{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:52:23Z","timestamp":1775638343401,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01NS104010"],"award-info":[{"award-number":["R01NS104010"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["U01NS124974"],"award-info":[{"award-number":["U01NS124974"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["P50AR085906"],"award-info":[{"award-number":["P50AR085906"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009210","name":"FDA","doi-asserted-by":"publisher","award":["7R01FD006071"],"award-info":[{"award-number":["7R01FD006071"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CCMDHI"},{"name":"CMTHI"},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PepGen"},{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dyne"},{"DOI":"10.13039\/100011022","name":"Vertex Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011022","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fulcrum Therapeutics"},{"name":"AskBio"},{"name":"ML Bio"},{"DOI":"10.13039\/100014943","name":"Sarepta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:p>This scientific commentary refers to \u2018Muscle transcriptomics of alpha-sarcoglycanopathy highlights inflammatory pathways driving disease\u2019 by Amaro et al. (https:\/\/doi.org\/10.1093\/brain\/awaf389).<\/jats:p>","DOI":"10.1093\/brain\/awag079","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:39:14Z","timestamp":1771936754000},"page":"1094-1096","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation at the core: rethinking pathology in limb-girdle muscular dystrophy R3"],"prefix":"10.1093","volume":"149","author":[{"given":"Ellie M","family":"Carrell","sequence":"first","affiliation":[{"name":"Center for Inherited Myology Research, Virginia Commonwealth University , Richmond, VA 23298 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-4257","authenticated-orcid":false,"given":"Nicholas E","family":"Johnson","sequence":"additional","affiliation":[{"name":"Center for Inherited Myology Research, Virginia Commonwealth University , Richmond, VA 23298 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"2026040804035925700_awag079-B1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13023-019-1021-9","article-title":"Clinical and genetic spectrum of sarcoglycanopathies in a large cohort of Chinese patients","volume":"14","author":"Xie","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"2026040804035925700_awag079-B2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/j.2040-4603.2018.tb00051.x","article-title":"Immunobiology of inherited muscular dystrophies","volume":"8","author":"Tidball","year":"2018","journal-title":"Compr Physiol"},{"key":"2026040804035925700_awag079-B3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.5414\/NP301393","article-title":"Muscle inflammatory pattern in alpha- and gamma-sarcoglycanopathies","volume":"40","author":"Panicucci","year":"2021","journal-title":"Clin Neuropathol"},{"key":"2026040804035925700_awag079-B4","article-title":"Muscle transcriptomics of alpha-sarcoglycanopathy highlights inflammatory pathways driving disease","author":"Amaro","journal-title":"Brain"},{"key":"2026040804035925700_awag079-B5","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.3390\/biomedicines10102629","article-title":"Nintedanib reduces muscle fibrosis and improves muscle function of the alpha-sarcoglycan-deficient mice","volume":"10","author":"Alonso-P\u00e9rez","year":"2022","journal-title":"Biomedicines"},{"key":"2026040804035925700_awag079-B6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1474-4422(18)30024-3","article-title":"Diagnosis and management of duchenne muscular dystrophy, part 1: Diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management","volume":"17","author":"Birnkrant","year":"2018","journal-title":"Lancet Neurol"},{"key":"2026040804035925700_awag079-B7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/(SICI)1097-4598(199811)21:11<1549::AID-MUS30>3.0.CO;2-T","article-title":"Primary alpha-sarcoglycan deficiency responsive to immunosuppression over three years","volume":"21","author":"Connolly","year":"1998","journal-title":"Muscle Nerve"},{"key":"2026040804035925700_awag079-B8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/(SICI)1097-4598(199806)21:6<769::AID-MUS9>3.0.CO;2-5","article-title":"Homozygous alpha-sarcoglycan mutation in two siblings: One asymptomatic and one steroid-responsive mild limb-girdle muscular dystrophy patient","volume":"21","author":"Angelini","year":"1998","journal-title":"Muscle Nerve"},{"key":"2026040804035925700_awag079-B9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1590\/0004-282X20140126","article-title":"Clinical aspects of patients with sarcoglycanopathies under steroids therapy","volume":"72","author":"Albuquerque","year":"2014","journal-title":"Arq Neuropsiquiatr"},{"key":"2026040804035925700_awag079-B10","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/jamaneurol.2022.2480","article-title":"Efficacy and safety of vamorolone vs placebo and prednisone among boys with duchenne muscular dystrophy: A randomized clinical trial","volume":"79","author":"Guglieri","year":"2022","journal-title":"JAMA Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag079\/67135907\/awag079.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/4\/1094\/67135907\/awag079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/4\/1094\/67135907\/awag079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:04:07Z","timestamp":1775635447000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/4\/1094\/8499594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2,26]]},"published-print":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awag079","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,2,26]]}}}