{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:31:48Z","timestamp":1792809108902,"version":"4.5.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1093\/brain\/aws292","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T14:42:28Z","timestamp":1355841748000},"page":"3584-3598","source":"Crossref","is-referenced-by-count":85,"title":["Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy"],"prefix":"10.1093","volume":"135","author":[{"given":"Jone","family":"L\u00f3pez-Erauskin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Galino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Fourcade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni L.","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidre","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mu\u00f1oz-Pinedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"key\n\t\t\t\t20170522100753_aws292-B1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2009.01.012","article-title":"Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation","volume":"9","author":"Acin-Perez","year":"2009","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20170522100753_aws292-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2012.03.058","article-title":"Evidence of oxidative stress in very long chain fatty acid - Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins","volume":"213","author":"Baarine","year":"2012","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170522100753_aws292-B3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuro.2011.10.007","article-title":"Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes","volume":"33","author":"Baarine","year":"2012","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170522100753_aws292-B4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522100753_aws292-B5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1523\/JNEUROSCI.4065-10.2011","article-title":"Axonal degeneration is mediated by the mitochondrial permeability transition pore","volume":"31","author":"Barrientos","year":"2011","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522100753_aws292-B6","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1471-4159.1990.tb03128.x","article-title":"Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A","volume":"55","author":"Begley","year":"1990","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B7","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1742-4658.2006.05213.x","article-title":"The mitochondrial permeability transition from in vitro artifact to disease target","volume":"273","author":"Bernardi","year":"2006","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20170522100753_aws292-B8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncb0511-521","article-title":"Mitochondria unite to survive","volume":"13","author":"Blackstone","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B9","doi-asserted-by":"crossref","first-page":"11658","DOI":"10.1074\/jbc.M510303200","article-title":"Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria","volume":"281","author":"Brown","year":"2006","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/ars.2009.2788","article-title":"Potential therapeutic benefits of strategies directed to mitochondria","volume":"13","author":"Camara","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170522100753_aws292-B11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3020321","article-title":"Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel","volume":"302 (Pt 2)","author":"Connern","year":"1994","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170522100753_aws292-B12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0300-9084(02)01368-8","article-title":"Mitochondrial intermembrane junctional complexes and their involvement in cell death","volume":"84","author":"Crompton","year":"2002","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170522100753_aws292-B13","first-page":"357","article-title":"Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress","volume":"255","author":"Crompton","year":"1988","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170522100753_aws292-B14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat Chem Biol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer\u2019s disease","volume":"14","author":"Du","year":"2008","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170522100753_aws292-B16","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neurobiolaging.2009.03.003","article-title":"Cyclophilin D deficiency improves mitochondrial function and learning\/memory in aging Alzheimer disease mouse model","volume":"32","author":"Du","year":"2011","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20170522100753_aws292-B17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2009.07.005","article-title":"Mitochondrial permeability transition pore in Alzheimer\u2019s disease: cyclophilin D and amyloid beta","volume":"1802","author":"Du","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170522100753_aws292-B18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2174\/187152710791556113","article-title":"Oxidative stress and altered mitochondrial function in neurodegenerative diseases: lessons from mouse models","volume":"9","author":"Fernandez-Checa","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"key\n\t\t\t\t20170522100753_aws292-B19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1750-3639.2010.00390.x","article-title":"General aspects and neuropathology of X-linked adrenoleukodystrophy","volume":"20","author":"Ferrer","year":"2010","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<829::AID-JNR19>3.0.CO;2-W","article-title":"Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice","volume":"50","author":"Forss-Petter","year":"1997","journal-title":"J.Neurosci Res"},{"key":"key\n\t\t\t\t20170522100753_aws292-B21","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1073\/pnas.0702228104","article-title":"Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis","volume":"104","author":"Forte","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170522100753_aws292-B22","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/hmg\/ddn085","article-title":"Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy","volume":"17","author":"Fourcade","year":"2008","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170522100753_aws292-B23","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1523\/JNEUROSCI.18-14-05151.1998","article-title":"Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death","volume":"18","author":"Friberg","year":"1998","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170522100753_aws292-B24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.bbadis.2012.02.005","article-title":"Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?","volume":"1822","author":"Galea","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170522100753_aws292-B25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1089\/ars.2010.3877","article-title":"Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of x-adrenoleukodystrophy","volume":"15","author":"Galino","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170522100753_aws292-B26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2009.02.013","article-title":"PINK1-associated Parkinson\u2019s disease is caused by neuronal vulnerability to calcium-induced cell death","volume":"33","author":"Gandhi","year":"2009","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20170522100753_aws292-B27","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1074\/jbc.M210285200","article-title":"Leber\u2019s hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium","volume":"278","author":"Ghelli","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B28","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/jnen\/59.12.1063","article-title":"Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy","volume":"59","author":"Gilg","year":"2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B29","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.freeradbiomed.2011.09.017","article-title":"Sulforaphane inhibits mitochondrial permeability transition and oxidative stress","volume":"51","author":"Greco","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t20170522100753_aws292-B30","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/434578a","article-title":"Biochemistry: a pore way to die","volume":"434","author":"Halestrap","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522100753_aws292-B31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1042\/BST0340232","article-title":"Calcium, mitochondria and reperfusion injury: a pore way to die","volume":"34","author":"Halestrap","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"key\n\t\t\t\t20170522100753_aws292-B32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What is the mitochondrial permeability transition pore?","volume":"46","author":"Halestrap","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj2680153","article-title":"Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase","volume":"268","author":"Halestrap","year":"1990","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170522100753_aws292-B34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170522100753_aws292-B35","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s11064-007-9466-y","article-title":"Effect of chronic N-acetyl cysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum","volume":"33","author":"Harvey","year":"2008","journal-title":"Neurochem Res"},{"key":"key\n\t\t\t\t20170522100753_aws292-B36","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1002\/j.1460-2075.1996.tb00755.x","article-title":"The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae","volume":"15","author":"Hettema","year":"1996","journal-title":"Embo J"},{"key":"key\n\t\t\t\t20170522100753_aws292-B37","doi-asserted-by":"crossref","first-page":"13155","DOI":"10.1074\/jbc.271.22.13155","article-title":"Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber\u2019s hereditary optic neuropathy","volume":"271","author":"Hofhaus","year":"1996","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/cyto.a.21017","article-title":"Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis","volume":"79","author":"Kahn","year":"2011","journal-title":"Cytometry A"},{"key":"key\n\t\t\t\t20170522100753_aws292-B39","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3171\/jns.2004.101.1.0128","article-title":"Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis","volume":"101","author":"Karlsson","year":"2004","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20170522100753_aws292-B40","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00702-011-0607-8","article-title":"Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer\u2019s disease","volume":"118","author":"Lassmann","year":"2011","journal-title":"J Neural Transm"},{"key":"key\n\t\t\t\t20170522100753_aws292-B41","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0891-5849(00)00366-X","article-title":"Hydrogen peroxide inhibits activation, not activity, of cellular caspase-3 in vivo","volume":"29","author":"Lee","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t20170522100753_aws292-B42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522100753_aws292-B43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.abb.2009.09.002","article-title":"Redox characterization of human cyclophilin D: identification of a new mammalian mitochondrial redox sensor?","volume":"491","author":"Linard","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20170522100753_aws292-B44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/cyto.990210308","article-title":"Kinetics of plasma membrane and mitochondrial alterations in cells undergoing apoptosis","volume":"21","author":"Lizard","year":"1995","journal-title":"Cytometry"},{"key":"key\n\t\t\t\t20170522100753_aws292-B45","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.bbamcr.2010.12.008","article-title":"Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion","volume":"1813","author":"Loor","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170522100753_aws292-B46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ana.22363","article-title":"Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy","volume":"70","author":"Lopez-Erauskin","year":"2011","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B47","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1073\/pnas.94.17.9366","article-title":"A mouse model for X-linked adrenoleukodystrophy","volume":"94","author":"Lu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170522100753_aws292-B48","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer\u2019s disease neurons","volume":"20 (Suppl 2)","author":"Manczak","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20170522100753_aws292-B49","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbadis.2009.07.009","article-title":"The mitochondrial permeability transition pore: a molecular target for amyotrophic lateral sclerosis therapy","volume":"1802","author":"Martin","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170522100753_aws292-B50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.expneurol.2009.02.015","article-title":"The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice","volume":"218","author":"Martin","year":"2009","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1750-3639.2009.00326.x","article-title":"Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates","volume":"20","author":"Martinez","year":"2010","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B52","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1073\/pnas.92.14.6319","article-title":"Cyclophilin catalyzes protein folding in yeast mitochondria","volume":"92","author":"Matouschek","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170522100753_aws292-B53","first-page":"3257","article-title":"X-linked adrenoleukodystrophy","volume-title":"The metabolic and molecular bases of inherited disease","author":"Moser","year":"2001"},{"key":"key\n\t\t\t\t20170522100753_aws292-B54","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522100753_aws292-B55","doi-asserted-by":"crossref","first-page":"40184","DOI":"10.1074\/jbc.M111.243469","article-title":"Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore","volume":"286","author":"Nguyen","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.arr.2007.06.002","article-title":"Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity","volume":"6","author":"Pamplona","year":"2007","journal-title":"Ageing Res Rev"},{"key":"key\n\t\t\t\t20170522100753_aws292-B57","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1016\/S0021-9258(19)89437-1","article-title":"The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents","volume":"269","author":"Petronilli","year":"1994","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B58","doi-asserted-by":"crossref","first-page":"H1487","DOI":"10.1152\/ajpheart.00163.2009","article-title":"Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening","volume":"297","author":"Petrosillo","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B59","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00401-004-0961-9","article-title":"Adreno-leukodystrophy: a personal historical note","volume":"109","author":"Powers","year":"2005","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/jnen\/59.2.89","article-title":"Adrenomyeloneuropathy: a neuropathologic review featuring its noninflammatory myelopathy","volume":"59","author":"Powers","year":"2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B61","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1196\/annals.1427.010","article-title":"Evidence of oxidative stress in Alzheimer\u2019s disease brain and antioxidant therapy: lights and shadows","volume":"1147","author":"Pratico","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170522100753_aws292-B62","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/hmg\/ddh323","article-title":"Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy","volume":"13","author":"Pujol","year":"2004","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170522100753_aws292-B63","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/hmg\/11.5.499","article-title":"Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy","volume":"11","author":"Pujol","year":"2002","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170522100753_aws292-B64","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0885-4505(92)90056-5","article-title":"Nonviability of cells with oxidative defects in galactose medium: a screening test for affected patient fibroblasts","volume":"48","author":"Robinson","year":"1992","journal-title":"Biochem Med Metab Biol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B65","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/abio.1998.2932","article-title":"Determination of protein carbonyl groups by immunoblotting","volume":"266","author":"Robinson","year":"1999","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B66","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.0505294102","article-title":"Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia","volume":"102","author":"Schinzel","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170522100753_aws292-B67","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/hmg\/ddr536","article-title":"Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy","volume":"21","author":"Schluter","year":"2012","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170522100753_aws292-B68","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3858\/emm.2009.41.4.030","article-title":"Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells","volume":"41","author":"Seo","year":"2009","journal-title":"Exp Mol Med"},{"key":"key\n\t\t\t\t20170522100753_aws292-B69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbadis.2009.08.012","article-title":"Mitochondrial dysfunction in amyotrophic lateral sclerosis","volume":"1802","author":"Shi","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170522100753_aws292-B70","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington\u2019s disease: implications for selective neuronal damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170522100753_aws292-B71","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1750-3639.2010.00392.x","article-title":"Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis","volume":"20","author":"Singh","year":"2010","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20170522100753_aws292-B72","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1196\/annals.1427.008","article-title":"Evidence of oxidant damage in Huntington\u2019s disease: translational strategies using antioxidants","volume":"1147","author":"Stack","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170522100753_aws292-B73","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11910-009-0060-3","article-title":"Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis","volume":"9","author":"Su","year":"2009","journal-title":"Curr Neurol Neurosci Rep"},{"key":"key\n\t\t\t\t20170522100753_aws292-B74","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/ars.2010.3849","article-title":"Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson\u2019s disease","volume":"16","author":"Thomas","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170522100753_aws292-B75","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1096\/fj.08-110866","article-title":"The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters","volume":"22","author":"van Roermund","year":"2008","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170522100753_aws292-B76","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1089\/ars.2011.4313","article-title":"Redox sensing by proteins: oxidative modifications on cysteines and the consequent events","volume":"16","author":"Wang","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170522100753_aws292-B77","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/sj.cdd.4401682","article-title":"Mitochondrial permeability transition in apoptosis and necrosis","volume":"12 (Suppl 2)","author":"Zamzami","year":"2005","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170522100753_aws292-B78","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1196\/annals.1427.023","article-title":"Oxidative stress in Parkinson\u2019s disease: a mechanism of pathogenic and therapeutic significance","volume":"1147","author":"Zhou","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170522100753_aws292-B79","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1074\/jbc.M109.041319","article-title":"Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis","volume":"285","author":"Zhou","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170522100753_aws292-B80","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/cvr\/cvp151","article-title":"Regulation and pharmacology of the mitochondrial permeability transition pore","volume":"83","author":"Zorov","year":"2009","journal-title":"Cardiovasc Res"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/135\/12\/3584\/17347367\/aws292.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T17:09:05Z","timestamp":1643908145000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article-lookup\/doi\/10.1093\/brain\/aws292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":80,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,14]]},"published-print":{"date-parts":[[2012,12]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/aws292","relation":{},"ISSN":["1460-2156","0006-8950"],"issn-type":[{"value":"1460-2156","type":"electronic"},{"value":"0006-8950","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}