{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:53:02Z","timestamp":1791913982009,"version":"4.3.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Y010949\/1"],"award-info":[{"award-number":["MR\/Y010949\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/brain\/awag340","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:58:07Z","timestamp":1790769487000},"source":"Crossref","is-referenced-by-count":0,"title":["Not letting go: tRNA sequestration as a unifying mechanism driving synthetase-linked neuropathies"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-9045","authenticated-orcid":false,"given":"James N","family":"Sleigh","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London , London WC1N 3BG ,","place":["UK"]},{"name":"UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London , London WC1N 3BG ,","place":["UK"]},{"name":"UK Dementia Research Institute, University College London , London WC1E 6BT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101313280076300_awag340-B1","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1074\/jbc.REV118.002955","article-title":"Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases","volume":"294","author":"Wei","year":"2019","journal-title":"J Biol Chem"},{"key":"2026101313280076300_awag340-B2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4103\/NRR.NRR-D-24-01080","article-title":"Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies","volume":"21","author":"Rhymes","year":"2026","journal-title":"Neural Regen Res"},{"key":"2026101313280076300_awag340-B3","doi-asserted-by":"crossref","first-page":"12307","DOI":"10.1073\/pnas.1104293108","article-title":"Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening","volume":"108","author":"He","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026101313280076300_awag340-B4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awag204","article-title":"Tyrosyl-tRNA sequestration triggers tyrosyl-tRNA synthetase-associated peripheral neuropathy","author":"Mallik","journal-title":"Brain"},{"key":"2026101313280076300_awag340-B5","doi-asserted-by":"crossref","first-page":"7520","DOI":"10.1038\/ncomms8520","article-title":"Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases","volume":"6","author":"Niehues","year":"2015","journal-title":"Nat Commun"},{"key":"2026101313280076300_awag340-B6","doi-asserted-by":"crossref","first-page":"e1002399","DOI":"10.1371\/journal.pgen.1002399","article-title":"Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels","volume":"7","author":"Motley","year":"2011","journal-title":"PLoS Genet"},{"key":"2026101313280076300_awag340-B7","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.abb3356","article-title":"tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase","volume":"373","author":"Zuko","year":"2021","journal-title":"Science"},{"key":"2026101313280076300_awag340-B8","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.abb3414","article-title":"The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy","volume":"373","author":"Spaulding","year":"2021","journal-title":"Science"},{"key":"2026101313280076300_awag340-B9","doi-asserted-by":"crossref","first-page":"10007","DOI":"10.1093\/nar\/gkab730","article-title":"Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response","volume":"49","author":"Mendonsa","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026101313280076300_awag340-B10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41419-020-02798-y","article-title":"Developmental demands contribute to early neuromuscular degeneration in CMT2D mice","volume":"11","author":"Sleigh","year":"2020","journal-title":"Cell Death Dis"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag340\/71544848\/awag340.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awag340\/71544848\/awag340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:28:07Z","timestamp":1791912487000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awag340\/8857161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1093\/brain\/awag340","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"awag340"}}