{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:55:21Z","timestamp":1791176121874,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"DOI":"10.1093\/brain\/awh526","type":"journal-article","created":{"date-parts":[[2005,5,11]],"date-time":"2005-05-11T20:24:36Z","timestamp":1115843076000},"page":"1764-1777","source":"Crossref","is-referenced-by-count":379,"title":["Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates"],"prefix":"10.1093","volume":"128","author":[{"given":"Beau M.","family":"Ances","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Vitaliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Voloschin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Galetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abass","family":"Alavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrna R.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Dalmau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,5,11]]},"reference":[{"key":"key\n\t\t\t\t20171011234355_B1","doi-asserted-by":"crossref","unstructured":"Alamowitch S, Graus F, Uchuya M, Re\u00f1\u00e9 R, Bescansa E, Delattre JY. Limbic encephalitis and small cell lung cancer\u2014clinical and immunological features. Brain1997; 120: 923\u20138.","DOI":"10.1093\/brain\/120.6.923"},{"key":"key\n\t\t\t\t20171011234355_B2","doi-asserted-by":"crossref","unstructured":"Bataller L, Dalmau J. Paraneoplastic disorders of the central nervous system: update on diagnostic criteria and treatment. Semin Neurol2004; 24: 461\u201371.","DOI":"10.1055\/s-2004-861540"},{"key":"key\n\t\t\t\t20171011234355_B3","doi-asserted-by":"crossref","unstructured":"Bataller L, Rosenfeld MR, Graus F, Vilchez JJ, Cheung NK, Dalmau J. Autoantigen diversity in the opsoclonus\u2013myoclonus syndrome. Ann Neurol2003; 53: 347\u201353.","DOI":"10.1002\/ana.10462"},{"key":"key\n\t\t\t\t20171011234355_B4","doi-asserted-by":"crossref","unstructured":"Benyahia B, Liblau R, Merle-Beral H, Tourani JM, Dalmau J, Delattre JY. Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. Ann Neurol1999; 45: 162\u20137.","DOI":"10.1002\/1531-8249(199902)45:2<162::AID-ANA5>3.0.CO;2-R"},{"key":"key\n\t\t\t\t20171011234355_B5","doi-asserted-by":"crossref","unstructured":"Bernal F, Graus F, Pifarre A, Saiz A, Benyahia B, Ribalta T. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta Neuropathol2002; 103: 509\u201315.","DOI":"10.1007\/s00401-001-0498-0"},{"key":"key\n\t\t\t\t20171011234355_B6","doi-asserted-by":"crossref","unstructured":"Bien CG, Schulze-Bonhage A, Deckert M, Urbach H, Helmstaedter C, Grunwald T, et al. Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy. Neurology2000; 55: 1823\u20138.","DOI":"10.1212\/WNL.55.12.1823"},{"key":"key\n\t\t\t\t20171011234355_B7","doi-asserted-by":"crossref","unstructured":"Buchhalter JR, Dichter MA. Electrophysiological comparison of pyramidal and stellate nonpyramidal neurons in dissociated cell culture of rat hippocampus. Brain Res Bull1991; 26: 333\u20138.","DOI":"10.1016\/0361-9230(91)90003-3"},{"key":"key\n\t\t\t\t20171011234355_B8","doi-asserted-by":"crossref","unstructured":"Buckley C, Oger J, Clover L, Tuzun E, Carpenter K, Jackson M, et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol2001; 50: 73\u20138.","DOI":"10.1002\/ana.1097"},{"key":"key\n\t\t\t\t20171011234355_B9","doi-asserted-by":"crossref","unstructured":"Dadparvar S, Anderson GS, Bhargava P, Guan L, Reich P, Alavi A, et al. Paraneoplastic encephalitis associated with cystic teratoma is detected by fluorodeoxyglucose positron emission tomography with negative magnetic resonance image findings. Clin Nucl Med2003; 28: 893\u20136.","DOI":"10.1097\/01.rlu.0000093284.54060.aa"},{"key":"key\n\t\t\t\t20171011234355_B10","unstructured":"Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB. The expression of the Hu (paraneoplastic encephalomyelitis\/sensory neuronopathy) antigen in human normal and tumor tissues. Am J Pathol1992; 141: 881\u20136."},{"key":"key\n\t\t\t\t20171011234355_B11","doi-asserted-by":"crossref","unstructured":"Dalmau J, Graus F, Villarejo A, Posner JB, Blumenthal D, Thiessen B, et al. Clinical analysis of anti-Ma2-associated encephalitis. Brain2004; 127: 1831\u201344.","DOI":"10.1093\/brain\/awh203"},{"key":"key\n\t\t\t\t20171011234355_B12","doi-asserted-by":"crossref","unstructured":"Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, et al. ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP\/GPT exchange factor for ARF6. EMBO Rep2004; 5: 1171\u20135.","DOI":"10.1038\/sj.embor.7400292"},{"key":"key\n\t\t\t\t20171011234355_B13","doi-asserted-by":"crossref","unstructured":"Graus F, Keime-Guibert F, Re\u00f1\u00e9 R, Benyahia B, Ribalta T, Ascaso C, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain2001; 124: 1138\u201348.","DOI":"10.1093\/brain\/124.6.1138"},{"key":"key\n\t\t\t\t20171011234355_B14","doi-asserted-by":"crossref","unstructured":"Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain2000; 123: 1481\u201394.","DOI":"10.1093\/brain\/123.7.1481"},{"key":"key\n\t\t\t\t20171011234355_B15","doi-asserted-by":"crossref","unstructured":"Honnorat J, Antoine JC, Derrington E, Aguera M, Belin MF. Antibodies to a subpopulation of glial cells and a 66 kDa developmental protein in patients with paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry1996; 61: 270\u20138.","DOI":"10.1136\/jnnp.61.3.270"},{"key":"key\n\t\t\t\t20171011234355_B16","doi-asserted-by":"crossref","unstructured":"Kassubek J, Juengling FD, Nitzsche EU, Lucking CH. Limbic encephalitis investigated by 18FDG-PET and 3D MRI. J Neuroimaging2001; 11: 55\u20139.","DOI":"10.1111\/j.1552-6569.2001.tb00011.x"},{"key":"key\n\t\t\t\t20171011234355_B17","doi-asserted-by":"crossref","unstructured":"Law AJ, Weickert CS, Hyde TM, Kleinman JE, Harrison PJ. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Am J Psychiatry2004; 161: 1848\u201355.","DOI":"10.1176\/ajp.161.10.1848"},{"key":"key\n\t\t\t\t20171011234355_B18","doi-asserted-by":"crossref","unstructured":"Lee BY, Newberg AB, Liebeskind DS, Kung J, Alavi A. FDG-PET findings in patients with suspected encephalitis. Clin Nucl Med2004; 29: 620\u20135.","DOI":"10.1097\/00003072-200410000-00004"},{"key":"key\n\t\t\t\t20171011234355_B19","doi-asserted-by":"crossref","unstructured":"Liguori R, Vincent A, Clover L, Avoni P, Plazzi G, Cortelli P, et al. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain2001; 124: 2417\u201326.","DOI":"10.1093\/brain\/124.12.2417"},{"key":"key\n\t\t\t\t20171011234355_B20","doi-asserted-by":"crossref","unstructured":"Llado A, Mannucci P, Carpentier AF, Paris S, Blanco Y, Saiz A, et al. Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes. Neurology2004; 63: 1947\u20139.","DOI":"10.1212\/01.WNL.0000144340.03364.BF"},{"key":"key\n\t\t\t\t20171011234355_B21","doi-asserted-by":"crossref","unstructured":"Pozo-Rosich P, Clover L, Saiz A, Vincent A, Graus F. Voltage-gated potassium channel antibodies in limbic encephalitis. Ann Neurol2003; 54: 530\u20133.","DOI":"10.1002\/ana.10713"},{"key":"key\n\t\t\t\t20171011234355_B22","doi-asserted-by":"crossref","unstructured":"Rojas I, Graus F, Keime-Guibert F, Re\u00f1\u00e9 R, Delattre JY, Ramon JM, et al. Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies. Neurology2000; 55: 713\u20135.","DOI":"10.1212\/WNL.55.5.713"},{"key":"key\n\t\t\t\t20171011234355_B23","doi-asserted-by":"crossref","unstructured":"Sakagami H, Matsuya S, Nishimura H, Suzuki R, Kondo H. Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and involvement in dendritic formation. Eur J Neurosci2004; 19: 863\u201370.","DOI":"10.1111\/j.0953-816X.2004.03195.x"},{"key":"key\n\t\t\t\t20171011234355_B24","doi-asserted-by":"crossref","unstructured":"Scheid R, Lincke T, Voltz R, von Cramon DY, Sabri O. Serial 18F-fluoro-2-deoxy-d-glucose positron emission tomography and magnetic resonance imaging of paraneoplastic limbic encephalitis. Arch. Neurol2004; 61: 1785\u20139.","DOI":"10.1001\/archneur.61.11.1785"},{"key":"key\n\t\t\t\t20171011234355_B25","doi-asserted-by":"crossref","unstructured":"Thieben MJ, Lennon VA, Boeve BF, Aksamit AJ, Keegan M, Vernino S. Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology2004; 62: 1177\u201382.","DOI":"10.1212\/01.WNL.0000122648.19196.02"},{"key":"key\n\t\t\t\t20171011234355_B26","doi-asserted-by":"crossref","unstructured":"Vincent A, Buckley C, Schott JM, Baker I, Dewar BK, Detert N, et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain2004; 127: 701\u201312.","DOI":"10.1093\/brain\/awh077"},{"key":"key\n\t\t\t\t20171011234355_B27","doi-asserted-by":"crossref","unstructured":"Watanabe Y, Shimizu Y, Ooi S, Tanaka K, Inuzuka T, Nakashima K. Steroid-responsive limbic encephalitis. Intern Med2003; 42: 428\u201332.","DOI":"10.2169\/internalmedicine.42.428"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/128\/8\/1764\/13733756\/awh526.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T23:47:35Z","timestamp":1507765655000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/brain\/article\/128\/8\/1764\/481343\/Treatmentresponsive-limbic-encephalitis-identified"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,11]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2005,5,11]]},"published-print":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awh526","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,8]]},"published":{"date-parts":[[2005,5,11]]}}}