{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:09:19Z","timestamp":1788797359495,"version":"build-2803163510"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"DOI":"10.1093\/brain\/awag279","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:42:01Z","timestamp":1786448521000},"page":"2909-2911","source":"Crossref","is-referenced-by-count":0,"title":["Untangling prognosis in multiple sclerosis"],"prefix":"10.1093","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-5834","authenticated-orcid":false,"given":"J William L","family":"Brown","sequence":"first","affiliation":[{"name":"Cambridge ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2026090711251670900_awag279-B1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1474-4422(22)00289-7","article-title":"Multiple sclerosis progression: Time for a new mechanism-driven framework","volume":"22","author":"Kuhlmann","year":"2023","journal-title":"Lancet Neurol"},{"key":"2026090711251670900_awag279-B2","first-page":"3254","article-title":"Spider-MS: An individualized polyhedral prediction of multiple sclerosis prognosis","volume":"149","author":"Tur","year":"2026","journal-title":"Brain"},{"key":"2026090711251670900_awag279-B3","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2025.106667","article-title":"Prediction of long-term outcome in multiple sclerosis: A systematic review","volume":"103","author":"Mrabet","year":"2025","journal-title":"Mult Scler Relat Disord"},{"key":"2026090711251670900_awag279-B4","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1093\/brain\/awz156","article-title":"Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis","volume":"142","author":"Brownlee","year":"2019","journal-title":"Brain"},{"key":"2026090711251670900_awag279-B5","article-title":"The Barcelona baseline risk score to predict long-term prognosis after a first demyelinating event: A prospective observational study","volume":"53","author":"Tur","year":"2025","journal-title":"Lancet Reg Health Eur"},{"key":"2026090711251670900_awag279-B6","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1093\/brain\/awx185","article-title":"Towards personalized therapy for multiple sclerosis: Prediction of individual treatment response","volume":"140","author":"Kalincik","year":"2017","journal-title":"Brain"},{"key":"2026090711251670900_awag279-B7","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jamaneurol.2023.3331","article-title":"Harmonizing definitions for progression independent of relapse activity in multiple sclerosis: A systematic review","volume":"80","author":"M\u00fcller","year":"2023","journal-title":"JAMA Neurol"},{"key":"2026090711251670900_awag279-B8","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-078378","article-title":"TRIPOD+ AI statement: Updated guidance for reporting clinical prediction models that use regression or machine learning methods","volume":"385","author":"Collins","year":"2024","journal-title":"BMJ"},{"key":"2026090711251670900_awag279-B9","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-082505","article-title":"PROBAST+ AI: An updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods","volume":"388","author":"Moons","year":"2025","journal-title":"BMJ"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/9\/2909\/70983765\/awag279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/149\/9\/2909\/70983765\/awag279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:25:21Z","timestamp":1788794721000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/149\/9\/2909\/8787317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,7]]},"published-print":{"date-parts":[[2026,9,7]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awag279","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,9]]}}}