{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:30:23Z","timestamp":1792150223545,"version":"4.4.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1093\/brain\/awn053","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T20:36:09Z","timestamp":1208464569000},"page":"1228-1240","source":"Crossref","is-referenced-by-count":175,"title":["Interrelation of inflammation and APP in sIBM: IL-1\u03b2 induces accumulation of \u03b2-amyloid in skeletal muscle"],"prefix":"10.1093","volume":"131","author":[{"given":"Jens","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstanze","family":"Barthel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Wrede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Salajegheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinos C.","family":"Dalakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,17]]},"reference":[{"key":"key\n\t\t\t\t20170508032633_B1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0008-6363(02)00228-6","article-title":"Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study","volume":"54","author":"Adams","year":"2002","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170508032633_B2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/clim.1999.4823","article-title":"Downregulation of TGF-beta1 mRNA and protein in the muscles of patients with inflammatory myopathies after treatment with high-dose intravenous immunoglobulin","volume":"94","author":"Amemiya","year":"2000","journal-title":"Clin Immunol"},{"key":"key\n\t\t\t\t20170508032633_B3","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1212\/01.wnl.0000192128.13875.1e","article-title":"Inclusion-body myositis: a myodegenerative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition","volume":"66","author":"Askanas","year":"2006","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170508032633_B4","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1073\/pnas.93.3.1314","article-title":"Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle","volume":"93","author":"Askanas","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170508032633_B5","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1212\/WNL.54.5.1033","article-title":"Alpha B-crystallin immunolocalization yields new insights into inclusion body myositis","volume":"54","author":"Banwell","year":"2000","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170508032633_B6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/brain\/123.2.374","article-title":"Synergistic effect of beta-amyloid protein and interferon gamma on nitric oxide production by C2C12 muscle cells","volume":"123","author":"Baron","year":"2000","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170508032633_B7","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.4049\/jimmunol.172.12.7713","article-title":"IL-1 beta impairs insulin-like growth factor I-induced differentiation and downstream activation signals of the insulin-like growth factor I receptor in myoblasts","volume":"172","author":"Broussard","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170508032633_B8","doi-asserted-by":"crossref","first-page":"53524","DOI":"10.1074\/jbc.M408473200","article-title":"Calcium dyshomeostasis in beta-amyloid and Tau-bearing skeletal myotubes","volume":"279","author":"Christensen","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170508032633_B9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2990.2004.00591.x","article-title":"Expression of the beta chemokines CCL3, CCL4, CCL5 and their receptors in idiopathic inflammatory myopathies","volume":"31","author":"Civatte","year":"2005","journal-title":"Neuropathol Appl Neurobiol"},{"key":"key\n\t\t\t\t20170508032633_B10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/00005072-199705000-00003","article-title":"Transforming growth factor-beta 1 in polymyositis and dermatomyositis correlates with fibrosis but not with mononuclear cell infiltrate","volume":"56","author":"Confalonieri","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170508032633_B11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/jnen\/59.2.164","article-title":"Increased expression of beta-chemokines in muscle of patients with inflammatory myopathies","volume":"59","author":"Confalonieri","year":"2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170508032633_B12","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.55.12.1509","article-title":"Molecular immunology and genetics of inflammatory muscle diseases","volume":"55","author":"Dalakas","year":"1998","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170508032633_B13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ncpneuro0261","article-title":"Sporadic inclusion body myositis-diagnosis, pathogenesis and therapeutic strategies","volume":"2","author":"Dalakas","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"key\n\t\t\t\t20170508032633_B14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(03)14368-1","article-title":"Polymyositis and dermatomyositis","volume":"362","author":"Dalakas","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170508032633_B15","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1212\/WNL.58.12.1779","article-title":"Differential expression of chemokines in inflammatory myopathies","volume":"58","author":"De Bleecker","year":"2002","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170508032633_B16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0960-8966(98)00126-6","article-title":"Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies","volume":"9","author":"De Bleecker","year":"1999","journal-title":"Neuromuscul Disord"},{"key":"key\n\t\t\t\t20170508032633_B17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1196\/annals.1398.050","article-title":"Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses","volume":"1109","author":"De Paepe","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170508032633_B18","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.2741\/2866","article-title":"Chemokines in idiopathic inflammatory myopathies","volume":"13","author":"De Paepe","year":"2008","journal-title":"Front Biosci"},{"key":"key\n\t\t\t\t20170508032633_B19","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1523\/JNEUROSCI.0901-04.2004","article-title":"Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease","volume":"24","author":"Fonseca","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170508032633_B20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jneuroim.2004.10.006","article-title":"IL-8 enhancement of amyloid-beta (A beta(1-42))-induced expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia","volume":"159","author":"Franciosi","year":"2005","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20170508032633_B21","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0002-9440(10)65682-9","article-title":"Amyloid-beta deposition in skeletal muscle of transgenic mice: possible model of inclusion body myopathy","volume":"153","author":"Fukuchi","year":"1998","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170508032633_B22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1749-6632.2000.tb05379.x","article-title":"Regulation of cytokine secretion and amyloid precursor protein processing by proinflammatory amyloid beta (A beta)","volume":"917","author":"Gitter","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170508032633_B23","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0006-291X(03)01270-1","article-title":"Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes","volume":"307","author":"Hong","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170508032633_B24","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0002-9440(10)65681-7","article-title":"Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis","volume":"153","author":"Jin","year":"1998","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170508032633_B25","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2353\/ajpath.2006.051232","article-title":"Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice","volume":"168","author":"Kitazawa","year":"2006","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170508032633_B26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.04-2364com","article-title":"TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1\/MAFbx in skeletal muscle","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170508032633_B27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/ana.10761","article-title":"Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes","volume":"54","author":"Lu","year":"2003","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170508032633_B28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/art.1780400514","article-title":"Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies","volume":"40","author":"Lundberg","year":"1997","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t20170508032633_B29","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ana.21115","article-title":"Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis","volume":"61","author":"Lunemann","year":"2007","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170508032633_B30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1365-2249.1998.00664.x","article-title":"A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli","volume":"113","author":"Nagaraju","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20170508032633_B31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/mcne.2001.0972","article-title":"Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy","volume":"17","author":"Querfurth","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170508032633_B32","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/brain\/awh518","article-title":"Gene expression profile in the muscles of patients with inflammatory myopathies: effect of therapy with IVIg and biological validation of clinically relevant genes","volume":"128","author":"Raju","year":"2005","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170508032633_B33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0165-5728(03)00218-2","article-title":"Expression of IFN-gamma-inducible chemokines in inclusion body myositis","volume":"141","author":"Raju","year":"2003","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20170508032633_B34","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/brain\/awh148","article-title":"Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8(+) T cell cytotoxicity","volume":"127","author":"Schmidt","year":"2004","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170508032633_B35","doi-asserted-by":"crossref","first-page":"14456","DOI":"10.1074\/jbc.M313747200","article-title":"Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells","volume":"279","author":"Sondag","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170508032633_B36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neurobiolaging.2005.02.011","article-title":"Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model","volume":"27","author":"Sugarman","year":"2006","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20170508032633_B37","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/intimm\/dxf062","article-title":"Increased IL-15 production of muscle cells in polymyositis and dermatomyositis","volume":"14","author":"Sugiura","year":"2002","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170508032633_B38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00005072-199603000-00009","article-title":"Cytokine expression profile in idiopathic inflammatory myopathies","volume":"55","author":"Tews","year":"1996","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170508032633_B39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s11926-007-0046-6","article-title":"Cytokine response in inflammatory myopathies","volume":"9","author":"Tournadre","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"key\n\t\t\t\t20170508032633_B40","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/S0140-6736(01)06969-0","article-title":"Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis","volume":"358","author":"Vattemi","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170508032633_B41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.it.2005.05.003","article-title":"Immunobiology of muscle: advances in understanding an immunological microenvironment","volume":"26","author":"Wiendl","year":"2005","journal-title":"Trends Immunol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/131\/5\/1228\/16695522\/awn053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T21:14:15Z","timestamp":1503436455000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awn053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,17]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,4,17]]},"published-print":{"date-parts":[[2008,5]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awn053","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4,17]]}}}