{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:01:59Z","timestamp":1790236919471,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Michael J. Fox Foundation for Parkinson\u2019s Research","id":[{"id":"https:\/\/ror.org\/03arq3225","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Parkinson\u2019s Foundation","id":[{"id":"https:\/\/ror.org\/05mx85j86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundacion de Investigacion HM Hospitales","id":[{"id":"https:\/\/ror.org\/0543ma965","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TARGET PD ANR"},{"DOI":"10.13039\/100015118","name":"French Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015118","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cl\u00e9ment Fayat Foundation"},{"DOI":"10.13039\/501100006251","name":"University of Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche"},{"name":"France Parkinson Foundation","id":[{"id":"https:\/\/ror.org\/03egfjv78","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Cl\u00e9ment Fayat Foundation"},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Proteinopathies are frequently accompanied by co-pathologies, which complicate understanding the pathophysiological mechanisms of neurodegenerative diseases.<\/jats:p>\n                  <jats:p>In this study, we employed a well-characterized baboon cohort to investigate the occurrence of tau pathology following intrastriatal injections of two distinct \u03b1-synuclein extracts [small aggregates (SA) and large aggregates (LA)] derived from the brains of patients with Parkinson\u2019s disease (PD).<\/jats:p>\n                  <jats:p>Biochemical and histopathological analyses (6, 12 or 24 months after injections) revealed significantly higher phosphorylated tau expression and greater frequency of neuropil threads in both LA- (n = 18) and SA-injected baboons (n = 12) compared with control animals. We also observed distinct patterns of tau pathology depending on the assembly of \u03b1-synuclein aggregates. Baboons injected with SA exhibited tangle-like phosphorylated tau lesions and neuropil threads, with no significant differences across post-injection time points. Moreover, a uniform distribution of tau pathology was detected along the rostro-caudal axis of the medial temporal lobe, affecting neuronal, oligodendroglial and astrocytic cell types. On the other hand, baboons injected with LA exhibited neuropil threads and few glial lesions but lacked phosphorylated tau intraneuronal aggregates. The occurrence of phosphorylated tau lesions was associated with phosphorylated synuclein pathology.<\/jats:p>\n                  <jats:p>These observations suggest a link between nigrostriatal synucleinopathy and limbic tau co-pathology, providing pathophysiological insights into PD dementia.<\/jats:p>","DOI":"10.1093\/brain\/awag284","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:44:24Z","timestamp":1787139864000},"source":"Crossref","is-referenced-by-count":0,"title":["Divergent tau pathology profiles induced by distinct alpha-synuclein aggregates in non-human primates"],"prefix":"10.1093","author":[{"given":"Morgane","family":"Darricau","sequence":"first","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Neu-Faber","sequence":"additional","affiliation":[{"name":"Univ. Toulouse III-Paul Sabatier , Toulouse F-31000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bourdenx","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Dovero","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Porras","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Thiolat","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Trigo-Damas","sequence":"additional","affiliation":[{"name":"HM CINAC, HM Puerta del Sur, Fundaci\u00f3n HM Hospitales and CIBERNED and CEU-San Pablo University , Madrid 28938 ,","place":["Spain"]},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Garcia-Carrillo","sequence":"additional","affiliation":[{"name":"Centro Experimental en Investigaciones Biom\u00e9dica (CEIB), Universidad de Murcia , Murcia 30100 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Trinidad","family":"Herrero","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia , Murcia 30100 ,","place":["Spain"]},{"name":"Institute of Research on Aging (IUIE), School of Medicine, University of Murcia , Murcia 30100 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-7470","authenticated-orcid":false,"given":"Miquel","family":"Vila","sequence":"additional","affiliation":[{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"Neurodegenerative Diseases Research Group, Vall d\u2019Hebron Research Institute (VHIR) , Barcelona 08035 ,","place":["Spain"]},{"name":"Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB) , Barcelona 08193 ,","place":["Spain"]},{"name":"Catalan Institution for Research and Advanced Studies (ICREA) , Barcelona 08010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A","family":"Obeso","sequence":"additional","affiliation":[{"name":"HM CINAC, HM Puerta del Sur, Fundaci\u00f3n HM Hospitales and CIBERNED and CEU-San Pablo University , Madrid 28938 ,","place":["Spain"]},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"CEU, San Pablo University , Madrid, Mostoles E-28938 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-227X","authenticated-orcid":false,"given":"Vincent","family":"Planche","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]},{"name":"Centre M\u00e9moire Ressources Recherches, Service de Neurologie des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, P\u00f4le de Neurosciences Cliniques, CHU de Bordeaux , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-4638","authenticated-orcid":false,"given":"Erwan","family":"Bezard","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, IMN, UMR 5293 , Bordeaux F-33000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-9045","authenticated-orcid":false,"given":"Benjamin","family":"Dehay","sequence":"additional","affiliation":[{"name":"Univ. 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