{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:09:35Z","timestamp":1788797375865,"version":"build-2803163510"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032469","name":"Jane Hodge Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/X00922X\/1"],"award-info":[{"award-number":["MR\/X00922X\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["207503\/Z\/17\/Z"],"award-info":[{"award-number":["207503\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002203","name":"Brain Tumour Charity Future Leader Fellow","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"MRC","doi-asserted-by":"publisher","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"MRC","doi-asserted-by":"publisher","award":["MR\/S07709\/1"],"award-info":[{"award-number":["MR\/S07709\/1"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"MRC","doi-asserted-by":"publisher","award":["MR\/X018318\/1"],"award-info":[{"award-number":["MR\/X018318\/1"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infections have long been implicated as causative factors in Alzheimer\u2019s disease (AD). Multiple studies have further suggested a key role for herpesviruses, such as cytomegalovirus (CMV).<\/jats:p>\n                  <jats:p>Using transgenic 3xTg-AD mice, we demonstrate that systemic infection with the \u03b2-herpesvirus murine CMV (MCMV) accelerates the development of cognitive decline, tauopathy and synaptic loss in the hippocampus, all of which are key features of AD.<\/jats:p>\n                  <jats:p>Accelerated disease progression after infection was associated with substantial lymphocyte infiltration into the brain, dominated by MCMV-specific effector memory CD8+ T cells expressing CXCR3. T cell receptor analyses revealed that clonally diverse virus-specific CD8+ T cells were selectively recruited into the brain during the development of AD. T cell depletion or treatment with the antiviral drug valganciclovir during chronic infection reduced lymphocytic infiltrates in the brain and reversed cognitive decline.<\/jats:p>\n                  <jats:p>These data provide a mechanistic link between chronic viral infections and the development of AD.<\/jats:p>","DOI":"10.1093\/brain\/awag043","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:37:22Z","timestamp":1769863042000},"page":"3214-3227","source":"Crossref","is-referenced-by-count":0,"title":["Cytomegalovirus-induced T cell responses accelerate Alzheimer\u2019s disease progression in mice"],"prefix":"10.1093","volume":"149","author":[{"given":"Morgan","family":"Marsden","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW 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CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Somerville","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N","family":"Lauder","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon H","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila-Blythe","family":"Maros","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"McGurk","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-7004","authenticated-orcid":false,"given":"Awen","family":"Gallimore","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-2737","authenticated-orcid":false,"given":"David A","family":"Price","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University , Cardiff CF14 4XN ,","place":["UK"]},{"name":"Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff CF14 4XW 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