-info":[{"award-number":["RR191051"]}],"id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"The Michael J. 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Because \u03b1-synuclein is a self-antigen, pathogenic \u03b1-synuclein aggregates do not elicit a strong immune response. Recent advances in structural biology elucidating the structure of \u03b1-synuclein fibrils have allowed us to design engineered protein fibrils that model conformational epitopes present on the surface of \u03b1-synuclein fibrils.<\/jats:p>\n                  <jats:p>HET-s is a soluble fungal protein capable of forming amyloid fibrils. We used HET-s(218-298) fibrils and four modified derivatives, each displaying a selected conformational epitope present on the surface of \u03b1-synuclein fibrils, to vaccinate TgM83+\/\u2212 mice, a model for Parkinson\u2019s disease-like synucleinopathies.<\/jats:p>\n                  <jats:p>Fibrillar vaccine candidates significantly extended the survival of immunized TgM83+\/\u2212 mice by \u226438% after intraperitoneal challenge and \u226442% after intragastric challenge with \u03b1-synuclein fibrils. Fully immunized mice developed antibodies that recognized \u03b1-synuclein fibrils and brain homogenates from patients with dementia with Lewy bodies, multiple system atrophy and Parkinson\u2019s disease.<\/jats:p>\n                  <jats:p>Fibrillar vaccine candidates that mimic conformational epitopes on the surface of pathological \u03b1-synuclein fibrils have the ability to induce immunity and protection against Parkinson\u2019s disease and other synucleinopathies.<\/jats:p>","DOI":"10.1093\/brain\/awag010","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:40:59Z","timestamp":1767789659000},"page":"2689-2701","source":"Crossref","is-referenced-by-count":4,"title":["Vaccines mimicking conformational epitopes on \u03b1-synuclein fibrils provide immunity to Parkinson\u2019s disease"],"prefix":"10.1093","volume":"149","author":[{"given":"Liang","family":"Ma","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, 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