{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:29:09Z","timestamp":1793158149970,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral immune cell infiltration and crosstalk with brain-resident cells critically drive Alzheimer\u2019s disease (AD)-associated neuroinflammation, highlighting its therapeutic potential.<\/jats:p>\n                  <jats:p>Here, we found that photobiomodulation (PBM) markedly reduced cerebral CD8+ T cells infiltration in the cortex of AD (APP\/PS1 and 3\u00d7Tg) mice, thereby improving cognition, and alleviating AD-related pathology by mitigating neuronal damage and gliosis. Immunofluorescence and transcriptomic analyses revealed that PBM inhibited the release of chemokines and pro-inflammatory cytokines from microglia, reducing endothelial adhesion molecules-mediated T cell migration. Concurrently, reduced secretion of tumor necrosis factor-\u03b1, interleukin-1\u03b1, and complement component 1q by pro-inflammatory microglia further diminished neurotoxic A1 astrocyte induction. Genetic overexpression or pharmacological inhibition further validated that PBM disrupted microglia NOD-like receptor protein 3 inflammasomes activation, attenuating astrocyte reactivity and T cells recruitment.<\/jats:p>\n                  <jats:p>These findings collectively suggest that the PBM-induced modulation of crosstalk between microglia, astrocytes, and CD8+ T cells is closely related to cognitive improvement. Reprogramming central-peripheral immune crosstalk with PBM resolves neuroinflammation and restores cognition in AD models-a translatable strategy for combating neurodegeneration.<\/jats:p>","DOI":"10.1093\/brain\/awag247","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:59:53Z","timestamp":1784721593000},"source":"Crossref","is-referenced-by-count":2,"title":["Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer\u2019s disease models"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-8234","authenticated-orcid":false,"given":"Qi","family":"Shen","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocai","family":"Chang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyun","family":"Guo","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Shi","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Yan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Ouyang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou 510120 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou 510120 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Xing","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihua","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag247\/69857747\/awag247.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag247\/69857747\/awag247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:26:21Z","timestamp":1784802381000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awag247\/8740372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/brain\/awag247","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"article-number":"awag247"}}