{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:01:49Z","timestamp":1791237709045,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1093\/brain\/awr142","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T19:32:42Z","timestamp":1309030362000},"page":"2134-2148","source":"Crossref","is-referenced-by-count":155,"title":["The histone acetyltransferase p300 promotes intrinsic axonal regeneration"],"prefix":"10.1093","volume":"134","author":[{"given":"Perrine","family":"Gaub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashashree","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Wuttke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Naumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Schnichels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Heiduschka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Di Giovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,6,23]]},"reference":[{"key":"key\n\t\t\t\t20170522101749_B1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0166-2236(96)10072-2","article-title":"GAP-43: an intrinsic determinant of neuronal development and plasticity","volume":"20","author":"Benowitz","year":"1997","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02284793","article-title":"Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve","volume":"25","author":"Berry","year":"1996","journal-title":"J Neurocytol"},{"key":"key\n\t\t\t\t20170522101749_B3","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1523\/JNEUROSCI.3931-04.2005","article-title":"Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats","volume":"25","author":"Bertrand","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-4547(19980515)52:4<405::AID-JNR4>3.0.CO;2-D","article-title":"Target contact regulates GAP-43 and alpha-tubulin mRNA levels in regenerating retinal ganglion cells","volume":"52","author":"Bormann","year":"1998","journal-title":"J Neurosci Res"},{"key":"key\n\t\t\t\t20170522101749_B5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1242\/dev.02762","article-title":"Getting axons onto the right path: the role of transcription factors in axon guidance","volume":"134","author":"Butler","year":"2007","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522101749_B6","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1523\/JNEUROSCI.21-13-04731.2001","article-title":"Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate","volume":"21","author":"Cai","year":"2001","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B7","first-page":"2022","article-title":"Adenovirus-mediated gene transfer to retinal ganglion cells","volume":"37","author":"Cayouette","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key\n\t\t\t\t20170522101749_B8","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1074\/jbc.M511451200","article-title":"CCAAT\/enhancer-binding protein (C\/EBP) beta is acetylated at multiple lysines: acetylation of C\/EBPbeta at lysine 39 modulates its ability to activate transcription","volume":"282","author":"Cesena","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522101749_B9","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0960-9822(02)01185-5","article-title":"Gene expression is required for correct axon guidance","volume":"12","author":"Condron","year":"2002","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170522101749_B10","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1038\/sj.emboj.7601292","article-title":"The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration","volume":"25","author":"Di Giovanni","year":"2006","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170522101749_B11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1089\/hum.2005.16.649","article-title":"Adeno-associated virus-vectored gene therapy for retinal disease","volume":"16","author":"Dinculescu","year":"2005","journal-title":"Hum Gene Ther"},{"key":"key\n\t\t\t\t20170522101749_B12","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1098\/rstb.2006.1885","article-title":"Recapitulate development to promote axonal regeneration: good or bad approach?","volume":"361","author":"Filbin","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key\n\t\t\t\t20170522101749_B13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/exnr.2001.7822","article-title":"Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats","volume":"172","author":"Fischer","year":"2001","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20170522101749_B14","first-page":"3943","article-title":"Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture","volume":"41","author":"Fischer","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key\n\t\t\t\t20170522101749_B15","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","article-title":"Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation","volume":"24","author":"Fischer","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B16","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/cdd.2009.216","article-title":"HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP\/p300 and P\/CAF-dependent p53 acetylation","volume":"17","author":"Gaub","year":"2010","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170522101749_B17","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1068428","article-title":"Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells","volume":"296","author":"Goldberg","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522101749_B18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1167\/iovs.09-4203","article-title":"Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys","volume":"51","author":"Hauk","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key\n\t\t\t\t20170522101749_B19","first-page":"339","article-title":"Axon regeneration in the peripheral and central nervous systems","volume":"48","author":"Huebner","year":"2009","journal-title":"Results Probl Cell Differ"},{"key":"key\n\t\t\t\t20170522101749_B20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0006-8993(00)02957-7","article-title":"Intravitreal adenoviral gene transfer evokes an immune response in the retina that is directed against the heterologous lacZ transgene product but does not limit transgene expression","volume":"892","author":"Isenmann","year":"2001","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170522101749_B21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-5793(94)00512-5","article-title":"Adenovirus-mediated gene transfer to murine retinal cells in vitro and in vivo","volume":"347","author":"Jomary","year":"1994","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170522101749_B22","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","article-title":"Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion","volume":"30","author":"Kurimoto","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuron.2010.05.002","article-title":"Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice","volume":"66","author":"Lee","year":"2010","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522101749_B24","doi-asserted-by":"crossref","first-page":"14334","DOI":"10.1523\/JNEUROSCI.2770-09.2009","article-title":"Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor","volume":"29","author":"Leibinger","year":"2009","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B25","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","article-title":"Lens injury stimulates axon regeneration in the mature rat optic nerve","volume":"20","author":"Leon","year":"2000","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B26","first-page":"2543","article-title":"In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector","volume":"35","author":"Li","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Pt 1","key":"key\n\t\t\t\t20170522101749_B27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/brain\/awm284","article-title":"ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells","volume":"131","author":"Lingor","year":"2008","journal-title":"Brain"},{"issue":"Pt 2","key":"key\n\t\t\t\t20170522101749_B28","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/brain\/awh706","article-title":"Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury","volume":"129","author":"Logan","year":"2006","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522101749_B29","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nprot.2007.135","article-title":"A protocol for rapid generation of recombinant adenoviruses using the AdEasy system","volume":"2","author":"Luo","year":"2007","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20170522101749_B30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1175737","article-title":"KLF family members regulate intrinsic axon regeneration ability","volume":"326","author":"Moore","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522101749_B31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.mcn.2009.03.002","article-title":"Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF","volume":"41","author":"Muller","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.mcn.2005.04.004","article-title":"A transcriptional role for C\/EBP beta in the neuronal response to axonal injury","volume":"29","author":"Nadeau","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B33","first-page":"5833","article-title":"Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand","volume":"61","author":"Naumann","year":"2011","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170522101749_B34","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522101749_B35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"issue":"Pt 10","key":"key\n\t\t\t\t20170522101749_B36","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/brain\/awn196","article-title":"BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity","volume":"131","author":"Planchamp","year":"2008","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522101749_B37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2004.06.005","article-title":"The AP-1 transcription factor c-Jun is required for efficient axonal regeneration","volume":"43","author":"Raivich","year":"2004","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522101749_B38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0169-328X(94)90116-3","article-title":"Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat","volume":"24","author":"Robinson","year":"1994","journal-title":"Brain Res Mol Brain Res"},{"key":"key\n\t\t\t\t20170522101749_B39","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jnr.22584","article-title":"Different spatial and temporal protein expressions of repulsive guidance molecule a and neogenin in the rat optic nerve after optic nerve crush with and without lens injury","volume":"89","author":"Schnichels","year":"2011","journal-title":"J Neurosci Res"},{"key":"key\n\t\t\t\t20170522101749_B40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/cdd.2008.175","article-title":"A p53-CBP\/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration","volume":"16","author":"Tedeschi","year":"2009","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170522101749_B41","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1083\/jcb.72.3.604","article-title":"Myelinogenesis in optic nerve. A morphological, autoradiographic, and biochemical analysis","volume":"72","author":"Tennekoon","year":"1977","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170522101749_B42","doi-asserted-by":"crossref","first-page":"24679","DOI":"10.1074\/jbc.M705066200","article-title":"C\/EBPbeta activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein\/P300","volume":"282","author":"Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522101749_B43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/nbdi.2000.0285","article-title":"Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo","volume":"7","author":"Weise","year":"2000","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20170522101749_B44","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","article-title":"HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention","volume":"26","author":"Yang","year":"2007","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170522101749_B45","doi-asserted-by":"crossref","first-page":"19587","DOI":"10.1073\/pnas.0907085106","article-title":"Oncomodulin links inflammation to optic nerve regeneration","volume":"106","author":"Yin","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170522101749_B46","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nn1701","article-title":"Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells","volume":"9","author":"Yin","year":"2006","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","volume":"7","author":"Yiu","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20170522101749_B48","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.conb.2003.09.006","article-title":"Signaling mechanisms of the myelin inhibitors of axon regeneration","volume":"13","author":"Yiu","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"key\n\t\t\t\t20170522101749_B49","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.exer.2008.03.020","article-title":"STAT3 activation protects retinal ganglion cell layer neurons in response to stress","volume":"86","author":"Zhang","year":"2008","journal-title":"Exp Eye Res"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/134\/7\/2134\/17346536\/awr142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:37:32Z","timestamp":1560332252000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/awr142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,23]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,6,23]]},"published-print":{"date-parts":[[2011,7]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awr142","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6,23]]}}}