{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:26:56Z","timestamp":1791224816027,"version":"4.1.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1093\/brain\/awr041","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T20:24:29Z","timestamp":1300998269000},"page":"987-1002","source":"Crossref","is-referenced-by-count":130,"title":["Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital"],"prefix":"10.1093","volume":"134","author":[{"given":"Romain","family":"Nardou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumii","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Chazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Bhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Ferrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehezkel","family":"Ben-Ari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilgam","family":"Khalilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"key\n\t\t\t\t20170424192837_B1","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1523\/JNEUROSCI.5041-06.2007","article-title":"Kinetic properties of Cl- uptake mediated by Na+-dependent K+-2Cl(-) cotransport in immature rat neocortical neurons","volume":"27","author":"Achilles","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B2","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1002\/jnr.21752","article-title":"Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia","volume":"86","author":"Andre","year":"2008","journal-title":"J Neurosci Res"},{"key":"key\n\t\t\t\t20170424192837_B3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.pediatrneurol.2008.03.003","article-title":"Neonatal seizures: dilemmas in workup and management","volume":"38","author":"Bassan","year":"2008","journal-title":"Pediatr Neurol"},{"key":"key\n\t\t\t\t20170424192837_B4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1113\/jphysiol.1989.sp017762","article-title":"Giant synaptic potentials in immature rat CA3 hippocampal neurones","volume":"416","author":"Ben-Ari","year":"1989","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170424192837_B5","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1152\/physrev.00017.2006","article-title":"GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations","volume":"87","author":"Ben-Ari","year":"2007","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170424192837_B6","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2009.03.003","article-title":"Cation-chloride cotransporters and neuronal function","volume":"61","author":"Blaesse","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B7","doi-asserted-by":"crossref","first-page":"10407","DOI":"10.1523\/JNEUROSCI.3257-06.2006","article-title":"Oligomerization of KCC2 correlates with development of inhibitory neurotransmission","volume":"26","author":"Blaesse","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nm.2107","article-title":"Downregulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury","volume":"16","author":"Boulenguez","year":"2010","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170424192837_B9","doi-asserted-by":"crossref","first-page":"F165","DOI":"10.1136\/fn.86.3.F165","article-title":"Phenobarbitone, neonatal seizures and video-EEG","volume":"86","author":"Boylan","year":"2002","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"key\n\t\t\t\t20170424192837_B10","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1528-1157.1999.tb00849.x","article-title":"Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection","volume":"40","author":"Bragin","year":"1999","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B11","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1523\/JNEUROSCI.0633-10.2010","article-title":"Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy","volume":"30","author":"Brandt","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0024-3205(00)00658-5","article-title":"Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning","volume":"67","author":"Brown-Croyts","year":"2000","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170424192837_B13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1523\/JNEUROSCI.3378-07.2008","article-title":"Thermodynamic regulation of NKCC1-mediated Cl-cotransport underlies plasticity of GABA(A) signaling in neonatal neurons","volume":"28","author":"Brumback","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1528-1167.2007.01293.x","article-title":"Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia","volume":"48","author":"Cepeda","year":"2007","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.seizure.2010.01.007","article-title":"Unusual consequences of status epilepticus in Dravet syndrome","volume":"19","author":"Chipaux","year":"2010","journal-title":"Seizure"},{"key":"key\n\t\t\t\t20170424192837_B16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1113\/jphysiol.2005.089821","article-title":"Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses","volume":"566","author":"Chudotvorova","year":"2005","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170424192837_B17","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1126\/science.1076510","article-title":"On the origin of interictal activity in human temporal lobe epilepsy in vitro","volume":"298","author":"Cohen","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170424192837_B18","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Y. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170424192837_B19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.21229","article-title":"Bumetanide enhances phenobarbital efficacy in a neonatal seizure model","volume":"63","author":"Dzhala","year":"2008","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170424192837_B20","doi-asserted-by":"crossref","first-page":"11745","DOI":"10.1523\/JNEUROSCI.1769-10.2010","article-title":"Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures","volume":"30","author":"Dzhala","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B21","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nm1301","article-title":"NKCC1 transporter facilitates seizures in the developing brain","volume":"11","author":"Dzhala","year":"2005","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170424192837_B22","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nn.2609","article-title":"Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2","volume":"13","author":"Foldy","year":"2010","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B23","first-page":"521","article-title":"GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition","volume":"105","author":"Ganguly","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B24","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.3426-07.2008","article-title":"Subunit-specific trafficking of GABA(A) receptors during status epilepticus","volume":"28","author":"Goodkin","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B25","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1111\/j.1528-1167.2009.02257.x","article-title":"The impact of diazepam's discovery on the treatment and understanding of status epilepticus","volume":"50","author":"Goodkin","year":"2009","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1528-1167.2007.01297.x","article-title":"GABA(A) receptor internalization during seizures","volume":"48","author":"Goodkin","year":"2007","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B27","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1523\/JNEUROSCI.0900-05.2005","article-title":"Status epilepticus increases the intracellular accumulation of GABAA receptors","volume":"25","author":"Goodkin","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1528-1157.1998.tb01413.x","article-title":"Lamotrigine and seizure aggravation in severe myoclonic epilepsy","volume":"39","author":"Guerrini","year":"1998","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/0883073807301917","article-title":"Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis","volume":"22","author":"Guillet","year":"2007","journal-title":"J Child Neurol"},{"key":"key\n\t\t\t\t20170424192837_B30","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1523\/JNEUROSCI.23-23-08237.2003","article-title":"Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra","volume":"23","author":"Gulacsi","year":"2003","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B31","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1046\/j.0953-816x.2001.01600.x","article-title":"The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus","volume":"13","author":"Gulyas","year":"2001","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B32","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/MCB.26.1.182-191.2006","article-title":"Mice with a targeted disruption of the Cl\u2212\/HCO3\u2212 exchanger AE3 display a reduced seizure threshold","volume":"26","author":"Hentschke","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170424192837_B33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/9142","article-title":"Deficit in quantal release of GABA in experimental models of temporal lobe epilepsy","volume":"2","author":"Hirsch","year":"1999","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B34","doi-asserted-by":"crossref","first-page":"9866","DOI":"10.1523\/JNEUROSCI.2761-07.2007","article-title":"Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy","volume":"27","author":"Huberfeld","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B35","first-page":"20","article-title":"Perturbed CI-homeostasis and gabaergic signaling in human temporal lobe epilepsy","volume":"47","author":"Huberfeld","year":"2006","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0896-6273(01)00297-5","article-title":"Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition","volume":"30","author":"Hubner","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B37","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/j.1528-1167.2008.01656.x","article-title":"Interictal high-frequency oscillations (80-500\u2009Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain","volume":"49","author":"Jacobs","year":"2008","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1073\/pnas.0705487105","article-title":"Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability","volume":"105","author":"Jacobs","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170424192837_B92","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1152\/jn.00728.2004","article-title":"Impaired Cl-extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex","volume":"93","author":"Jin","year":"2005","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170424192837_B39","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncpneuro0883","article-title":"Roles of the cation-chloride cotransporters in neurological disease","volume":"4","author":"Kahle","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"key\n\t\t\t\t20170424192837_B40","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1074\/mcp.M800030-MCP200","article-title":"Brief alteration of NMDA or GABAA receptor-mediated neurotransmission has long term effects on the developing cerebral cortex","volume":"7","author":"Kaindl","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"key\n\t\t\t\t20170424192837_B41","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0896-6273(00)80956-3","article-title":"A novel in vitro preparation: the intact hippocampal formation","volume":"19","author":"Khalilov","year":"1997","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B42","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nn1125","article-title":"In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures","volume":"6","author":"Khalilov","year":"2003","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2005.09.026","article-title":"Epileptogenic actions of GABA and fast oscillations in the developing hippocampus","volume":"48","author":"Khalilov","year":"2005","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B44","doi-asserted-by":"crossref","first-page":"12028","DOI":"10.1523\/JNEUROSCI.3154-10.2010","article-title":"A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus","volume":"30","author":"Khirug","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B45","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.neuropharm.2007.06.015","article-title":"Model-specific effects of bumetanide on epileptiform activity in the in vitro intact hippocampus of the newborn mouse","volume":"53","author":"Kilb","year":"2007","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170424192837_B46","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/adc.54.11.855","article-title":"Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children","volume":"54","author":"Knudsen","year":"1979","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20170424192837_B47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mcn.2010.06.008","article-title":"Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2","volume":"45","author":"Lee","year":"2010","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B48","doi-asserted-by":"crossref","first-page":"29777","DOI":"10.1074\/jbc.M705053200","article-title":"Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2","volume":"282","author":"Lee","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170424192837_B49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2008.04.047","article-title":"Long-term expressional changes of Na+\u2009-K+\u2009-Cl-\u2009co-transporter 1 (NKCC1) and K+\u2009-Cl-\u2009co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE)","volume":"1221","author":"Li","year":"2008","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170424192837_B50","first-page":"S24","article-title":"The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin","volume":"43","author":"Lortie","year":"1993","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170424192837_B51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0014-2999(89)90294-X","article-title":"Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats","volume":"162","author":"Loscher","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170424192837_B52","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/(SICI)1097-4695(19990615)39:4<558::AID-NEU9>3.0.CO;2-5","article-title":"Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains","volume":"39","author":"Lu","year":"1999","journal-title":"J Neurobiol"},{"key":"key\n\t\t\t\t20170424192837_B53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.eplepsyres.2006.01.002","article-title":"Devastating epileptic encephalopathy in school-aged children (DESC): a pseudo encephalitis","volume":"69","author":"Mikaeloff","year":"2006","journal-title":"Epilepsy Res"},{"key":"key\n\t\t\t\t20170424192837_B54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.410360314","article-title":"Phenobarbital modifies seizure-related brain injury in the developing brain","volume":"36","author":"Mikati","year":"1994","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170424192837_B55","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1152\/jn.90761.2008","article-title":"Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus","volume":"101","author":"Nardou","year":"2009","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170424192837_B56","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1523\/JNEUROSCI.4944-04.2005","article-title":"Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus","volume":"25","author":"Naylor","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B57","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrn919","article-title":"Is there more to gaba than synaptic inhibition?","volume":"3","author":"Owens","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B58","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM199908123410704","article-title":"Phenobarbital compared with phenytoin for the treatment of neonatal seizures","volume":"341","author":"Painter","year":"1999","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170424192837_B59","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuroscience.2008.03.072","article-title":"Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia","volume":"154","author":"Papp","year":"2008","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170424192837_B91","doi-asserted-by":"crossref","first-page":"14012","DOI":"10.1523\/JNEUROSCI.4390-07.2007","article-title":"Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy","volume":"27","author":"Pathak","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B60","doi-asserted-by":"crossref","first-page":"C1516","DOI":"10.1152\/ajpcell.1997.273.5.C1516","article-title":"Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation","volume":"273","author":"Payne","year":"1997","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170424192837_B61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-2236(03)00068-7","article-title":"Cation-chloride co-transporters in neuronal communication, development and trauma","volume":"26","author":"Payne","year":"2003","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B62","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1523\/JNEUROSCI.1377-08.2009","article-title":"NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development","volume":"29","author":"Pfeffer","year":"2009","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B63","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuropharm.2004.04.002","article-title":"Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus","volume":"47","author":"Pond","year":"2004","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170424192837_B64","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2174\/1568026054367629","article-title":"Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia","volume":"5","author":"Price","year":"2005","journal-title":"Curr Top Med Chem"},{"key":"key\n\t\t\t\t20170424192837_B65","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/j.1528-1157.1999.tb01597.x","article-title":"Efficacy of five days' barbiturate anesthesia in the treatment of intractable epilepsies in children","volume":"40","author":"Rantala","year":"1999","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1113\/jphysiol.2004.077495","article-title":"Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII","volume":"562","author":"Rivera","year":"2005","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170424192837_B67","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170424192837_B68","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1523\/JNEUROSCI.5265-03.2004","article-title":"Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2","volume":"24","author":"Rivera","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B69","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/NEN.0b013e3181dd25bc","article-title":"Loss of cation-chloride cotransporter expression in preterm infants with white matter lesions: implications for the pathogenesis of epilepsy","volume":"69","author":"Robinson","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170424192837_B70","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/j.1460-9568.2006.04757.x","article-title":"Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na current and terminated by a slow Ca-activated K current","volume":"23","author":"Sipila","year":"2006","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B71","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1152\/jn.1994.72.1.273","article-title":"The role of an inwardly rectifying chloride conductance in postsynaptic inhibition","volume":"72","author":"Staley","year":"1994","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170424192837_B72","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0896-6273(00)80186-5","article-title":"Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel","volume":"17","author":"Staley","year":"1996","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B73","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121325","article-title":"Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits","volume":"311","author":"Szabadics","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170424192837_B74","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1528-1157.1994.tb01782.x","article-title":"EEG changes and seizure exacerbation in young children treated with carbamazepine","volume":"35","author":"Talwar","year":"1994","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B75","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1528-1167.2007.01295.x","article-title":"Timing of the developmental switch in GABA(A) mediated signalling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings","volume":"48","author":"Tyzio","year":"2007","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170424192837_B76","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1152\/jn.00172.2003","article-title":"Membrane potential of CA3 hippocampal pyramidal cells during postnatal development","volume":"90","author":"Tyzio","year":"2003","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170424192837_B77","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ana.21711","article-title":"Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome","volume":"66","author":"Tyzio","year":"2009","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170424192837_B78","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1111\/j.1460-9568.2008.06234.x","article-title":"Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus","volume":"27","author":"Tyzio","year":"2008","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B79","doi-asserted-by":"crossref","first-page":"30570","DOI":"10.1074\/jbc.M705095200","article-title":"A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2","volume":"282","author":"Uvarov","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170424192837_B80","article-title":"Temporal coding at the immature depolarizing GABAergic synapse","volume":"4","author":"Valeeva","year":"2010","journal-title":"Front Cell Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B82","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1523\/JNEUROSCI.3104-06.2007","article-title":"Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation","volume":"27","author":"Wake","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B83","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1523\/JNEUROSCI.5599-07.2008","article-title":"GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation","volume":"28","author":"Wang","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170424192837_B84","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1113\/jphysiol.2008.167635","article-title":"Defining the role of GABA in cortical development","volume":"587","author":"Wang","year":"2009","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170424192837_B85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1684\/epd.2007.0144","article-title":"Treatment of pediatric epilepsy: European expert opinion, 2007","volume":"9","author":"Wheless","year":"2007","journal-title":"Epileptic Disord"},{"key":"key\n\t\t\t\t20170424192837_B86","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0896-6273(03)00507-5","article-title":"Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity","volume":"39","author":"Woodin","year":"2003","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170424192837_B87","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1113\/jphysiol.2004.062471","article-title":"Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1","volume":"557","author":"Yamada","year":"2004","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170424192837_B88","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jcrc.2004.07.008","article-title":"Continuous pentobarbital infusion in children is associated with high rates of complications","volume":"19","author":"Yanay","year":"2004","journal-title":"J Crit Care"},{"key":"key\n\t\t\t\t20170424192837_B89","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1152\/jn.00616.2004","article-title":"Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride","volume":"93","author":"Zhu","year":"2005","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170424192837_B90","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.eplepsyres.2008.02.005","article-title":"NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus","volume":"79","author":"Zhu","year":"2008","journal-title":"Epilepsy Res"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/134\/4\/987\/13735975\/awr041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T07:49:23Z","timestamp":1712303363000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awr041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,21]]},"references-count":91,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,3,21]]},"published-print":{"date-parts":[[2011,4]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awr041","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3,21]]}}}