{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:38:42Z","timestamp":1791250722484,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1093\/brain\/aws279","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T01:02:08Z","timestamp":1360198928000},"page":"e230-e230","source":"Crossref","is-referenced-by-count":155,"title":["Persistence of the treatment effect of idebenone in Leber\u2019s hereditary optic neuropathy"],"prefix":"10.1093","volume":"136","author":[{"given":"T.","family":"Klopstock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Yu-Wai-Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"B\u00fcchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gallenm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bailie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Nwali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. G.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"von Livonius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Reznicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Coppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Chinnery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"key\n\t\t\t\t20170405101931_aws279-B1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4321\/S0365-66912007000600012","article-title":"Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy","volume":"82","author":"Barnils","year":"2007","journal-title":"Arch Soc Esp Oftalmol"},{"key":"key\n\t\t\t\t20170405101931_aws279-B2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-510X(98)00239-1","article-title":"Leber's hereditary optic neuropathy (LHON) with 14484\/ND6 mutation in a North African patient","volume":"160","author":"Carelli","year":"1998","journal-title":"J Neurol Sci"},{"key":"key\n\t\t\t\t20170405101931_aws279-B3","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1093\/brain\/awr180","article-title":"Idebenone treatment in Leber's hereditary optic neuropathy","volume":"134","author":"Carelli","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170405101931_aws279-B4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/jnnp.71.6.813","article-title":"Leber's hereditary optic neuropathy (LHON\/11778) with myoclonus: report of two cases","volume":"71","author":"Carelli","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170405101931_aws279-B5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-510X(96)00311-5","article-title":"Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study","volume":"148","author":"Cortelli","year":"1997","journal-title":"J Neurol Sci"},{"key":"key\n\t\t\t\t20170405101931_aws279-B6","doi-asserted-by":"crossref","first-page":"e17963","DOI":"10.1371\/journal.pone.0017963","article-title":"NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels","volume":"6","author":"Haefeli","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170405101931_aws279-B7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0042-6989(97)00444-6","article-title":"Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve","volume":"38","author":"Howell","year":"1998","journal-title":"Vision Res"},{"key":"key\n\t\t\t\t20170405101931_aws279-B8","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/brain\/awr170","article-title":"A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy","volume":"134","author":"Klopstock","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170405101931_aws279-B9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0140-6736(92)91442-B","article-title":"Remission of Leber's hereditary optic neuropathy with idebenone","volume":"340","author":"Mashima","year":"1992","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170405101931_aws279-B10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00041327-200020030-00006","article-title":"Do idebenone and vitamin therapy shorten the time to achieve visual recovery in Leber hereditary optic neuropathy?","volume":"20","author":"Mashima","year":"2000","journal-title":"J Neuroophthalmol"},{"key":"key\n\t\t\t\t20170405101931_aws279-B11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/WNO.0b013e318241da45","article-title":"Is leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case","volume":"32","author":"Sabet-Peyman","year":"2012","journal-title":"J Neuroophthalmol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/136\/2\/e230\/11137140\/aws279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T16:11:35Z","timestamp":1503418295000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/aws279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,6]]},"published-print":{"date-parts":[[2013,2]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/aws279","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}