{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:52:43Z","timestamp":1791492763033,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Reported prevalence estimates of Lewy body pathology (LBP) vary widely, often without considering brain regional distributions or demographic influences. Large, population-representative autopsy cohorts are needed to provide estimates and clarify the distribution and clinical implications of LBP.<\/jats:p>\n                  <jats:p>Neuropathological, genetic, and clinical data were pooled from nine community- or population-based brain autopsy cohorts in the USA (n=6), Brazil, Austria, and Finland (n=7309 total; 59% women; mean age of death 84.2 years). Cognitive status was available for 6166 participants: dementia (38.5%), mild cognitive impairment (14.8%), and cognitively unimpaired (47.0%). Frequency of LBP was examined by anatomical distribution (neocortical, limbic, brainstem, amygdala, olfactory) and stratified by covariates. Prevalence was calculated in meta-analysis, and mixed-effect logistic regression examined associations with sex, cognitive status, Alzheimer\u2019s disease neuropathological change (ADNC), and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) co-pathology.<\/jats:p>\n                  <jats:p>Overall, 27.3% of participants had LBP: neocortical 8.4%, limbic 6.8%, brainstem 4.8%, amygdala 3.7%, and olfactory 3.6%. Neocortical LBP was associated with dementia (present in 15%; OR=4.06 [95%CI 3.24-5.10]) and with increased odds of ADNC (OR=2.30 [95%CI 1.88\u20132.81]) and LATE-NC (OR=2.03 [95%CI 1.69-2.44]). Sex differences were not observed in the frequencies of neocortical or limbic LBP. However, amygdala-predominant LBP was more frequent in women (OR=1.53 [95%CI 1.06-2.21]) whereas brainstem-predominant LBP was more common in men (OR=0.64 [95%CI 0.49-0.84]). Additionally, amygdala-predominant LBP was associated with increased odds of comorbid ADNC (OR=12.7 [95%CI 5.30\u201330.6]) while brainstem-predominant LBP was not associated with greater odds of ADNC co-pathology (OR=0.88 [95%CI 0.67\u20131.16]).<\/jats:p>\n                  <jats:p>Pooling data from large, international community-based autopsy cohorts allows for more robust estimates of region-specific LBP prevalence and their associations with cognitive status. The observed sex- and co-pathology\u2013specific differences in brainstem and amygdala-predominant LBP highlight potential biological heterogeneity and suggest that distinct disease pathways may underlie these patterns.<\/jats:p>","DOI":"10.1093\/brain\/awag112","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:45:42Z","timestamp":1774442742000},"source":"Crossref","is-referenced-by-count":3,"title":["The prevalence of Lewy body pathology across nine international community-based cohorts"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-3616","authenticated-orcid":false,"given":"Lucy L","family":"Gibson","sequence":"first","affiliation":[{"name":"King's College London, Institute of Psychiatry, Psychology and Neuroscience , London, SE5 9RS ,","place":["UK"]},{"name":"South London and Maudsley NHS Foundation Trust , London, SE5 8AZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-4778","authenticated-orcid":false,"given":"Claudia K","family":"Suemoto","sequence":"additional","affiliation":[{"name":"University of Sao Paulo Medical School , Sao Paulo, 05508-220 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Attems","sequence":"additional","affiliation":[{"name":"Newcastle University , Newcastle upon Tyne, NE2 4HH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L","family":"Abner","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M","family":"Corrada","sequence":"additional","affiliation":[{"name":"University of California, Irvine School of Medicine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gomez-Isaza","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea T","family":"Grinberg","sequence":"additional","affiliation":[{"name":"University of Sao Paulo Medical School , Sao Paulo, 05508-220 ,","place":["Brazil"]},{"name":"Mayo Clinic , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-8482","authenticated-orcid":false,"given":"Alifiya","family":"Kapasi","sequence":"additional","affiliation":[{"name":"Rush University Medical Center , Chicago, IL 60612 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Jicha","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kawas","sequence":"additional","affiliation":[{"name":"University of California, Irvine School of Medicine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-5511","authenticated-orcid":false,"given":"Gabor G","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]},{"name":"Tanz Centre for Research in Neurodegenerative Disease, University of Toronto , Toronto, ON M5T 2S8 ,","place":["Canada"]},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, ON M5S 1A8 ,","place":["Canada"]},{"name":"Laboratory Medicine Program, University Health Network , Toronto, ON M5G 2C4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin S","family":"Latimer","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata E P","family":"Leite","sequence":"additional","affiliation":[{"name":"University of Sao Paulo Medical School , Sao Paulo, 05508-220 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Montine","sequence":"additional","affiliation":[{"name":"University of California, Irvine School of Medicine , Irvine, CA 92697 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-5466","authenticated-orcid":false,"given":"Liisa","family":"Myllykangas","sequence":"additional","affiliation":[{"name":"University of Helsinki and Helsinki University Hospital , Helsinki 00029 HUS ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M","family":"Neltner","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Troncoso","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keenan A","family":"Walker","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-9805","authenticated-orcid":false,"given":"Rod","family":"Walker","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute , Seattle, WA 98101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsiu J","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke University , Durham, NC 27710 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"King's College London, Institute of Psychiatry, Psychology and Neuroscience , London, SE5 9RS ,","place":["UK"]},{"name":"Centre for Age-Related Medicine, Stavanger University Hospital , Stavanger 4068 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY 40536 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,26]]},"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag112\/67529348\/awag112.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag112\/67529348\/awag112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:11:28Z","timestamp":1774523488000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awag112\/8541480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/brain\/awag112","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"article-number":"awag112"}}