{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:52:32Z","timestamp":1790909552583,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"DOI":"10.1093\/brain\/awn198","type":"journal-article","created":{"date-parts":[[2008,8,30]],"date-time":"2008-08-30T20:25:41Z","timestamp":1220127941000},"page":"2564-2578","source":"Crossref","is-referenced-by-count":202,"title":["Persistent inflammation alters the function of the endogenous brain stem cell compartment"],"prefix":"10.1093","volume":"131","author":[{"given":"Stefano","family":"Pluchino","sequence":"first","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Muzio","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Imitola","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases and Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Deleidi","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Alfaro-Cervello","sequence":"additional","affiliation":[{"name":"Department Comparative Neurobiology, Instituto Cavanilles, University of Valencia, 46980 Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Salani","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Porcheri","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cavasinni","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Manuel","family":"Garcia-Verdugo","sequence":"additional","affiliation":[{"name":"Department Comparative Neurobiology, Instituto Cavanilles, University of Valencia, 46980 Valencia"},{"name":"Department of Cellular Therapy, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, 46013 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia J.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases and Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianvito","family":"Martino","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, DIBIT"},{"name":"Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,8,30]]},"reference":[{"key":"key\n\t\t\t\t20180324094349_B1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002","article-title":"Neurogenesis in adult subventricular zone","volume":"22","author":"Alvarez-Buylla","year":"2002","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/mus.20463","article-title":"Motor evoked potentials in a mouse model of chronic multiple sclerosis","volume":"33","author":"Amadio","year":"2006","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20180324094349_B3","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1073\/pnas.93.15.7673","article-title":"Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma","volume":"93","author":"Bromberg","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180324094349_B4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/cne.21307","article-title":"Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis","volume":"502","author":"Brown","year":"2007","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180324094349_B5","doi-asserted-by":"crossref","first-page":"10815","DOI":"10.1523\/JNEUROSCI.3249-05.2005","article-title":"The adult mouse hippocampal progenitor is neurogenic but not a stem cell","volume":"25","author":"Bull","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mcn.2005.10.006","article-title":"Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem\/progenitor cells","volume":"31","author":"Butovsky","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B7","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1073\/pnas.95.6.3209","article-title":"Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor","volume":"95","author":"Calza","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180324094349_B8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nn1048","article-title":"Becoming a new neuron in the adult olfactory bulb","volume":"6","author":"Carleton","year":"2003","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/glia.20232","article-title":"Interferon-gamma inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells","volume":"52","author":"Chew","year":"2005","journal-title":"Glia"},{"key":"key\n\t\t\t\t20180324094349_B10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nn1144","article-title":"The glial identity of neural stem cells","volume":"6","author":"Doetsch","year":"2003","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180324094349_B12","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997","article-title":"Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain","volume":"17","author":"Doetsch","year":"1997","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3181\/00379727-213-44046","article-title":"p21 \u2013 negative regulator of the cell cycle","volume":"213","author":"Gartel","year":"1996","journal-title":"Proc Soc Exp Biol Med"},{"key":"key\n\t\t\t\t20180324094349_B14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuron.2006.06.012","article-title":"PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling","volume":"51","author":"Jackson","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180324094349_B15","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1073\/pnas.0603512103","article-title":"Evidence for stroke-induced neurogenesis in the human brain","volume":"103","author":"Jin","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180324094349_B16","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1634\/stemcells.2007-0867","article-title":"Enumeration of neural stem and progenitor cells in the Neural Colony Forming Cell Assay","volume":"26","author":"Louis","year":"2008","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20180324094349_B17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/76630","article-title":"Area identity shifts in the early cerebral cortex of Emx2-\/- mutant mice","volume":"3","author":"Mallamaci","year":"2000","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrn1908","article-title":"The therapeutic potential of neural stem cells","volume":"7","author":"Martino","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B19","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1523\/JNEUROSCI.1299-06.2006","article-title":"Origin of oligodendrocytes in the subventricular zone of the adult brain","volume":"26","author":"Menn","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B20","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/brain\/awl135","article-title":"A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination","volume":"129","author":"Merkler","year":"2006","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180324094349_B21","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20180324094349_B22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nbt1216","article-title":"Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration","volume":"24","author":"Montini","year":"2006","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180324094349_B23","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.125.12.2251","article-title":"In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain","volume":"125","author":"Morshead","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20180324094349_B24","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0896-6273(94)90046-9","article-title":"Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells","volume":"13","author":"Morshead","year":"1994","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180324094349_B25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.12-01-00249.1992","article-title":"Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain","volume":"12","author":"Morshead","year":"1992","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B26","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1093\/cercor\/bhi077","article-title":"A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus","volume":"15","author":"Muzio","year":"2005","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20180324094349_B27","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1073\/pnas.0606835104","article-title":"Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors","volume":"104","author":"Nait-Oumesmar","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180324094349_B28","doi-asserted-by":"crossref","first-page":"13211","DOI":"10.1073\/pnas.192314199","article-title":"Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice","volume":"99","author":"Picard-Riera","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180324094349_B29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pneurobio.2007.02.010","article-title":"Radial glial cell heterogeneity\u2013the source of diverse progeny in the CNS","volume":"83","author":"Pinto","year":"2007","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t20180324094349_B30","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature01552","article-title":"Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis","volume":"422","author":"Pluchino","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180324094349_B31","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1634\/stemcells.2007-0037","article-title":"Magnetic resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis","volume":"25","author":"Politi","year":"2007","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20180324094349_B32","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1523\/JNEUROSCI.03-06-01289.1983","article-title":"Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics","volume":"3","author":"Raff","year":"1983","journal-title":"J Neurosci"},{"issue":"Pt 2","key":"key\n\t\t\t\t20180324094349_B33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1101\/SQB.1983.048.01.061","article-title":"Glial cell lineages in the rat optic nerve","volume":"48","author":"Raff","year":"1983","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"key\n\t\t\t\t20180324094349_B34","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20180324094349_B35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S1074-7613(02)00331-X","article-title":"Further checkpoints in Th1 development","volume":"16","author":"Robinson","year":"2002","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20180324094349_B36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nmeth926","article-title":"Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology","volume":"3","author":"Singec","year":"2006","journal-title":"Nat Methods"},{"key":"key\n\t\t\t\t20180324094349_B37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF01194977","article-title":"BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone","volume":"21","author":"Takahashi","year":"1992","journal-title":"J Neurocytol"},{"key":"key\n\t\t\t\t20180324094349_B38","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1523\/JNEUROSCI.1109-04.2004","article-title":"Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat","volume":"24","author":"Zhang","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180324094349_B39","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nn1629","article-title":"Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood","volume":"9","author":"Ziv","year":"2006","journal-title":"Nat Neurosci"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/131\/10\/2564\/24475368\/awn198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T16:54:00Z","timestamp":1631724840000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/131\/10\/2564\/1746463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,30]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,8,30]]},"published-print":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awn198","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1123795.580879","asserted-by":"object"}]},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,10]]},"published":{"date-parts":[[2008,8,30]]}}}