{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:54:11Z","timestamp":1790564051899,"version":"4.1.0"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Brazilian Council for Scientific and Technological Development","award":["465346\/2014-6"],"award-info":[{"award-number":["465346\/2014-6"]}]},{"name":"Rio de Janeiro Foundation","award":["E-26\/010.000080\/2018"],"award-info":[{"award-number":["E-26\/010.000080\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Here, we propose a new concept linked to neuroplasticity and cognitive reserve: \u2018Connectomic reserve\u2019. It is suggested and discussed as a hypothesis, aiming to stimulate experimental testing, taking as an example the exuberant circuits formed during development by commissural neurons and their projections. Upon reviewing the developmental strategies of the formation of callosal circuits, from axonal emission by cortical cell bodies to the choice of trajectories within the ipsi and contralateral hemispheres, we identified the formation of many ectopic and heterotopic projections.<\/jats:p>\n                  <jats:p>Ectopic projections were first described in cases of congenital malformations but later shown to exist in typical adult brains as well. Heterotopic projections are usually presumed to be eliminated and give way to the more restricted set of connections of adult brains. However, many experiments have shown that they, in fact, remain \u2018hidden\u2019 in the brain throughout life in typical subjects of many species.<\/jats:p>\n                  <jats:p>Morphological shaping (pruning or enlargement) and physiological modulation (inhibition or enhancement) of these circuits would be resources for optimizing the function of the alternative bundles and preterminal arbors typical of neuroplasticity. The former mechanisms would take place during development, the latter in adulthood. \u2018Connectomic reserve\u2019, thus, would consist of a pervasive set of connections broadly distributed throughout the brain, susceptible to selective neuroplastic shaping or modulation depending on the requirements of the external or internal environment. Of course, being a hypothesis, this requires experimental testing in brain circuits other than commissural tracts and functional validation using emerging high-resolution imaging techniques.<\/jats:p>","DOI":"10.1093\/brain\/awag082","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:43:58Z","timestamp":1772109838000},"page":"2273-2285","source":"Crossref","is-referenced-by-count":2,"title":["The secret connections of the brain: a connectomic reserve for neuroplasticity?"],"prefix":"10.1093","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8989-4009","authenticated-orcid":false,"given":"Roberto","family":"Lent","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Center for Health Sciences, Federal University of Rio de Janeiro , Rio de Janeiro CEP 21.941-902 ,","place":["Brazil"]},{"name":"D\u2019Or Institute of Research and Education , Rio de Janeiro CEP 22.281-100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Tovar-Moll","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute of Research and Education , Rio de Janeiro CEP 22.281-100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Szczupak","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"2026070619573484900_awag082-B1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.21974","article-title":"Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain","volume":"513","author":"Azevedo","year":"2009","journal-title":"J Comp Neurol"},{"key":"2026070619573484900_awag082-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2011.07923.x","article-title":"How many neurons do you have? 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